Health Of Male Patients Research Articles

Hyaluronic Acid-Modified Luteolin-Copper Complex Nanodelivery System for Bacterial Prostatitis.

Bacterial prostatitis is a common disease of the male genitourinary system, which seriously affects the normal life and health of male patients. Antibiotics are commonly used in the clinical treatment of bacterial prostatitis, but the efficacy of fluoroquinolones is gradually declining due to the increasing drug resistance of bacteria. Hence, it is necessary to find new antibacterial drugs to treat bacterial prostatitis. Luteolin is a natural flavonoid compound with many pharmacological activities such as antibacterial and anti-inflammatory activities, but its poor water solubility and low structural stability seriously limit its clinical application. In this study, we designed a targeting drug delivery system via a luteolin-copper complex grafted with hyaluronic acid. The results of the characterization proved the successful synthesis of the system. The results of the in vitro performance test show that the system has a good antibacterial effect and excellent blood compatibility and can be effectively released under different pH conditions. The prepared nanodrug delivery system not only provides a new idea for the treatment of bacterial prostatitis but also lays a theoretical and practical foundation for the wide application of luteolin in clinical practice.

Association of body composition with bone mineral density and fractures in Chinese male type 2 diabetes mellitus

The association between body composition and bone health in men over 50 years with type 2 diabetes mellitus remains unclear. We aimed to investigate how fat and lean mass affect bone health in male patients with diabetes over 50 years. A total of 233 hospitalized male type 2 diabetes mellitus patients with aged 50 to 78 years were enrolled. Lean mass, fat mass and bone mineral density (BMD) were estimated. The clinical fractures were also assessed. Glycosylated hemoglobin, bone turnover markers, and biochemical parameters were measured. The normal BMD group had a higher lean mass index (LMI) and fat mass index (FMI) and lower levels of bone turnover markers. glycosylated hemoglobin was negatively correlated with LMI (r = -0.224, P = .001) and FMI (r = -0.158, P = .02). In partial correlation adjusted for age and body weight, FMI was negatively correlated (r = -0.135, P = .045) with lumbar spine, while LMI was still positively correlated with lumbar spine (R = 0.133, P = .048) and total hip (R = 0.145, P = .031). In multiple regression analysis, LMI was consistently associated with BMD at the spine (β = 0.290, P < .01), hip (β = 0.293, P < .01), and femoral neck (β = 0.210, P = .01), whereas FMI was only positively associated with BMD at the femoral neck (β = 0.162, P = .037). A total of 28 patients diagnosed with diabetic osteoporotic fractures had lower LMI and FMI than their non-fractured counterparts. LMI was negatively associated with fracture, whereas FMI had such an effect only before adjusting for BMD. Lean mass is dominant in maintaining BMD and is a BMD-independent protective factor for diabetic osteoporotic fracture in male patients aged over 50 years. Fat mass in gravity is positively associated with BMD in the femoral neck, which may mediate fracture protection.

Some features of reproductive health in male patients in Samara

In the past few decades, there has been a decline in male fertility worldwide. The article is devoted to the study of the reproductive health of subfertile men. Purpose of the work: analysis of the biochemical composition of sperm plasma, spermogram and sperm morphology in subfertile men of reproductive age. The study included 85 patients aged 25 to 45 years, who were under observation in the clinic of Professor M.A. Florova (Samara): 60 patients seeking help to optimize reproductive health and procreation planning (a group of subfertile men, spermogram indices have deviations) and 25 clinically healthy men - a comparison group (control, spermogram indices are within the WHO norm). In subfertile men, morphological abnormalities of spermatozoa and changes in the biochemical composition of sperm plasma (increased concentration of transamination enzymes) were established. Spermatozoa with immature chromatin were identified. Electron microscopic analysis revealed fragmentation of sperm DNA: the highest percentage of spermatozoa with fragmented DNA was found in subfertile men (more than 22%).

Proximal Hip Geometry, Trabecular Bone Score, Bone Mineral Density and Bone Mineral Parameters in Patients With Cryptogenic and Hepatitis B Related Cirrhosis- A Study From the Indian Subcontinent

