Hazard Characterization Research Articles

Spatially Explicit Assessments of Heat-Related Health Risks: A Literature Review

Extreme heat events, or heatwaves, exert significant impacts on human society, ecosystems, and the economy. The continuous development of remote sensing technology has facilitated the acquisition of high-quality data for assessing health risks associated with these extreme heat events. This study systematically reviews the evaluation factors and assessment framework for a spatially explicit assessment of heat-related health risks. The contribution of geospatial big data, with a particular focus on satellite observations, to these assessments was investigated. The Moderate Resolution Imaging Spectroradiometer (MODIS) and Landsat surface temperature (LST) are identified as the two most widely utilized data sources for mapping heat hazards. The incorporation of multi-sensor observations, along with the implementation of spatiotemporal fusion and downscaling techniques, enhances both the spatial resolution and temporal frequency of heat hazard characterization. It is essential to consider issues of justice and equality in heat-resilient planning and mitigation practices. Integrating heatwave risk assessment results with analyses of urban morphology, land use functions and infrastructure can provide critical information for government agencies to strategically plan urban layout, functions, and public service facilities while optimizing and enhancing urban green infrastructures.

Natural Hazard Assessment in the Southeastern Margin of the Ría de Arosa (Pontevedra, Spain) Using GIS Techniques

The characterization of natural hazards in coastal environments is of great necessity, especially in the current context of global climate change and increasing population concentrations. This research focuses on a multi-hazard analysis of the main geotechnical, geomorphological, hydrological, and lithological risks in the southeastern margin of the Ría de Arosa using Geographic Information System techniques. The integration of geotechnical characterization maps and natural hazard maps has allowed for the identification of areas with a high susceptibility to natural disasters, which is crucial for territorial planning and management in the context of growing urban pressure and global climate change. The results indicate that poorly consolidated surface formations, especially in transitional areas such as dunes and marshes, are particularly vulnerable. Additionally, areas with higher lithological competence have been identified, where slope changes contribute to ground instability. This analysis provides valuable tools for decision-making and the implementation of risk management policies, promoting sustainable development, the protection of coastal ecosystems, and the prevention of risks from urban planning and civil engineering activities in the Ría de Arosa.

Assessment of Formaldehyde’s Impact on Indoor Environments and Human Health via the Integration of Satellite Tropospheric Total Columns and Outdoor Ground Sensors

Formaldehyde (HCHO) is harmful to human health and an adequate assessment of its concentrations, both in outdoor and indoor environments, is necessary in the context of sustainable policies designed to mitigate health risks. In this research, ground indoor and outdoor HCHO measurements are integrated with the analysis of tropospheric total columns obtained by satellite surveys to assess the concentrations of HCHO in a number of environments, exploiting the proximity of a World Meteorological Organization—Global Atmosphere Watch (WMO/GAW) observation site in Calabria, Southern Italy to a National Institute for Insurance against Accidents at Work (INAIL) department in the municipality of Lamezia Terme. The meteorological parameters used by the WMO station are also used to provide additional data and test new correlations. Using statistical significance tests, this study demonstrates the presence of a correlation between indoor and outdoor HCHO concentrations, thus showing that an exchange between indoor and outdoor formaldehyde does occur. Rooms located in the local INAIL building where indoor measurements took place also demonstrate degrees of susceptibility to HCHO exposure, which are correlated with the orientation of prevailing wind corridors in the area. The new findings constitute an unprecedented characterization of HCHO hazards in Calabria and provide regulators with new tools with which to mitigate formaldehyde-related risks.

