The B4 topology is an interesting alternative to the conventional B6 inverter due to its reduced number of parts and lower cost. Although it has been widely used in the past, especially in low-power motor drive applications, its application as a grid-connected inverter is an open area of research. In this regard, this paper analyses the feasibility of the B4 inverter topology for grid-connected applications. A versatile 7 kW inverter prototype, which may be configured as B4 and B6, was built, allowing for a comprehensive evaluation of the performance of both topologies. Through an analytical study and experimental tests, the performance of the B4 and B6 topologies was comparatively evaluated in terms of efficiency, total harmonic distortion of line currents, current unbalance, cost, and mean time between failures. The study was carried out in the context of microgrid systems, highlighting their role in the integration of renewable energy and distributed generation.