Health Remedies Research Articles

Assessment of intranasal in-situ gel efficacy of ethanolic extract of Mimosa pudica for anxiolytic and antidepressant activity: Formulation optimization and stability studies.

This research delves into the therapeutic potential of Mimosa pudica, known as chuimui or lajwanti in Hindi, for alleviating anxiety and depression, capitalizing on its diverse pharmacological activities. Renowned for analgesic, antidiarrheal, antiinflammatory, hepatoprotective, antiasthmatic, anti-ulcer, and antioxidant properties, the plant emerges as a promising herbal remedy for mental health. The study specifically accentuates its antidepressant and anxiolytic properties, aiming for minimal side effects compared to synthetic alternatives. Pre-formulation considerations involve optimizing the concentration of polymer for in-situ gelation. Preliminary phytochemical screening unveils the presence of bioactive compounds, including terpenoids, flavonoids, glycosides, alkaloids, quinines, phenols, tannins, and saponins, known for modulating neurotransmission and exhibiting anxiolytic effects. The concentration of deacetylated gellan gum for gelation is fine-tuned using simulated nasal fluid, emphasizing minimal viscosity. Compatibility studies using Fourier-transform infrared spectroscopy (FTIR) confirm the absence of significant drug-polymer interactions. Differential scanning calorimetry (DSC) provides insights into thermal behavior. Six trial batches with varying concentrations are prepared, and final formulations are evaluated for different physicochemical parameters. Stability studies are conducted under different conditions for three months. The comprehensive investigation aims to inspire advanced research into the manifold benefits of Mimosa pudica, particularly in mental health treatment, paving the way for potential herbal formulations with reduced side effects.

Network Pharmacology Analysis Reveals Multi-target Interactions of Phytochemicals in Cardiospermum halicacabum and their Potential in Breast Cancer Therapy

Aims: This present study aims to probe the interrelationships between phytochemical components and drug targets in Cardiospermum halicacabum. Background: Indian traditional medicine, often called Ayurveda, has a rich history of using medicinal plants for various health remedies and treatments. Network pharmacology plays a significant role in understanding the complex interactions between bioactive compounds in herbal medicinal plants and the human body. Objective: Medicinal plants are abundant in bioactive compounds, each possessing unique biological activities. However, certain unexplored biological activities of medicinal plants remain underrepresented in therapeutic studies. This study seeks to explore the connections between phytochemical components and drug targets specifically within Cardiospermum halicacabum. Methods: Metabolites were associated with various targets, and network analysis was conducted to assess the gene-metabolite network using cytoHubba. Genes were clustered to understand their involvement in gene ontology, biological processes, and metabolic pathways. K-means clustering illustrated a network of genes related to breast cancer pathways. Molecular docking analysis was performed for common genes within multiple targets to assess docking scores and interactions. result: Network analysis revealed six key metabolites closely interacting with multiple targets. Antioxidant activity was assessed using the DPPH assay, demonstrating significant effects (inhibition 74.08 ± 0.67%). Cytotoxicity against MCF-7 and MDA-MBA 231 cell lines showed IC50 values of 110.7 µg/mL and 141.2 µg/ml, respectively, indicating potential cytotoxic effects. Results: Network analysis revealed six key metabolites closely interacting with multiple targets. Antioxidant activity was assessed using the DPPH assay, demonstrating significant effects (inhibition 74.08 ± 0.67%). Cytotoxicity against MCF-7 and MDA-MBA 231 cell lines showed IC50 values of 110.7 μg/mL and 141.2 μg/ml, respectively, indicating potential cytotoxic effects. Conclusion: This study highlights the importance of plant metabolites and their interactions with multiple targets through network pharmacology analysis. It suggests the synergistic potential of compounds with multiple targets, providing insights into their therapeutic value, particularly in breast cancer therapy.

A Snapshot of Lead in Consumer Products Across Four US Jurisdictions.