Towards realism in hazard assessment of plastic and rubber leachates – Methodological considerations

While plastic chemicals are key drivers of observed effects to aquatic species, there remains a lack of standardized and fit-for-purpose approaches for experimentally deconvoluting the effects of plastic chemicals from particle effects. This study investigated differences in chemical composition determined using two different organic solvents for extractions (dichloromethane-ethyl acetate, methanol) and by thermal desorption applied to 51 thermoplastic and elastomer products. The composition of natural water leachates of four select elastomers was also investigated. The number of chemical features in each material varied according to the extraction method, with solvent extracts exhibiting the most chemicals, and only 19 compounds commonly identified by all three methods. The number of chemical features in leachates was generally similar to the corresponding chemical extracts, but strong differences in relative composition were detected. While turbulence had minimal impact on leachate composition, particle loading strongly influenced leachate composition, temperature and salinity influenced the leachate concentration for some chemicals, and leaching time depended upon chemical mobility. Leachate composition cannot be readily predicted from particle characterization and multiple parameters are drivers of compositional variance in aquatic leachates. Recommendations for performing leaching studies that are relevant for hazard characterization in a realistic aquatic environment risk assessment scenario are suggested, with a particular focus on particle loading.

Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals.

Vitamins and essential minerals are micronutrients that are required for the normal functioning of the human body. However, they may lead to adverse health effects if consumed in excess. A tolerable upper intake level (UL) is a science-based reference value that supports policy-makers and other relevant actors in managing the risks of excess nutrient intake. EFSA's principles for establishing ULs for vitamins and minerals were originally developed by the Scientific Committee on Food in 2000. This guidance from the EFSA Panel on Nutrition, Novel Foods and Food Allergens provides an updated framework for UL assessments. A draft was published in 2022 and underwent a 2-year piloting period. The present document incorporates revisions based on the experience gained through its practical implementation. It covers aspects related to the planning of the risk assessment (problem formulation and definition of methods) and its implementation (evidence retrieval, appraisal, synthesis, integration, uncertainty analysis). As in the previous framework, the general principles developed for the risk assessment of chemicals in food are applied, i.e. hazard identification, hazard characterisation, intake assessment, risk characterisation. Specific to nutrients are their biochemical and physiological roles and the specific and selective mechanisms that maintain the systemic homeostasis and accumulation of the nutrient in the body. Such considerations must also be taken into account when conducting risk assessments of nutrients.

An automated computational data pipeline to rapidly acquire, score, and rank toxicological data for ecological hazard assessment.

Biological Evaluations support Endangered Species Act (ESA) consultation with the US Fish and Wildlife Service and National Marine Fisheries Service by federal action agencies, such as the USEPA, regarding impacts of federal activities on threatened or endangered species. However, they are often time-consuming and challenging to conduct. The identification of pollutant benchmarks or guidance to protect taxa for states and tribes when USEPA has not yet developed criteria recommendations is also of importance to ensure a streamlined approach to Clean Water Act program implementation. Due to substantial workloads, tight regulatory timelines, and the often-protracted length of ESA consultations, there is a need to streamline the development of biological evaluation toxicity assessments for determining the impact of chemical pollutants on ESA-listed species. Moreover, there is limited availability of species-specific toxicity data for many contaminants, further complicating the consultation process. New approach methodologies are being increasingly used in toxicology and chemical safety assessment to rapidly and cost-effectively provide data that can fill gaps in hazard and/or exposure characterization. Here, we present the development of an automated computational pipeline-RASRTox (Rapidly Acquire, Score, and Rank Toxicological data)-to rapidly extract and categorize ecological toxicity benchmark values from curated data sources (ECOTOX, ToxCast) and well-established quantitative structure-activity relationships (TEST, ECOSAR). As a proof of concept, points-of-departure (PODs) generated in RASRTox for 13 chemicals were compared against benchmark values derived using traditional methods-toxicity reference values (TRVs) and water quality criteria (WQC). The RASRTox PODs were generally within an order of magnitude of corresponding TRVs, though less concordant compared with WQC. The greatest utility of RASRTox, however, lies in its ability to quickly and systematically identify critical studies that may serve as a basis for screening value derivation by toxicologists as part of an ecological hazard assessment. As such, the strategy described in this case study can potentially be adapted for other risk assessment contexts and stakeholder needs. Integr Environ Assess Manag 2024;20:2203-2217. © 2024 Society of Environmental Toxicology & Chemistry (SETAC). This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Probabilistic health risk assessment of primary aromatic amines in polyamide cooking utensils in China by Monte Carlo simulation

