Telemedicine, the use of telecommunications technology to deliver health-care services remotely, has witnessed significant growth worldwide, offering new possibilities for enhancing health-care accessibility and delivery. This review explores the progress and challenges of implementing telemedicine in the unique context of Africa. Despite the continent’s diverse health-care landscape and infrastructural variations, telemedicine has shown promise in addressing critical health-care challenges. The study outlines the progress made in telemedicine adoption across Africa, highlighting successful initiatives, such as mobile health applications, teleconsultations, and telemonitoring programs. These efforts have contributed to improved health-care access, particularly in remote and underserved areas. In addition, the utilization of telemedicine has played a crucial role in disease management, prevention, and health education. However, the implementation of telemedicine in Africa is not without challenges. Infrastructure limitations, including inadequate Internet connectivity and inconsistent electricity supply, pose significant hurdles. Furthermore, the shortage of trained health-care professionals and concerns related to data security and privacy must be addressed to ensure the sustainable and widespread adoption of telemedicine. This study critically examines the regulatory landscape surrounding telemedicine in various African countries, emphasizing the need for harmonized policies to encourage cross-border collaboration and standardization. The sociocultural factors influencing the acceptance of telemedicine among diverse populations are also discussed, acknowledging the importance of community engagement and awareness. While telemedicine presents a promising avenue for improving health-care delivery in Africa, careful consideration of the continent’s unique challenges is essential. Collaborative efforts involving governments, health-care providers, technology developers, and communities are crucial for overcoming barriers and maximizing the potential benefits of telemedicine in advancing health-care equity and quality across Africa.