Following the removal of lead from gasoline, paint and pipes were thought to be the main sources of lead exposure in the United States. However, consumer products, such as certain spices, ceramic and metal cookware, traditional health remedies, and cultural powders, are increasingly recognized as important sources of lead exposure across the United States. This paper reviews data from four US jurisdictions that conduct in-home investigations for children with elevated blood lead levels (BLLs) to examine the prevalence of lead exposures associated with consumer products, in comparison with housing-related sources. Authors reviewed investigation data (2010-2021) provided by California, Oregon, New York City, and King County, Washington, and compared the extent of lead exposures associated with housing-related vs. consumer products-related sources. The proportion of investigations identifying consumer products-related sources of lead exposure varied by jurisdiction (range: 15%-38%). A review of US CDC and US FDA alerts and New York City data indicates that these types of lead-containing products are often sourced internationally, with many hand carried into the United States during travel. Based on surveillance data, we believe that US immigrant and refugee communities are at an increased risk for lead exposures associated with these products. To engage health authorities, there is a need for evidentiary data. We recommend implementing a national product surveillance database systematically tracking data on consumer products tested by childhood lead poisoning prevention programs. The data repository should be centralized and accessible to all global stakeholders, including researchers and governmental and nongovernmental agencies, who can use these data to inform investigations. Effectively identifying and addressing the availability of lead-containing consumer products at their source can focus resources on primary prevention, reducing lead exposures for users abroad and in the United States. https://doi.org/10.1289/EHP14336.

Highly sensitive adulteration detection in kelulut honey utilizing fiber Bragg grating technology with Q-switched pulse erbium-doped fiber laser and innovative spider silk substrate

The growing field of photonics has seen significant developments in optical pulse fiber-based sensing technologies. In this research, a novel fiber Bragg grating using a Q-switched erbium-doped fiber laser source and innovative spider silk as a base material is presented, specifically designed for the detection of adulteration in pure kelulut honey. Kelulut honey has attracted much attention from Malaysian researchers as it is a highly prized, versatile local health remedy. During the experimental setup, concentrations of the adulterant isoglucose ranging from 0 % to 8 % and 10–50 % were intentionally added to the pure kelulut honey. The sensor showed remarkable sensitivity and detected subtle shifts in both the wavelength and radio frequency spectrum. The experimental results obtained emphasize the effectiveness of the proposed sensor and demonstrate its exceptional sensitivity in detecting adulteration in pure kelulut honey. This inherent property makes the derived pulse fiber laser sensor a promising tool for various applications in clinical detection and diagnosis as well as in the food industry. The results presented here not only contribute to the field of photonics but also have the potential to advance the quality control and authenticity assessment of kelulut honey in various fields.

The Stigmatization of Health Remedies (Herbs, Stones and Charms) in King James I’s Daemonologie

This paper aims to analyze the stigmatization of concepts related to medicine and healing in King James I's Daemonologie as republished in 1604. In the early 1600's, witchcraft trials and persecutions were prevalent, and there was a widespread belief in the existence of witches and their malevolent activities. King James I had a strong interest in the subject and was involved in witch trials. The study's hypothesis is that in the King’s view, healing effects and properties of plants, stones or charms could be attributed to God or Satan. Therefore, when God’s help was excluded, such as in the case of witches, all beneficial or healing effects of witchcraft were considered the work of the Devil, who was thus deluding mankind. Through these ideas expressed in Daemonologie, King James I contributed to the stigmatization of healing practices and encouraged the fear and persecution of individuals suspected of engaging in such practices. This study of medical and health terminology will bring the traditional beliefs and practices that influenced medical knowledge at the time to the foreground. Some key points that will be detailed here are the influence of Galenic ideas, the different categories of medical practitioners and their social status, the knowledge of herbal medicines that had been passed down through generations as well as astrological influences, while also considering a comparison with the various medical treatises that were available at the time.