The migration of primary aromatic amines (PAAs) from food contact materials raises significant public health concerns. In this study, the migration levels of 26 PAAs were analyzed in 242 nylon cooking utensils using ultra-performance liquid chromatography-tandem mass spectrometry. A total of 18 PAAs were detected, of which 14 were quantified, with 4,4′-diaminodiphenylmethane (4,4′-MDA) and aniline being the most prevalent ones. The compliance rates for nylon kitchenware were similar under both legislation of European Commission (76.9%) and Chinese legislation (77.9%). Probabilistic non-carcinogenic and carcinogenic risk assessment were conducted using Monte Carlo simulation, with read-across approach applied to fill the gap of toxicity data. The hazard quotients for 18 PAAs were calculated, revealing that 17 PAAs (excluding 4,4′-MDA) had acceptable hazard quotients (<1). Lifetime cancer risks for 17 PAAs were determined, with 15 PAAs (excluding benzidine and 4,4′-MDA) showing acceptable cancer risks (<10−4). The study suggests that the non-carcinogenic and carcinogenic health risks posed by PAAs migrating from FCMs can be effectively mitigated by promptly identifying non-compliant products and reducing exposure to high-risk PAAs such as 4,4′-MDA and benzidine. Enhancing the understanding of PAA hazard characterization and implementing measures to minimize health risks associated with PAA migration from FCMs is hence recommended.

Hazard Characterization of Antibiotic-resistant Aeromonas spp. Isolated from Mussel and Oyster Shellstock Available for Retail Purchase in Canada

Surveillance and monitoring of foods for the presence of antimicrobial-resistant (AMR) bacteria are required to assess the risks these bacteria pose to human health. Frequently consumed raw or lightly cooked, live bivalve shellfish such as mussels and oysters can be a source of exposure to AMR bacteria. This study sought to determine the prevalence of third-generation cephalosporin (3GC) and carbapenem-resistant bacteria in live mussel and oyster shellstock available for retail purchase through the course of one calendar year. Just over half of the 180 samples (52%) tested positive for the presence of 3GC-resistant bacteria belonging to thirty distinct bacterial species. Speciation of the isolates was carried out using the Bruker MALDI Biotyper. Serratia spp., Aeromonas spp., and Rahnella spp. were the most frequently isolated groups of bacteria. Antibiotic resistance testing confirmed reduced susceptibility for 3GCs and/or carbapenems in 15 of the 29 Aeromonas isolates. Based on AMR patterns, and species identity, a subset of ten Aeromonas strains was chosen for further characterization by whole genome sequence analysis. Genomic analysis revealed the presence of multiple antibiotic resistance and virulence genes. A number of mobile genetic elements were also identified indicating the potential for horizontal gene transfer. Differences in gene detection by the bioinformatic tools and databases used (ResFinder. CARD RGI, PlasmidFinder, and MobSuite) are discussed. This study highlights the strengths and limitations of using genomics tools to perform hazard characterization of diverse foodborne bacterial species.

A Remote-Sensing-Based Method Using Rockfall Inventories for Hazard Mapping at the Community Scale in the Arequipa Region of Peru

