Health Research Output Research Articles

Faculty Adoption of Open Science and Their Practices Towards Data Sharing in Tanzanian Health Universities

Open science (OS) is widely recognized as a new method of knowledge sharing using digital technologies. Despite the potential benefits OS offers, there is a low level of inspiration toward adopting it among researchers in higher learning institutions. The purpose of this study was to assess the faculty adoption of OS and their practices toward data sharing at Health Sciences University in Tanzania. The study employed a cross-sectional design, whereby a total of 252 faculties were systematically sampled from two purposefully selected health universities. Using a survey, the study employed SPSS to generate descriptive statistics and a coding strategy using ATLAS.ti software to analyze qualitative resultant data. Moreover, regression analysis determined the predicting factors that hindered faculty adoption of OS and data-sharing practices. The findings demonstrate that faculty had poor data-sharing practices triggered by a lack of institutional data-sharing policies, fear of data misinterpretation, and parasitic use of clinical research datasets with other researchers. However, the presence of a data repository, journal guidelines, and intellectual property rights are instrumental variables that allow faculty to practice OS and data sharing. Therefore, university libraries should take affirmative action to create awareness of the importance of practicing OS and data sharing among faculty and researchers. Such undertakings will allow other researchers to carry out comprehensive follow-up research to meet the increasing demand for innovative health research output in Tanzania.

Analysis of biomedical and health research in the Eastern Mediterranean Region.

Several bibliometric analyses have been conducted in the Eastern Mediterranean Region (EMR), however, there is limited data from such analyses for the establishment of national or regional health research agenda. To assess the biomedical and health research outputs in EMR countries for 2004-2018 and their alignment with the regional strategic health priority areas identified by the WHO Regional Office for the Eastern Mediterranean. We searched and reviewed health-related articles indexed in PubMed and originating from EMR countries from 2004 to 2018 and used these as indicators of the country's total biomedical research publication level. Data from a very large collection of over 300 000 articles were weighted to EMR's contribution to the global research output. We used the mean and standard deviation to summarise the continuous variables and used frequencies and percentages to summarise the categorical variables. Biomedical research publication in the EMR increased between 2004 and 2018. Five countries - Islamic Republic of Iran (43%), Egypt (14%), Saudi Arabia (11%), Pakistan (8%), and Tunisia (6%) - contributed 82% of all the publications, while the other countries contributed less than 4%. On average, EMR contributed 2.0% of the global biomedical research publications and 3.12 publications per 100 000 population for 2004-2018. Biomedical and health research publication increased unevenly across the EMR countries during the study period. Considering the complexity of the public health challenges in the region, there is a need for multidisciplinary and holistic approaches to health research to generate evidence for policy and to improve clinical and public health outcomes.

Mathematical Modeling of COVID‐19 Disease Dynamics With Contact Tracing: A Case Study in Ethiopia

In this paper, we developed a mathematical model for the dynamics of coronavirus disease (COVID‐19) transmission. The model embraces the notion of contact tracing and contaminated surfaces which are vital for disease control and contribute to disease transmission, respectively. We analyzed the model properties such as the positivity of the solution, invariant region, existence, and stability nature of equilibria. Besides, we computed the basic reproduction number R0. The local stability and the global stability of disease‐free equilibrium (DFE) points are proved by using the Routh–Hurwitz criteria and the Castillo‐Chavez and Song approach, respectively. LaSalle’s invariant principle is applied to prove the stability of an endemic equilibrium (EE) point. The possibility of bifurcation is discussed using the center manifold theory. We used real data on the spread and control of COVID‐19 disease in Ethiopia. Based on the data reported, we estimated the values of the parameters using the least squares method together with the fmin function in the MATLAB optimization toolbox. The sensitivity analysis of the model is explored numerically to illustrate the impact of the parameters on disease transmission. The study addressed that contact tracing is especially important because COVID‐19 often has asymptomatic carriers, and there are many asymptomatic individuals unaware in Ethiopia. The new infections would decrease in the communities by detecting and isolating COVID‐19 cases before they could spread the virus to others. Moreover, the study endorsed that the contaminated surface has contributed to disease transmission. The sensitivity analysis shows that if the rate of disinfected contaminated objects (ϕ) rises, then the transmission of the disease is reduced. Consequently, this study will aid in the fight against COVID‐19 policymakers and NGOs. It can also be used as a policy input for different countries under this crisis. Because of the mathematical modeling of this global pandemic, there is another point of view rather than public health research outputs. Additionally, with the concept of contact tracing and contaminated surfaces incorporated into the model, the result provides insight for disease prevention.

