Health Effects Research Articles

Chinese Minimum Wages and Health

Variation in the timing of changes in the minimum wage across provinces in China is exploited using individual/household longitudinal survey data from 2010 to 2018 to examine potential health effects on working age individuals in households that are likely affected by minimum wages. Minimum wage increases are estimated to improve self-reported health particularly by reducing the incidence of self-reported overall poor health. There is also reasonably strong evidence that they reduce unhappiness and lower dissatisfaction with less robust evidence that they improve mental health and lower recent discomfort. Importantly, there is a type of “dose-response” effect: the estimates indicate no health effects of minimum wage increases on those in households likely not affected financially by the minimum wage with health effects increasing the more likely the household is financially affected. The results are driven by the findings for males.

Attenuation of inflammation, oxidative stress and TGF-β1/Smad3 signaling and upregulation of Nrf2/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity

Heavy metals are toxic environmental pollutants with serious health effects on humans and animals. Cadmium (Cd) is known for its serious nephrotoxic effect and its toxicity involves oxidative stress (OS) and inflammation. Diallyl disulfide (DADS), a main constituent of garlic, exhibited cytoprotective and antioxidant activities. This study investigated the effect of DADS on OS, inflammation, and fibrosis induced by Cd in rat kidney, pointing to the involvement of transforming growth factor-β (TGF-β)/Smad3 and nuclear factor erythroid 2–related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling, and peroxisome proliferator-activated receptor gamma (PPARγ). Rats received DADS for 14 days and Cd on day 7 and blood and kidney samples were collected. Cd elevated serum creatinine, urea and uric acid, provoked kidney histopathological alterations and collagen deposition, increased kidney malondialdehyde (MDA) level, and decreased glutathione (GSH) and antioxidant enzymes. Nuclear factor-kappaB (NF-κB) p65, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, and CD68 were upregulated in Cd-administered rat kidney. DADS prevented kidney injury, mitigated OS, suppressed NF-κB, CD68 and pro-inflammatory mediators, and boosted antioxidants. DADS downregulated TGF-β1, Smad3 phosphorylation and Kelch-like ECH-associated protein-1 (Keap1), and increased Nrf2, HO-1, cytoglobin, and PPARγ. In conclusion, DADS protects the kidney against Cd toxicity by attenuating OS, inflammation, and TGF-β1/Smad3 signaling, and enhancement of Nrf2/HO-1 signaling, antioxidants, and PPARγ.

Exploring Alternative Anthelmintic Compounds: Impact of Peruvin, Hentriacontane/1-Nonacosanol and Their Synergistic Effect on the Health of Meriones unguiculatus infected with Haemonchus contortus

Haemonchus contortus is a highly pathogenic blood-feeding parasite affecting sheep and goats, leading to significant economic losses. With increasing resistance to conventional anthelmintics, exploring plant-based alternatives is crucial. In vitro, studies suggest that peruvin and hentriacontane/1-nonacosanol, isolated from Artemisia cina (Asteraceae), may synergistically control Haemonchus contortus. However, their in vivo efficacy and safety are unestablished. This study evaluated these compounds' anthelmintic activity and health effects and their synergistic mixture in Meriones unguiculatus (gerbils). The compounds were isolated using open-column chromatography and identified by spectroscopic techniques. Gerbils were artificially infected with H. contortus following dexamethasone treatment to enhance infection. Anthelmintic activity was assessed by larval reduction in the stomach, blood biochemical parameters using a blood chemistry analyzer, and the anatomopathological changes in kidney and liver tissues. Peruvin (0.4mg/kg) and hentriacontane/1-nonacosanol (2.60mg/kg) achieved larvicidal reductions of 84.86% and 74.05%, respectively, while their synergistic mixture (0.08/0.0017mg/kg) resulted in a 100% reduction. Histopathological analysis revealed minor inflammation and albuminous degeneration, primarily affecting the liver. The peruvin-treated group showed notable kidney damage, while hepatic alterations were similar across both compounds. Although effective, further research is needed to optimize dosing and ensure safety

Mode of action Criteria for selection of the critical effect and safe dose range for PFOA by the Alliance for risk assessment.

