Health Paradigm Research Articles

Homeostasis control in health and disease by the unfolded protein response.

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized transmembrane and secretory proteins - essential for cellular structure-function and for both intracellular and intercellular communication. To ensure the operative fidelity of the ER, eukaryotic cells leverage the unfolded protein response (UPR) - a stress-sensing and signalling network that maintains homeostasis by rebalancing the biosynthetic capacity of the ER according to need. The metazoan UPR can also redirect signalling from cytoprotective adaptation to programmed cell death if homeostasis restoration fails. As such, the UPR benefits multicellular organisms by preserving optimally functioning cells while removing damaged ones. Nevertheless, dysregulation of the UPR can be harmful. In this Review, we discuss the UPR and its regulatory processes as a paradigm in health and disease. We highlight important recent advances in molecular and mechanistic understanding of the UPR that enable greater precision in designing and developing innovative strategies to harness its potential for therapeutic gain. We underscore the rheostatic character of the UPR, its contextual nature and critical open questions for its further elucidation.

Positioning plant health within the evolving human-animal-environmental health paradigms

The evolution of the global scenario, which involves such converging crises as the climate crisis, the COVID-19 pandemic and its aftermath, and the Russia-Ukraine and Israel-Palestine wars, has underscored the fragility of the current food systems and the interdependence of human, animal, plant, and environmental health. Plant health is an important element in all these crises as plants provide food and feed, fix CO2, produce oxygen, and stabilize the soil. As a result of the Covid 19 pandemic, the One Health concept has finally obtained the attention of scientists and funding agencies. However, despite their role in global nutrition, the economy, and in climate crisis, plants are often excluded from the One Health efforts and funding streams. This paper advocates the need for an updated and more holistic view of plant health as public goods within the context of the evolving global challenges and explores opportunities within the Circular Health paradigm.

Analyzing the Public Health Impact of Adopting Telehealth after a Pandemic: A Business Model

Abstract: In response to the global shift in healthcare delivery due to the COVID-19 pandemic, this study investigates the adoption of telehealth technologies and assesses their long-term sustainability within new public health paradigms. Telehealth, accelerated by the pandemic's demands, offers a unique perspective on evolving healthcare delivery methods that emphasize accessibility and efficiency. By employing a mixed-methods approach, which synthesizes quantitative data with qualitative insights from various stakeholders, this research evaluates how telehealth has enhanced the delivery of medical services, especially in remote and underserved communities. Despite challenges related to technological infrastructure and regulatory constraints, our analysis of revenue models and cost-benefit evaluations suggests that telehealth is economically feasible and possesses significant market potential. The findings advocate for robust policy support and technological investment to enhance global telehealth accessibility and implementation. Additionally, the study highlights the necessity of expanding educational training for healthcare professionals to effectively adapt to telehealth systems. These strategic measures are pivotal for promoting the widespread application and sustainable development of telehealth, positioning it as a cornerstone in the future landscape of global healthcare. Continued research is recommended to further refine telehealth models and develop comprehensive frameworks that address emerging healthcare challenges and disparities.

Media Portrayals of Suicide's Risk and Protective Factors in Slovenia (1959 – 1999)

This study examined the historical shifts in Slovenian public attitudes towards suicide by analyzing media coverage in two major Slovenian newspapers from 1959 to 1999. We conducted a database search and analyzed 1,785 relevant articles from an initial pool of 13,042 hits. Our findings reveal that the media reported more frequently on risk factors for suicide than on protective factors across the decades. The most frequently mentioned risk factors included individual characteristics such as gender and mental health issues, with community factors becoming more prominent over time. Regarding protective factors, the focus paralleled the emphasis on individual risk factors, with interpersonal factors primarily reported in the 1960s and a growing recognition of community factors by the 1990s. This underscores a broader shift towards holistic understanding of risk and protecitve factors, with community-based approaches in suicide prevention, reflecting evolving public health paradigms.

Exploring the Probiotic Potential of Bacteroides spp. Within One Health Paradigm.