A Survey of Submission and Review Standards across Clinical Radiation Oncology and Medical Physics Journals: Devising the Optimal Criteria for Reproducibility and Sustained Impact

Publishing and editorial policies differ substantially across the Radiation Oncology (RO) and Medical Physics (MedPhys) compendium of journals. Adoptance of modern standards in scientific publishing and data sharing have the potential to improve the impact and reliability of the RO literature. We characterized the editorial, authorship and peer reviewer policies of various prominent clinical RO (N = 16) and medical physics (N = 9) peer-reviewed journals affiliated with professional societies for characteristics that are associated with improved reproducibility and rigorous review. A combination of tools including Enhancing the QUAlity and Transparency Of health Research (EQUATOR), Findability, Accessibility, Interoperability, and Reuse (FAIR), and Quality Output Checklist and Content Assessment (QuOCCA) principles were used to quantify the value and reproducibility of journal policies. Cohen's kappa coefficient was utilized to assess agreement between reviewers. Components of the above tools were regressed against various scientometric indices (H-index, IF, etc.) to identify factors that are associated with perceived relative importance within the field. Reviewer agreement (κ) for scientometric indices was highest (1.0) for criteria for statistical review and data submission standards and lowest (-0.246) for various submission checklists. Data availability statements were endorsed (44%) or required (31%) in a higher proportion of RO journals relative to MedPhys journals (44%, 0% respectively). Data repository submission was required in <10% of journals. FAIR adoptance was poor (31%, 22%) in RO and MedPhys journals. ≥1 EQUATOR guideline checklist was endorsed or required in 76% of journals. While there were no glaring differences in editorial policies between RO and MedPhys journals, there was substantial heterogeneity of scientometrics evaluating the rigor of data submission, reproducibility standards, and statistical review criteria. Linear regression of journal impact factors indicated a predictive relationship between FAIR adoption standards, use of EQUATOR checklists, and more rigorous statistical method submission criteria. The present review documented and confirmed significant variation in submission, review, and publication policies across RO and MedPhys journals. Established scientometric standards, FAIR principle adoptance, and more rigorous statistical methodology were predictive of increasing journal impact factor.

Status of mental health in South Asian countries

Status of mental health in South Asian countries

Assessment of public health research output by Bangladeshi authors: A scientometric study

Assessment of public health research output by Bangladeshi authors: A scientometric study

Using Natural Language Processing to Explore Mental Health Insights From UK Tweets During the COVID-19 Pandemic: Infodemiology Study.

There is need to consider the value of soft intelligence, leveraged using accessible natural language processing (NLP) tools, as a source of analyzed evidence to support public health research outputs and decision-making. The aim of this study was to explore the value of soft intelligence analyzed using NLP. As a case study, we selected and used a commercially available NLP platform to identify, collect, and interrogate a large collection of UK tweets relating to mental health during the COVID-19 pandemic. A search strategy comprised of a list of terms related to mental health, COVID-19, and lockdown restrictions was developed to prospectively collate relevant tweets via Twitter's advanced search application programming interface over a 24-week period. We deployed a readily and commercially available NLP platform to explore tweet frequency and sentiment across the United Kingdom and identify key topics of discussion. A series of keyword filters were used to clean the initial data retrieved and also set up to track specific mental health problems. All collated tweets were anonymized. We identified and analyzed 286,902 tweets posted from UK user accounts from July 23, 2020 to January 6, 2021. The average sentiment score was 50%, suggesting overall neutral sentiment across all tweets over the study period. Major fluctuations in volume (between 12,622 and 51,340) and sentiment (between 25% and 49%) appeared to coincide with key changes to any local and/or national social distancing measures. Tweets around mental health were polarizing, discussed with both positive and negative sentiment. Key topics of consistent discussion over the study period included the impact of the pandemic on people's mental health (both positively and negatively), fear and anxiety over lockdowns, and anger and mistrust toward the government. Using an NLP platform, we were able to rapidly mine and analyze emerging health-related insights from UK tweets into how the pandemic may be impacting people's mental health and well-being. This type of real-time analyzed evidence could act as a useful intelligence source that agencies, local leaders, and health care decision makers can potentially draw from, particularly during a health crisis.

