Harmful Entities Research Articles

Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions.

The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), and shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported in both animal and human studies, which may contribute to cognitive decline and neurodegenerative disorders. Limited data also suggest that being female may be associated with protective effects on BBB function. Here, we investigated age and sex-dependent trajectories of perfusion and BBB water exchange rate (kw) across the lifespan in 186 cognitively normal participants spanning the ages of 8-92 years old, using a non-invasive diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) MRI technique. We found that the pattern of BBB kw decline with aging varies across brain regions. Moreover, results from our DP-pCASL technique revealed a remarkable decline in BBB kw beginning in the early 60 s, which was more pronounced in males. In addition, we observed sex differences in parietal and temporal regions. Our findings provide in vivo results demonstrating sex differences in the decline of BBB function with aging, which may serve as a foundation for future investigations into perfusion and BBB function in neurodegenerative and other brain disorders.

Keeping the sanctuary pure: Movements and frictions in an Argentine gated community

ABSTRACT Located on the outskirts of Buenos Aires, Nordelta is one of the largest gated communities in Latin America. To produce a purified sanctuary, the Nordelta compound has deployed fenced walls, guards, barriers, CCTV cameras, dogs, movement sensors and a dozen other power mechanisms aimed at controlling human and non-human movements and behaviors in and around the compound. Its three accesses gates are crossed every day by thousands of cars, buses, students, visitors, workers, animals and objects. Looking closely at the issues of exchange and circulation, this article addresses the following questions: which entities—humans, objects and information—can access the compound and how; which cannot; and which are prevented from leaving. Further, it analyses the normalization processes through which potentially harmful entities must go through to be accepted inside Nordelta. The analysis not only reviews these dispositives but also considers the tactics devised and deployed by propietarios, workers and visitors to avoid, re-appropriate and/or resist them.

Impact of Dietary Choices on Immune System Functionality

In our daily lives, we are invariably exposed to a diverse spectrum of bacteria, some posing potential hazards. The human immune system, an extraordinary assemblage of interconnected organs and cells, serves as our defense against these harmful bacteria, viruses, and various diseases. A critical function of the immune system is to combat harmful entities such as viruses, germs, and parasites. Essential to the optimal functioning of the immune system is the consumption of a diet rich in both macroand micronutrients. Embracing a healthy lifestyle, which includes increasing the intake of water, essential minerals (notably magnesium and zinc), micronutrients, herbs, and foods rich in vitamins C, D, and E, is fundamental to maintaining health and preventing infections. This article conducts a thorough analysis of common foods renowned for their immune-enhancing properties. It highlights the vital role of a nutritious, balanced diet in promoting effective immune function and discusses the impact of dietary habits on immunological responses. The article provides an in-depth examination of numerous popular foods, scrutinized for their ability to strengthen the immune system. This category encompasses foods derived from animals, as well as fruits, vegetables, and whole grains. We explore various food groups, focusing on the nutrients and bioactive compounds they contain, and how these contribute to immune system support. Particular emphasis is placed on the consumption of foods like milk, eggs, fruits, leafy greens, and spices such as turmeric, garlic, and onion, all rich in beneficial compounds. These compounds have the potential to activate and inhibit immune cells, as well as to interfere with various biological pathways, thereby enhancing immune responses and defense mechanisms. The development of this article involved an extensive search and critical review of relevant literature, primarily sourced from online resources, ensuring a comprehensive and scientifically grounded exploration of diet's role in bolstering the immune system.

Bridging science and accessibility: a tactile journey from gluten through to coeliac disease.

As part of the Monash Sensory Science Exhibition, our team guided participants through a multisensory journey unraveling coeliac disease development and pathology. Through tactile and sensory exhibits, we showed how benign dietary gluten can be transformed into a harmful entity for the 1 in 70 Australians with this illness. In contrast to the common misconception of coeliac disease as a food allergy, our exhibits revealed its closer association with autoimmune diseases such as type 1 diabetes, involving genetic susceptibility linked to specific human leukocyte antigens, crucial antigen-specific T- and B-cell responses and autoantibody production. Tactile models underscored the severe consequences of the proinflammatory immune response to gluten on patient health and quality of life. This educational event affirmed to us the value and importance of fostering inclusivity in science education.

