Children's Health Risk Assessment Research Articles

HPLC-MS/MS monitoring and health risk assessment of carbosulfan and its metabolites in date palm fruit (Phoenix dactylifera).

This study investigated residual levels of carbosulfan and its metabolites in date palm fruit in the UAE using HPLC-MS/MS and QuEChERS method. The method demonstrated excellent linearity (R2 > 0.998), low LOD (0.001-0.04 μg/kg) and LOQ (0.003-0.1 μg/kg), and high recoveries (92-103%) with low RSD values (1-9%). The matrix effect was negligible (-16.43-17.09%), and uncertainty measurements did not exceed the 50% limit. Carbosulfan was present in all samples, exceeding its MRL in 46% of the samples. Carbofuran and 3-hydroxycarbofuran exceeded their MRL in 4.87% and 40% of the samples, respectively, while 3-ketocarbofuran levels were below the MRL. Dibutylamine was found in 82% of the samples, with an average concentration of 9.01µg/kg. The health risk assessment for children and adults showed that all HQ values were below the safety limit of 1.0, indicating that date consumption poses no adverse health risks for either adults or children.

Health Risk Assessment in Children Occupationally and Para-Occupationally Exposed to Benzene Using a Reverse-Translation PBPK Model

Health Risk Assessment in Children Occupationally and Para-Occupationally Exposed to Benzene Using a Reverse-Translation PBPK Model

Aflatoxin M1 Exposure and Health Risk Assessment in Children and Adults due to Pasteurized Milk Consumption in Addis Ababa, Ethiopia

Milk and dairy products stand as essential sources of nutrition across all age groups. However, the presence of Aflatoxin M1, particularly common and risky for young children, necessitates careful assessment of milk. This study, conducted in Addis Ababa, Ethiopia, aimed to evaluate the prevalence of Aflatoxin M1 using High-Performance Liquid Chromatography in pasteurized milk and assess associated health risks using deterministic techniques. The prevalence of Aflatoxin M1 in pasteurized milk was 56.6%, with Aflatoxin M1 levels ranging from 0 to 6.27 μg/L and a mean value of 1.237 μg/L. The risk assessment revealed substantial Aflatoxin M1 exposure risk from pasteurized milk consumption, as reflected by margin of exposure values <10,000, specifically 25.9, 109.6, and 380 for children aged 2–5, 6–9, and adults, respectively. The hazard index values for pasteurized milk consumers were 110, 26, and 7.5 for children aged 2–5, 6–9, and adults, respectively. Furthermore, cancer risk calculations yielded values of 0.18, 0.04, and 0.01 per 100,000 population for children aged 2–5, 6–9, and adults, respectively, with an average potency of 0.007978 cases per 100,000/yr ng Aflatoxin M1/kg bw/day. Notably, children aged 2–5 and 6–7 face elevated risks, whereas adults face relatively lower risks.

Heavy metal pollution status, children health risk assessment and source apportionment in farmland soils in a typical polluted area, Northwest China

Heavy metal pollution status, children health risk assessment and source apportionment in farmland soils in a typical polluted area, Northwest China

Research on Physical and Mental Health Risk Assessment of Relative Poverty Children

Background: The health of relatively poor children is a common concern of governments around the world. Family poverty has a huge impact on children's physical and health. Child health is the most important indicator of a child's growth and development. It is vital to adult health, socioeconomic status, and even lifelong achievement, and is the key to social harmony, stability, and prosperity. Subjects and Methods: But there is not much comment and summary on the latest research progress in this field. Therefore, this paper aims to provide support for the health risk assessment of relatively poor children, explore the internal mechanism of relatively poor children's health risk assessment, and study various factors that affect the growth of relatively poor children.Results: Through the experiment, the health gap between relatively poor children and non-relatively poor children was found. Therefore, people should pay attention to the healthy growth of children. Conclusions: Especially empirical research on the impact of relatively poor families on children's health, and research on the impact of parents on children's health in relatively poor environments; favorable health policy recommendations for promoting the health of relatively poor children, and new research directions and suggestions for promoting the health of relatively poor children.

