Different from the previous trial-and-error and empirical development process of new materials, the failure and deformation of meso-structure of lattice structures are considered as a means to customize the mechanical response in this paper. Based on this, a novel metal-ceramic dual phase hybrid lattice structure (DPHLS) with both high peak stress and long plateau stage mechanical response is designed here, which can satisfy the complex mechanical response requirements of impact target materials in hard target penetration research. DPHLS is composed of ceramic-based SC plate lattice structure and metal-based FCC plate lattice structure, which has a large range of mechanical properties control. Besides, combining the advantages of ceramic and metal, DPHLS also has seemingly conflicting properties of load-withstanding and energy absorption. In the present work, the contribution of failure and deformation behavior to the mechanical response of the structure is deeply analyzed at the mesoscopic level using theoretical analysis and numerical simulation. And the quantitative relationship between the geometrical parameters of the structure and the mechanical response is established actively. The results show that the three dimensionless geometric parameters, which characterize the geometry of DPHLS, can effectively regulate its mechanical response. This study not only provides a reliable theoretical basis for the meso-structure design of DPHLS, but also proposes a new strategy for the customization of mechanical response.