Probiotics are pivotal in maintaining or restoring the balance of human intestinal microbiota, a crucial factor in mitigating diseases and preserving the host's health. Exploration into Bacteroides spp. reveals substantial promise in their development as next-generation probiotics due to their profound interaction with host immune cells and capability to regulate the microbiome's metabolism by significantly impacting metabolite production. These beneficial bacteria exhibit potential in ameliorating various health issues such as intestinal disorders, cardiovascular diseases, behavioral disorders, and even cancer. Though it's important to note that a high percentage of them are as well opportunistic pathogens, posing risks under certain conditions. Studies highlight their role in modifying immune responses and improving health conditions by regulating lymphocytes, controlling metabolism, and preventing inflammation and cancer. The safety and efficacy of Bacteroides strains are currently under scrutiny by the European Commission for authorization in food processing, marking a significant step towards their commercialization. The recent advancements in bacterial isolation and sequencing methodologies, coupled with the integration of Metagenome-Assembled Genomes (MAGs) binning from metagenomics data, continue to unveil the potential of Bacteroides spp., aiding in the broader understanding and application of these novel probiotics in health and disease management.

The Right to Healthcare Must Include the Right to Ease of Physical Access: Exploring Geography-Health Nexus in GIDA Communities in the Philippines.

Using the United Nations' 'leave no one behind' framework for the achievement of sustainable development goals, this article underscores the key role of geography as one of the core factors why certain people are left behind, deprived, and continue to experience inequality in terms of access to (quality) health care facilities and services. This article specifically examines the consequences of physical inaccessibility to health outcomes and health-seeking behavior in geographically isolated and disadvantaged areas (GIDAs) in the Philippines. This article illustrates that physical accessibility is an ignored aspect of the public health paradigm. For that reason, public health facilities, no matter how critical the facility is to a person's care, are not an immediate option for GIDA residents who seek medical aid. Responsive policy measures are vital to address this seemingly paradigmatic error. Subsidizing transportation costs and allocating funds for road improvements are called for, among other changes. The government must act on the people's right to ease of access as part of fulfilling fundamental health-related state obligations. But for the government to act, it will be crucial for claimants to health rights to proactively demand these changes. The latter is key for the fulfillment of the affected people's right to get easier access to meaningful health care.

SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing via STAT3 activation

Oral mucosal wounds exhibit accelerated healing with reduced scarring compared to cutaneous wounds, representing an optimal wound healing paradigm. However, the specific cellular subtypes orchestrating the efficient healing of mucosal tissues remain elusive. Through a comprehensive analysis integrating bulk-mRNA and single-cell sequencing data during the wound healing process in oral mucosa and skin, we have delineated a distinct set of genes markedly upregulated during tissue repair. This collection of wound healing-associated genesets was highly enriched in a specific keratinocyte subpopulation identified as STAT3-activated SPRR1B+ keratinocytes. Notably, despite the inherent rapidity of oral mucosal healing, the induction of SPRR1B+ keratinocytes is evident in both skin and mucosal wound healing processes in murine model. Intriguingly, these wound healing-promoting SPRR1B+ keratinocytes, which are induced via STAT3 activation, inherently abundant in unwounded normal mucosa but absent in normal skin. SPRR1B knockdown significantly inhibits mucosal keratinocyte migration, a critical attribute for effective wound healing. In summary, through analysis of human oral and skin wound healing processes at single-cell resolution, coupled with validation in murine model, suggests STAT3-activated SPRR1B+ keratinocytes are associated with the rapid mucosal repair process. This discovery underscores the potential application of SPRR1B+ keratinocytes in the therapeutic management of chronic or non-healing wounds.

Newman’s theory of health as expanding consciousness: an evolutionary concept analysis

BackgroundThe health as expanding consciousness (HEC) theory posits that health and disease are interconnected components of a comprehensive process aimed at expanding consciousness.AimThe objective of this study is to introduce the concept, research status and applications of HEC and offer a comprehensive understanding of its various key components.Data sourcesDatabases including EMBASE, PubMed, ScienceDirect, ProQuest, Wiley, Web of Science, Sinomed, China National Knowledge Infrastructure, Wanfang, and CQVIP, covering the period from 1986 to 2023.MethodEmploying Rodgers’ evolutionary concept analysis approach, this study included and analysed 70 studies.ResultsThe characteristics of HEC comprise aspects such as movement, time, space, energy, rhythm, and paradigm of health. The antecedents of HEC encompass disease, chaos, binding, centring, and choice point. Consequences associated with HEC include self-transcendence, unbinding, decentring, expanded consciousness, real freedom, pattern recognition, absolute consciousness, and death.ConclusionThis study has identified substitute terms, related concepts, attributes, antecedents, consequences, and empirical references associated with HEC. The findings provide valuable information applicable across various domains of nursing, encompassing practice, education, research, and management.

