Health Expectancy Research Articles

Educational inequalities in mental health expectancy. Analysis based on registry data and survey data from the Danish National Health Survey.

Social inequality in life expectancy (LE) and various indicators of health expectancy have received much attention. Mental health expectancy (MHE) has received less attention, although research has shown an increasing prevalence of poor mental health. We aimed to investigate educational differentials in LE in relation to good, moderate, and poor mental health. Nationwide registry data on education and mortality were linked and combined with data from the Danish National Health Survey for 2017 and 2021 on mental health and education. The sample group consisted of data on Danes aged 30 and over. MHE was estimated by Sullivan's method. From 2017 to 2021, a general decline in the MHE of Danes was observed. Furthermore, the educational inequality in MHE remained substantial between genders, and was larger than the inequality in LE. Changes in MHE differed across educational groups. For Danes with short education, good MHE tended to increase for men, while the increase was statistically significant among women. MHE is associated with educational attainment. Despite the observed changes in educational differential, substantial inequality persists, raising important questions about the underlying causes of social disparity in MHE.

THE ROLE OF MITOCHONDRIAL DYSFUNCTION IN THE PATHOGENESIS AND TREATMENT OF INFLAMMATORY DISEASES IN THE ORAL CAVITY

Inflammatory diseases of the oral cavity (IOD) include many common diseases such as periodontitis and pulpitis. The main causes of IOD are microorganisms, trauma, occlusive factors, autoimmune diseases and radiation therapy. If not treated correctly, such diseases can not only affect oral health, but also pose a threat to people's overall health. Therefore, identifying IOD at an early stage and exploring new therapeutic strategies are important research goals related to oral therapy. Mitochondria are essential organelles for many cellular processes. Mitochondrial dysfunction not only affects cellular metabolism, but also indirectly affects people's health and life expectancy. Mitochondrial dysfunction is implicated in many common polygenic diseases, including cardiovascular and neurodegenerative diseases. Recently, increasing evidence suggests that mitochondrial dysfunction plays a critical role in the development and progression of IOD and associated systemic diseases. This review outlines critical insights into mitochondrial dysfunction and its role in inflammatory responses in IOD. The results of recent studies in the field of treatment of IOD, aimed at mitochondrial dysfunction, are presented, and the underlying mechanisms are also considered.

The Health-Employment-Longevity Nexus: Implications for Retirement Age Policies in European Countries

Abstract Background Advances in medical knowledge and technology have led to increased general and healthy life expectancy in Europe. Combined with declining fertility rates, these trends have resulted in an aging population. Many European countries have been reluctant to adjust the retirement age, putting pension funds and Pay-As-You-Go social insurance systems at risk. Linking entitlement age to life expectancy could mitigate this risk and extend working life, but such policies are politically unpopular. This study investigates the empirical relationship among self-perceived health, employment, job quality, and life expectancy in the European context. Methods The study analyzes the determinants of self-rated health using the SHARE database, combined with general and healthy life-expectancy data from EUROSTAT and, where missing, the WHO, focusing on European countries. Results In Europe, both past and present employment improve self-rated health. Job quality has a detrimental effect on self-rated health for women and a positive effect on men. Life expectancy and healthy life expectancy raise self-rated health, while poverty rates negatively affect it. Job quality is widespread among European women, and its negative effect on health rises with age. For European men, job quality has a positive effect, peaking around age 56. The effects of employment and job quality on self-rated health are simultaneous. In European countries with an elasticity >1, healthy life expectancy rises faster than general life expectancy at higher ages, suggesting an improved ability to work at older ages. This finding indicates that adjusting the retirement age could be a powerful tool for improving the sustainability of social insurance systems in Europe. Conclusions For younger European women, it may be rational to set higher retirement-age increments and put them on a declining course as they age, considering the gender-specific age dynamics and job quality effects on health. Key messages • In Europe, employment and job quality significantly influence self-rated health, with gender-specific effects that vary with age and impact retirement age policies. • Adjusting retirement age in line with healthy life expectancy could improve the sustainability of European social insurance systems, considering health-employment dynamics.