Occurrence, toxicity load, pollution index and health risk assessment of trace elements in drinking water of two catchments in North-western Himalayas

ABSTRACT The study focuses on the analysis of trace metals in drinking water from the Ganderbal and Budgam districts of Jammu and Kashmir. We have used high-resolution inductively-coupled plasma mass spectrometry (HR-ICP-MS) to measure the concentrations of 31 trace metals in the water samples. The measured concentrations were then compared with the permissible limits set by the United States Environmental Protection Agency (USEPA), Bureau of Indian Standards (BIS), and World Health Organization (WHO). The results of the study indicate that arithmetic mean of several trace elements, including aluminum (Al = 781), chromium (Cr = 139), manganese (Mn = 41.86), nickel (Ni = 25.89), molybdenum (Mo = 1.30), cadmium (Cd = 36.86), and mercury (Hg = 67.65), in µg l−1 were found to have concentrations higher than their respective permissible limits. On the other hand, the arithmetic mean of elements, such as beryllium (Be = 0.14), boron (B = 32.72), iron (Fe = 233), cobalt (Co = 1.79), copper (Cu = 10.71), arsenic (As = 0.93), selenium (Se = 3.13), strontium (Sr = 257), zinc (Zn = 43), antimony (Sb = 1.44), barium (Ba = 28.56), gold (Au = 0.91), and lead (Pb = 0.91) in µg l−1, had concentrations below the permissible limits recommended by USEPA, BIS, and WHO. To assess the toxicity of the heavy metals in the study area, we calculated the Heavy Metal Toxicity Load (HMTL) for each metal. Based on these calculations, we concluded that only cadmium (Cd) and chromium (Cr) need to be removed from drinking water to ensure safety. The study also conducted a health risk assessment for children and adults based on the measured concentrations of heavy metals. The assessment considered the ingestion and dermal contact routes of exposure. The Hazard Index (HI), which indicates the non-carcinogenic health effects, exceeded unity for only one element, cadmium (Cd), in the children and adult groups. This suggests potential non-carcinogenic health risks associated with the ingestion of water and dermal contact. Additionally, the potential carcinogenic risk of cadmium (Cd) and arsenic (As) was identified and recommended for further attention. The study further evaluated the Heavy Metal Pollution Index (HPI) to assess the overall quality of drinking water in the study area. The HPI results indicated that the quality of drinking water was good, and the pollution levels in the study area were low. Overall, the findings of this study provide valuable information for water resource development and supply agencies. The results can be used as a baseline for future research and monitoring efforts in the region.

HEALTH RISKS ASSESSMENT OF HEAVY METALS FROM THE CONTAMINATED SOILS OF OKENE METROPOLIS, NORTH-CENTRAL, NIGERIA.

This study revealed the health risk associated with selected heavy metals (Mn, Cu, Zn, Cr, Co, Pb, Ni and Cd) in Okene Metropolis. Soil samples from workshops and other anthropogenic activities were collected and their heavy metal contents analyzed. The two pathways of exposure to heavy metals in soils are: ingestion and by dermal contact pathways. Children are the most susceptible part of the population and highly venerable to health risk Health risk assessment showed that the order of exposure was children > adults. This research revealed the health risk assessment for children and adults are less than 1 and therefore, heavy metals were not accessible to any health risks. Despite the lack of health risk at present, continuous activities from these workshops and other anthropogenic activities may likely lead to soil pollution in future. Therefore, it is recommended that there should be continuous monitoring of heavy metals in Okene Metropolis to ascertain the health risk associated with heavy metals.

Carcinogenic and human health risk assessment of children's and adults' exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia.

With global urbanization and industrialization, air pollution has become an inevitable problem. Among air pollutants, toxic metals bound to particulate matter (PM) have a high hazardous potential, contributing to the development of several diseases, including various types of cancer. Due to PM pollution, Serbia is considered to be among the most polluted countries in Europe. Therefore, the objective of the study was to assess and characterize the non-carcinogenic and carcinogenic risks of children's and adults' exposure to metal(oid)s (Pb, Cd, Ni, and As) bound to PM10 in five of the most polluted areas in the Republic of Serbia (Subotica, Smederevo, Bor, Valjevo, and Kraljevo). Non-carcinogenic (HQ and HI) and carcinogenic risk (CR) were calculated using USEPA methodology. Our results show that PM10 concentrations exceeded the annual limit of 40μg/m3 at four out of five monitoring sites (ranging from 44.33 to 63.25μg/m3). Results obtained from Bor monitoring station show that safe limits were exceeded for both children and adults, indicating an unacceptable risk (> 1) obtained for inhalation exposure to the As (HQ = 6.14) and Cd (HQ = 1.17), while total HI was 7.43, which characterized the risk as unacceptable. For the same station, the CR value was 1.44E-04 (> 1 × 10-4). In other sites, the risks were acceptable. The characterized risk from exposure to the toxic elements via PM10 in critical locations in Serbia contributes to improving air quality by requiring regulatory organs to take new actions and adopt new measures to reduce air pollution.