Community-led transformation principles: Transforming public health learning systems by centering authentic collaboration with community-based organizations.

In the face of evolving public health challenges, including emerging diseases, pervasive health disparities, and escalating environmental threats, the integration of learning health system (LHS) principles emerges as a vital strategy for enhancing the adaptability and efficacy of public health initiatives. Traditional approaches within these systems often overlook the potential to deeply involve community-based organizations (CBO) that are led and staffed by the communities they serve as equal and essential partners in the public health discourse. This commentary proposes a suite of nine community-led transformation (CLT) principles aimed at reimagining LHS frameworks to authentically incorporate CBOs at their core. Drawing on the experiences from initiatives supporting Afghan refugees, we illustrate the application of these principles through two detailed case studies. These examples demonstrate the CLT principles in action and spotlight the enhanced cultural competency, effectiveness, and equitable power distribution that arise from such partnerships. Centering small to mid-sized CBOs including ethnic-led and/or faith based within LHS structures enables the system to access invaluable cultural insights, strengthen community bonds, and empower those communities to spearhead their transformative journey toward sustainable health, equity, and well-being improvements. The CLT principles herald a shift toward a more inclusive and co-led public health paradigm by offering a blueprint for stakeholders eager to forge strong, trust-based coalitions and cocreate initiatives with community leaders including Black, Indigenous, and People of Color (BIPOC) leaders from ethnic-led and/or faith-based CBOs. By embracing these principles, public health systems can evolve into truly inclusive, responsive, and sustainable entities poised to advance health equity for all community members.

The emergence of a modern paradigm for urban health

The importance of urban health in achieving global and planetary health goals is increasingly recognized. Cities offer important opportunities to improve health while also presenting significant challenges. As our understanding of and evidence for the importance of determinants of health beyond health care have grown, the need for urban health policies and actions that transcend disciplinary and sectoral boundaries and involve multiple stakeholders in urban decision-making has become clearer. Current urban health practice builds on decades of conceptual and operational work. This paper traces the evolution of the urban health paradigm through research, policy and practice in recent decades. We suggest that, despite the proven utility of urban health as a paradigm and its conceptual and practical evolution for effective urban health governance, significant challenges remain, especially related to implementing the systems approaches needed to improve health amidst the complexity of urban dynamics.

Generalized Denoising Coder with Multi-modal Approach for Handling Incomplete Information in Public Health Big Data Analytics

A data-driven health model incorporates many missing and incomplete values, and the effectiveness of a health model that relies on characteristics not captured by the consumer is low. A Deep Learning (DL) health paradigm aims to improve the precision of learning weights. A DL-based health model is trained by optimizing the weights to maximize accuracy. If the learning process is excluded, the accuracy of applying a DL-based health model to the user's circumstance may be reduced, and it becomes the responsibility of people to manage Public Health Big Data Records (PHBDR). To handle incomplete information, this study suggested a generalized denoising coder with a multi-modal approach in public health big data records (GDC-MM-PHBDR). The suggested technique uses a Generalized Denoising Coder (GDC), which estimates the output values following the relevant input values using Neural Networks (NN). The National Health and Nutrition Examination Study (NHNES) provided data for this investigation. This approach allows for the estimation of incomplete information in the PHBDR. Multimodality, which the PHBDRs provide, enables compiling data for a single item from many sources. The layout of the GDC is multi-modal. The GDC-MM-PHBDR approach continuously demonstrates excellent performance, attaining maximum accuracy across all noise levels. It begins at 98.31% accuracy with a noise factor of 0.05 and significantly decreases to 94.5% with a noise factor of 0.25.

Food Supplements Marketed Worldwide: A Comparative Analysis Between the European and the U.S. Regulatory Frameworks.