The impact of cryptogenic cirrhosis on skeleton has not been studied in Indian context. So this study investigated bone health in male patients with early cryptogenic cirrhosis as defined by Child-Turcot-Pugh A (CTP-A) categorization and compared it with patients diagnosed to have hepatitis B related chronic liver disease (CLD) on treatment and age, sex-matched healthy controls. It was a cross-sectional study, in which thirty male subjects were recruited in each group. Bone mineral density (BMD), trabecular bone score (TBS), hip structural analysis (HSA) and bone mineral parameters were assessed. The mean ±SD age of the study subjects was 39.3 ± 9.2 years. The mean 25-hydroxy vitamin D was significantly lower in subjects with cryptogenic cirrhosis as compared to controls (p = 0.001). Subjects with cryptogenic cirrhosis had significantly lower (1.297 ± 0.099) TBS as compared to hepatitis-B related CLD (1.350 ± 0.094) control subjects (1.351 ± 0.088) (p = 0.04). BMD at the hip and lumbar spine was also significantly lower in subjects with cryptogenic cirrhosis as compared to hepatitis-B related CLD and healthy age matched controls (p < 0.05). Most components of HSA were significantly affected in subjects with cryptogenic cirrhosis as compared to control subjects (p < 0.05). Patients with cryptogenic cirrhosis had significantly low TBS and BMD lumbar spine and hip as well as poor proximal hip geometry which may be good predictor of future fragility fractures.

Sexual Health in HIV-Positive Men Under Stable Antiretroviral Therapy During a 12-Month Period

BackgroundSexual health is becoming increasingly important for many HIV-positive men undergoing highly effective antiretroviral therapy (ART) but remains frequently unaddressed in routine clinical consultation. AimTo comprehensively evaluate sexual health in male patients with HIV on stable ART over a 12-month period. MethodsThe prospectively registered cohort study comprising 87 HIV-positive men on stable ART (median age: 43 years) was conducted between 2011 and 2015 at a university hospital. Patients were enrolled from the outpatient infectious disease unit and underwent an extensive andrological workup to assess parameters of sexual health (questionnaires, sex hormones, ultrasound, 2-glass urine test including semen analysis with microbiological and viral diagnostics). The study period per patient lasted 12 months. OutcomeThe primary endpoint was the impact of chronic HIV infection on sexual health. ResultsAlthough, on average, sexual health was fine at baseline, 56% of the patients reported erectile dysfunction, 28% experienced reduced libido, 5% had hypogonadism, 36% showed at least 1 atrophic testicle with a volume of <10 ml, 8% suffered bacterial sexually transmitted infections, 35% had seminal inflammation, and up to 47% showed reduced sperm quality. Sexual satisfaction was linked to mental health (12-Item Short Form Health Survey questionnaire) and International Index of Erectile Function scores. During the study period, the collected parameters on sexual health were generally stable. However, 35% of patients had new sex partners (median: 5 partners), 7% had fathered a child or were planning procreation, 47% reported changed libido, 17% suffered bacterial sexually transmitted infections in the urogenital tract, 16% revealed a positive HIV viral load in blood, 11% had a positive HIV viral load in semen, and 28% were treated for andrological disorders. Clinical implicationsSexual ill-health exists in about one third of patients. This manifests itself in sexual dysfunction, sexually transmitted infections, urogenital tract inflammation, and abnormal sperm parameters, all of which require adequate counseling and therapy. Strength and limitationsThe strength of this study is its comprehensive analysis of male sexual health over a 12-month period of stable ART treatment. Limitations are a heterogeneous patient cohort and a rather small percentage of patients with a positive HIV viral load in blood or semen, which prevented multivariate risk analysis. ConclusionOur study provides evidence that sexual health should be actively taken into account in the routine consultation by infectious disease specialists, and an interdisciplinary approach is desirable in the case of symptoms or signs of sexual ill-health.Pilatz A, Maresch CC, Discher T, et al. Sexual Health in HIV-Positive Men Under Stable Antiretroviral Therapy During a 12-Month Period. J Sex Med 2021;18:284–294.

Effects of psoriasis and metabolic syndrome on male sexual functions

Background and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis. Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded. Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = –0.405, –0.217 and –0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment. Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.

Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer

Background: Prostate cancer is one of the most common cancer threats to men. The incidence rate and mortality rate are second only to lung cancer in Europe and America. At present, the 5-year survival rate of prostate cancer is only 29% when metastasis occurs. Prostate cancer seriously endangers the health of male patients. Early prostate cancer surgery and radiotherapy and chemotherapy effect is better, advanced endocrine therapy effect is better, because of drug resistance, eventually progress to castration resistant prostate cancer (CRPC). Although new drugs such as abiraterone acetate, enzalutamide, apalutamide and darutamide have brought new hope to patients with CRPC, when CRPC progresses to metastatic castration resistant prostate cancer (mCRPC), the effect of endocrine therapy is limited. Objective: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy bring new hope to patients with CRPC. This article will review the new progress of immunotherapy and molecular targeted therapy. Methods: A number of clinical and experimental studies were reviewed to indicate the novel advancement in the progressive therapy of CRPC. Results: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy can improve median survival time and have a decrease of PSA level. Conclusion: With the advancements in CRPC therapy made by the researchers, some novel potential methods will occupy more and more important position in the treatment of CRPC.