Group membership, social identification and mental health: A test of social cure or curse narrative in resource-poor communities in Ghana

Mainstream psychology research promotes social group membership as a remedy for poor mental health. However, empirical evidence from African communities is limited. Using a survey of 384 respondents (female = 55.7%; mean age = 34.38 years, SD = 14.37 years), we examined this in two resource-poor Ghanaian urban communities. Depressive symptoms ranged from 11.5% to 28.1%, with severe symptom rates higher in male participants. Anxiety symptoms varied from 6.5% to 14.6%. Hierarchical regression showed that after accounting for demographic variables, multiple group membership, group stigma, and identity centrality were associated with heightened depressive and anxiety symptoms. Ingroup homogeneity, satisfaction with the group, and perceived solidarity were associated with lower levels of symptoms. The findings reveal a dual-edge impact of social identification on mental health, underscoring the need for the development of context-specific interventions to effectively harness social group membership as psychosocial resources to improve mental health within African contexts.

Efficacy and Safety of Shatavari Root Extract for the Management of Menopausal Symptoms: A Double-Blind, Multicenter, Randomized Controlled Trial.

Background Menopause is a physiological state that occurs in all women and refers to the halt of the reproductive phase. The cessation of the reproductive phase occurs through various stages and presents different symptoms such as hot flashes, night sweats, insomnia, anxiety, depression, and irritability. Such pre- and post-menopausal symptoms may affect the daily activities and production capacities of women, impacting the quality of life (QoL) of women. Hormone replacement therapy (HRT) is primarily used to manage menopausal symptoms. However, various side effects have been reported related to HRT. Therefore, women are choosing alternative medicine such as Ayurveda that can benefit them with less or no adverse effects. Shatavari (Asparagus racemosus) is known in Ayurveda as an effective medicinal plant source for various women's health remedies since ancient times.This study aimed to evaluate the safety and efficacy of the Ayurvedic Shatavari formulation on menopausal symptoms compared to the placebo. Methodology This is a randomized, double-blinded, multicenter, placebo-controlled, clinical study. Altogether, 70 patients were randomized to two groups, i.e., the test group (active group) and the placebo group (microcrystalline cellulose), with 35 participants in each group. Results The study outcomes showed a positive and significant effect of the active test ingredient over the placebo in terms of reduction in hot flashes, night sweats, insomnia, anxiety, nervousness, vaginal dryness, and loss of libido. The Utian QoL improved significantly in the test group compared to the placebo group. No significant adverse events were recorded in the test group, suggesting the safety of this formulation. Conclusions The test compound could be a safe alternative to modern drugs. The findings of this study support the traditional use of Shatavari. Further clinical and pharmacological studies with longer duration and larger and more diverse sample sizes are required to understand the generalized effect of Shatavari root extract in menopausal women.

Unlocking the potential of Lion’s Mane Mushroom (Hericium erinaceus)

The Lion's Mane mushroom, botanically known as Hericium erinaceus, stands out as a unique and esteemed member of the fungal kingdom. This extraordinary mushroom not only possesses an alluring appearance but also holds a significant historical presence in diverse cultures, especially within the context of ancient herbal medicine practices. This fungus holds promising prospects in several domains. Its potential as a natural remedy for cognitive health is gaining attention. This mushroom has neuroprotective properties and could play a role in supporting brain function, which is particularly relevant in the present aging population where neurodegenerative conditions like Alzheimer's disease are a growing concern. Furthermore, Lion's Mane has been explored for its potential in addressing mood disorders. It is a rich source of bioactive compounds, including β-glucans, that can positively affect the immune system. The fungus produces bioactive compounds that can be used to treat various chronic diseases like obesity, high blood pressure, hepatic disorders, and cancer ; it also has other benefits like wound healing and improving the immune system. This review endeavours to elucidate the multifaceted potential of Lion's Mane mushroom within the domains of nutrition, health, and wellness. Through a comprehensive examination of its properties and benefits, the review explored how Lion's Mane mushrooms can be harnessed to enhance human well-being. By unlocking the secrets hidden within this remarkable fungus, the study provides insights that can empower individuals to incorporate Lion's Mane into their daily lives, fostering a healthier and more balanced lifestyle.

