Heart Rate Variability In Patients Research Articles

Spectral analysis of heart rate variability in patients with newly diagnosed atrial fibrillation

Spectral analysis of heart rate variability gives an idea of the role of the autonomic nervous system in the regulation of chronotropic heart function and can be used to evaluate the effectiveness of drug therapy. The selection of drug therapy taking into account the individual clinical form of atrial fibrillation, as well as the vegetative status of the patient, will undoubtedly increase the effectiveness of treatment. In this study, spectral parameters were studied in patients with newly diagnosed atrial fibrillation and the effect of the antiarrhythmic drug class III miodarone on these parameters.

208. Heart Rate Variability in Patients With Treatment-Resistant Depression During Ketamine Infusion

208. Heart Rate Variability in Patients With Treatment-Resistant Depression During Ketamine Infusion

Effect of Piracetam and Iron Treatment on Heart Rate Variability in Patients With Breath-Holding Spell

BackgroundBreath-holding spells are a benign condition primarily seen in 3% to 5% of healthy children aged between six months and five years. Although no specific treatment is recommended due to its benign nature, iron and piracetam are used in severe or recurrent cases. We planned to compare the heart rate variability (HRV) before and after treatment with 24-hour Holter monitoring in patients receiving iron and piracetam treatment and investigate the treatment's effectiveness. MethodsTwenty-five patients who applied to the outpatient clinic between 2013 and 2015 due to breath-holding spells were included in the study. The patients who received piracetam and iron therapy and underwent 24-hour rhythm Holter monitoring were evaluated retrospectively. ResultsFourteen (56%) of these patients were evaluated as having cyanotic-type and 11 (44%) patients were assessed as having pale-type breath-holding spells. A significant difference was found only between hourly peak heart rate and total power in the group receiving iron treatment. Significant differences were also found among the minimum heart rate, mean heart rate, the standard deviation of RR intervals, the mean square root of the sum of the squares of their difference between adjacent RR intervals, spectpow, and low frequency before and after the treatment in the patients who started piracetam treatment (P < 0.05). ConclusionsOur study is critical as it is the first to investigate the effects of treatment options on various HRV in patients with breath-holding spells. There were statistically significant changes in HRV parameters in patients receiving piracetam, and the number of attacks decreased significantly. Piracetam treatment contributes positively to the breath-holding spell with regard to efficacy and HRV, therefore it can be used to treat breath-holding spells.

Effect of needling at an acupuncture point zusanli (ST-36) on blood pressure and heart rate variability in patients with hypertension: A randomized placebo-controlled study

BackgroundAcupuncture is a traditional healing system used to prevent and treat hypertension in many countries. Acupuncture point “Zusanli (ST-36)” is used to nourish blood and yin. However, no known studies reported the effect of needling at only ST-36 on cardiovascular parameters. ObjectivesThis study was performed to find the effectiveness of ST-36 on blood pressure (BP) and heart rate variability (HRV) in patients with hypertension. MethodsA total of 100 participants with primary hypertension aged between 30 years and70 years were randomly assigned into either acupuncture group (AG) or control group (CG). AG underwent only one session of bilateral needling at ST-36 acupuncture point for duration of 20 minutes, while the CG underwent only one session of bilateral needling at non-acupuncture point for the same duration. ResultsResults of the study showed a significant reduction in systolic blood pressure, pulse pressure and mean arterial pressure in the AG compared to the CG. In addition, a significant increase in intervals between adjacent QRS complexes (R-R interval), and a significant reduction in heart rate were observed in AG, unlike CG. ConclusionsNeedling at ST-36 acupuncture point may improve cardiovascular function better than needling at non-acupuncture points in patients with hypertension.