In response to the current disparity in risk assessment values for PFOA from different agencies and countries, an international effort facilitated by the Alliance for Risk Assessment (ARA) was recently undertaken to characterize the range of scientifically supportable safe dose estimates. In this assessment (Burgoon et al., 2023), an evaluation of the evidence regarding the potential modes of action (MOA) for PFOA toxicity was performed first, so that it could be used to inform subsequent decisions regarding potential critical effects and studies. This review describes the evidence considered in the MOA evaluations that were performed as part of the ARA effort. The overall conclusions of this evaluation are that the available mechanistic data do not support any conclusion that reported epidemiological associations of blood concentrations of PFOA as low as 10ng/mL with various health effects should be considered causal. It is more likely that the reported associations may instead reflect reverse causality/pharmacokinetic confounding. These conclusions are consistent with the opinions of the World Health Organization (WHO, 2022).

Source and Bioavailability of Quaternary Ammonium Compounds (QACs) in Dust: Implications for Nationwide Exposure in China

Quaternary ammonium compounds (QACs), widely used in various disinfectants products during the COVID-19 Pandemic, raised the concerns on their exposure and health effect. To date, the sources of QACs in indoor environments have been largely ignored. Additionally, there is no information on the nationwide human exposure assessment of QACs in China after the COVID-19. Herein, analysis of QACs in household products, including personal care (n=27), cleaning (n=6) and disinfection products (n=11) from different manufacturing companies further confirmed there are extensive application of QACs in household products, raising their potential exposure to humans. QACs were frequently detected in indoor dust samples (n=370) from 111 cities of 31 provinces/municipalities across China, with median concentration of 6778ng/g. Benzalkyldimethylammonium compounds (BACs) and alkyltrimethylammonium compounds (ATMACs) were identified as the dominant QACs in dust samples, with the proportions of 44% and 46%, respectively. The in vivo bioavailability experiment (C57BL/6 male mice) showed that the relative bioavailability (RBA) of QACs through dust ingestion ranged from 5.08% to 66.3% and 60.3% to 118% in the low and high-dose group, respectively. Compared to the pre-adjustment scenario of RBA values, the exposure risk of QACs was overestimated by 2.23 – 5.14 times.

Identification and analysis of NAC genes related to S-alk(en)yl cysteine sulfoxides (CSOs) biosynthesis in Onion (Allium cepa L.)

The NAC family, a specific type of plant transcription factor, has been identified in various horticultural crops. Nevertheless, the comprehensive bioinformatics and biological function of the NAC family in onion remain unclear. S-alk(en)yl cysteine sulfoxides (CSOs) are crucial for onion flavor quality and health effects. There is a growing interest in studying the mechanism of CSOs synthesis regulation in onions due to the increased realization of their potential value. In this study, sixty members of the NAC family was identified based on transcriptomic data. These transcription factors were distributed on eight chromosomes of onion. Phylogenetic tree showed that AcNAC members were divided into three groups with similar conserved protein motifs. Cis-acting elements analysis showed that the promoter of AcNACs contained a large number of photoresponsive and hormone-responsive elements. The correlation analysis of the expression patterns of transcriptome data selected 18 AcNACs that might regulate the synthesis of CSOs. Two putative NAC transcription factors, AcNAC12 and AcNAC17, were speculated as potential regulators in the biosynthesis of CSOs in onions through the analysis of expression patterns of AcNAC genes across different growth stages and cultivars, as well as Y1H, dual luciferase, GUS staining, and gene suppression experiments. This study aims to provide suggestions and research directions for further investigation of the functions of AcNAC family members and regulatory pathways for CSO biosynthesis.

Effects of dental insurance and dental care utilization on oral health-related daily life activities among federally qualified healthcare center patients in the United States.