Characteristics of Soil Heavy Metal Pollution and Health Risk Assessment in Urban Parks at a Megacity of Central China

In this study, we compared the concentrations of the heavy metals Cd, Cr, Cu, Zn, Ni, and Pb in the surface soils of urban parks in Wuhan, Hubei Province, with those in the surface soils of urban parks worldwide. The soil contamination data were assessed using enrichment factors and spatial analysis of heavy metals using inverse distance weighting and quantitative analysis of heavy metal sources with a positive definite matrix factor (PMF) receptor model. Further, a probabilistic health risk assessment of children and adults using Monte Carlo simulation was performed. The average Cd, Cr, Cu, Zn, Ni, and Pb concentrations in the surface soils of urban parks were 2.52, 58.74, 31.39, 186.28, 27.00, and 34.89 mg·kg-1, respectively, which exceeded the average soil background values in Hubei. From the inverse distance spatial interpolation map, heavy metal contamination was primarily observed to be present to the southwest of the main urban area. The PMF model resolved four sources: mixed traffic and industrial emission, natural, agricultural, and traffic sources, with relative contributions of 23.9%, 19.3%, 23.4%, and 33.4%, respectively. The Monte Carlo health risk evaluation model demonstrated negligible noncancer risks for both adult and child populations, whereas the health effects of Cd and Cr on children were a concern for cancer risks.

Health Risk Assessment in Children Occupationally and Para-Occupationally Exposed to Benzene Using a Reverse-Translation PBPK Model.

Benzene is a known human carcinogen and one of the ten chemicals of major public health concern identified by the World Health Organization. Our objective was to evaluate benzene's carcinogenic and non-carcinogenic health risks (current and projected) in highly exposed children in Yucatan, Mexico. Benzene exposure was estimated through a reverse-translation, four-compartment, physiologically based pharmacokinetic model (PBPK) based on previously performed urine trans, trans-muconic acid (benzene metabolite) determinations. Using a risk assessment methodology, the carcinogenic and non-carcinogenic risks of benzene were estimated for 6-12-year-old children from a family of shoemakers. The children's hazard quotients for decreased lymphocyte count were 27 and 53 for 4 and 8 h/day exposure, respectively, and 37 for the projected 8 h/day exposure in adults. The risks of developing leukemia were 2-6 cases in 1000 children exposed 4 h/day; 4-10 cases in 1000 children exposed 8 h/day, and 2-9 cases in 1000 adults with an 8 h/day lifetime exposure. Children in Yucatan working in shoe-manufacturing workshops, or living next to them, are exposed to benzene concentrations above the reference concentration and have unacceptably high risks of presenting with non-carcinogenic and carcinogenic hematologic symptoms, now and in the future. Interventions to prevent further exposure and mitigate health risks are necessary.

Priority Polycyclic Aromatic Hydrocarbons and Heavy Metals in Urban Roadside Soils of Heavy-Traffic Density Areas in Ibadan, Nigeria: Levels, Sources and Health Risk Assessment

Priority polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) were investigated in heavy-traffic roadside soils in Ibadan, Nigeria to assess the level of contamination and human health risk. PAHs and HMs were analyzed using gas chromatography-mass spectrometry (GC-MS) and atomic absorption spectroscopy. The concentrations of ∑11PAHs were 263.2 ± 20.9 to 380.0 ± 23.8 µg kg–1, with a dominance of the higher molecular PAHs, and the soils can be classified as weakly contaminated. The most abundant PAH was fluoranthene. Also, five carcinogenic PAH were identified in the study. PAH diagnostic ratios suggested mixed pyrogenic and petrogenic sources. Roadside soil concentrations (mg kg−1) of Cd, Ni and Pb were 1.3 ± 1.2–5.3 ± 7.4, 15.0 ± 7.3–24.5 ± 4.8 and 41.6 ± 13.7–56.8 ± 8.3, respectively. Pollution indices revealed roadside soils were highly contaminated with Cd and Pb according to contamination factor and geoaccumulation index. Cd presented a considerable to high ecological risk. Health risk assessment for children and adults revealed soil ingestion was the main exposure pathway to metals. The hazard quotient (HQ) and health index (HI) were within the safe level (<1.0), although, HI values were higher for children. The cancer risk of exposure to Pb in roadside soils (1.18 E–06 to 1.61 E–06) was within safe limit (1.0 E–04 to 1.0 E–06). This study provides the basis for the reduction of anthropogenic emissions of PAHs and HMs.