Health research in the state of Odisha, India: A decadal bibliometric analysis (2011-2020).

Bibliometric analyses are an important tool for evaluating health research outputs in terms of their distribution, trends, contributors, focus, and funding sources. The transition from millennium to sustainable development goals has led to a gradual shift in the health policy, and possibly, research priorities of low-income settings in the Empowered Action Group (EAG) states lagging in socioeconomic and health parameters, and also ranking low on innovations and research. In this study, we depict the recent trends, quantity, type, focus, and sources of health-related research in the EAG state of Odisha, India. Peer-reviewed published original research articles related to human health published between 1 January, 2011 and 31 December, 2020 and where the study population was the residents of Odisha, or the study site was in Odisha, exclusively or partially, were analyzed. The publication characteristics were tabulated, including the title, journal name, open access, date of publication, number of authors, designation of the authors, number of institutes involved, and name of the institute of the first author. The details of the study setting, study site, ethical clearance, and funding source were also analyzed. The study identified 2,285 articles from database searches and included 666 articles after screening for bibliometric analysis. Most of the manuscripts had between three and six authors (43.5%). Two institutes from the state, the Regional Medical Research Center (ICMR-RMRC) and Kalinga Institute of Industrial Technology (KIIT), together contributed to 22.4% of the published manuscripts. Nearly 45.9% of the studies were community-based while 45.3% were hospital-based. While most of the published work was on infectious diseases, the proportion came down with time. An overwhelming majority of the studies were observational and less than 10% were experimental in design. The analysis shows a substantial increase in the number of publications in this decade. Priority setting of healthcare problems, increased funding, and capacity-building can give a much-necessitated impetus to more quality- and evidence-based research for aiding policy implementation and improvement of the overall health.

Period-prevalence and Publication Rate of Health Research Productivity in Seven Arabian Gulf Countries: Bibliometric Analysis from 1996 to 2018.

ObjectivesDespite the worldwide increase in health research, few studies have evaluated the health research productivity in member states of the Gulf Health Council (GHC). This study solicited the period-prevalence and publication rates of health research productivity in the seven GHC countries.MethodsWe searched the Scopus database for publications between 1996 and 2018 and used the SCImago Journal and Country Rank portal to obtain the relevant information. We also recorded qualitative (citation-based) and quantitative (document recount) indicators. Overall and country-specific period-prevalence and publication rates were estimated and standardized to the corresponding overall Gulf Cooperation Council (GCC) population and country-specific population size.ResultsOverall, 112 409 articles were enumerated during the study period. The majority (59.8%) were from Saudi Arabia, followed by UAE (11.9%). The GCC publications were associated with 1 315 778 citations, which revealed a 46.0 Hirsch-index. The period-prevalence of health publications for the overall GCC region was 1320 publications per million population over 22 years, and the publication rate estimate was 13.2 (95% confidence interval (CI): 13.1–13.3) publication per 10 000 population. The highest publication rate estimate was noted in Qatar (36.5; 95% CI: 35.8–37.3), followed by Kuwait, Bahrain, Saudi Arabia, UAE, Oman, and Yemen.ConclusionsThis study is the first study in the context of GCC to utilize period-prevalence and publication rates to chart health research productivity in the GCC region. Concerted efforts are required to improve the quality and quantity of the health research output in the GCC region.