Gender differences of heart rate variability in patients with ischemic stroke

Abstract: Background: Heart rate variability (HRV) is a parameter useful in monitoring post stroke cardiac dysautonomia. Our study is aimed at investigating HRV modifications in patients with stroke; (2) Methods: We investigated HRV parameters in 35 men and 35 women with stroke, data compared to 70 age and sex similar healthy subjects. We collected and interpreted HRV data related to resting state, deep breathing, and standing situations; (3) Results: The variables identified by classification methods to be discriminative in stroke groups for men and women classes are VLFms2, LFms2, LFnu, HFnu, and ApEn in resting state conditions, mean RR, HR, pNN50, VLFms2, LFnu, HFnu, ApEn and SampEn in deep breathing conditions, and mean RR, HR, HFnu, ApEn, and DFA1 in standing conditions; (4) Conclusions: Monitoring of HRV in patients who have suffered an ischemic stroke is essential, as it is known that stoke contributes to an increased risk of cardiac autonomic dysfunction and consequently to a second unwanted vascular event.

Effects of perioperative clinical hypnosis on heart rate variability in patients undergoing oncologic surgery: secondary outcomes of a randomized controlled trial.

Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU). After REB approval, trial registration and informed consent, 92 participants were randomized to receive CH (n = 45) or TAU (n = 47). CH participants received a CH session before surgery and during post-surgical in-hospital stay HRV was assessed during rest (5 min) and relaxation (10 min) before and 1-month after surgery. Pain intensity was obtained using a 0-10 numeric rating scale pre and post 1-week and 1-month post surgery. One month after surgery, HRV was significantly higher in CH group (n = 29) during rest and relaxation (both p < 0.05, d = 0.73) than TAU group (n = 28). By contrast, rest and relaxation HRV decreased from pre- to 1-month post-surgery for the TAU (both p < 0.001, d > 0.48) but not the CH group. Pain intensity increased from pre-surgery to 1-week post-surgery (p < 0.001, d = 0.50), and decreased from 1-week to 1-month post-surgery (p = 0.005, d = 0.21) for all participants. The results suggest that hypnosis prevents the deleterious effects of surgery on HRV by preserving pre-operative vagal activity. These findings underscore the potential of clinical hypnosis in mitigating the adverse effects of surgery on autonomic function and may have significant implications for enhancing post-surgical recovery and pain management strategies. ClinicalTrials.gov, identifier (NCT03730350).

Effect of pranayama on pulmonary functions and heart rate variability in patients with mild-to-moderate persistent bronchial asthma

Background: The global burden of bronchial asthma is on the rise. Asthma is a disorder of airflow obstruction associated with deranged pulmonary functions and autonomic imbalance. Though past studies have shown the beneficial effects of various asanas and breathing exercises in bronchial asthma, the role of such non-pharmacological alternative modalities in reducing morbidity and financial burden in patients is far from clear. Aims and Objectives: To assess the effect of Pranayama techniques on pulmonary functions and heart rate variability parameters in bronchial asthma patients. Materials and Methods: In our present study, we have recruited patients with mild-to-moderate bronchial asthma after taking written and informed consent. These patients were then asked to perform three pranayama techniques, namely Suryanadi, Bhastrika, and Kapalabhati pranayama, for 30 min a day, 3 days a week, for up to 4 weeks. Pulmonary function test parameters (forced vital capacity [FVC], forced expiratory volume in 1st s [FEV1], FEV1/FVC, peak expiratory flow rate) and Autonomic function test parameters (Time domain: mean HR, mean RR, NN50, pNN50, SDNN; Frequency domain: very low frequency (LF), LF, LF/high frequency (HF) ratio, total power) were compared before and after the intervention using a paired t-test. Results: After the intervention, improvements were recorded in pulmonary functions. Furthermore, pranayama was found to cause a shift in the sympathovagal balance toward the parasympathetic system. However, the changes recorded were not statistically significant. This shows further research in this field is required with a larger sample size, which may yield statistically significant data. Conclusion: Thus, we conclude that pranayama can be a useful alternative therapy for reducing morbidity and mortality in bronchial asthma patients.