PROPHETIC MEDICINE AND HERBS IN ORAL CARE A REVIEW OF LITERATURE

Prophetic medicine comprises the teaching of the prophet Mohammad with regards to nutrition, hygiene, sickness, cure and prevention of the ailments. “Whenever the Prophet (ﷺ) would visit an ill person, he would said:‘[O Allah,] make the harm go away, Lord of mankind, and heal him, You are the Healer, there is no healing except your healing, a healing that does not leave any sickness. Healing with the Medicine of the Prophet (PBUH) is the remedy for well-being, good health and soul. Prophetic medicines promote healing, prevention and cure of ailments. The review article is an effort to explore detailed analysis of prophetic medicines and natural herbs in oral care. The article is focused on the uses of miswak, honey, black seed, olives, senna and idhkhir for oral therapeutic uses. The studies, experiments and research have demonstrated that the prophetic medicines and herbs provide benefits in oral care. However, the research conducted on some herbs are limited to in vitro studies, thus further studies are required to be carried out on animals or humans to achieve accurate results. Furthermore, other herbs mentioned in prophetic medicines like tannumah (aloes), daghabis (dill seed), dates, cortus, need to be explored and further studied for therapeutic use in oral care.

Exploring the Challenges Faced by Primary Care Physicians in Providing Optimal Care for Patients With Hypertension: A Qualitative Study.

Globally, most patients with hypertension have suboptimal blood pressure (BP) control. Multiple barriers prevent primary care physicians (PCPs) from effectively caring for these patients. This study aimed to explore the challenges faced by PCPs in providing optimal care for patients with hypertension, with a specific focus on identifying new barriers. This qualitative study involved 17 PCPs across 5 primary care clinics in Singapore. A trained researcher conducted individual in-depth interviews using a topic guide. Purposive sampling was employed to ensure adequate representation of seniority until data saturation was achieved. The audio-recorded interviews were transcribed verbatim and independently checked. The data were managed using NVivo and thematic analysis was conducted. New barriers were divided into patient, physician, drug, and systemrelated factors. Patient factors included a preference for natural health remedies and the inconvenience of blood tests. Meanwhile, physicians faced challenges diagnosing and treating patients with various BP phenotypes and BP variability. The initiation of dual therapy was a drugrelated barrier. Finally, system factors included the suboptimal layout of the electronic medical records (EMR) that impeded effective hypertension management. A multi-pronged approach is required to address the significant barriers to providing optimal hypertension care. Patients should be empowered through education and minimizing the inconvenience of medication titrations. Additionally, physicians should be better equipped to diagnose and treat patients with more challenging BP phenotypes. Finally, improved access to combination pills and an optimized EMR would contribute to improved care for patients with hypertension.

The Soft Power Synergy: Ayurveda and Yoga in Contemporary Diplomacy

Ayurveda and Yoga which are the part of ancient Indian system of life have become the symbols of India’s soft power diplomacy in international forum. These customs and patterns embody the core values of cultural norms and values and have great implications of enhancing overall health and harmony between the soul and the body. At first, Ayurveda and Yoga play the role of the link and communication between countries in terms of the shared cultural values and ethical standards, which are based on the ideas of health and relaxation. These activities consist of Ayurveda wellness facilities and Yoga diplomacy initiatives to strengthen the two countries’ relations while fostering the levels of consciousness and well-being of the global society. However, in addition to the cultural strategic relations, Ayurveda and Yoga are the other important economic diplomacy of India. The increasing global concern towards natural health remedies makes India, a major exporter of Ayurvedic antibiotics and other well-being products. At the same time, the demand for Yoga generates a lot of business: workshops, professional boot camps, and well-being tourism centres that positively affect India’s economy. Last, between their globalization, Ayurveda and Yoga have faced criticism of cultural imperialism, and between the quality of products and services and their becoming a commodity. India manages these threats through endorsing local culture and ethic, protecting the product originality and fostering proper cultural transfer. Thus, India meets these challenges and raises awareness of Ayurveda and Yoga as an Indian contribution to global health and cultural events and meetings. The abstract signifies how Ayurveda and Yoga symbiotically develop India’s soft power diplomacy, exceeding cultural, social, and economic dynamics. By influencing these old traditions and values, India improves its global impact. It promotes a more interrelated and cordial global society stranded in common and shared values of healthiness, knowledge, and consciousness.