Health research funding and its output in Pakistan.

Health research is very important for formulating evidence-based policies. To assess the health research funding and its output in the last 5 fiscal years (2013/14 to 2018) in Pakistan. Information about health research funding was retrieved from 3 major local agencies, the Higher Education Commission, the Pakistan Science Foundation and the Pakistan Health Research Council. Details of funding from international donors were retrieved and the number of publications was estimated from Pubmed and Pakmedinet. A total of 1261.6 million Pakistan rupees (Rs) (US$ 8.4 million) was spent on health research in the last 5 fiscal years, the majority from local donors (P < 0.02). Overall funding increased from Rs 104.7 million in 2013-2014 to Rs 349.8 million 2017-2018. In publications data, 24 796 original articles were published, including 16 137 Medline and 8659 non-Medline indexed. Overall there was a gradual increase in the number of publications per year, statistically significant for Medline indexed journals. Research funding had a strong correlation (Cronbach α=0.88) with publications. Health research funding directly affects health research output. The funding on health research should be considered an investment rather than expenditure.

A decade of Ecuador´s efforts to raise its health research output: a bibliometric analysis

ABSTRACT Background: Over the past decade, the political movement called ‘Revolución Ciudadana’ implemented a variety of policies and interventions (P&I) in Ecuador to improve higher education and strengthen local research capacity. We refer specifically to the ‘Mandato 14’ and the Higher Education Law (LOES, Spanish acronym) launched in 2008 and 2010, respectively. Objective: To assess the impact of these P&I (Mandato 14/LOES) on the production of health sciences-related articles (HSRA), and the relationship of these HSRA with the country’s health priorities. Methods: A Scopus search was performed to retrieve HSRA published from 1999 to 2017. Bivariate analysis was used to assess variation between the period I (1999–2008) and period II (2009–2017). Further, we examined the association between the top 10 causes of mortality and the total HSRA output. Results: The final study sample consisted of 2784 articles. After 2008, Ecuadorian production of HSRA increased steadily from 671 to 2133 publications (p<.001). Overall (1999–2017), the most common study design was cross-sectional (32.3%), the primary research focus was in the clinical-surgical area (49.3%), and the academic institutions were the primary drivers of scientific production during period II (56.9% vs. 29.5%, p<.001). Further, we found a decrease in the production of randomized controlled trials (6.7% vs. 1.8%, p<.001). Only 9% of research production involved the primary causes of mortality, and the proportion has remained unchanged over time (8.2% vs. 9.3%, p>.05). Conclusions: Ecuadorian HSRA output increased significantly after 2008. This larger volume of scientific output could be the result to the Mandato 14/LOES implemented in the last decade. However, a low percentage of HSRA are dedicated to addressing the country’s health priorities. Proper planning, execution and monitoring of national health research agendas would reduce the mismatch between health burden and the HSRA output in Ecuador and other low-and middle-income countries.

Mental health research in response to the COVID-19, Ebola, and H1N1 outbreaks: A comparative bibliometric analysis

IntroductionBoth the COVID-19 pandemic and its management have had a negative impact on mental health worldwide. There is a growing body of research on mental health as it relates to the pandemic. The objective of this study is to use bibliometric analyses to assess the mental health research output related to the COVID-19 pandemic and compare it to that of the West Africa Ebola and H1N1 outbreaks. MethodologyWe performed comprehensive searches in Embase, PubMed, and Scopus databases, and included all types of documents related to the three outbreaks published since the respective beginnings up to August 26, 2020. ResultsDespite the shorter time since the beginning of the COVID-19 pandemic, relative to Ebola and H1N1, we found a much greater number of mental health documents related to COVID-19 (n = 3070) compared to the two other outbreaks (127 for Ebola and 327 for H1N1). The proportion of documents in the top 10% journals was 31% for COVID-19, 24% for Ebola, and 40% for H1N1. Authors affiliated with institutions located in high-income countries published or contributed to 79% of all documents followed by authors from upper-middle-income countries (23%), lower-middle-income countries (10%), and low-income countries (2%). Approximately 19% of the documents reported receiving funding and 23% were the product of international collaboration. ConclusionMental health research output is already greater for COVID-19 compared to Ebola and H1N1 combined. A minority of documents reported funding, was the product of international collaboration, or was published by authors located in low-income countries during the three outbreaks in general, and the COVID-19 pandemic in particular.