2型糖尿病患者血压昼夜节律变化与空腹血糖、心率变异性的相关性研究

2型糖尿病患者血压昼夜节律变化与空腹血糖、心率变异性的相关性研究

Chronic effect of resistant physical exercise on linear and nonlinear dynamics of heart rate variability in patients with type 2 diabetes mellitus

Introduction: Diabetes Mellitus (DM) can promote changes in the autonomic nervous system. Training with resistance exercise can contribute to the decrease of the glycemic level and improve the neural control of the heart. Objective: to verify the effects of resistance exercise training (RT) on linear and non-linear dynamics of autonomic heart rate (HR) modulation in patients with DM2. Methods: Eight patients with DM2 were studied. The R-R intervals of the HR were recorded in the supine resting condition and HRV was analyzed by linear and non-linear method. RT was performed for 12 weeks, with 60% 1RM, 5 exercises for large muscle groups. Results: data variations between post-RT and initial ones did not show statistical difference (p&gt;0.05) in HRV calculated both by linear and non-linear methods. Conclusion: 12 weeks of moderate RT does not promote positive effects on HRV in patients with T2DM.

Stress Response Pattern of Heart Rate Variability in Patients with Functional Somatic Syndromes.

Functional somatic syndromes (FSSs) represent a clinically important group of disorders that are often stress-related. Their autonomic pathophysiology, including reduced heart rate variability (HRV), has been reported. However, the response pattern to mental stress and recovery in FSSs remains unclear. Thus, we aimed to clarify the pattern of autonomic stress response and recovery to mental arithmetic stress in patients with FSS compared to that in healthy controls. This cross-sectional study included 79 patients with FSS who visited the Department of Psychosomatic Medicine at a university hospital in Japan and 39 healthy controls. Following a mood questionnaire and obtaining epidemiologic information, HRV was measured during three periods (5 min each): relaxation baseline resting, stress (mental arithmetic task), and post-stress recovery period. The HRV analysis included inter-beat interval, low frequency power, and high frequency power. Compared to healthy controls, patients with FSS exhibited significantly higher scores on the mood questionnaire, prolonged duration of illness, and decreased functionality in daily activities. While the healthy control group showed a pronounced stress response pattern with a significant decrease in vagal HRV and recovery, the FSS group showed a "flat" vagal stress response pattern, and the HRV in the FSS group was lower at relaxation baseline, remained low during the stress, and did not change post stress. Patients with severe FSS exhibit an altered stress response pattern. Our results could provide significant clues for the diagnosis and treatment of such patients, as well as useful insights into the relationship between stress and illness.

The peculiarities of changes in myocardial electrical activity and heart rate variability in patients with coronary artery disease depending on the stage of concomitant iron deficiency

The aim of the study: to assess changes in myocardial electrical activity and heart rate variability (HRV) in patients with coronary artery disease (CAD) depending on the stage of iron deficiency (ID) and identify their relationship with ferrokinetic parameters. Materials and methods. In total, 90 patients with CAD, stable angina II–III FC were examined (men – 35, women – 55, age – 69 (61; 72) years). The patients were divided into 4 groups: the 1st group (n = 16) consisted of patients with concomitant ID anemia (IDA) of mild and moderate severity, the 2nd (n = 15) – with latent ID, the 3rd (n = 14) – with functional ID, the 4th (n = 45) – patients with CAD without iron metabolism disorders. The HRV features during 24 hours, daytime and nighttime as well as their relationships with ferrokinetic and hematological parameters were analyzed. The data analysis was performed using Statistica 13.0. Results. CAD patients with concomitant IDA demonstrated a tendency to have a higher average daytime heart rate value (U = 14.0; p ≈ 0.08), a longer duration of tachycardia (U = 20.0; p ≈ 0.06), and a significantly greater number (2.4 times) of ventricular extrasystoles (VE) (U = 7.0; p &lt; 0.05) compared to patients without iron metabolism disorders. There were no statistically significant differences in heart rate, episodes of tachycardia, and the number of arrhythmic events in CAD patients with different stages of ID. During the temporal analysis of HRV indicators, patients with different stages of concomitant ID demonstrated a decrease in overall HRV due to SDNN-index, rMSSD (%) and HRVT triangular index both in active and passive periods as compared to patients without iron metabolism disorders. Spectral analysis of HRV has revealed reduced parasympathetic activity of the autonomic nervous system due to HF indicator in patients of the 1st–3rd groups. The presence of concomitant IDA was characterized by maximum changes in HRV indicators and the predominance of central mechanisms of HRV regulation over autonomic ones, which was confirmed by a significant increase in the centralization index (IC) and stress index (SI). For CAD patients with concomitant IDA and latent ID, a number of relationships between ferrokinetic and HRV parameters was found. There were no statistically significant correlations between indicators of iron metabolism and HRV in patients with CAD and functional ID. Conclusions. The decrease in iron stores in the body due to its tissue and transport reserves is accompanied by changes in the myocardial electrical activity, a progressive reduction in heart rate variability, autonomic dysfunction towards a suppression of the parasympathetic domain activity, confirming the relevant correlations with the ferrokinetic parameters.