In recent decades, a new health paradigm emerged which increasingly places diet and nutrition at the center of citizens' healthcare. The resulting evolution of the food market has prompted country governments to adapt their regulatory frameworks to ensure product safety and preserve the health of citizens. Dietary supplements (DS) are products which are increasingly occupying a significant market share in Western countries, contributing to meeting the nutritional and physiological needs of a large portion of the global population. Food supplements must be safe for use by the final consumer who has access to the global market, but currently they are framed by a different legislation worldwide. This search aimed of comparing the legislative frameworks currently in force in the European Union (EU) and in the United States (USA), the two main markets in which DS are purchased, to focus on the strengths, similarities and possible shortcomings, against the backdrop of a global market which often transcends the regulatory barriers of individual countries. Both in the EU and the USA, food supplements are governed by specific regulations to ensure their safety and quality. However, the regulatory approaches differ sharply in some cases. It is expected that more and more operators will launch new DS in Western markets. As a result, it is crucial for competent authorities in food safety to deepen and develop additional regulatory tools aimed to control and safeguard the DS market.

Leveraging Geo-Profiling to Address Rape as a Public Health and Criminal Epidemic in the United States

Abstract Rape, as a pervasive societal issue, transcends the boundaries of public safety, criminal justice, legal jurisprudence, and public health, casting a long shadow of fear, trauma, and profound consequences across communities. This article delves into the multifaceted nature of rape, recognizing it not solely as a criminal phenomenon but as a complex public health crisis demanding comprehensive intervention. In response to the imperative of addressing rape and serial rapists as a criminal and public health epidemic, this study introduces an innovative approach that harnesses the potential of artificial intelligence (AI) and geo-profiling. Through synthesizing criminological and epidemiological insights, this research elucidates the transformative role of geo-profiling in understanding, preventing and solving rape crimes. Geo-profiling data analytics capabilities are harnessed to dissect the intricate details, patterns and dynamics of rape incidents, offering a data-driven foundation for preventive strategies. Moreover, integrating geo-profiling techniques empowers law enforcement and public health agencies to map high-risk behaviors, areas and optimize resource allocation geographically. This holistic approach advances our understanding of rape as a public health crisis and informs targeted, evidence-based interventions to reduce its prevalence. In a contemporary landscape marked by the imperative of innovation and interdisciplinarity, this article contributes a nuanced perspective to the discourse surrounding rape. By unifying law enforcement, criminal justice, legal, and public health paradigms and harnessing geo-profiling as a powerful tool, we embark on a path to address rape comprehensively, recognizing its profound impact on individuals and society.

Constructing a One Health governance architecture: a systematic review and analysis of governance mechanisms for One Health.

The integration of human, animal, and environmental health in the One Health framework is crucial for tackling complex health and environmental issues. Governance structures in One Health initiatives are essential for coordinating efforts, fostering partnerships, and establishing effective policy frameworks. This systematic review, registered with PROSPERO, aims to evaluate governance architectures in One Health initiatives. Searches in PubMed, Scopus, WoS, and Cochrane from 2000 to 2023 were conducted. Key terms focused on peer-reviewed articles, systematic reviews, and relevant grey literature. Nine eligible studies were selected based on inclusion criteria. Data synthesis aimed to assess governance mechanisms' functionality and effectiveness. Among 1277 sources screened, nine studies across diverse regions were eligible. An adapted framework assessed implementation mechanisms of international agreements, categorizing them into Engagement, Coordination, Policies, and Financial domains. The findings highlight the importance of effective governance, stakeholder engagement, and collaborative approaches in addressing One Health's challenges. Identified challenges include deficient intersectoral collaboration, funding constraints, and stakeholder conflicts. Robust governance frameworks are pivotal in One Health paradigms, emphasizing stakeholder engagement and collaboration. These insights guide policymakers, practitioners, and researchers in refining governance structures to enhance human-animal health and environmental sustainability. Acknowledging study limitations, such as methodological variations and limited geographical scope, underscores the importance of further research in this area.

Building Public Health Workforce Capacity: Longer-Term Effectiveness of a Capacity Building Intervention to Improve Community-Based Public Health Prevention Work