Where there is no research: a bibliometric analysis of health research output from the resource-constrained Bihar state of India

Background Significant gap exists in health research output globally, both in terms of geographic distribution and priorities. In India, wide inter-state disparity in health research output is reported and eight large states with a combined population of nearly half of India contribute to less than one-tenth of total research output. Bihar is one of the most resource-constrained states in this group with multiple health systems challenges. The objectives of this study were to understand the trend, distribution, focus, actors, and funding sources of health research on Bihar in order to propose policy recommendations. Methods A bibliometric analysis was carried out for all PubMed indexed original research papers on health, which is either focused on Bihar or authored by an author from an organization in Bihar. Trend, author affiliation, location, theme, and funding source was analysed by review of either abstract or if required by review of the full text. Results A total of 982 research papers were extracted, out of which 40% was basic or clinical research and nearly 60% was public health research. There was an extraordinary surge in research output during the last decade. Clinical subjects (25 %) followed by leishmaniasis (23%) were the most common theme. Medical institutions (45%) were the biggest contributor to health research. More than 60% of papers were authored by a lead author from outside Bihar and the majority do not have a local co-author. 11 leading organizations published more than 35% of total research papers. ‘Leishmaniasis’ contributed to more than 35% of the research output by the author based in Bihar and more than 90% research output of the leading research institution in Bihar. The majority of the funded research in the last decade was supported by international agencies. Conclusions The health research output from Bihar is very limited. The recent surge in research output is driven by global actors or from actors located in bigger cities and more developed states within India. To strengthen the health research systems, a specific health research policy should be formulated to steward and improve the health research ouput from Bihar.

From Raw Data to FAIR Data: The FAIRification Workflow for Health Research

FAIR (findability, accessibility, interoperability, and reusability) guiding principles seek the reuse of data and other digital research input, output, and objects (algorithms, tools, and workflows that led to that data) making them findable, accessible, interoperable, and reusable. GO FAIR - a bottom-up, stakeholder driven and self-governed initiative - defined a seven-step FAIRification process focusing on data, but also indicating the required work for metadata. This FAIRification process aims at addressing the translation of raw datasets into FAIR datasets in a general way, without considering specific requirements and challenges that may arise when dealing with some particular types of data. This scientific contribution addresses the architecture design of an open technological solution built upon the FAIRification process proposed by "GO FAIR" which addresses the identified gaps that such process has when dealing with health datasets. A common FAIRification workflow was developed by applying restrictions on existing steps and introducing new steps for specific requirements of health data. These requirements have been elicited after analyzing the FAIRification workflow from different perspectives: technical barriers, ethical implications, and legal framework. This analysis identified gaps when applying the FAIRification process proposed by GO FAIR to health research data management in terms of data curation, validation, deidentification, versioning, and indexing. A technological architecture based on the use of Health Level Seven International (HL7) FHIR (fast health care interoperability resources) resources is proposed to support the revised FAIRification workflow. Research funding agencies all over the world increasingly demand the application of the FAIR guiding principles to health research output. Existing tools do not fully address the identified needs for health data management. Therefore, researchers may benefit in the coming years from a common framework that supports the proposed FAIRification workflow applied to health datasets. Routine health care datasets or data resulting from health research can be FAIRified, shared and reused within the health research community following the proposed FAIRification workflow and implementing technical architecture.

Maximising and evaluating the uptake, use and impact of golf and health studies

IntroductionThe dissemination of research, and evaluation of its impact is an increasing priority for the scientific community and funders. We take the topic of golf and health and aim to...

Biomedical and health research geography in the Eastern Mediterranean Region.