P204: Heart rate variability in patients with dementia or neurocognitive disorders: A systematic review and meta-analysis

Objective:Heart rate variability (HRV), a quantitative measure of mainly parasympathetic activity, has been applied in evaluating many types of psychiatric and neurological disorders, including dementia (or neurocognitive disorders). However, although dementia patients often showed significantly lower HRV (various indices) than healthy controls, and different types of dementia had distinct HRV features, the results were not identical across studies. We designed a systematic review and meta-analysis for incorporating data from different studies.Methods:We gathered studies comparing HRV in patients with dementia and in healthy controls. HRV was analysed in several ways: parasympathetic function in hierarchical order (main analysis); total variability; comparison of HRV between different subtypes of dementia; specific indices of HRV; HRV reactivity.Results:In initial search, we found 3425 relevant articles; 24 studies with a total of 1107 dementia patients and 1017 control participants finally entered the meta-analysis. The dementia patients had a significantly lower resting HRV for parasympathetic function (Hedges’g=−0.3596, p=0.0002) and total variability (Hedges’g=−0.3059, p=0.0002) than the controls. For diagnostic subgroup analysis relative to the controls, HRV was significantly lower in mild cognitive impairment (MCI) patients (Hedges’g=−0.3060) and in patients with dementia with Lewy bodies (DLB) (Hedges’g=−1.4154, p&lt;0.0001). Relative to patients with Alzheimer’s disease, HRV in patients with DLB was significantly lower (Hedges’g=−1.5465, p=0.0381). Meta-regression revealed that gender proportion was significantly associated with effect size.Conclusion:Our results support that dementia (especially DLB and MCI) patients to have lower parasympathetic activity than health people. The influence of gender on the results should be carefully interpreted.

Impact of comorbidities on heart rate variability in patients with high cardiovascular risk