A mixed methods examination of a text message-based mHealth media literacy intervention for U.S. college students amid the COVID-19 pandemic

Objective: During the COVID-19 pandemic, college students were navigating confusing and often conflicting information on social media. Media literacy can help people interpret information online. We developed and tested a text-message media literacy intervention designed for college students. Participants: 267 U.S. college students from a university in the Pacific Northwest. Methods: We used an explanatory mixed methods design with a pretest-posttest field experiment (N = 267) and in-depth interviews (N = 15) to test a text message-based media literacy intervention in April 2020. Results: The intervention influenced media literacy for source and interacted with elaboration to influence media literacy for content and COVID-19 expectancies. Interviews highlighted how media literacy can be bolstered by emphasizing the salience of the role the message source plays in message interpretation. Conclusions: A media literacy text message intervention can prompt college students to consider media literacy related to the source and impact health expectancies.

Health inequalities and health-related economic inactivity: Why good work needs good health

Tackling health inequalities demands whole systems strategies with reach beyond the traditional sphere of influence of health care systems. Practitioners and researchers have long recognised that wider social determinants, where people are born, the communities they live in, their built environment, access to education and resources and, most significantly for this discussion, their relationship to the labour market, profoundly shape health experiences and expectations over the lifecourse. At macro-level, economic structures and systems play a fundamental role in the distribution of good health and incidence of inequalities. Regionally, the health of local labour markets, a phenomenon shaped by macro, national and global economic forces, is a powerful determinant of opportunities to access and remain in work. Simultaneously, health status impacts significantly on ability to participate in paid employment. Absence from the labour market is both a cause and symptom of health inequalities.Economic inactivity, where people are both not participating in the labour market, or actively seeking or available for work, is strongly correlated with poor health. In the UK, over one third of the economically inactive experience long-term health problems. The implications for health inequalities, as both cause and symptom are clear. Participation in paid work, where appropriate, can be beneficial both economically and for health and wellbeing. Continued absence from the labour market is directly correlated with ill health. The determinants of health-related economic inactivity are complex and can only be understood using ecological models of public health. This presents significant challenges for politicians and policymakers alike concerned with reducing economic inactivity, delivering economic growth and redressing regional disparities.

Evidence for global increases in urban ammonia pollution and their drivers

Ammonia (NH3) affects air quality, human health, and life expectancy through its important role in forming fine particulate matter. However, the spatial patterns and trends of NH3 concentrations in the urban environment remain unknown worldwide. Here we use satellite measurements to produce a global distribution of NH3 at fine resolution, and then identify, categorize and quantify NH3 air concentrations in urban clusters throughout the world, as well as explore associated trends and drivers. Based on satellite records, a significant increase is evident in global urban NH3 concentrations between 2008 and 2019, with an annual increase of 1.2 % yr−1. Our results show that the decline of acidic gas (NOx/SO2) explains the largest part of the increasing NH3 concentrations (42 %), exceeding the contribution of local NH3 emissions. Our results also show that increasing temperature can explain 20 % of the increase in urban NH3 concentrations implying that efforts to reduce NH3 emissions need to be greatly strengthened to compensate for increases in urban NH3 pollution induced by global warming and so improve the urban environment.

Exploration of the relationship between general health-related problems and subclinical coronary artery disease: a cross-sectional study in a general population

ObjectiveTo explore associations between general health-related problems and subclinical coronary artery disease (CAD), determined by CT coronary calcium score (CT-CCS), in a general population.DesignA cross-sectional design.SettingThis study was performed in...

Antecedents of Life Satisfaction Among Women in Kashmir: An Empirical Study From India

Psychologists believe that life satisfaction is a crucial indicator of an individual's overall health and happiness, regardless of their work or culture. This topic has been extensively researched, with the authors identifying novel antecedents of life happiness. Life satisfaction and health are strongly related, and enhancing one area can improve the other. Frequent shifts in life satisfaction can be harmful to overall health and life expectancy. However, there is still potential to investigate life satisfaction from a fresh perspective, particularly in the Indian context. This study aimed to investigate the factors influencing people's levels of pleasure in life, focusing on three categories of women in the Kashmir region: single women, married women, and widowed women. The study used a quantitative research design, including all three types of women: married, unmarried, and widowed. The research objectives were to study optimism, spirituality, resilience, and social support as predictors of life satisfaction among unmarried, married, and widowed women in Kashmir. The findings showed that optimism, spirituality, resilience, and perceived social support all have a beneficial impact on one's level of life satisfaction. Self-confidence under pressure has the biggest impact on life satisfaction, while optimism has the lowest effect amongst all variables.