To assess the association between dental insurance, dental care utilization and oral health-related impact on daily activities among patients visiting Health Resources and Services Administration (HRSA)-funded health centers in the United States. This cross-sectional study examined the 2014 Health Center Patient Survey (HCPS), a survey of patients who received care at US health centers. Logistic regression analyses were conducted to explore the likelihood of the oral health-related impact on daily activities domains such as school/work performance, sleeping, eating/chewing, social and home activities considering sociodemographic, dental insurance, and dental care utilization. Among 7002 total participants, 6890 self-reported oral health-related impact on daily activities. Adults aged 18-44 were 2.6 times more likely to report an overall impact on everyday life activities compared to children and adolescents. After adjusting for sociodemographics, Hispanic patients were less likely to report any oral health-related impacts, while patients visiting rural centres reported higher odds of oral health related impairment. Patients who experienced delays in receiving dental care or were unable to access dental care when needed were 4.5 times more likely to encounter difficulties in their daily activities. This study linked limited dental insurance and care to increased oral health issues impacting daily life, particularly among adults, rural populations, and those facing delay in dental care. This highlights the need for policy reforms and interventions aimed at improving dental care access to mitigate the detrimental effects of poor oral health on daily functions for vulnerable populations.

Mortality burden and economic loss attributable to cold and heat in Central and South America.

We quantify the mortality burden and economic loss attributable to nonoptimal temperatures for cold and heat in the Central and South American countries in the Multi-City Multi-Country (MCC) Collaborative Research Network. We collected data for 66 locations from 13 countries in Central and South America to estimate location-specific temperature-mortality associations using time-series regression with distributed lag nonlinear models. We calculated the attributable deaths for cold and heat as the 2.5th and 97.5th temperature percentiles, above and below the minimum mortality temperature, and used the value of a life year to estimate the economic loss of delayed deaths. The mortality impact of cold varied widely by country, from 9.64% in Uruguay to 0.22% in Costa Rica. The heat-attributable fraction for mortality ranged from 1.41% in Paraguay to 0.01% in Ecuador. Locations in arid and temperate climatic zones showed higher cold-related mortality (5.10% and 5.29%, respectively) than those in tropical climates (1.71%). Arid and temperate climatic zones saw lower heat-attributable fractions (0.69% and 0.58%) than arid climatic zones (0.92%). Exposure to cold led to an annual economic loss of $0.6 million in Costa Rica to $472.2 million in Argentina. In comparison, heat resulted in economic losses of $0.05 million in Ecuador to $90.6 million in Brazil. Most of the mortality burden for Central and South American countries is caused by cold compared to heat, generating annual economic losses of $2.1 billion and $290.7 million, respectively. Public health policies and adaptation measures in the region should account for the health effects associated with nonoptimal temperatures.

Poultry manure application enhances the phytochemical contents, antioxidant, and fixed oil of Momordica charantia L

Due to its rich sources of bioactive compounds, Momordica charantia (bitter melon) is used as a food and natural medicine, resuting in many beneficial health effects. Poultry manure is a valuable source of organic fertilizer used to enrich soil fertility to obtain high yields from agricultural products. It contains high levels of essential macro and micronutrients. The present study aimed to determine the effects of chicken and turkey manure applications on the protein content, extract content, antioxidant activity, total phenolic and flavonoid contents, and mineral matter productivity of bitter melon fruits. In addition, the study evaluated the chicken and turkey manure applications on the fixed oil quality of bitter melon seeds. In this context, different doses of chicken (T1:10, T2:12.5, T3:15, T4:17.5 t/ha) and turkey (T5: 10, T6: 12.5, T7:15, T8:17.5 t/ha) manures were applied by sowing. The crude protein contents values of the bitter melon fruits ranged from 4.79 to 7.80 %, and a maximum crude protein content of bitter melon fruits was obtained from T8 application. The highest DPPH activity was observed with the T7 (88.43 %) and T4 (86.23 %) applications, while the highest FRAP value was obtained from T4 application (73.52 mg TE/g). In addition, the highest total phenolic content (21.13 mg GAE/g) and total flavonoid amount (11.44 mg QE/g) of bitter melon fruits were obtained from T6 application. Maximum capric acid (50.40 %) was recorded in the seed oil after applying the T1, while the highest concentration of lauric acid (30.09 %) were reflected by applying the T5. The highest Fe, Cu and Mn concentrations were found in the T4, while the highest concentration of Zn and B recorded in the fruit extract appeared after applying the T6. The PCA analysis showed 56.2 % of total variation. Thus, the results suggest that the application of poultry manure could be employed to get maximum benefits regarding protein and extract contents, antioxidant activity, total phenolic and flavonoid contents, fixed oil component and mineral content values.