Design and implementation of secured file delivery protocol using enhanced elliptic curve cryptography for class I and class II transactions

<p>This research study introduces an ID-based identity authentication protocol that utilizes the enhanced elliptic curve digital signature algorithm, a cryptographic method developed on elliptic curve cryptography. The protocol enhances the Consultative Committee for Space Data Systems (CCSDS) File Delivery Protocol (CFDP), a pioneering protocol explicitly defined for distant space communications. This study employs both dependable and uncertain modes of the CFDP protocol. To make more secure data transactions, two key security risks are effectively mitigated in this research as a result of applying the proposed enhanced elliptic curve cryptography algorithm (ECC) over the ternary galois field. First, it thwarts the impersonation of a harmful entity during a passive attack. Second, it prevents masquerade attacks, further reinforcing the security of space data transmission. This ID-based authentication protocol, therefore, offers a significant advancement in protecting far-space communications, optimizing the integrity of data exchanged across vast distances.<strong><em></em></strong></p>

Different Dietary Approaches, Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A Literature Review.

Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease and is also associated with other harmful entities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a significant public health concern worldwide, impacting individuals of all ages, and its prevalence is projected to increase in the near future due to its connection with obesity. Intrinsic (genetics) and external (lifestyle) factors may also modulate NAFLD, and, in turn, may partly explain the observed relationship between NAFLD and cardiovascular disease (CVD). Although many drugs are been tested to treat NAFLD, to date, no drug has indication to specifically treat this disorder. Thus, the current management of NAFLD relies on lifestyle modifications and specifically on weight loss, physical activity, and the intake of a healthy diet. In the present narrative review, we will discuss the effects of certain dietary patterns on NAFLD incidence and progression.

A Framework for Biosensors Assisted by Multiphoton Effects and Machine Learning.

The ability to interpret information through automatic sensors is one of the most important pillars of modern technology. In particular, the potential of biosensors has been used to evaluate biological information of living organisms, and to detect danger or predict urgent situations in a battlefield, as in the invasion of SARS-CoV-2 in this era. This work is devoted to describing a panoramic overview of optical biosensors that can be improved by the assistance of nonlinear optics and machine learning methods. Optical biosensors have demonstrated their effectiveness in detecting a diverse range of viruses. Specifically, the SARS-CoV-2 virus has generated disturbance all over the world, and biosensors have emerged as a key for providing an analysis based on physical and chemical phenomena. In this perspective, we highlight how multiphoton interactions can be responsible for an enhancement in sensibility exhibited by biosensors. The nonlinear optical effects open up a series of options to expand the applications of optical biosensors. Nonlinearities together with computer tools are suitable for the identification of complex low-dimensional agents. Machine learning methods can approximate functions to reveal patterns in the detection of dynamic objects in the human body and determine viruses, harmful entities, or strange kinetics in cells.

Perceived Intensification in Harmful Algal Blooms Is a Wave of Cumulative Threat to the Aquatic Ecosystems.

Simple SummaryHarmful algal blooms (HABs) are a serious threat to aquatic environments. The intensive expansion of HABs across the world is a warning signal of environmental deterioration. Global climatic change enforced variations in environmental factors causing stressed environments in aquatic ecosystems that favor the occurrence, distribution, and persistence of HABs. Perceived intensification in HABs increases toxin production, affecting the ecological quality as well as serious consequences on organisms including humans. This review outlines the causes and impacts of harmful algal blooms, including algal toxicity, grazing defense, management, control measures, emerging technologies, and their limitations for controlling HABs in aquatic ecosystems.Aquatic pollution is considered a major threat to sustainable development across the world, and deterioration of aquatic ecosystems is caused usually by harmful algal blooms (HABs). In recent times, HABs have gained attention from scientists to better understand these phenomena given that these blooms are increasing in intensity and distribution with considerable impacts on aquatic ecosystems. Many exogenous factors such as variations in climatic patterns, eutrophication, wind blowing, dust storms, and upwelling of water currents form these blooms. Globally, the HAB formation is increasing the toxicity in the natural water sources, ultimately leading the deleterious and hazardous effects on the aquatic fauna and flora. This review summarizes the types of HABs with their potential effects, toxicity, grazing defense, human health impacts, management, and control of these harmful entities. This review offers a systematic approach towards the understanding of HABs, eliciting to rethink the increasing threat caused by HABs in aquatic ecosystems across the world. Therefore, to mitigate this increasing threat to aquatic environments, advanced scientific research in ecology and environmental sciences should be prioritized.