Can Ashwagandha Benefit the Endocrine System?-A Review.

Withania somnifera, also known as Ashwagandha, has been used in traditional medicine for thousands of years. Due to the wide range of its activities, there has been interest in its possible beneficial effects on the human body. It is proved that, among others, Ashwagandha has anti-stress, anti-inflammatory, antimicrobial, anti-cancer, anti-diabetic, anti-obesity, cardioprotective, and hypolipidemic properties. Particularly interesting are its properties reported in the field of psychiatry and neurology: in Alzheimer's disease, Parkinson's disease, multiple sclerosis, depression, bipolar disorder, insomnia, anxiety disorders and many others. The aim of this review is to find and summarize the effect that Ashwagandha root extract has on the endocrine system and hormones. The multitude of active substances and the wide hormonal problems faced by modern society sparked our interest in the topic of Ashwagandha's impact on this system. In this work, we also attempted to draw conclusions as to whether W. somnifera can help normalize the functions of the human endocrine system in the future. The search mainly included research published in the years 2010-2023. The results of the research show that Ashwagandha can have a positive effect on the functioning of the endocrine system, including improving the secretory function of the thyroid gland, normalizing adrenal activity, and multidirectional improvement on functioning of the reproductive system. The main mechanism of action in the latter appears to be based on the hypothalamus-pituitary-adrenal (HPA) axis, as a decrease in cortisol levels and an increase in hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in men were found, which results in stress level reduction and improvement in fertility. In turn, other studies prove that active substances from W. somnifera, acting on the body, cause an increase in the secretion of triiodothyronine (T3) and thyroxine (T4) by the thyroid gland and a subsequent decrease in the level of thyroid-stimulating hormone (TSH) in accordance with the hypothalamus-pituitary-thyroid (HPT) axis. In light of these findings, it is clear that Ashwagandha holds significant promise as a natural remedy for various health concerns, especially those related to the endocrine system. Future research may provide new insights into its mechanisms of action and expand its applications in both traditional and modern medicine. The safety and toxicity of Ashwagandha also remain important issues, which may affect its potential use in specific patient groups.

Computer vision syndrome among students during remote learning periods: harnessing digital solutions for clear vision.

This study aimed to assess the prevalence of Computer Vision Syndrome (CVS) among children and adolescents in Qatar during the period of remote learning and explore the associated factors and discuss some digital health remedies that might reduce the risk. We conducted an analytical cross-sectional study between June and August 2022 by collecting data via telephone interviews with parents of selected students utilizing the Computer Vision Syndrome Questionnaire (CVS-Q). We completed 1,546 interviews. The mean age of the students was (11 ± 2), male: female ratio was almost 1:1. About one quarter (368, 23.8%) of parents reported a previous diagnosis of visual disturbances among their children with over 88% of them wearing eyeglasses or medical contact lenses. The prevalence of CVS in our sample was about 8% (95%CI: 6.8-9.6). Mother's employment, having positive history of visual disturbances, and excess screen time were found to be significant predictors of CVS. Health care providers in collaboration with teachers should provide parents with evidence-based strategies to prevent or minimize the digital eye strain among students. In the landscape of remote learning, the implementation of digital remedies emerges as a proactive approach to mitigate the risk of digital eye strain.