Exposure assessment of the European adult population to deoxynivalenol – Results from the HBM4EU Aligned Studies

Mycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the internal exposure of the adult European population and identify the most relevant determinants of exposure. tDON concentrations’ P50 and P95 were in the range of 0.41–10.16 µg/L (0.39–9.05 µg/g crt) and 3.25–46.58 µg/L (2.12–33.50 µg/g crt) respectively. Higher tDON levels were observed for (i) male participants from France and Germany, (ii) samples collected in spring and summer, (iii) participants with a lower educational level, (iv) participants living in rural areas, (v) individuals without a job in France and Luxembourg, while in Portugal higher exposure was observed in working individuals, (vi) individuals with higher consumption of cereals and bread. The proportion of individuals with exposure levels exceeding the HBM-GV of 23 µg/L was 12.3 %, ranging from 0.8 % to 20.7 % in the individual countries. This study on mycotoxins exposure has used post harmonized questionnaire data and validated analytical methodologies for analysis and covered countries representing the four geographical regions of Europe, having produced much needed knowledge on the exposure of the European adult population to deoxynivalenol.

Perceptions and Mental Health Effects of Therapeutic Farming across Age Groups: A Survey-based Study

We aimed to derive data that can serve as the basis for designing customized therapeutic farming programs (TFPs) for different life stages by collecting information regarding the mental health status and perceptions of therapeutic farming (TF). We created a survey encompassing individual mental health conditions, general perceptions and participation, demand, and policy requirements regarding TF. By targeting children, adolescents, adults, and older adults in the metropolitan area of South Korea, we collected 505 surveys online and face-to-face. Children and adolescents had worse mental health management than adults and older adults. More than half of the respondents reported experiencing stress and depressive symptoms. Regarding perceptions of TF, compared with other age groups, older adults were more likely to believe in the mental health benefits of plants. Additionally, those with relatively lower stress, depression, and anxiety levels agreed on these benefits. The primary purposes and expected activities regarding TFP participation differed by age group. However, pets and small farm animals were the most preferred animals for TF across all age groups. When promoting TF, children and adolescents prioritized improved introduction and promotion, whereas adults and older adults prioritized improved accessibility. These data can help develop customized TFPs for different life stages as well as the general public.

Organochlorine pesticides and polybrominated diphenyl ethers in giant African snail from the Niger Delta, Nigeria: Implications for dietary exposure and health risk assessment

The concentrations of organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) were evaluated in snails from different locations in the Niger Delta of Nigeria to provide data about their sources and possible risk to humans from the consumption of snails. The OCP and PBDE concentrations in snail samples ranged from 0.31 to 12.2 ng g-1 and 0.21 to 10.9 ng g-1, respectively. The distribution patterns indicated the dominance of chlordanes and penta-BDEs for OCPs and PBDEs, respectively. The hazard index and total cancer risk values for human exposure to OCPs and PBDEs through consumption of these snails were less than 1 and 10-6 (acceptable risk value), respectively, indicating unlikely adverse health effects. The isomer ratios of OCPs in these snails reflected both historical and recent contamination, while the distribution patterns of PBDEs in these snails indicated sources linked to the use of the penta-BDE and octa-BDE formulations rather than the deca-BDE mixture in this region.

Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort.