Measuring scientific outputs allows for objective evaluation of established health research systems and ranking countries according to scientific achievements. To our knowledge, attempts for systematic mapping health research output in the Eastern Mediterranean Region (EMR) are limited. We aimed to conduct a detailed bibliometric analysis of EMR biomedical and health research productivity during the period 2004-2013, considering country of first author. We applied an improved PubMed search strategy to obtain precise data on EMR research productivity, limiting articles to reviews, original research and case reports. Data were normalized to global research output, represented by total articles indexed in PubMed per year from 2004-2013, according to population size of each country. Second order polynomial trend lines were calculated and comparing 5-year periods: 2004-2008 with 2009-2013. Inspecting overall raw data, a clear increasing trend is observed. Regional share of global health related research ranged from 0.85-2.36% of total PubMed indexed publications during the study period. Five countries contributed to 80% of all published articles during study period; i.e., Islamic Republic of Iran (39%), Egypt (14%), Saudi Arabia (11%), Tunisia, and Pakistan (8% each). Overall, 2.35 articles are published per 100 000 population per year. While Kuwait maintained the highest per capita publication (followed by Tunisia, Lebanon, Qatar and Islamic Republic of Iran), Qatar, Islamic Republic of Iran and Saudi Arabia demonstrated the highest "per capita" population growth in publications. Three academic institutions accounted for over 10% of all publications that were led by an investigator from the Region. Collectively, most prolific 25 EMR institutions published 44% of all published biomedical and health research in the EMR. The overall global share of EMR health research publication is smaller than its global share of population or wealth. Biomedical and health research needs greater encouragement and supporting many EMR countries and/or institutions, especially those found to be least prolific in our analysis. The increase in academic publication on health has been more prominent in a few countries only. It is anticipated that the concentration of biomedical and health research in EMR academic institutions would help in translating knowledge into public health outcomes, if more suitable conditions are provided.

Achieving a Responsive Philippine Health Research Agenda: An Analysis of Research Outputs and Underlying Factors

Introduction. Priority setting in the context of health research is important for developing countries as it assists policymakers and researchers in effectively and efficiently targeting research topics with the greatest benefit for public health. In the local setting, the Philippine National Unified Health Research Agenda (NUHRA) was formulated to prioritize health research topics that address the health needs of the population alongside the health sector’s goal for universal health care. This paper attempts to understand the alignment of the health research outputs by the Philippine Council for Health Research and Development (PCHRD) in addressing the priority health needs of the country.&#x0D; Methods. Review of secondary data and key informant interviews was done. Using a thematic analysis approach, we extracted secondary data from the 2006 to 2017 PCHRD Annual Reports to identify the completed PCHRDfunded health research projects. Excluded in scoping of secondary data were the zonal and other unpublished or not readily available online reports.&#x0D; Results. Results show that most research outputs address NUHRA priorities on health technology development and on the health needs on all life stages and triple burden of diseases under the Philippine Health Agenda. However, for research outputs to improve health outcomes, efforts must first be focused on health systems strengthening and the utilization of existing research information.&#x0D; Conclusion. Gaps and challenges in the previous NUHRAs suggest that even as researches are aligned to the agenda, they do not necessarily address the health needs of the Philippines.

Evolution of Iran's health research system over the past 50 years: a narrative review.

BackgroundA substantial growth has been reported in Iran’s health research output over the last recent decades, throughout the times of economic, social, and political instability. This study reviewed the existing literature to provide a better understanding of the evolution of Iran’s health research system over this period.MethodsA narrative review of studies addressing health research system (HRS) in Iran was performed. The search strategy and categorization of the retrieved data was informed by the HRS framework of the World Health Organization (WHO). This framework proposes four functions for HRS: (i) stewardship; (ii) financing; (iii) creating and sustaining resources; and (iv) producing and using research. Searches in MEDLINE through PubMed (using MeSH terms) complemented with semantic searches through PubMed and Google Scholar were conducted.ResultsAfter removing the duplicates, 805 articles were retrieved, of which 601 were irrelevant, and 204 were reviewed.ConclusionsIran has made substantial progress in different components of its HRS over the last few decades, such as starting a discourse surrounding health research ethics, priority-setting, and placing monitoring mechanisms while increasing the capacity for conducting and publishing research. However, there is still room for improvements, or even a need for fundamental changes, in several components, such as regarding increasing the research budget and improving the funding allocation mechanisms; improving the education curriculum; and promoting the use of evidence. The findings emphasized that improvement of HRS functions requires addressing context-specific problems. This review provides essential lessons to share with other low- and middle-income countries and international organizations, eg, the WHO.