Clinician actions in response to Adverse Childhood Experience (ACE) screening

Background and ObjectiveAdverse Childhood Experiences(ACEs) have a powerful influence on mental health, physical health, and life expectancy. Screening for ACEs and the clinician response to ACEs are critical to addressing the health and well-being of children; however, little is known about the actions clinicians take in response to ACE screening. Therefore, we aimed to examine clinician responses to ACE screening at five California pediatric clinics in a large public health care system. MethodsPatient demographics, indicators of social and behavioral determinants of health (e.g., housing insecurity), the number of ACEs endorsed on a screening instrument, and the actions clinicians took in response to each ACE screen were collected. Data was collected from May to October 2021. These data were used to examine the association between number of ACEs reported and clinician response, controlling for patient demographics and their social and behavioral determinants of health using multiple logistic regression. ResultsFive participating pediatric clinics conducted 2,652 ACE screens in six-months. Clinicians documented an action twice as often when ACEs were present, after controlling for patient demographics and their social and behavioral determinants of health (odds ratio(OR) = 2.2, 95 % confidence interval(CI): 1.5–3.3, p-value < 0.0001). Clinicians were three times more likely to record referrals to mental health clinicians, social workers, and community organizations relative to anticipatory guidance when the number of ACEs increased from one to three to four or more (OR=3.2, 95 %CI: 1.6–6.5, p < 0.0001). ConclusionFindings provide early information that ACE screening results are associated with patient care.

‘Sex ed’ exemptions in Ontario schools

This project explores how ‘sex ed’ exemptions are being enacted in Ontario classrooms. In August 2019, the Ministry of Education issued Policy/Program Memorandum 162, requiring Ontario school boards to have a policy or procedure allowing Grade 1-8 students to be exempted from Human Development and Sexual Health curriculum expectations at their parents' request. However, rather than limiting exemptions to formal lessons in the HDSH expectations of elementary Health and Physical Education, many teachers believe that they must exempt students from any conversation, formal or not, involving 2SLGBTQ+ topics. This has the potential to further stigmatize queer identities, as well as related topics and discussions. This research is also connected the conversation of how much sway “parental rights” have in the classroom. The first stage of this project has involved collecting exemption policy documents and board exemption forms, along with tracking how findable these documents are. As of today, 56 boards appear to have responded to PPM 162, either by passing a new policy or revising an existing one. Only 41% of school boards have a description of their exemption process available through Google search, while 30% of boards do not have their process available online at all. Unfortunately, problematic organizations like Parents as First Educators and Canadian Gender Report—both of which publish ‘resources’ claiming that parents have the right to exempt their children from all content about gender and sexual diversity—have materials which appear easily on Google search, sometimes even before authorized school board pages. If school boards do not have official exemption processes and forms readily available online, it is possible that parents will turn to these problematic documents instead. These gaps in the online availability of official board information may contribute to the dangerous misunderstandings present in how ‘sex ed’ exemptions are handled in Ontario schools.

Dynamics of Health Expectancy: An Introduction to the Multiple Multistate Method (MMM)

Many studies have compared individual measures of health expectancy across older populations by time-invariant characteristics. However, very few have included time-varying variables when calculating health expectancy. Even among older adults, socioeconomic and demographic characteristics are likely to change over the life course, and these changes may have substantial implications for health outcomes. This paper proposes a multiple multistate method (MMM) that situates the multistate model within the broader family of vector autoregressive models. Our approach allows the incorporation of the coevolution of multiple life course factors and provides a flexible yet simple way to model two or more time-varying variables with the multistate model. We demonstrate the MMM in two empirical applications, showing the flexibility of the approach to explore health expectancies with complex state spaces.

Trends in Distress‐Free Life Expectancy in Japan, 2010–2022

ABSTRACTExtensive literature exists on the physical health of the Japanese population whereas relatively little is known about their mental health. Moreover, most studies have assessed physical and mental health separately, and this further confounds the relationship between the two. Using the concept of health expectancy, this study investigated the trends in the relationship between physical and mental health among Japanese men and women aged 20 years or more between 2010 and 2022. Psychological distress, based on the Comprehensive Survey of Living Conditions, was used as an indicator of mental health. We employed Sullivan's method to estimate the length of life with or without distress of varying degrees. Our results showed substantial improvements in distress‐free life expectancy for both genders during the study period. Younger people have gained more distress‐free years than their older counterparts, placing older individuals, especially men, at an increased risk of psychological distress. These findings contribute to the literature on longevity in Japan by quantifying the role of mental health in the population's overall health. Given the recent increase in mental health problems, greater policy emphasis on the relationship between physical and mental health status is required.

