The fight against weeds in crops and plantings of agricultural crops, both annual and perennial, has been and remains one of the most important scientific problems of agricultural production. The relevance of the research lies in a comprehensive study of the effectiveness of the use of modern promising herbicides in hazelnut orchards, in order to optimize measures to combat weeds. The research results made it possible to develop a system for maintaining soil in a walnut orchard using modern herbicides. To solve the problem, it is necessary to conduct geobotanical studies of the weed component in the walnut orchard, to determine the magnitude of the negative impact of various doses of herbicides in the inter-rows and rows of hazel. The authors first obtained data on the use of herbicides on gray forest soils, with alluvial deposits, skeletonized and rocky in the Iraf region of the Republic of North Ossetia, which are characterized by a humus content of 6-8%, phosphorus up to 200 mg/kg, potassium up to 42 mg/kg and acidic reaction of the soil solution (pH 5.1). The object of the study was weeds in perennial walnut plantations, among them difficult-to-eradicate root shoot thistles (Cirsium arvense), (Sonchus arvensis), creeping bitterweed (Acroptilon repens); rhizome creeping wheatgrass (Agropirum repens) and others. It was established that the use of herbicides Lontrel -300, VR (3 l/ha), Hurricane Forte, VR (2 l/ha), Basta, VR (5 l/ha), Sprut Extra VR (3 l/ha) reduced the number of weeds ranging from 84.8% to 89.9%. Recommendations are given on the timing of application of the most promising herbicides in perennial hazelnut plantations. The predominant effectiveness among the herbicides studied was shown by Octopus Extra VR.