Objective: There is an urgent need to build capacity among existing and incoming public health workers to enhance community-based work focused on prevention and health promotion. Public Health Essentials (PHE), a cohort-based facilitated asynchronous online capacity building intervention, was designed to build public health workers’ strategic skills and professional confidence. Earlier research reported on the short-term learning outcomes of the intervention; here we report on results from a longer-term outcomes evaluation, including skill retention, skill application, and possible indicators of workforce retention and community health improvement.Methods: A sequential mixed-methods research study was used to assess and explore longer-term outcomes among a sample of PHE graduates working in community public health roles.Results: Some 46% of eligible PHE graduates (n=70) completed a skills survey at three timepoints: Pre-PHE, post-PHE, and 3-to-6 months post-PHE completion. Longitudinal analysis of responses showed statistically significant skill gains over baseline (Beginner → Proficient, p<0.005), despite a slight drop in self-perceived ability in the 3-6 months post-PHE completion. Qualitative interviews with respondents and focus groups with their supervisors suggest PHE completion benefits participants’ everyday work by developing strategic skills, and grounding their work in shared public health language, paradigms, and values. Broader reported benefits include the ability to apply new skills to community public health prevention projects and expressed motivation to continue to work in public health.Conclusions: Successful completion of PHE provides learners with durable skills applicable to public health work and may spur interest in continuing to work in the field of public health. The importance of developing and retaining a competent community-focused public health workforce cannot be overstated. Comprehensive facilitated, online asynchronous capacity building programs may be an effective tool.

Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons

PFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products. Although there has been a voluntary phase out of PFOA since 2005, it is still widely detected in various water supplies. A growing body of evidence suggests an association between PFOA exposure, particularly during developmental stages, with increased risks of neurodegenerative diseases (NDs). The neurotoxic mechanism of developmental PFOA exposure, however, remains poorly understood. Utilizing human induced-pluripotent stem cell (hiPSC)-derived cortical neurons, we investigated the effect of PFOA exposure prior to differentiation and assessed changes in neuronal characteristics, transcriptome, and neurodegeneration markers mimicking a Developmental Origin of Health and Disease (DoHAD) paradigm. Exposure to PFOA before neuron differentiation resulted in persistent alterations in nuclear morphology, neuronal network, and calcium activity. RNA sequencing analysis further revealed transcriptomic changes aligning with Alzheimer’s Disease (AD) after PFOA exposure. These observations were further corroborated by alterations in tau phosphorylation markers, the presence of fibrillar tau, an increase in liquid droplets, and a decrease in RNA translational efficiency characterized using a battery of biochemical assays. Taken together, our results revealed persistent deficits of key neuronal characteristics induced by pre-differentiation PFOA exposure, suggesting impairments in several AD-related pathways that can together contribute to the elevation of AD risk after pre-differentiation PFOA exposure.

EROD activity in the native fish Cnesterodon decemmaculatus as a biomarker for assessing aquatic pollution by AhR agonist chemicals within the Rio de la Plata Basin

The 7-ethoxyresorufin-O-deethylase (EROD) activity was first time characterized in the neotropical fish Cnesterodon decemmaculatus as a biomarker for assessing environmental health in aquatic ecosystems of the Rio de la Plata Basin impacted by organic pollutants agonist of the aryl-hydrocarbon receptor (AhR). Both laboratory and field studies were conducted. Laboratory experiments were run using β-naphthoflavone (BNF) as an AhR agonist model. A clear concentration-response relationship was found between 1 and 100 μg/L, with a NOEC and LOEC of 1 and 10 μg/L. A fast time-dependent response was observed with a significant induction after 24 h and a plateau from 24 to 48 h up to 264 h of exposure. Differences in basal activity were found between juveniles, females, and males, but induction levels were similar. Both basal activities and induction levels were distinct in the whole body, liver, gill, muscle, brain, and embryos. Fold-change inductions in the respective tissues were: 20, 114, 3, 5, 1, and 14. Maternal transfer and early cyp1a activation were unveiled by embryonic induction. Clear differences in EROD activity were found among juveniles collected in hydrocarbon-polluted streams, beside the La Plata Petrochemical hub, and a reference stream. Similar EROD activities were observed in laboratory and feral fish, usually with values below or above 1,000 pmol/min x mg protein for unexposed or exposed organisms. The study contributes with original information about EROD activity in C. decemmaculatus that encourages the use of both the response as a robust biomarker of exposure and the species as a good sentinel organism to be included in surveillant programs for assessing aquatic pollution by AhR agonist chemicals within the Rio de la Plata Basin within the One Health paradigm.

