Sierpinski graphs are studied in fractal theory and have applications in diverse areas including dynamic systems, chemistry, psychology, probability, and computer science. Polymer networks and WK-recursive networks can be modeled by generalized Sierpinski graphs. The degree sequence of (ordinary) Sierpi\'nski graphs and Hanoi graphs (and some of their topological indices) are determined in the literature. The number of leaves (vertices of degree one) of the generalized Sierpinski graph $S(T, t)$ of any tree $T$ was determined in 2017 and in terms of $t$, $|V(T)|$, and the number of leaves of the base graph $T$. In this paper, we generalize these results. More precisely, for every simple graph $G$ of order $n$, we completely determine the degree sequence of the generalized Sierpinski graph $S(G,t)$ of $G$ in terms of $n$, $t$ and the degree sequence of $G$. By using it, we determine the exact value of the general first Zagreb index of $S(G,t)$ in terms of the same parameters of $G$.
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