Cross-Sectional Association Between Life Expectancy and Unhealthy Life Years: Proof of Concept Tests of the CroHaM Hypothesis

The recently presented CroHaM hypothesis says (1) that longitudinal health domain-specific expansion and compression effects depend primarily on the health domains’ mortality risk and (2) that these effects exist equivalently in the cross-sectional context, affecting differences in healthy life years (HLY) between populations and subpopulations with different levels of life expectancy (LE). We test this hypothesis by analysing the association between LE and unhealthy life years (ULY) at age 50 for a large number of subpopulations. The analyses are carried out for three health domains which are differently related to mortality: poor self-perceived health and strong activity limitation with comparatively high mortality, and chronic morbidity with comparatively low risk of dying. Data on gender- and subpopulation-specific prevalence of these health conditions are taken from the Actual German Health Study 2012 (GEDA). LEs are estimated with the “Longitudinal Survival Method”, using data of the German Life Expectancy Survey. ULY are estimated with the “Sullivan Method”. Differences in ULY between each subpopulation and the total population and between women and men for each subpopulation are decomposed into the effects caused by differences in health (“health effect”) and mortality (“mortality effect”) with the “Nusselder/Looman Method”. The results confirm the CroHaM hypothesis: we find a positive relationship between LE and ULY only for chronic morbidity, whereas this relationship is negative for poor self-perceived health and strong activity limitation. However, when the mortality effect is controlled for, we find a negative relationship between LE and ULY for all three health domains. The practical relevance of these findings is discussed using the example of the so-called “gender paradox” in health and mortality. We conclude that the CroHaM hypothesis may describe an important determinant of life years spent with and without health impairment, and it may help to better understand and interpret trends and differentials in HLY or ULY based on cross-sectional data. * This article belongs to a special issue on “Levels and Trends of Health Expectancy: Understanding its Measurement and Estimation Sensitivity”.

Comparative analysis of COVID-19 vaccine booster dose (VBD) acceptance among trainees and students of health professions in Bangladesh

BackgroundDespite the proven therapeutic potential of bivalent vaccine primer doses against COVID-19, acceptance of vaccine booster doses (VBD) varies among various subgroups of the global population. This study investigated the acceptance of COVID-19 VBD among trainees and students of health professions in Bangladesh and compared the potential factors influencing their VBD decisions. MethodsThe questionnaire was deployed in an online-enabled layout and conveniently sent to encounters between 10th June 2023 and 10th September 2023. Data from 501 trainees and 501 students were compared (response rate 80.8% vs.78.3%) to explore the study objectives. ResultsThe pooled COVID-19 VBD acceptance rates were 90.2% (95% Confidence Interval [CI]:87.6─92.8) vs. 93.2% (95% [CI]: 91.2─95.2) between trainees and students. The binary logistic analysis revealed that out of twelve factors “equal safety” (Adjusted odds ratio [aOR]: 4.476 vs. 6.459), “efficacy” ([aOR]:3.673 vs. 2.913), “repeated immunity” ([aOR]: 1.729 vs. 2.247), and “self-priority” ([aOR]:3.108 vs. 4.645) had a significant positive association (p<0.01 and p<0.05) with VBD acceptance in both groups. There were varied effects on several predictors. Among trainee professionals, "communication" and "booster mandate" were associated significantly ([aOR]:1.534 and 1.748, respectively; p<0.05) with VBD acceptance, whereas "information source" and "culture" were associated ([aOR]:3.692 and 3.151, respectively; p<0.05) significantly with VBD acceptance in the student cohort. ConclusionsThere was a satisfactory acceptance level of COVID-19 VBD among healthcare participants, and several multidimensional factors influenced their VBD decisions in different ways. For enhancing public booster immunization decisions against COVID-19, individual health expectations must be linked to wider societal influences.

