In this paper, we study a new statistical distribution called the hybrid odd exponential-exponential distribution (HOE-E distribution for short) we the aim of applying it to real data sets. This new distribution appears as a sub-model of the larger HOEE-Φ family in (Mahdi et al., 2024). We explore many mathematical and statistical properties of this distribution such as the series expansion of the PDF, the quantile function, moments and their generating function, incomplete moments, the shape of the PDF, and the shape of the hazard rate function, order statistics, and parameter estimation using the maximum likelihood estimation. We use this distribution to model a plasma concentration data set. Moreover, this we show that the suggested HOE-E distribution outperformance many other distributions based on various statistical criteria like AIC, CAIC, BIC, HQIC, W, and A.