Health Risk Assessment of Children Exposed to the Soil Containing Potentially Toxic Elements: A Case Study from Coal Mining Areas

Coal mine activities lead to the release of potentially toxic elements (PTEs) to the surrounding areas. The present study concerns the health risk caused due to the exposure of PTEs (Hg, As, Cd, Cr, and Pb) in the children residing in the areas around coal mines. The PTEs content and bioaccumulation coefficient (BAC) in the plant, viz., Albizia lebbeck and Madhuca longifolia growing on the nearby soils of the coal mine affected areas were also estimated. The results demonstrated that the hazard quotient (HQ) for Cr (0.211) in the roadside soil (RSS) was higher than other PTEs. The hazard index (HI) was also at the maximum in the RSS (0.553) followed by the core zone soil (0.541). In RSS, Cr contributed the maximum for the HI value (38%) which elucidated that Cr might cause health problem in the long term. The Cr concentration (5.49 mg kg−1) was also higher than other PTEs in the plant leaves of M. longifolia and was two-fold higher than A. lebbeck. Except Cd, the accumulation of other PTEs in the leaves of both the species were low, which could be due to their low availability in soils. The BAC for Cr in M longifolia was comparatively higher than A. lebbeck and was found at the maximum for Cd (0.29) in M longifolia. The outcomes of the study elucidated that although there is no severe health risk in children, the data indicated that the prolonged exposure to PTEs might lead to serious health issues.

Tin Concentrations and Human Health Risk Assessment for Children and Adults in Seafood and Canned Fish commonly consumed in Bayelsa State, Nigeria

Tin is a naturally occurring element in the environment, and the most important dietary intake is from tin-plates steel cans used for food packaging. The objective of this paper is to evaluate the tin concentrations and human health risk assessment of children and adults in seafood and canned fish (Sardine and Mackerel) obtained from Bayelsa State, Nigeria using the Thermo-Elemental Atomic Absorption Spectrometer (S4-71096 model) after mixed-acid digestion. Data obtained reveal tin concentrations (mean ± SD, mg/kg) in seafood in the order of fresh water fish (0.99 ± 0.07) salt water fish (0.98 ± 0.16) salt water–Blood Clam (0.75 0.022) fresh water- Clam (0.17 ± 0.12) fresh water-Prawn (0.06 ± 0.01) salt water shrimp (0.02 ± 0.01) respectively, tin concentrations in the brands of canned fish were significantly higher than the concentration in seafood (p &lt; 0.05). However, the mean concentrations of tin in the seafood and brands of canned fish were lower than the standard guideline limits set by regulatory bodies (200 mg/kg - 250 mg/kg). The health risk exposure assessment revealed that the values of all the samples were lower than the provisional maximum tolerable daily intake (PMTDI) of tin. The target hazard quotient (THQ) values of tin for both children and adults in all the samples were also lower than the reference dose (RfD). The health risk index (HRI) values of the seafood and the brands of canned fish for both children and adults were less than 1.0, which indicates that there are no adverse effects at the moment. However, the HRI values of the brands of canned fish were higher than the seafood for children and adults. Hence, assessment of tin in seafood and canned food could be periodically assessed by Nigerian food and drug regulatory organizations for efficient policy regulations.

A regional numerical environmental multimedia modeling approach to assess spatial Eco-Environmental exposure risk of perfluorooctane sulfonate (PFOS) in the Pearl river basin.