Enhancing sustainable food innovation through consumer participatory co-creation: A case study on plant-based dietary snack bars in Thailand

The veggie bar is a novel dietary concept that caters to the growing trend of individuals who prioritize their health and search for wholesome meal options. However, developing new food products without essential customer insights may put the potential success of food innovation at risk. Our study adopted a participatory co-creation approach to investigate market segmentation and innovate veggie snack bar product features. Focus group discussions at 4 locations across Thailand were employed to examine target segments and examine customers’ insights. A total of 64 respondents, who are fitness enthusiasts (n = 32) and office workers with busy lifestyles (n = 32), participated in this study. This research presented how to co-create a sustainable food product and led to creative ingredient compositions for a new line of veggie bars that reduce sugar and boost nutrition with fiber and probiotics. Scent and taste were also adjusted to disguise vegetable aromas with natural flavor enhancers and add exotic fruits and savory spices to satisfy various consumer tastes. The study also stressed the importance of texture for ease of consumption and produced environmentally friendly and informative packaging to meet customer expectations for sustainability and health. These findings show that product innovation in the food industry can suit consumers’ changing tastes and health concerns.

Community perspectives on the use of electronic health data to support reflective practice by health professionals

BackgroundElectronic health records and other clinical information systems have crucial roles in health service delivery and are often utilised for patient care as well as health promotion and research. Government agencies and healthcare bodies are gradually shifting the focus on how these data systems can be harnessed for secondary uses such as reflective practice, professional learning and continuing professional development. Whilst there has been a presence in research around the attitudes of health professionals in employing clinical information systems to support their reflective practice, there has been very little research into consumer attitudes towards these data systems and how they would like to interact with such structures. The study described in this article aimed to address this gap in the literature by exploring community perspectives on the secondary use of Electronic Health Data for health professional learning and practice reflection.MethodsA qualitative methodology was used, with data being collected via semi-structured interviews. Interviews were conducted via phone and audio recordings, before being transcribed into text for analysis. Reflective thematic analysis was undertaken to analyse the data.ResultsFifteen Australians consented to participate in an interview. Analysis of interview data generated five themes: (1) Knowledge about health professional registration and professional learning; (2) Secondary uses of Electronic Health Data; (3) Factors that enable the use of Electronic Health Data for health professional learning; (4) Challenges using Electronic Health Data for health professional learning and (5) Expectations around consent to use Electronic Health Data for health professional learning.ConclusionsAustralians are generally supportive of health professionals using Electronic Health Data to support reflective practice and learning but identify several challenges for data being used in this way.

Implication of the EU Countries’ Energy Policy Concerning Scenarios Affecting the Air Quality Improvement

Energy policy has a significant impact on the state of the environment and, therefore, on residents’ health and life expectancy, especially in highly urbanized areas. Reducing emissions is currently one of the necessary actions that must be taken at the scale of individual countries to ensure sustainable development. The article aims to identify the best ways to shape energy policy by evaluating development scenarios for air protection and their environmental impact. The realization of the goal is based on the data included in three groups: (1) Economic factors, Health factors, and Demographic factors; (2) Clima-e related economic losses, Renewable Energy sources in electricity, heating, and cooling, Premature deaths due to exposure to fine particulate matter (PM2.5), Health impacts of air pollution, Population change; (3) Demographic balance and crude rates at the national level, GDP per capita in purchasing power PPS, GDP, and principal components; covering 36 EU countries in 2019 and 2021. The study proposes an advanced methodology for assessing development strategies by integrating the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) and Bayesian networks (BN) and incorporating them into a multicriteria decision-making (MCDM) support system. The TOPSIS model based on BN allowed for the illustration of the features of many criteria and the identification of relationships between scenarios, allowing for selecting the best way to develop energy policy. The results showed a 60.39% chance of achieving success in extending the life of residents by five years. At the same time, the most favorable development path was the scenario promoting activities aimed at reducing air pollution by introducing renewable energy sources to produce energy used for lighting and preparing domestic hot water urban areas. By presenting possible scenarios and the probability of success, it is possible to achieve the goal of practical energy policy at the level of the country and individual European cities and also by extending the life of city inhabitants, as presented by the authors in this study.