Semen analysis in adolescents with familial Mediterranean fever

Little is known about sperm health in male patients with familial Mediterranean fever (FMF). In this study, the authors aimed to search the frequency of sperm abnormalities of adolescent boys with FMF and also to investigate whether disease activity or colchicine treatment have negative effects on sperm parameters. The male adolescents older than 14 years with a diagnosis of FMF were investigated retrospectively. Tel Hashomer and pediatric FMF clinical criteria were used for diagnosis of FMF. Patients who had semen analysis were included in the study. Mean age at the diagnosis was 11.13±3.82 years, and mean age at the study was 14.50±0.70 years. The mean sperm concentration was found as 66.26±41.02 million/ml (N>15 million/ml), the mean total sperm count 113.42±132.39 million (N>39 million), and the mean sperm motility 51.78±23.70% (N>40%). Only 8 of 19 (42.1%) patients had normal sperm parameters. Sperm concentration was reduced in two cases, total sperm count was reduced in four patients, and motility was reduced in nine cases. The presence of FMF attacks under treatment was found to be a risk factor for decreased motility in the study group by multivariate regression analysis (odds ratio 0.076, [95% confidence interval 0.005-0.648], P=0.031). Erythrocyte sedimentation rate at the time of diagnosis was high in patients with low sperm counts compared with those with normal sperm counts (56.00±8.51 vs 24.35±6.32, P: 0.03). Mean colchicine dose at the time of sperm analysis was higher in patients with low sperm motility than that with normal sperm motility (1.72±0.18 vs 1.25±0.08, P: 0.02). Sperm abnormalities of male patients with FMF is not infrequent, and it is linked to both inflammation due to uncontrolled disease and colchicine therapy.

Men's health.

The Queen's Nursing Institute is offering a funding opportunity for community and primary care-based nurses with an interest in men's health. Up to £5,000 is available for initiatives to improve the health of male patients or clients of any age. The projects are expected to start in March 2017 and the closing date for applications is 24 November.

Association Between Body Composition and Bone Mineral Density in Men on Hemodialysis

Studies have revealed complex interactions between bone and fat, however there are few studies about this crosstalk in patients with chronic kidney disease. This study investigated possible relationship between bone mineral density (BMD) and body composition in patients who underwent hemodialysis. Twenty patients were enrolled in a cross-sectional study (47.0 [42.3–56.8] years, body mass index 26.0± kg/m2, dialysis vintage of 48.5 [26.7–95.7] months). Body composition and BMD were assessed by dual-energy X-ray absorptiometry. Leptin and parathormone levels were analyzed using Multiplex kits (R&D System Inc). Low bone mass in the femoral neck was reported in 54.8% of patients. Total BMD and total T-score were positively correlated with lean mass (r = 0.46, P = 0.04; r = 0.47, P = 0.04, respectively), but not with leptin or body fat mass. In conclusion, lean body mass is probably important to maintain bone health in male patients who underwent hemodialysis.

The Effects of a 12-week Cardiac Rehabilitation Program on Four Measures of Health Outcomes

PURPOSE: To assess the effects of a 12-week supervised phase 2 and 3 Cardiac Rehabilitation Program on 4 health outcomes (physical functioning, physical health, vitality, and general health). Method: Self-administered health status was assessed using the SF-36 survey at the beginning and after approximately 12 weeks of participation in the program. The subjects were men (n = 102) between the ages of 50 and 69 years (Mean 59.9 ± 5.2 yrs) after a recent CAD incident (bypass, myocardial infarct, or angioplasty). The Cardiac Rehabilitation Program consisted of supervised exercise sessions twice a week for 1.5 hours (including a warm up, 40 minutes of cardio-vascular training, 20 minutes of strength training, and 5 minutes of cool down with stretching) plus educational sessions on healthy eating, stress management, physiology of the heart, importance of exercise, and facts about CAD medications. RESULTS: Dependent t-tests revealed statistically significant (p<0.001) improvements in all four measures: physical functioning (denned as limitations in physical activities, such as walking, climbing stairs, bending, lifting, and moderate to vigorous exercise), physical health (denned as the ability to perform daily activities like work or house chores), vitality (denned as the degree of feeling energetic), and general health (denned as a personal evaluation of health, including current health, health outlook, and resistance to illness). The effect sizes (effect size d) for all four measures are between −0.33 and −0.52, indicating a small to moderate difference between the initial survey outcome at the beginning of the program and after 12 weeks of participation. CONCLUSION: These findings indicate that a 12-week Cardiac Rehabilitation Program with multi-factorial interventions may increase physical functioning, physical health, vitality, and general health in male patients with a recent cardiac event.