The article is devoted to analyze the digitalization process in the development of public-private partnership mechanism in informational healthcare infrastructure. The importance of information asymmetry problem is shown in the health insurance market, and the mechanisms that can minimize it are analyzed: public-private partnership and concession. Based on the analysis of report “The Development of Digital Economy in Russia”, the importance of the digitalization process was identified for the social sphere, and the main directions were outlined for the development of the digital economy in Russia. Aim of the article is to analyze the features of public private partnership mechanism in healthcare related to the process of digitalization of the economy. The object of study is the public-private partnership mechanism. Subject of the study include economical, organizational and social relations arising in the process of applying the PPP mechanism for the development of digitalization. The analysis method made it possible to comprehend the main trends of the digitalization process in relation to the healthcare sector. The method of synthesis helped to find the relationship between these trends. Comparative analysis allowed comparing two key models of health insurance. The article allows understanding the key trends of the digitalization process in health care. Аs a result, it will be useful for experts involved in the development of healthcare infrastructure based on the PPP mechanism.