Living in Harmony with the Community’s Nature and Socio-culture: An Ethnography of Healthy Older People in a Northeastern Thai Rural Community

Preparing to enter old age is crucial for accommodating longevity. However, a holistic view of socio-culture and natural environments that influences the healthiness of older people is not clearly explained. This focused ethnographic study was conducted between December 2017 and July 2019 and aimed to describe the healthy ways of life of older people in a rural community of northeastern Thailand (Isan) and the influence of socio-culture and natural environment. Fifteen people 70-87 years old and 15 of the people involved were interviewed in-depth, and focus group interviews, participant observations, and document reviews were also conducted. The study found that healthiness was determined by physical strength and self-reliance and a peaceful mind and happy life. Living in harmony with the community’s nature and socio-culture was the healthy way of life indicated by natural/Isan food, modest physicalactivities, a peaceful life, community participation, and folk/modern health remedies. Their sense of healthiness was influenced by the conversion of the community in a concordant interweaving manner, including the preserved nature in the developed infrastructure,sufficiency/reliance in expanding networks, and spirituality in contemporary viewpoints. Healthy older people benefited from the community development mediated by the younger people. A holistic approach to natural resources and socio-culture with a balance between conservation and development is recommended for developing rural community nursing guidelines to achieve a healthy way of life for older people and others who are aging.

Kampung Jamu: Pilar Peningkatan Kemampuan Bersaing Kota Semarang

Enhancing a city's competitiveness in the era of globalization requires harnessing local potential, particularly traditional health remedies. These remedies encapsulate unique knowledge of natural ingredients and healing techniques proven effective over centuries. Promoting the utilization and development of traditional health recipes not only enriches local culture but also improves the quality of life for communities. Cities can leverage their cultural and natural heritage by creating new economic opportunities through industries based on traditional health remedies, such as herbal products and natural medicines. In the long run, this contributes to the city's economic growth and competitiveness across various sectors. Empowering local potential through traditional health recipes is a sustainable strategy for winning the urban competition, enriching local culture, and promoting sustainable economic development by blending local wisdom with modern innovation.

Aromatherapy in anxiety, depression, and insomnia: A bibliometric study and visualization analysis

Aromatherapy is a natural treatment method that uses essential oils (EOs) extracted from aromatic plants; EOs and their components exhibit a wide range of pharmacological activities, with a special focus on their implementation toward mental disorders, such as anxiety and depression. This study aimed to identify the scientific output and activity related to aromatherapy in anxiety, depression, and insomnia through bibliometric approaches. In this bibliometric study, we utilized CiteSpace and VOSviewer to evaluate the Web of Science Core Collection publications and to build visualizing maps to analyze the research progress on this topic between 2001 and 2021. A total of 1159 original and review articles in English, published in 578 different peer-reviewed journals by 260 authors, were identified. In the recent two decades, there was a steady increase in the number of published articles, especially in the following five years. All publications were distributed among 88 countries/regions. The United States had the most publications, with 188 (16.22%) articles, followed by China [131 (11.30%)], Brazil [110 (9.49%)], and Japan [85 (7.33%)]. Most studies were published in the Journal of Ethnopharmacology, and Physiology & Behavior was the most cited journal. Hritcu L was the top published scientist and Gupta SC was the most frequently co-cited. The knowledge base of this field research mainly included the related efficacy of aromatherapy/EOs, application status, and biochemical mechanism. And the keyword co-occurrence analysis revealed that the topics “oxidative stress,” “chemical composition,” “systematic review,” and “sleep quality” were research frontiers. In conclusion, this comprehensive bibliometric study provides an updated perspective on research hotspots of aromatherapy in anxiety or depression and developmental tendencies of natural remedies for mental health. In addition, this study could also provide valuable information for research teams, practitioners, and decision-makers when designing and implementing natural treatment methods for mental health-promoting interventions for individuals with mood disorders.

Wildfire smoke, environmental justice, and young children in urban Pacific Northwest communities

Pacific Northwest wildfires are expected to increase in frequency and scale, with more communities exposed to smoke. We explored the environmental justice context for wildfire smoke impact to young children in urban communities in the Pacific Northwest with a focus on Seattle, Washington. We found substantial evidence that young children are vulnerable during wildfire smoke events due to a residential building stock that was primarily built before meaningful energy codes were enacted, along with low air conditioning rates; both contribute to a high transfer of air pollutants indoors from the outdoor environment. While our results are limited to PM2.5, we suggest that preventing injustices at child care settings during wildfire smoke events depends primarily on access to real-time information, use of that information to reduce exposure, and the strategies used by policy actors to make these adaptation options available and affordable for vulnerable communities. To date, adaptation during wildfire smoke events relies on voluntary efforts which may not be effective public health remedies in general, and particularly for vulnerable communities. Licensed child care settings could provide feasible and just risk management options for urban communities in the Pacific Northwest.