This paper presents a novel numerical environmental multimedia modeling system (RNEMM) for assessing the environmental fate of emerging organic contaminants and their relative health risk at a regional scale. The RNEMM is developed based on an integrated numerical algorithm that comprises four sub-models: a river network simulation module, a gaseous phase simulation module, a mass balance based simulation module for soil compartment, and a food web analysis module. This RNEMM has been applied to simulate the spatial distribution of PFOS and assess the consequent health risks for a central water basin region of the Pearl River in China. The study region includes the urban areas of Guangzhou, Foshan, and Dongguan Cities with emission sources of PFOS, which was detected in local water, sediments, and air environment. The spatial concentration distributions of PFOS in water, sediment, air, soil, and various fish species are examined based on RNEMM and compared with the measured data. With a focus on water environment, it shows that the simulated results essentially agree well with measured concentrations. Comparing the simulated results and the measured data collected in 2013, the relative errors are mostly less than 40 % in the surface water and sediment zones for this regional scale field study. Whereas the relative error in the atmosphere zone is less than 5%. In addition, the health risk assessment for children and adults is conducted based on the RNEMM approach. The hazard quotient (HQ) values for the 95th percentile in most subareas of the study region are higher than 0.1, showing a low-risk level for the study period. The results indicate that the RNEMM is a useful modeling tool to manage the environmental and health risks associated with emerging contaminants on regional air, water, soil, and ecosystem at an adequate spatial-temporal resolution.

The Intake of Phosphorus and Nitrites through Meat Products: A Health Risk Assessment of Children Aged 1 to 9 Years Old in Serbia

This study provides the data on dietary exposure of Serbian children to nitrites and phosphorus from meat products by combining individual consumption data with available analytical data of meat products. A total of 2603 and 1900 commercially available meat products were categorized into seven groups and analysed for nitrite and phosphorous content. The highest mean levels of nitrite content, expressed as NaNO2, were found in finely minced cooked sausages (40.25 ± 20.37 mg/kg), followed by canned meat (34.95 ± 22.12 mg/kg) and coarsely minced cooked sausages (32.85 ± 23.25 mg/kg). The EDI (estimated daily intake) of nitrites from meat products, calculated from a National Food Consumption Survey in 576 children aged 1–9 years, indicated that the Serbian children population exceeded the nitrite ADI (acceptable daily intake) proposed by EFSA (European Food Safety Authority) in 6.4% of children, with a higher proportion in 1–3-year-old participants. The mean phosphorus concentration varied from 2.71 ± 1.05 g/kg to 6.12 ± 1.33 g/kg in liver sausage and pate and smoked meat products, respectively. The EDI of phosphorus from meat products was far below the ADI proposed by EFSA, indicating that the use of phosphorus additives in Serbian meat products is generally in line with legislation.

Health risk assessment in children living in an urban area with hydrofluorosis: San Luis Potosí Mexico case study

BackgroundFluoride is an inorganic element, which can be found in high concentrations in groundwater. Its consumption and exposure have consequences on human health. The objective of this study was to evaluate fluoride exposure and develop a health risk assessment in children from an urban area with hydrofluorosis in Mexico. MethodsWater fluoride levels in active wells were provided by the Water State Agency and divided into three zones: agriculture zone (Zone A), metallurgical zone (Zone B), and industrial zone (Zone C). Urinary fluoride levels were determined by potentiometric method using an ion-selective electrode. Health risk assessment was performed through Monte Carlo model analysis and hazard quotient was calculated. ResultsAccording to fluoride well concentration, all zones have high concentration especially Zone B (2.55 ± 0.98 mg/L). Urinary fluoride concentrations were highest in children in Zone B (1.42 ± 0.8 mg/L). The estimated median daily intake dose of fluoride was 0.084 mg/Kg-day for the children living in zone B. The highest mean HQ value was to Zone B (1.400 ± 0.980), followed by Zone C (0.626 ± 0.443). ConclusionThe levels of fluoride exposure registered are a potential risk to generate adverse health effects in children in the San Luis Potosi metropolitan area.