A comparison between health research output and burden of disease in Arab countries: evidence from Palestine

BackgroundResearch conducted on conditions responsible for the greatest disease burden should be given the highest priority, particularly in resource-limited settings. The present study aimed to assess the research output in relation to disease burden in Palestine and to identify the conditions which are under- or over-investigated, if any.MethodsWe searched PubMed and Scopus for reports of original research relevant to human health or healthcare authored by researchers affiliated with Palestinian institutions and published between January 2000 and December 2015. We categorised the condition studied in included articles using the Global Burden of Disease (GBD) taxonomy. Data regarding burden of disease (percentage of deaths and disability-adjusted life years (DALYs)) was obtained from the Palestine profile in the GBD study. We examined the degree of discordance between the observed number of published articles for each disease/condition with the expected number based on the proportion of disease burden of that disease/condition.ResultsOur search identified 2469 potentially relevant records, from which 1650 were excluded following the screening of titles and abstracts. Of the remaining 819 full-text articles, we included 511 in our review. Communicable (infectious) diseases (n = 103; 20%) was the condition with the highest number of published studies. However, cancer (n = 15; 3%) and chronic respiratory diseases (n = 15; 3%) were the conditions with the lowest number of published studies. Research output was poorly associated with disease burden, irrespective of whether it was measured in terms of DALYs (rho = −0.116, P = 0.7) or death (rho = 0.217, P = 0.5). Cardiovascular disease, cancer, and maternal and neonatal deaths accounted for more than two-thirds of the total deaths in Palestine (67%), but were infrequently addressed (23%) in published articles.ConclusionsThere is evidence of research waste measured by a mismatch between the health burden of certain diseases/conditions and the number of published research reports on those diseases/conditions in Palestine. A national research priority-setting agenda should be developed to meet the local community’s need for quality evidence to implement independent and informed health policies.

The relation between health research output and burden of disease in Palestine: a systematic review

BackgroundHighest priority should be given to research on conditions responsible for the greatest disease burden. This is particularly important in settings where resources are scarce. The aim of this study was to assess the association between research output and disease burden in the occupied Palestinian territory and to identify the conditions that are under-investigated or over-investigated, if any. MethodsWe searched PubMed and Scopus for reports of original research relevant to human health or health care that was authored by researchers affiliated with Palestinian institutions and published between Jan 1, 2000, and Dec 31, 2015. We categorised the health condition studied in included articles using the Global Burden of Disease (GBD) taxonomy. Data about the burden of disease (percentage of deaths and disability-adjusted life-years [DALYs]) were obtained from the Palestine profile in the GBD study. We examined the degree of discordance between the observed number of published articles for each disease or health condition with the expected number based on the proportion of disease burden for that disease or health condition. FindingsWe identified 2469 records and excluded 1650 records after screening titles and abstracts. We included 511 of the remaining 819 full-text articles in our review. Research output was poorly associated with disease burden, irrespective of whether measured in DALYs (ρ: −0·116; p=0·7) or death (0·217; p=0·5). Cardiovascular disease, maternal and neonatal health, and cancer accounted for 212 (67%) deaths per 100 000 population in the occupied Palestinian territory, but this was addressed in only 117 (23%) articles. InterpretationWe found evidence of research waste, as measured by a mismatch between the health burden of disease or health condition and the number of published research reports about that disease or condition in Palestine. National research priority setting should be developed to meet the local community's need of quality evidence in order to develop independent and informed health policies. FundingNone.