EMPOWERED ORAL CARE: NAVIGATING SELF-MEDICATION IN DENTISTRY

Self-medication in dentistry is an emerging practice wherein individuals diagnose, select, and administer oral health remedies without professional guidance. This review article aims to provide a comprehensive overview of self-medication in dentistry, focusing on its types, benefits, risks, influencing factors, and the role of dental professionals. The article explores the different types of self-medication commonly observed in dentistry, including over-the-counter products, alternative therapies, natural home remedies, and the use of nutraceuticals. It also highlights emerging trends such as online information and e-commerce, mobile health applications, and the influence of social media on self-medication practices in dentistry. The benefits of self-medication in dental care, such as accessibility, convenience, immediate symptom relief, and cost-effectiveness, are discussed. However, the potential risks and limitations, such as delayed diagnosis and treatment, misdiagnosis, masking underlying issues, adverse reactions, and overreliance on self-medication, are also addressed. The article explores the influencing factors behind self-medication in dentistry, including cultural beliefs, healthcare accessibility, and patient knowledge. It emphasizes the role of dental professionals in guiding and educating patients about self-medication practices, and highlights strategies for promoting safe and effective self-medication. KEYWORDS – Dental practice, analgesics, OTC medicines, toothache.

Covid-19 vaccination landscape in Malta through social media: Correspondence.

We would like to discuss om article entitled “A cross-sectional study exploring the Covid-19 vaccination landscape in Malta through social media: An insight into experiences, attitudes, and perspectives.”1 Even while vaccine hesitancy is still low, Cuschieri et al.1 came to the conclusion that vaccination resistance may operate as a barrier to controlling the pandemic. According to Cuschieri et al.,1 unified statement from governing authorities are essential for open public health communication that addresses issues and maximizes population safety. To increase immunization rates and convert doubters, public confidence in authorities, professionals, and scientists must grow. A lack of confidence in the community's healthcare system, for instance, has been linked to antivaccine beliefs.2 The degree of readiness is determined by one's confidence in their ability to carry out public health measures in the case of a catastrophe. Similar to immunization trends, epidemic conditions can much change over time. Furthermore, vaccination rates may change over time. As epidemic conditions change and new information about vaccinations becomes available, immunization usage patterns regularly change.3 The acceptance rate of COVID-19 vaccinations as of right now is the main cause for concern. Distribution of vaccines continues to be a very difficult problem for public health organizations all around the world. One study found that those who consistently reject immunizations have lower confidence in the local healthcare system.2 People may resort to public health solutions more or less frequently during a crisis, depending on how much faith they have in them. Depending on how much they trust their local public health administration, people may resort to public health remedies more or less frequently during a crisis. The public's trust in their local public health crisis response will have a significant impact on the effectiveness of public health initiatives during the COVID-19 pandemic.3 The authors declare no conflict of interest.

Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review.

In recent years, there has been a significant surge in reports on the health-promoting benefits of winter cherry (Withania somnifera), also known as Ashwagandha. Its current research covers many aspects of human health, including neuroprotective, sedative and adaptogenic effects and effects on sleep. There are also reports of anti-inflammatory, antimicrobial, cardioprotective and anti-diabetic properties. Furthermore, there are reports of reproductive outcomes and tarcicidal hormone action. This growing body of research on Ashwagandha highlights its potential as a valuable natural remedy for many health concerns. This narrative review delves into the most recent findings and provides a comprehensive overview of the current understanding of ashwagandha's potential uses and any known safety concerns and contraindications.