Current social-technical and political conditions threaten the integrity of the Amazon biome. Overcoming these lock-ins requires structural transformations away from conventional economies towards 'socio-bioeconomies' (SBEs). SBEs are economies based on the sustainable use and restoration of Amazonian ecosystems, as well as Indigenous and rural livelihood systems in the region. They include sustainable eco-tourism as well as diversified production and innovative processing of fruits, nuts, oils, medicines, fish and other products deriving from socio-biodiversity. Using a sustainability transitions perspective, we argue for multi-scalar policy changes to sustain, enhance and scale-out and scale-up SBE initiatives. To nurture niche SBE acitivities, we advocate for improvements in infrastructure, value chains and social organizations. To dismantle structural barriers, we call for an end to harmful subsidies, greater representation of marginalized communities in territorial planning, enhanced rural-urban and intersectoral linkages, international collaboration, shifts in demand, and changes in conservation and production narratives. Policies for SBEs must also use clear definitions, participatory processes and a multi-biome approach to avoid perverse outcomes.