Marine coastal chemistry related to inland inputs in San Jorge gulf and the adjacent north coast

Coastal regions are sectors where human activities impact the marine ecosystem, and if necessary control measures are not taken, they can generate negative consequences for health and ecosystem services. Within the framework of the Pampa Azul initiative and under the One Health paradigm, the interconnection between the terrestrial and marine environments of the San Jorge Gulf and the adjacent north coast has been studied. In November, 2022, a campaign was carried out aboard the R/V “Mar Argentino” at thirty-four stations near the coast. There, for the first time, simultaneously with in-situ measurements of physical variables, macronutrients (NO3−, PO4−3, Si(OH)4 and NH4+), particulate silica (BSi and LSi), trace metals in the particulate material (Cd, Cu, Cr, Fe and Pb) and the phytoplankton community were analyzed. The results showed a high nutrient dynamic, with a significant influence of natural stratification and anthropogenic condition due to the discharge of effluents off the cities of Comodoro Rivadavia and Caleta Olivia. Under natural conditions, NO3− and Si(OH)4 limited the surface primary production by 47 % and 41 %, respectively. Additionally, due to the anthropogenic contribution, NH4+ concentration reached 3 μM, increasing the proliferation of nanophytoplankton, among other consequences. As a result of nutrient dynamics, the uptake of Si(OH)4, the growth rate of diatoms and their production of BSi were decoupled. Furthermore, a significant correlation between LSi and Fe in particulate matter was evidenced, opening new lines of research that relate dust storms to primary productivity in this marine environment. The measured concentrations of trace metals do not appear to be a biological risk; however, contamination by Cd (37.6 μg g− 1 d.w.) and Cu (214.97 μg g− 1 d.w.) off Camarones poses a significant concern that must be addressed in the immediate future.

Advances in the Clinical Application of High-throughput Proteomics.

High-throughput proteomics has become an exciting field and a potential frontier of modern medicine since the early 2000s. While significant progress has been made in the technical aspects of the field, translating proteomics to clinical applications has been challenging. This review summarizes recent advances in clinical applications of high-throughput proteomics and discusses the associated challenges, advantages, and future directions. We focus on research progress and clinical applications of high-throughput proteomics in breast cancer, bladder cancer, laryngeal squamous cell carcinoma, gastric cancer, colorectal cancer, and coronavirus disease 2019. The future application of high-throughput proteomics will face challenges such as varying protein properties, limitations of statistical modeling, technical and logistical difficulties in data deposition, integration, and harmonization, as well as regulatory requirements for clinical validation and considerations. However, there are several noteworthy advantages of high-throughput proteomics, including the identification of novel global protein networks, the discovery of new proteins, and the synergistic incorporation with other omic data. We look forward to participating in and embracing future advances in high-throughput proteomics, such as proteomics-based single-cell biology and its clinical applications, individualized proteomics, pathology informatics, digital pathology, and deep learning models for high-throughput proteomics. Several new proteomic technologies are noteworthy, including data-independent acquisition mass spectrometry, nanopore-based proteomics, 4-D proteomics, and secondary ion mass spectrometry. In summary, we believe high-throughput proteomics will drastically shift the paradigm of translational research, clinical practice, and public health in the near future.

When regulation ignores evidence: The case of Denmark’s Ashwagandha ban and the Technical University of Denmark’s misguided risk assessment

The recent ban on Ashwagandha (Withania somnifera (L.) Dunal) supplements in Denmark, based on a risk assessment by the Technical University of Denmark (DTU), exemplifies the challenges in regulating traditional herbal medicines within modern frameworks. This article critically examines the DTU report, highlighting methodological flaws including overreliance on animal studies and selective literature review. The report’s disregard for Ashwagandha's long history of traditional use and mischaracterization of its effects, particularly alleged abortifacient properties, contradicts a growing body of scientific evidence supporting its safety and efficacy. The current research demonstrating Ashwagandha's benefits in stress reduction, sleep improvement, and cognitive function further underscores the disparity between scientific findings and the DTU’s conclusions. The ban’s implications extend beyond Denmark, raising questions about regulatory consistency and proportionality in evaluating herbal products globally. The Indian Ministry of Ayush’s critique emphasizes the need for a more comprehensive, evidence-based approach for assessing traditional medicines. This controversy may catalyze the development of integrated evaluation methods, such as the Collaborative Medicine and Science framework, bridging diverse knowledge systems in regulatory decision-making. The case underscores the necessity for a global health paradigm that harmonizes traditional and modern medical approaches, ensuring public safety while preserving access to beneficial traditional remedies.