米国の対日要求としてのTPPと事前協議の害悪(TPP問題の到達と参加阻止の課題-理論と運動の視点から-,2012年度大会ミニシンポジウム報告)

米国の対日要求としてのTPPと事前協議の害悪(TPP問題の到達と参加阻止の課題-理論と運動の視点から-,2012年度大会ミニシンポジウム報告)

Hair-Snakes. To the Issue of the Semantics of Byzantine Phylacteries with “Hystera”

Introduction. The article is devoted to analyzing the specific type of Byzantine phylacteries (amulets), which are a vivid manifestation of folk beliefs that combine pagan, magical and Christian components. The author talks about the so-called “coils” – pendants with the image of a head with reptiles instead of hair or simply in combination with snakes. Many of them have a magical inscription mentioning “hysteria” (uterus), which can be understood as this particular organ, as well as various harmful entities. For this reason, there is a problem of correlation of the image and the magic inscription. But the article attempts to interpret the serpentine composition in the context of its functional purpose. Methods. In historiography, there are many opinions about what the images could represent on this type of monuments. At different times, researchers saw in the image of a head with snakes Medusa Gorgon, the dragon-Satan, Russian Aphrodite – goddess Lada, Abrasax, Sophia of Ophites, Moses’ brazen serpent, Eve and the devil, the seven-headed serpent and seven deadly sins, sisters-Likhoradkas, the dragon from the Apocalypse, the serpent of Aesculapius transformed into Satan. In addition, the composition was recognized as a “portrait” of the demon and his machinations elevated to the image of Khnubis and was considered the personification of the hysterical uterus itself. Analysis. In the article, the meaning of the serpentine composition is considered in the comparative analysis with other images on amulets. This is possible due to the presence of stereotypes and general principles in the construction of magical drawings applied to the amulets, as well as the general meaning that is associated with the functional purpose of the phylacteries. In different types of the images on amulets, semantic emphasis is placed on reproducing the desired action. For this, phylacteries were made and used, and magical texts, signs, images of saints, the Mother of God and even Christ himself were applied to the amulet. Results. The symbolism of the serpentine composition is revealed within the same sign system. The drawing combining a head (face) and wriggling snakes clearly represents the desired effect – the outcome, the flight of illnesses or the forces of the evil symbolized by reptiles from a person.

Security and Confidentiality of the Data using Block Level in Health Care System

Nowadays rapid development of cloud computing in smart healthcare system has significantly improved the quality of health. However, data security and user privacy are a major concern for smart healthcare systems. These days any kind of data can be used for malicious purposes. Many harmful entities constantly try to gain access to the personal data of internet users. This data includes sensitive information that doctors store of patients and is often stored using some kind of third party cloud providing service that is not very secure. To take care of this issue, in this paper, Symmetric Balanced Incomplete Block Design (SBIBD) is utilized for key Security so that unauthorized client can’t get access to the data easily. It also allows the patients immediate and easy access to the data using unique user ID. This system makes use of double encryption using Blowfish algorithm to ensure maximum security of data and the concept of block level is used where data is stored using multiple blocks.

Trust and Reputation Management in Healthcare Systems: Taxonomy, Requirements and Open Issues

Trust is a salient feature in the context of health care, which is characterized by uncertainty and an element of risk. It is a fundamental requirement for the acceptance and adoption of new services related to health care. Soft trust, based on social control mechanisms, has yielded to evidence-based trust management, where the level of trust is explicitly computed by a trust engine termed the trust and reputation system (TRS). In e-health, soft trust can be used for access control, for assessing the quality of data represented in electronic health records , to address privacy and security requirements of healthcare systems, and to compute the credibility of an entity in the presence of unknown, possibly harmful entities. Despite the importance of soft trust in healthcare, related literature that explore soft trust issues, associated challenges and requirements are largely missing. To address this deficiency, the main contributions of this paper include: (i) taxonomy related to the soft trust in healthcare systems; (ii) reference model for measuring the performance and features of TRSs; and (iii) future areas of research related to the soft trust in healthcare.