Small communities in the Arequipa region of Peru are susceptible to rockfall hazards, which impact their lives and livelihoods. To mitigate rockfall hazards, it is first necessary to understand their locations and characteristics, which can be compiled into an inventory used in the creation of rockfall hazard rating maps. However, the only rockfall inventory available for Arequipa contains limited data of large, discrete events, which is insufficient for characterizing rockfall hazards at the community scale. A more comprehensive inventory would result in a more accurate rockfall hazard rating map—a significant resource for hazard mitigation and development planning. This study addresses this need through a remote method for rockfall hazard characterization at a community scale. Three communities located in geographically diverse areas of Arequipa were chosen for hazard inventory and characterization, with a fourth being used for validation of the method. Rockfall inventories of source zones and rockfall locations were developed using high-resolution aerial imagery, followed by field confirmation, and then predictions of runout distances using empirical models. These models closely matched the actual runout distance distribution, with all three sites having an R2 value of 0.98 or above. A semi-automated method using a GIS-based model was developed that characterizes the generation and transport of rockfall. The generation component criteria consisted of source zone height, slope angle, and rockmass structural condition. Transport was characterized by rockfall runout distance, estimated rockfall trajectory paths, and hazard ratings of corresponding source zones. The representative runout distance inventory model of the validation site matched that of a nearby site with an R2 of 0.98, despite inventorying less than a third of the number of rockfalls. This methodology improves upon current approaches and could be tested in other regions with similar climatic and geomorphic settings. These maps and methodology could be used by local and regional government agencies to warn residents of rockfall hazards, inform zoning regulations, and prioritize mitigation efforts.

An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart

Many foods including edible oils contain 2-monochloropropane-1,3-diol (2-MCPD), a processing-induced chemical contaminant. Cardiotoxic effects have been shown to result from oral 2-MCPD exposure in rodents, but the underlying mechanisms of action remain poorly understood. We undertook a comprehensive multi-omics approach to assess changes at the transcriptomic, proteomic, and oxylipin levels in heart tissues from male F344 rats that were exposed to 0 or 40 mg/kg BW/day of 2-MCPD in the diet for 90 days, in a regulatory compliant rodent bioassay. Heart tissues were collected for RNA sequencing, quantitative PCR analysis, proteomic analysis via two-dimensional gel electrophoresis and mass spectrometry, and targeted lipidomic profiling by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). Transcriptomic and proteomic data analyses revealed upregulation of immune/inflammatory response processes and downregulation of energy metabolism and cardiac structure and functions. Among differentially expressed gene–protein pairs, coronin-1A, a key leukocyte-regulating protein, emerged as markedly up-regulated. Oxylipin profiling highlighted a selective suppression of docosahexaenoic acid-derived metabolites, suggesting a disruption in cardioprotective lipid pathways. These findings suggest that 2-MCPD disrupts homeostasis through inflammatory activation and suppression of metabolic and cardiac function. This research provides insights into 2-MCPD's cardiotoxicity, emphasizing the need for further studies to support hazard characterization.

Flame propagation, explosion hazard, and pollutant emission characterization of typical clean fuels leaks in plateau low-pressure region

To accelerate energy transformation and sustainable development, various countries are rushing to lay hydrogen doped natural gas pipelines. However, the installation of pipelines will pass through plateau low-pressure region, and the impact of low-pressure environments on the flame propagation, explosion hazards, and pollutant emission characteristics of hydrogen doped natural gas is not yet clear. To solve this problem, a combination of constant volume combustion experiment and numerical simulations is used. The characterization parameters of flame, explosion and pollutant concentration of natural gas/H2/air under low-pressure environment are obtained, and their chemical reaction kinetics are analyzed. When the pressure drops, the laminar burning velocity (LBV) of them increases, and the Lewis number (Le) gradually increases by more than 1. Thermal diffusion is stronger than mass diffusion, and the growth rate of flame thickness exceeds 26 %. The effect of hydrodynamic instability enhances, causing an increment in the average size of flame cells, the critical instability radius, and the Markstein length (Lu). At the equivalent ratio (φ) of 1, there is a change from negative to positive in the Lu, and flame stability continuously strengthens. The explosion overpressure is reduced by 78 % to 90 %, the explosion temperature by 16 % to 20 %. As the φ increases, the LBV exhibits an inverted U-shaped relationship, reaching its maximum value near “φ = 1″. The flame stability first weakens and then strengthens. The explosion hazard is strongest in the range of ”φ = 1–1.2″. With a decrease in pressure, the total reaction rate of fuel consumption is reduced by more than 50 %. The continuous reaction distance is extended by 12 %. Changes in pressure have a relatively weak impact on the content of CO and CO2. The increase in the φ results in an increase in CO content of over 7 %. The content of CO2 reaches its maximum value around “φ = 1″. It is an essential reference for the safe delivery of hydrogen energy and the reduction of environmental pollution.