Abstract Introduction Heart rate variability (HRV) measures the variation in time intervals between successive heartbeats (RR intervals) and is considered a measure of a healthy regulatory system. It is influenced by a variety of factors, including age and comorbidities. We estimate temporal HRV metrics, such as the standard deviation of RR intervals (SDNN), and frequency metrics, such as the normalized high frequency component of the RR intervals (HFNU), to identify which were best for characterizing inter-individual differences by age, gender, and health status. Purpose Understand inter-individual differences in HRV and the influence of age, gender, and available comorbidities. Methods Data from at least one 2-week single-lead ECG were obtained from the 1,742 participants of the trial. Inclusion criteria for the study are defined as follows: age of 75 years or older, or a male older than age 55 years or female older than 65 years with 1 or more comorbidities that are risk factors for cardiovascular diseases. We adopted a linear regression method, where each HRV measure constitutes the outcome of a separate model, while the demographic characteristics (age and gender), the heart rate (HR), and the presence of comorbidities (yes/no for each comorbidity) are used as predictor variables. Age has been evaluated as a quadratic term to assess non-linearity of the association, and an age-gender interaction term has also been evaluated. Coefficients are expressed in terms of standard deviations, allowing for a direct comparison between metrics with different scales and variability. The HRV metrics are evaluated every 5 minutes, then the average value over a 1-day period is considered as input for the model. Results Temporal HRV metrics were lower among women compared with men and increased with age. They were higher in the presence of many disease states, including chronic heart failure (CHF), obesity (OBE), chronic obstructive pulmonary disease (COP), and sleep apnea (SA), but were lower among those with history of myocardial infarction (MI), chronic renal failure (CRF), and use of beta blocker medications (BB). There was no significant association of these metrics with hypertension or diabetes. For frequency metrics, analysis was limited to HFNU due to the high correlations among these measures. HFNU had strong positive associations with all co-morbidities except stroke, with particularly large coefficients for CHF, COP, and MI. HFNU values were also higher among subjects taking beta blockers. (Figure) Conclusion HRV can be an indicator of autonomic nervous system (ANS) dysfunction, which is often present in many diseases. By measuring HRV, clinicians can gain insights into the state of the ANS and potentially identify early warning signs of disease progression or complications.HRV and comorbidities

The effect of amiodarone on the spectral parameters of heart rate variability in patients with various forms of atrial fibrillation

In this study, spectral parameters in patients with various forms of atrial fibrillation and the effect of the class III antiarrhythmic drug amiodarone on these parameters were studied. The use of spectral analysis of heart rate variability (hereinafter referred to as HRV) when choosing a drug for the treatment of arrhythmia and arterial hypertension is becoming increasingly widespread in experimental and clinical practice. This method, thanks to the mathematical analysis of the time and frequency characteristics of heart rate variability, allows you to get an idea of slow oscillatory processes that constantly exist in the body and have the properties of autowaves. The use of this method gives an idea of the role of various departments of the autonomic nervous system (sympathetic and parasympathetic), as well as the implementation of humoral mechanisms in the implementation of the chronotropic function of the heart.

Assessing Heart Rate Variability in Patients with CKD: Association with Vascular Dysfunction

Assessing Heart Rate Variability in Patients with CKD: Association with Vascular Dysfunction

Immediate and Intermediate-Term Effects of Disease Mitigation Measures on Activity Levels as Measured by Implantable Cardiac Devices.

Routine activities of daily living are known to effect overall wellbeing, cardiovascular health, and quality of life. A decrease in daily activity level is recognized as a contributing factor to increasing rates of obesity and a decline in overall health. This study sought to evaluate the effect of disease mitigation strategies on activity level by evaluating changes in recorded cardiac parameters as measured by implantable cardiac devices for a period of time prior to and following implementation of COVID-19 mitigation efforts in Arizona. A retrospective cohort study of cardiac device data from January 1, 2019-December 31, 2020 was performed. Linear mixed-effects models with restricted maximum likelihood estimation were utilized to test for the fixed effects of Year, day, and the interaction between them. A significant decrease in daily activity minutes, daytime heart rates, and heart rate variability coincident with the initiation of disease mitigation strategies was observed. An increase in nighttime heart rates also coincided with initiation of disease mitigation strategies. These effects were noted to persist through the end of the study period. Implementation of statewide disease mitigation strategies resulted in both immediate and intermediate-term effects on activity levels, day and nighttime heart rates trends, and heart rate variability in patients with implanted cardiac devices. These data may serve useful in counseling patients regarding the importance of activity, movement, and exercise to routine health and encourage a return to pre-pandemic levels of activity.