Real-time multitarget tracking for sensor-based sorting

Utilizing parallel algorithms is an established way of increasing performance in systems that are bound to real-time restrictions. Sensor-based sorting is a machine vision application for which firm real-time requirements need to be respected in order to reliably remove potentially harmful entities from a material feed. Recently, employing a predictive tracking approach using multitarget tracking in order to decrease the error in the physical separation in optical sorting has been proposed. For implementations that use hard associations between measurements and tracks, a linear assignment problem has to be solved for each frame recorded by a camera. The auction algorithm can be utilized for this purpose, which also has the advantage of being well suited for parallel architectures. In this paper, an improved implementation of this algorithm for a graphics processing unit (GPU) is presented. The resulting algorithm is implemented in both an OpenCL and a CUDA based environment. By using an optimized data structure, the presented algorithm outperforms recently proposed implementations in terms of speed while retaining the quality of output of the algorithm. Furthermore, memory requirements are significantly decreased, which is important for embedded systems. Experimental results are provided for two different GPUs and six datasets. It is shown that the proposed approach is of particular interest for applications dealing with comparatively large problem sizes.

Amyloid Prions in Fungi.

Prions are infectious protein polymers that have been found to cause fatal diseases in mammals. Prions have also been identified in fungi (yeast and filamentous fungi), where they behave as cytoplasmic non-Mendelian genetic elements. Fungal prions correspond in most cases to fibrillary β-sheet-rich protein aggregates termed amyloids. Fungal prion models and, in particular, yeast prions were instrumental in the description of fundamental aspects of prion structure and propagation. These models established the "protein-only" nature of prions, the physical basis of strain variation, and the role of a variety of chaperones in prion propagation and amyloid aggregate handling. Yeast and fungal prions do not necessarily correspond to harmful entities but can have adaptive roles in these organisms.

Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli.

The intestinal epithelium consists of a single cell layer, which is a critical selectively permeable barrier to both absorb nutrients and avoid the entry of potentially harmful entities, including microorganisms. Epithelial cells are held together by the apical junctional complexes, consisting of adherens junctions, and tight junctions (TJs), and by underlying desmosomes. TJs lay in the apical domain of epithelial cells and are mainly composed by transmembrane proteins such as occludin, claudins, JAMs, and tricellulin, that are associated with the cytoplasmic plaque formed by proteins from the MAGUK family, such as ZO-1/2/3, connecting TJ to the actin cytoskeleton, and cingulin and paracingulin connecting TJ to the microtubule network. Extracellular bacteria such as EPEC and EHEC living in the intestinal lumen inject effectors proteins directly from the bacterial cytoplasm to the host cell cytoplasm, where they play a relevant role in the manipulation of the eukaryotic cell functions by modifying or blocking cell signaling pathways. TJ integrity depends on various cell functions such as actin cytoskeleton, microtubule network for vesicular trafficking, membrane integrity, inflammation, and cell survival. EPEC and EHEC effectors target most of these functions. Effectors encoded inside or outside of locus of enterocyte effacement (LEE) disrupt the TJ strands. EPEC and EHEC exploit the TJ dynamics to open this structure, for causing diarrhea. EPEC and EHEC secrete effectors that mimic host proteins to manipulate the signaling pathways, including those related to TJ dynamics. In this review, we focus on the known mechanisms exploited by EPEC and EHEC effectors for causing TJ disruption.

Ancient Binding Spells, Amulets and Matt 16.18–19: Revisiting August Dell's Proposal a Century Later

The goal of this essay is to reopen the unfortunately unrefined but still illuminating proposal of August Dell a century ago – a proposal to read the motif of ‘bind and unbind’ in Matt 16.19 against the backdrop of ancient magical conventions – and to corroborate this hypothesis with philological precision and contextualisation. The present study seeks to demonstrate how central the motif of ‘bind and unbind’ was to most binding spells and amulets, and how the verbs λύειν and δέειν and their cognates might have evoked the conventions of binding magic when heard in religious and ritual contexts. We see Matt 16.19 as a literary reappropriation of a typical binding spell, crafted to highlight Peter's authority to ‘bind’ and ‘break’ whatever entities he should choose. Jesus' guarantee that he/God will ‘unbind’ whatever target Peter ‘unties' is to be understood as a clear indication that Peter is endowed with an invincible potency over every other spiritual entity, symbolised by the power to break any ‘binding’ spell. The security of the church against malevolent and harmful spiritual entities is further guaranteed by Christ's promise, if read in ancient binding magical conventions: Christ will give Peter the key of the kingdom of heaven so that Peter as the key-bearer may become a figure who can channel the full potency of the keyed object.