Isolation of ovatoxin-a from Ostreopsis cf. ovata cultures. A key step for hazard characterization and risk management of ovatoxins

Ostreopsis cf. ovata, a benthic/epiphytic marine dinoflagellate, is currently spreading in tropical, sub-tropical and temperate areas, causing periodic Harmful Algal Blooms (HABs). It produces a wide array of palytoxin-like compounds named ovatoxins (OVTXs), with OVTX-a generally the most abundant congener. Despite numerous cases of human poisonings and environmental damage associated with the presence of OVTXs and O. cf. ovata proliferations, a complete characterization of the toxicity of this class of molecules cannot be performed until Reference Material (RM) for individual congeners is available. This, in turn, requires the availability of sufficient amounts of toxin at a high purity grade. To achieve this goal, herein an analytical re-evaluation of critical-steps of OVTX-a isolation from O. cf. ovata cell pellets is reported. The overall procedure consists of four steps, namely an extraction, a Medium Pressure Liquid Chromatography (MPLC) separation, and two preparative High Performance Liquid Chromatography (HPLC) steps. Particular attention was paid to the extraction step to evaluate the repeatability in OVTX-a yields. For subsequent steps, loading sample preparation and chromatographic conditions were refined. As a result, a significant increase in recovery yields (from 12.5 to 20 ± 3%) and in purity grade (from 51% to 94%) of the isolated OVTX-a was achieved in comparison to previous studies. The improved procedure can easily be applied to isolate sufficient quantities of a good candidate RM for OVTX-a.

Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update

Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update

P20-31 The re-evaluation of sweeteners by the European Food Safety Authority (EFSA): the revised protocols for the assessment of hazard identification and hazard characterisation and exposure of sweeteners

P20-31 The re-evaluation of sweeteners by the European Food Safety Authority (EFSA): the revised protocols for the assessment of hazard identification and hazard characterisation and exposure of sweeteners

P26-01 Hexagonal boron nitride (hBN) and hBN-reinforced thermoplastic polyurethane composite: an in vitro hazard characterization using human skin and lung cells

P26-01 Hexagonal boron nitride (hBN) and hBN-reinforced thermoplastic polyurethane composite: an in vitro hazard characterization using human skin and lung cells

P06-23 Integration of metabolomics and transcriptomics for improved mechanism-based hazard characterization of drug-induced liver injury

P06-23 Integration of metabolomics and transcriptomics for improved mechanism-based hazard characterization of drug-induced liver injury

P19-21 Hazard characterization and quantification of health risk from chronic exposure to metofluthrin through contamination of the air environment of human life

P19-21 Hazard characterization and quantification of health risk from chronic exposure to metofluthrin through contamination of the air environment of human life

RegionGrow3D: A Deterministic Analysis for Characterizing Discrete Three‐Dimensional Landslide Source Areas on a Regional Scale