Effectiveness of Cold Spinal Spray on Blood Pressure and Heart Rate Variability in Patients with Hypertension—A Randomized Controlled Trial

Background: The application of cold to the spine is documented as favourable for reducing blood pressure in patients with hypertension (HTN). However, hydriatic application in the form of a cold spinal spray (CSS) has not yet been explored.Objective: To find the effectiveness of CSS on cardio autonomic variables among males with HTN. Methods: One hundred male patients with HTN visiting the outpatient service were included in this randomized controlled trial. A single session of CSS (15°C–19°C) was given to 50 patients for a period of 20 minutes for the study group, and the control group was made to lie down on the spinal spray tub for 20 minutes without any intervention. Baseline blood pressure and short-term heart rate variability (HRV) measurements were obtained prior to the intervention, followed by a subsequent assessment after a 20-minute interval for both groups. Results: Following 20 minutes of CSS a significant decrease was observed in systolic blood pressure (136.48±14.15 mmHg to 126.20±13.18 mmHg, p&lt;0.001), diastolic blood pressure (87.96±6.77 mmHg to 84.06±6.84 mmHg, p&lt;0.006), pulse pressure (48.44±11.99 mmHg to 42.08±10.88 mmHg, p&lt;0.007), and mean arterial pressure (104.09±8.12 mmHg to 98.05±7.88 mmHg, p&lt;0.001). No significant changes were noted in HRV variables in either of the two patient groups. Conclusion: The current study findings suggest that a single session of CSS intervention could lower both systolic &amp; diastolic blood pressure, pulse pressure and mean arterial pressure in male hypertensive patients. Further studies are needed to find the long-term effect of CSS among patients with HTN.

Heart rate variability in patients with acute ST-segment elevation myocardial infarction after COVID-19

Aim. To compare heart rate variability parameters in patients after a coronavirus disease 2019 (COVID-19) with acute ST elevation myocardial infarction (STEMI) during the inhospital and post-hospital periods.Material and methods. A total of 140 patients with STEMI were divided into 2 groups: I — patients with STEMI who had COVID-19 (n=52) in the period of 1,5-6 months before acute coronary syndrome, II — comparison group (n=88), which included patients with STEMI without prior COVID-19. All patients underwent infarct-related artery stenting within the first 24 hours from the onset. Heart rate variability (HRV) parameters were determined for all patients on days 2-3 and days 9-11 and 6 months after the hospitalization for STEMI.Results. Patients in group I showed more pronounced changes in HRV indicators on days 2-3 of STEMI: RMSSD (root square of successive RR intervals) by 21% (p=0,026), variations (Var) (the difference between the minimum and maximum RR intervals) by 33% (p=0,013), VLF (total very low-frequency HRV) by 7% (p=0,009) were higher, and HF (highfrequency HRV) by 40% (p=0,003), pNN50% (ratio of the number of consecutive RR interval pairs differing by &gt;50 ms to the total number of RR intervals) by 66% (p=0,038) were lower than in the control group, respectively. On days 9-11 of the disease in patients with a history of STEMI and COVID-19, in contrast to the control group, there was a more pronounced increase in the SDNN (standard deviation of RR intervals) by 46% (p=0,005), VLF by 42% (p=0,031), whereas in the control group there were an increase of only 22% (p=0,004) and 11% (p=0,022), respectively. The HF value in the main group increased by 25% (p=0,007), while in the control group it decreased by 19% (p=0,030). Six months after STEMI in the main group, the RMSSD decreased by 19% (p=0,009), Var by 16% (p=0,041), VLF by 30% (p=0,025), LF (low-frequency component HRV) by 11% (p=0,005), while the control group these parameters decreased by 20% (p=0,006), 21% (p=0,001), 9% (p=0,011), and 7% (p=0,016), respectively.Conclusion. In patients with STEMI and prior COVID-19, the initial HRV values differ from similar HRV parameters in patients with STEMI without prior COVID-19. In the hospital and post-hospital periods, the changes of HRV in patients with and without COVID-19 are multidirectional as follows: pronounced sympathetic hyperactivity predominates, and slower recovery of HRV in patients after COVID-19 predominates.