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent synthetic chemicals that are found in human milk and are associated with negative health effects. Research suggests that PFAS affect both lactation and the human metabolome. We measured perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A nontargeted metabolomics assay was performed using LC with high-resolution MS, and metabolites were identified based on in-house database matching. We observed six metabolic profiles among our milk samples using self-organizing maps, and multinomial logistic regression was used to identify sociodemographic and perinatal predictors of these profiles, including infant sex, parity, participant body mass index, participant age, education, race, smoking status, gestational weight gain, and infant age at time of milk collection. Elevated PFOA was associated with profiles containing higher amounts of triglyceride fatty acids, glycerophospholipids and sphingolipids, and carnitine metabolites, as well as lower amounts of lactose and creatine phosphate. Lower concentrations of milk PFOS were associated with lower levels of fatty acids. Our findings suggest that elevated PFOA in human milk is related to metabolomic profiles consistent with enlarged milk fat globule membranes and altered fatty acid metabolism. Further, our study supports the theory that PFAS share mammary epithelial membrane transport mechanisms with fatty acids and associate with metabolic markers of reduced milk production.

Apex carnivores coping with metal(loid) pollution and oxidative stress: biological and environmental drivers of variation in kidney of European brown bear

Induction of oxidative stress and the associated lipid peroxidation is a prevalent mechanism through which certain metal(loid)s exert nephrotoxic effects in mammals. Research on the toxic impacts of metal(loid)s in free-ranging large mammals at high trophic positions is exceedingly rare, yet crucial for understanding environmental exposure scenarios relevant to both human and animal risk assessment. Renal cortex tissues (N=457) of free-ranging brown bears (Ursus arctos) from the Dinara-Pindos population sampled in Croatia were analysed herein for toxic metal(loid)s and the underlying biological and environmental drivers of variation, with their time trend monitored during the 2009-2022 period. In 28 individuals from the 2021-2022 period, we additionally investigated associations between metal(loid)s and oxidative stress and damage biomarkers in renal cortex cells. The principal generalized linear models used to approximate variations in biomarkers of oxidative stress and damage included non-essential As, Cd, Pb, Tl and U, and essential Co, Cu, Fe and Zn. Age class and season of sampling had no impact on biomarker levels, except for lipid peroxidation, LP (April ↑). Age, sex (females ↑), body condition index (↓) and season of sampling significantly influenced metal(loid)s levels. Non-specific mammalian thresholds were crossed for Cd and Pb toxicity in 1-16% and 2% of population, respectively. Renal levels of metal(loid) did not exhibit a clear trend over the 13-year period. The levels found in this study were higher than in sympatric carnivorous and herbivorous species, but in line with findings in ursids worldwide. Potential adverse health effects from environmental exposure in brown bears may arise from disruption of oxidative balance, as evidence clearly indicated associated changes in catalase activity (↑), glutathione content (↑), LP (↓), reactive oxygen species (↓), total antioxidant capacity (↑) in the renal cortex due to the presence of the most toxicologically relevant Cd and Pb.

Methodological steps forward in toxicological in vitro screening of mineral wools in primary rat alveolar macrophages and normal rat mesothelial NRM2 cells.

Man-made vitreous fibers (MMVF) comprise diverse materials for thermal and acoustic insulation, including stone wool. Depending on dimension, durability, and dose, MMVF might induce adverse health effects. Therefore, early predictive in vitro (geno)toxicity screening of new MMVF is highly desired to ensure safety for exposed workers and consumers. Here, we investigated, as a starting point, critical in vitro screening determinants and pitfalls using primary rat alveolar macrophages (AM) and normal rat mesothelial cells (NRM2). A stone wool fiber (RIF56008) served as an exemplary MMVF (fibrous vs. ground to estimate impact of fiber shape) and long amosite (asbestos) as insoluble fiber reference. Materials were comprehensively characterized, and in vivo-relevant in vitro concentrations defined, based on different approaches (low to supposed overload: 0.5, 5 and 50µg/cm2). After 4-48h of incubation, certain readouts were analyzed and material uptake was investigated by light and fluorescence-coupled darkfield microscopy. DNA-strand break induction was not morphology-dependent and nearly absent in both cell types. However, NRM2 demonstrated material-, morphology- and concentration-dependent membrane damage, CINC-1 release, reduction in cell count, and induction of binucleated cells (asbestos > RIF56008 > RIF56008 ground). In contrast to NRM2, asbestos was nearly inactive in AM, with CINC-1 release solely induced by RIF56008. In conclusion, to define an MMVF-adapted, predictive in vitro (geno)toxicity screening tool, references, endpoints, and concentrations should be carefully chosen, based on in vivo relevance, and sensitivity and specificity of the chosen cell model. Next, further endpoints should be evaluated, ideally with validation by in vivo data regarding their predictivity.

