Pedigree Dog Health Research Articles

The challenges of pedigree dog health: approaches to combating inherited disease.

The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnostic DNA disease tests, the full extent and prevalence of inherited disorders in pedigree dogs is now being realized. In this review we discuss the challenges facing pedigree dog breeds: the common pitfalls and problems associated with combating single gene mediated disorders, phenotypic selection on complex disorders, and ways of managing genetic diversity. Breeding strategies incorporating screening schemes have been shown to be successful in significantly reducing the prevalence of an inherited disorder and improving the overall health in certain breeds. However, with 215 breeds officially recognized by the Kennel Club in the United Kingdom and 396 inherited disorders currently identified, many breeds have reached the point at which successfully breeding away from susceptible individuals at a population-wide scale will require new genomic selection strategies in combination with currently available breeding schemes. Whilst DNA-based tests identifying disease causing mutation(s) remain the most informative and effective approach for single gene disorder disease management, they must be used along with current screening schemes, genomic selection, and pedigree information in breeding programs in the effort to maintain genetic diversity while also significantly reducing the number of inherited disorders in pedigree dogs.Electronic supplementary materialThe online version of this article (doi:10.1186/s40575-015-0014-9) contains supplementary material, which is available to authorized users.

Pedigree dog health and welfare part 2. Findings of the Bateson inquiry into dog breeding

Pedigree dog health and welfare part 2. Findings of the Bateson inquiry into dog breeding

Pedigree dog health and welfare: Findings of the APGAW inquiry

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The pedigree dog – aesthetics versus ethics and law

Selective breeding of the domestic dog, Canis familiaris, has resulted in greater morphological diversity than any other single species (Clutton-Brock, 1999). Initially this selection was to satisfy functional requirements; however, the inception of dog shows in the mid 19th century gave weight to the aesthetic perspective and in the late 20th and early 21st century this has become paramount. Pedigree dogs are morphologically far removed from their progenitor, the wolf, and some dogs appear to have paid a high price, as selective breeding has led to the existence of over 350 known diseases and conditions in pedigree dogs (Gough and Thomas, 2005). Whilst the UK Kennel Club, and many breed clubs, recognise there is a need to ensure both the physical and behavioural health of pedigree dogs (Kisko, 2007), many breed standards are still linked to specific problems. This study adapts the four principles of bioethics (Beauchamp & Childress, 1994) - beneficence, non-malificence, autonomy and justice - to welfare ethics, and considers whether the practice of selectively breeding pedigree dogs to meet breed standards is compatible with these four principles. Questionnaires sent to the secretaries of 167 national breed societies investigated the society views of ethical aspects of dog breeding, through an understanding of the current practices of breed clubs. Forty-Two (24%) responses were returned, and 22 (13%) codes of ethics and rule books were provided. Qualitative analysis was conducted on the content of the breed society’s published rule books and codes of ethics. Although efforts are being made to improve the health of pedigree dogs, current codes of ethics, rule books and breed standards do not fully satisfy the principles of welfare ethics, and only 21.4% considered these would be affected by the provisions of the UK Animal Welfare Act 2006. These ethical issues need to be considered by the pedigree dog world and have implications for the show standards for other species (CAWC, 2006).