Assessing BTEX concentrations emitted by hookah smoke in indoor air of residential buildings: health risk assessment for children

Hookah smoke is one of the major indoor sources of Volatile Organic Compounds (VOCs), including Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX). The present study aimed to investigate potential exposure to BTEX compounds among primary school children whose parents smoked hookah at home. BTEX concentrations in indoor air were measured in 60 residential buildings of Khesht, southwestern Iran (case = 30 and control = 30). Target compounds were sampled by charcoal tubes, and the samples were then analyzed by GC-FID. Monte Carlo simulation was used to assess the carcinogenic and non-carcinogenic risks of BTX exposure for the children aged 7-13years. The concentrations of benzene (7.19 ± 3.09 vs. 0.82 ± 0.5μg/m3), toluene (1.62 ± 0.69 vs. 0.3 ± 0.22μg/m3), and xylenes (2.9 ± 1.66 vs. 0.31 ± 0.22μg/m3) were considerably higher in the indoor air of the case houses compared with the control houses (p < 0.05). The Incremental Lifetime Cancer Risk (ILCR) of benzene for non-smoking and smoking houses were estimated 1.8 × 10-6 and 15 × 10-6, respectively, exceeding the recommendations of the World Health Organization (WHO) and the Environmental Protection Agency (EPA) (1 × 10-6). Moreover, Hazard Quotients (HQs) of all BTX compounds were < 1. The indoor benzene concentration was significantly influenced by the floor at which families lived and type of the kitchen. In order to prevent children's exposure to BTX emitted by hookah, banning indoor smoking is the only way to eliminate these compounds in the indoor air.

Health risk assessment in children by PM10 inhalation in Guadalajara metropolitan area over 2011–2018

The Guadalajara Metropolitan Area (GMA) has continuously presented atmospheric pollution problems due to particulate matter with an aerodynamic diameter less than or equal to 10 micrometers (PM10). Therefore, this research aims to evaluate the risk of developing adverse health effects in children from 0 to 10 years old due to the inhalation of PM10 during 2011–2018 in the GMA. As part of the methodology, the daily, monthly, seasonal, and annual average concentrations were calculated using ten monitoring stations that conform to the Jalisco Atmospheric Monitoring System. Subsequently, the daily and annual concentrations were compared with the current national and international regulatory concentrations. Besides, the hazard index was estimated to know the number of times that the concentrations recorded in the GMA exceed the regulatory concentrations. Finally, the risk was characterized by age groups, calendar year, and seasons by estimating the hazard quotient (HQ). The total HQ results ranged from 1.94 to 4.18, indicating that children from 0 to 10 years old who live in GMA have been at high risk of developing adverse health effects from inhaling high concentrations of PM10 that each year exceeded the annual guideline levels established by the current national and international regulation levels.

Potential health risk assessment of heavy metal content in Perlis soil

A determination of soil heavy metal (Cu, Mn and Ni) concentrations in Perlis state, Malaysia was performed to define the level of soil pollution. Six soil samples were collected at depth of 0 – 15 cm in industrial, residential and school areas around Perlis. The highest concentration of Mn (57.80 mg/kg) and Ni (2.83 mg/kg) were detected at limestone quarry in Bukit Air, Cu (17.43 mg/kg) in Kampung Wang Ulu. The concentration of Cu, Mn and Ni were well below their soil geochemical background values. The single pollution indices assessment revealed that the soil contamination due to heavy metals in Perlis is insignificant. On the basis of the heavy metal content, the potential health risk assessment for children and adults was calculated for a lifetime of exposure through ingestion, inhalation and dermal contact based on the USEPA model. The exposure assessment found that the exposure pathways of heavy metals to both children and adults are through ingestion. Both Hazard Quotient (HQ) and Hazard Index (HI) values are lower than 1, indicating no health risk. From the result, the HI values indicated that the soil heavy metal contamination could pose more impacts on children as compared to adults.

Health risk assessment of children’s population on the delivery of metals with drinking water

In the work, we assessed the carcinogenic risk to the health of the child population when drinking tap water is consumed in the city based on the calculation of the risk to public health taking into account regional exposure factors. For this, a retrospective study of the quality indicators of drinking water in the city of Kazan at the final consumption point (houses and apartments) in the city was carried out. The calculation results showed that when using regional exposure factors that reflect the specific characteristics of the studied population, the carcinogenic risk values increase by 45%. The use of regional values of exposure factors, which are characteristic of a particular population, increases the accuracy and reliability of risk assessment. It was shown that the carcinogenic risk to health from drinking tap water by children 3-6 years old calculated by regional values of exposure factors in a number of zones exceeds the value recommended by WHO by more than 2 times, which requires the use of effective methods of purification of drinking water from ions that are carcinogenic potential.