Assessing the impact of radiofrequency radiation from cellular towers on human health: A comprehensive review

The proliferation of cellular communication towers, driven by the rapid advancement of wireless technologies like 4G and 5G, has raised significant public health concerns regarding the potential effects of long-term exposure to radiofrequency (RF) electromagnetic radiation (EMR). This review explores the implications of RF radiation emitted by these towers, which is classified as non-ionizing and typically associated with thermal effects, albeit at levels considered safe by major health organizations such as the World Health Organization (WHO) and the International Commission on Non-Ionizing Radiation Protection (ICNIRP). Key topics addressed include the mechanisms of RF radiation interaction with biological systems, public concerns about health effects including cancer risks, neurological impacts, reproductive health, and the controversial condition known as electromagnetic hypersensitivity (EHS). While numerous studies suggest that RF exposure does not lead to significant adverse health outcomes at permissible levels, evidence regarding potential non-thermal effects, such as oxidative stress and changes in cell signaling, remains inconclusive. The review emphasizes the need for further research into the long-term effects of RF radiation, particularly with the expansion of 5G technology, and considers the regulatory frameworks established to ensure public safety. The conclusion highlights a cautious approach, advocating for ongoing scientific inquiry and the application of the precautionary principle, especially concerning vulnerable populations like children and pregnant women.

Potential link between vaping and hypothyroidism: A case report

Background: Vaping has gained popularity as an alternative to traditional smoking, but its potential health effects, particularly on endocrine function, remain under-explored. This case report highlights a possible association between vaping and the development of subclinical hypothyroidism in a young adult female. Case Presentation: A 25-year-old female with a history of vaping for 30 minutes daily over the course of one year presented with symptoms of fatigue, weight gain, and dry skin. Initial thyroid function tests showed elevated TSH (5.08 uIU/mL), reduced T3 (64 ng/dL), and T4 (4.8 ug/dL), consistent with subclinical hypothyroidism. After discontinuing or reducing vaping, repeat thyroid function tests revealed an improvement in thyroid hormone levels (TSH: 4.69 uIU/mL, T3: 136.4 ng/dL, T4: 5.77 ug/dL) and symptom relief. The use of a vaping device with a lithium-ion battery raised concerns about possible lithium exposure, a known factor in thyroid dysfunction. Conclusion: This case suggests a potential reversible association between vaping and subclinical hypothyroidism, possibly exacerbated by lithium toxicity from battery leakage. Further research is necessary to understand the mechanisms behind vaping-related thyroid dysfunction and the potential role of lithium in this process.

Sodium-glucose co-transporter 2 inhibitors and new-onset diabetes in cardiovascular or kidney disease.