AbstractRegional‐scale characterization of shallow landslide hazards is important for reducing their destructive impact on society. These hazards are commonly characterized by (a) their location and likelihood using susceptibility maps, (b) landslide size and frequency using geomorphic scaling laws, and (c) the magnitude of disturbance required to cause landslides using initiation thresholds. Typically, this is accomplished through the use of inventories documenting the locations and triggering conditions of previous landslides. In the absence of comprehensive landslide inventories, physics‐based slope stability models can be used to estimate landslide initiation potential and provide plausible distributions of landslide characteristics for a range of environmental and forcing conditions. However, these models are sometimes limited in their ability to capture key mechanisms tied to discrete three‐dimensional (3D) landslide mechanics while possessing the computational efficiency required for broad‐scale application. In this study, the RegionGrow3D (RG3D) model is developed to broadly simulate the area, volume, and location of landslides on a regional scale (≥1,000 km2) using 3D, limit‐equilibrium (LE)‐based slope stability modeling. Furthermore, RG3D is incorporated into a susceptibility framework that quantifies landsliding uncertainty using a distribution of soil shear strengths and their associated probabilities, back‐calculated from inventoried landslides using 3D LE‐based landslide forensics. This framework is used to evaluate the influence of uncertainty tied to shear strength, rainfall scenarios, and antecedent soil moisture on potential landsliding and rainfall thresholds over a large region of the Oregon Coast Range, USA.

Characterization of health and safety hazards of deconstruction activities.

Manual deconstruction-an alternative to mechanical demolition-is a crucial technique in the building industry that facilitates a circular economy for the built environment and achieves sustainable development goals (SDGs). However, the current body of literature lacks a thorough grasp of the OHS (occupational health and safety) hazards related to the deconstruction process. The current work closes this scholarly gap by outlining the deconstruction process as phases and sets of activities and highlighting potential health and safety hazards throughout different activities and phases. The study uses numerous case studies and applies a descriptive case study technique to gather and analyze primary data from hundreds of photos and notes from over 40 field visits. The primary data are first used to prepare a comprehensive process map of deconstruction. Six construction safety experts and four industrial hygiene experts were then interviewed to identify and characterize health and safety hazards in images representative of the deconstruction activities. A taxonomy of OHS hazards for deconstruction was developed based on identifying 35 unique safety and 51 unique health hazards. Significant safety hazards in deconstruction activities include "struck-by," "trip, slip, and fall" hazards, and "lack of personal protective equipment." Major health hazards include ergonomic concerns, respiratory diseases, and eye strain. The study highlights the occupational health and safety issues faced by the deconstruction trade with a granularity rarely covered in existing literature. The assessments can be helpful for OHS practitioners to identify potential health and safety improvements across various deconstruction phases.

Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides

Background: Test methods to inform hazard characterization and labeling of pesticides to protect human health are typically conducted using laboratory animals, and for skin irritation/corrosion the rabbit Draize test is currently required by many regulatory agencies. Although the Draize test is generally regarded to provide protective classifications for human health, new approach methodologies (NAMs) have been developed that offer more human relevant models that circumvent the uncertainty associated with species differences that exist between rabbits and humans. Despite wide applicability and use of these test methods across a broad range of chemicals, they have not been widely adopted for testing pesticides and pesticidal formulations. One of the barriers to adoption of these methods in this sector is low concordance with results from the Draize rabbit test, particularly for chemicals within the mild to moderate irritation spectrum. Methods: This review compares and contrasts the extent to which available models used in skin irritation testing mimic the anatomy and physiology of human skin, and how each aligns with the known key events leading to chemically-induced adverse skin irritation and corrosion. Doing so fully characterizes the human relevance of each method. Results: As alternatives to the rabbit Draize test, several protocols using ex vivo, in chemico, and in vitro skin models are available as internationally harmonized test guidelines. These methods rely on a variety of models of human skin, including excised rodent skin, synthetic biochemical models of barrier function, cell culture systems, and reconstructed human tissue models. We find these models exhibit biological and mechanistic relevance aligned with human skin irritation responses. Further, recent retrospective analyses have shown that the reproducibility of the Draize test is less than 50% for mild and moderate responses, with many of the replicate predictions spanning more than one category (e.g., a moderate response reported in one study followed by a non-irritant response reported in another study). Conclusions: Based on this comparative evaluation, we recommend top-down and bottom-up testing strategies that use the most human relevant in vitro test methods for skin irritation and corrosion classification of pesticides and pesticide formulations. To further discriminate among mild and non-irritant formulations, optimization of a cytokine release protocol and subsequent analyses of reference formulation test results is recommended.