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

Seaweed-microbial interactions: key functions of seaweed-associated bacteria

Seaweed-associated bacteria play a crucial role in morphogenesis and growth of seaweeds (macroalgae) in direct and/or indirect ways. Bacterial communities belonging to the phyla Proteobacteria and Firmicutes are generally the most abundant on seaweed surfaces. Associated bacterial communities produce plant growth-promoting substances, quorum sensing signalling molecules, bioactive compounds and other effective molecules that are responsible for normal morphology, development and growth of seaweeds. Also, bioactive molecules of associated bacteria determine the presence of other bacterial strains on seaweeds and protect the host from harmful entities present in the pelagic realm. The ecological functions of cross-domain signalling between seaweeds and bacteria have been reported as liberation of carpospores in the red seaweeds and settlement of zoospores in the green seaweeds. In the present review, the role of extracellular polymeric substances in growth and settlement of seaweeds spores is also highlighted. To elucidate the functional roles of associated bacteria and the molecular mechanisms underlying reported ecological phenomena in seaweeds requires a combined ecological, microbiological and biochemical approach.

School Administrators, ICT Coordinators and Teachers’ Metaphorical Conceptualizations of Technology

The purpose of this study is to investigate the perceptions of school administrators, ICT coordinators and teachers regarding the concept of “technology”. 87 participants completed the prompt “Technology is like…because…” by focusing on one metaphor about technology. Qualitative and quantitative techniques were used to figure out the metaphor categories and whether they differentiate according to participants’ position, gender and age variables. Content analysis was used to analyze the perceptions of the participants. Findings of the study showed that the participants indicated 60 valid metaphors which were grouped into five categories: 1) Technology as a changing and developing entity (e.g. children, fashion); 2) Technology as a facilitator (e.g. key, organ); 3) Technology as a needed entity (e.g. food, air); 4) Technology as a useful and harmful entity (e.g. viruses, sugar); 5) Technology as a diffusional entity (e.g. octopus, ocean). It was found that the majority of metaphorical conceptualization categories aligned with “a useful and harmful entity” by administrators, “a facilitator” by ICT coordinators and “a changing and developing entity” by teachers. According to the findings of the quantitative analyses there is no significant relationship between the participants’ perceptions of technology regarding age and gender. However significant relationship was found between the participants’ perceptions of technology and their position.

Nitric Oxide/Reactive Oxygen Species Generation and Nitroso/Redox Imbalance in Heart Failure: From Molecular Mechanisms to Therapeutic Implications

Adaptation of the heart to intrinsic and external stress involves complex modifications at the molecular and cellular levels that lead to tissue remodeling, functional and metabolic alterations, and finally to failure depending upon the nature, intensity, and chronicity of the stress. Reactive oxygen species (ROS) have long been considered as merely harmful entities, but their role as second messengers has gradually emerged. At the same time, our comprehension of the multifaceted role of nitric oxide (NO) and the related reactive nitrogen species (RNS) has been upgraded. The tight interlay between ROS and RNS suggests that their imbalance may implicate the impairment in physiological NO/redox-based signaling that contributes to the failing of the cardiovascular system. This review initially provides basic concepts on the role of nitroso/oxidative stress in the pathophysiology of heart failure with a particular focus on sources of ROS/RNS, their downstream targets, and endogenous modulators. Then, the role of NO/redox regulation of cardiomyocyte function, including calcium homeostasis, electrogenesis, and insulin signaling pathways, is described. Finally, an overview of old and emerging therapeutic opportunities in heart failure is presented, focusing on modulation of NO/redox mechanisms and discussing benefits and limitations.