Comparative Study of Heart Rate Variability in Patients with Major Depressive Disorder and Normal Subjects

Introduction: Major Depressive Disorder is a mood disorder diagnosed on the basis of DSM-5 criteria. Cardiovascular disorders are among the most common causes of deaths worldwide, accounting for about one-third of the mortality in both genders. Cardiac illnesses seem to have a bidirectional relationship with depression. Altered cardiac autonomic tone remains one of the most plausible explanations, which also appears to be a central biological substrate linking depression to a number of concurrent physical (e.g., cardiovascular) dysfunctions. Heart Rate Variability has become the conventionally accepted term to describe variations of both instantaneous heart rate and RR intervals (measured in ms) obtained from ECG or plethysmogram. Material and Method: This study was a prospective observational study involved 150 individuals divided into two groups. Group A – Patients having first episode major depression or new recurrent depressive episode recruited from psychiatric OPD (n=75), Group B– Age, Sex, Height and Weight matched healthy controls (n=75). Results: In our study, among the time domain indices, Mean heart rate was increased in MDD patients in comparison to healthy controls and the difference was statistically significant. Root mean square of successive differences was reduced in MDD patients in comparison to healthy controls and the difference was statistically significant. Standard deviation of NN intervals and percentage of NN intervals differing by &gt;50 ms also showed reduction in depressed patients than controls, but the difference was not statistically significant. The frequency domain indices Total power, very low frequency, High frequency were reduced in MDD patients in comparison to healthy controls and the difference was statistically significant. Low Frequency and Low Frequency / High Frequency ratio were increased in patients of MDD in comparison to healthy controls and the difference was statistically significant. Conclusion: From our study we can conclude that HRV is reduced in MDD patients. We suggest that HRV parameters can be used as diagnostic or predictive biomarkers of depression. Keywords: Major Depressive Disorder (MDD), cardiovascular disease (CVD), Heart Rate Variability (HRV), Time Domain Indices, Frequency Domain Indices.

Effect of Radiofrequency Current Application during Catheter Ablation on Heart Rate Variability in Patients with Supraventricular Tachycardia

Abstract Background The autonomic nervous system has a significant regulatory effect on heart function; in addition to heart rate, cardiac conduction properties, hemodynamics, the cellular properties of cardiac myocytes, and cardiac arrhythmogenesis are also affected by the autonomic nervous system. Objectives In this study, we aimed to assess the Relationship between RF current application during Catheter ablation and it's effect on Heart Rate variability in patients undergoing RF catheter ablation for supraventricular Tachycardia. Patients and Methods This study is a cohort study, randomized clinical study, recruiting 20 patients from Ain Shams University hospitals, Cairo, Egypt. All patients were symptomatic with drug refractory documented supraventricular tachycardias. who underwent RF ablation March 2020 till February 2021 and were followed up for 1 month after the procedure. Results Compared with preablation data, HRV were shorter in all the RFA at the follow-up assessment. The 24-h Holter monitoring showed that mean and maximal HR were increased, whereas the HRV parameters, including time domain indices (SDNN, rMSSD) and frequency domain index, which reflect the attenuation of parasympathetic tone, were decreased in the RFA during the postablation period. In this study, there was significant increasing in mean heart rate regarding basal and the subsequent follow up after 1 week and 1 month. Post ablation high sinus rate (PA-HSR) was defined as an increase in resting sinus rate &amp;gt; or = 20 bpm or a resting sinus rate &amp;gt; or = 92 bpm without physiological or hemodynamic causes. In this study PAHSR was found in 10 patients (50%) by month-1 follow up. There is relation between the target site of RF ablation and the difference of HRV parameters. Conclusion Cardiac autonomic dysfunction assessed by changes in time domain and frequency domain heart rate variability parameters persisted for 1 month after radiofrequency ablation. Parasympathetic denervation may be one mechanism of Post ablation high sinus rate.