Individuals with heart failure (HF), other forms of cardiovascular disease, or kidney disease are at increased risk for the development and adverse health effects of diabetes. As such, prevention or delay of diabetes is an important treatment priority in these groups. The aim of this meta-analysis was to determine the effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on incident diabetes in HF across the spectrum of left ventricular ejection fraction (LVEF) and across the broader spectrum of cardiovascular or kidney disease. First, the effects of dapagliflozin vs. placebo on new-onset diabetes were assessed in a pooled, participant-level analysis of the DAPA-HF and DELIVER trials. New-onset diabetes was defined as the new initiation of glucose-lowering therapy during follow-up, and time from randomization to new-onset diabetes was evaluated using Cox proportional hazards models. Second, PubMed and Embase were searched to identify large-scale randomized clinical outcomes trials (RCTs) comparing SGLT2i with placebo among adults with cardiovascular or kidney disease. A trial-level meta-analysis was then conducted to summarize the treatment effects of SGLT2i on the incidence of new-onset diabetes. In the pooled analysis of DAPA-HF and DELIVER including 5623 participants with HF but without diabetes at baseline, dapagliflozin reduced the incidence of new-onset diabetes by 33% [hazard ratio (HR), 0.67; 95% confidence interval (CI), .49-.91; P = .012] when compared with placebo. There was no evidence of heterogeneity across the spectrum of continuous LVEF or key subgroups. Among seven complementary RCTs including 17 855 participants with cardiovascular or kidney disease, SGLT2i reduced the of new-onset diabetes by 26% (HR, 0.74; 95% CI .65-.85; P < .001), with consistent effects across trials. SGLT2i reduced the incidence of new-onset diabetes among individuals with cardiovascular or kidney disease. These findings suggest that SGLT2i implementation may have an important ancillary benefit on prevention or delay of diabetes in these high-risk populations.

Impact of anthropogenic activities and the associated heavy metal pollution in Sundarbans waterways: threats to commercial fish and human health.

The exposure of fish to heavy metals is a significant concern for human health and natural ecosystems. Despite being a critical issue, the extent of contamination in tropical fish from developing countries like Bangladesh remains somewhat unexplored. In this study, ten economically vital fish species (Osteogeneiosus militaris, Arius gagora, Harpadon nehereus, Mugil ephalus, Pseudapocryptes elongates, Apocryptes bato, Labeo bata, Tenualosa toil, Notopterus notopterus, and Pampus chinensis) from the Pasur River, Bangladesh, were analyzed by atomic absorption spectrometer for the concentrations of four concerned heavy metals, viz., As, Cr, Cd, and Pb, and the associated human health risks. The mean concentrations (mg/kg) followed the order of As (3.30 ± 1.43) > Pb (2.32 ± 0.73) > Cr (0.63 ± 0.29) > Cd (0.37 ± 0.24). Additionally, the bioaccumulation factor of the metals in the investigated fish species followed a decreasing trend of As (824.75) > Cr (781.25) > Cd (744) > Pb (385.83). While most species fell below the minimum bioaccumulation line, a few exceptions were noted for some species specific to metals. Health risk assessments indicated no significant carcinogenic and non-carcinogenic risks for both children and adults, although children exhibited greater vulnerability to both types of health effects. Multivariate analysis and local perceptions supported the conclusion that heavy metals primarily originated from anthropogenic sources related to development activities adjacent to the riverine areas.

Environmental microplastic and phthalate esters co-contamination, interrelationships, co-toxicity and mechanisms. A review.

Plastics have been pervasive in society for decades, causing extensive environmental contamination. The co-occurrence of microplastics (MPs) and phthalate esters (PAEs) in the environment has significant implications for the global population. This review focuses on the simultaneous presence of MPs and PAEs, exploring co-pollution, leaching, adsorption, correlation, and co-toxicity. Both MPs and PAEs are found in various environmental compartments, including water, sediments, aquatic organisms, pig feed, masks, gloves, and liquid waste from garbage infiltration. Factors such as time, temperature, UV light exposure, and the type of MPs can influence the leaching and adsorption of PAEs onto MPs. The correlation between MPs and PAEs allows for the use of PAEs as indicators for the presence of MPs. However, current constraints, like limited data availability and regional coverage, impede the feasibility of comprehensive tracking. Additionally, the combined effects of MPs and PAEs demonstrate synergistic toxicity, leading to adverse health effects such as reproductive toxicity, neurotoxicity, hepatotoxicity, nephrotoxicity, and other toxicities, primarily mediated by oxidative stress processes. Consequently, the findings provide valuable insights for future researchers and regulatory bodies, enabling the development of more effective strategies to address the simultaneous presence of microplastics and PAEs and mitigate their harmful impacts on human health.