Mismatches in Health: A Global Analysis of Discrepancies Between Self-Reported and Tested Mobility and Cognition

The health of individuals is frequently assessed based on self-reported information derived from surveys. However, self-reports are often inconsistent with their tested equivalents, indicating measurement issues. While discrepancies between self-reported and tested health indicators have been investigated for high-income countries in Europe, little comparative research has been conducted involving other low-income regions. This paper analyses discrepancies between self-reported and tested health limitations across 25 countries from six world regions with different income-levels, cultural backgrounds, institutional settings, and epidemiological trajectories. Using harmonised data from the Gateway to Global Aging, we match self-reported mobility and cognition with their tested equivalent to assess discrepancies at the individual level. Our results suggest that the consistency between these measures is strongly correlated with the Human Development Index, with lower scores of development showing higher discrepancies. Examining patterns by age reveals that self-reports do not accurately reflect the deterioration of health associated with aging – tested health exhibits a pronounced age gradient, whereas self-reported health varies little over the life course, particularly self-reported memory. We find no persistent gender differences in consistency. These discrepancies cast doubt on the reliability of mobility and cognitive self-reports, especially when comparing health across nations with differing development levels. * This article belongs to a special issue on “Levels and Trends of Health Expectancy: Understanding its Measurement and Estimation Sensitivity”.

Professionals' and Intercultural Mediators' Perspectives on Communication With Ukrainian Refugees in the Czech Healthcare System.

A growing body of research is examining how healthcare systems are responding to the increasing numbers of migrants and the resulting superdiversity of patients. The aim of this article is to identify and explain communication barriers in the provision of healthcare to Ukrainian war refugees in the Czech Republic from the perspectives of healthcare professionals and intercultural mediators. The exploratory case study is based on a qualitative analysis of semi-structured interviews with frontline health professionals: 20 with doctors and 10 with nurses. The second source of data is two focus groups aimed at capturing communication problems from the perspective of intercultural mediators who accompany refugees to health facilities. The interview transcripts and FGs were analysed using six-stage thematic coding. The survey identified five main themes related to barriers to communication: (1) language barriers and interpreting, (2) cultural barriers, (3) differing expectations of health and the healthcare systems in the Czech Republic and Ukraine, (4) prejudices and negative attitudes and unethical behaviour towards refugees and migrants and (5) lack of awareness of patient rights. The arrival of large numbers of migrants has highlighted deficiencies in the system that may affect other vulnerable groups and the general population. These include the lack of general communication skills and legal awareness among many health professionals, which are barriers to the development of patient-centred care. The involvement of intercultural mediators fundamentally improves communication between health professionals and (not only) migrant patients. Nevertheless, it is necessary to legally anchor and define the position of intercultural mediators within the healthcare system. Collaboration with intercultural mediators who interpreted the extensive experiences of Ukrainian refugee patients and also have personal experience as migrant or migrant-origin patients contributed to shaping research questions, facilitating study participation and enriching evidence interpretation. Researchers with multicultural backgrounds and experience with working with people from refugee backgrounds were involved in the study design and analysis.

A Hybrid GNN Approach for Improved Molecular Property Prediction.

The development of new drugs is a vital effort that has the potential to improve human health, well-being and life expectancy. Molecular property prediction is a crucial step in drug discovery, as it helps to identify potential therapeutic compounds. However, experimental methods for drug development can often be time-consuming and resource-intensive, with a low probability of success. To address such limitations, deep learning (DL) methods have emerged as a viable alternative due to their ability to identify high-discriminating patterns in molecular data. In particular, graph neural networks (GNNs) operate on graph-structured data to identify promising drug candidates with desirable molecular properties. These methods represent molecules as a set of node (atoms) and edge (chemical bonds) features to aggregate local information for molecular graph representation learning. Despite the availability of several GNN frameworks, each approach has its own shortcomings. Although, some GNNs may excel in certain tasks, they may not perform as well in others. In this work, we propose a hybrid approach that incorporates different graph-based methods to combine their strengths and mitigate their limitations to accurately predict molecular properties. The proposed approach consists in a multi-layered hybrid GNN architecture that integrates multiple GNN frameworks to compute graph embeddings for molecular property prediction. Furthermore, we conduct extensive experiments on multiple benchmark datasets to demonstrate that our hybrid approach significantly outperforms the state-of-the-art graph-based models. The data and code scripts to reproduce the results are available in the repository, https://github.com/pedro-quesado/HybridGNN.