Hand Osteoarthritis In Women Research Articles

Impact of hand osteoarthritis in women on maximal forces in six different grasp types

This work aims to: (1) Provide maximal hand force data on six different grasp types for healthy subjects; (2) detect grasp types with maximal force significantly affected by hand osteoarthritis (HOA) in women; (3) look for predictors to detect HOA from the maximal forces using discriminant analyses. Thirty-three healthy subjects (37 ± 17 years, 17 women, 16 men) and 30 HOA patients (72 ± 9 years, all women) participated in the experiment. Participants were asked to exert their maximal force while performing six different grasp types 3 times. Two MANOVAs were conducted to detect if force depended on gender in healthy participants and if force significantly diminished in women with HOA. Finally, a linear discriminant analysis for detecting HOA was performed using forces of the grasp types that were significantly affected by HOA. Gender-disaggregated statistics are provided for healthy participants. Significant differences are obtained for all grasp types per gender. The women with HOA exerted significantly lower force values (p < 0.001) for all the grasp types than healthy ones. The discriminant analysis revealed that oblique grasp was the most significant one for detecting HOA. A discrimination equation was obtained with a specificity of 88.2% and a sensitivity of 83.3%. This work provides grip force data on six grasp types for healthy participants and for women with HOA. HOA women present reduced strength in all grasps due to pathology. Three of these grasps are a novelty. Oblique grasp strength may suffice to discriminate a patient with HOA, which might help non-invasive HOA detection.

Comparison of the effectiveness of peloid and paraffin treatment for symptomatic hand osteoarthritis in women: a single-blind randomized controlled study.

Although peloid and paraffin treatments may have a positive effect in the short term on pain, functional status, hand grip strength, and quality of life in patients with hand osteoarthritis (HOA), there are no comprehensive and comparative studies of these therapies for HOA. The aim of our study was to evaluate the short-term effects of peloid and paraffin treatments in symptomatic HOA patients. Eighty female patients diagnosed with HOA were randomly divided into two equal groups: peloid group (peloid therapy and home exercise) and paraffin group (paraffin therapy and home exercise). Peloid and paraffin applications were performed over 3 weeks for a total of 15 sessions. Patients were evaluated with visual analog scale (VAS)-rest, -activity, and -handgrip for pain, Jamar hand dynamometer for grip strength, Australian/Canadian (AUSCAN) Osteoarthritis Hand Index for function, health assessment questionnaire (HAQ) for physical activity, Beck depression inventory (BDI) for depression, and short form-36 (SF-36) for quality of life. Evaluations were performed before treatment, in the 3rd week, and 1 month after treatment. For all parameters except SF-36, statistically significant improvements were observed in short-term evaluations compared to the baseline in both groups (p = .000). Reductions in HAQ scores in the 3rd week and 1st month (p = .001 and p = .003), and the decrease in BDI scores in the 3rd week (p = .005) was statistically significantly higher in the peloid group. Improvements in some subparameters of the SF-36 were statistically significant in favor of the peloid group. In female patients with HOA, both groups experienced similar positive effects on pain, functional status, and hand grip strength for up to one month, but the peloid group was found to be superior in the short term in terms of physical activity and some quality of life parameters. Peloid therapy can be preferred as a natural and reliable method for symptomatic HOA.

Accelerated osteoarthritis in women with polycystic ovary syndrome: a prospective nationwide registry-based cohort study

BackgroundOsteoarthritis (OA) is the most common form of arthritis with multiple risk factors implicated including female sex and obesity. Metabolic dysregulation associated with obesity leading to metabolic syndrome is a proposed component of that association. Polycystic ovary syndrome (PCOS) commonly affects women of reproductive age and these women are at higher risk of developing metabolic syndrome and thus likely to represent a high-risk group for early OA development. There are no published studies exploring the epidemiology of knee, hip and hand OA in women diagnosed with PCOS.Study aimTo assess the prevalence and incidence of knee, hip and hand osteoarthritis (OA) in women with polycystic ovary syndrome (PCOS) when compared with age-matched controls.MethodsProspective Danish national registry-based cohort study. The prevalence of OA in 2015 and incidence rates of OA over 11.1 years were calculated and compared in more than 75,000 Danish women with either a documented diagnosis of PCOS ± hirsutism (during the period of 1995 to 2012) or age-matched females without those diagnoses randomly drawn from the same population register.ResultsIn 2015, the prevalence of hospital treated knee, hip and hand OA was 5.2% in women with PCOS diagnosis. It was 73% higher than that seen in age-matched controls. Significantly higher incidence rates were observed in the PCOS cohort compared with the age-matched controls during the follow-up period (up to 20 years), with the following hazard ratios (HR): 1.9 (95% CI 1.7 to 2.1) for knee, 1.8 (95% CI 1.3–2.4) for hand and 1.3 (95% CI 1.1 to 1.6) for hip OA. After excluding women with obesity, similar associations were observed for knee and hand OA. However, risk of developing hip OA was no longer significant.ConclusionsIn this large prospective study, women with PCOS diagnosis had higher prevalence and accelerated onset of OA of both weight and non-weight bearing joints, when compared with age-matched controls. Further studies are needed to understand the relative effect of metabolic and hormonal changes linked with PCOS and their role in promoting development of OA.

Vascular Pathology and Osteoarthritis: A Systematic Review.

Vascular pathology (changes in blood vessels) and osteoarthritis (OA) are both common chronic conditions associated with aging and obesity, but whether vascular pathology is a risk factor for OA is unclear. The aim of this study was to systematically review the evidence for an association between vascular pathology and risk of joint-specific OA. Scopus, Ovid Medline, and EMBASE were searched from inception to February 2019. MeSH terms and keywords were used to identify studies examining the association between vascular pathology and OA. Two reviewers independently extracted the data and assessed the methodological quality. Qualitative evidence synthesis was performed. Fifteen studies with high (n = 3), fair (n = 3), or low (n = 9) quality were included. Features of vascular pathology included atherosclerosis, vascular stiffness, and endothelial dysfunction in different vascular beds. There was evidence for an association between vascular pathology and risk of hand OA in women but not men, and between vascular pathology and risk of knee OA in both men and women. Only 2 studies examined hip OA showing no association between vascular pathology and risk of hip OA. There is evidence suggesting an association between vascular pathology and risk of hand and knee OA, with a potential causal relationship for knee OA. Based on the limited evidence, it is hard to conclude an association for hip OA. Further stronger evidence is needed to determine whether there is a causal relationship.

Hand and knee osteoarthritis are associated with reduced diameters in retinal vessels: the AGES-Reykjavik study.

To investigate the association between osteoarthritis (OA) and microvascular pathology, we examined the relationship between retinal microvascular caliber and osteoarthritis of the hand and knee in an elderly population. The AGES-Reykjavik is a population-based, multidisciplinary longitudinal cohort study of aging. Retinal vessel caliber, hand osteoarthritis and total knee joint replacements due to OA were examined in 4757 individuals (mean age 76 ± 5years; 57% female). Incident knee joint replacements during 5-year follow-up (n = 2961, mean age 75 ± 5years; 58% female) were also assessed. Logistic regression analysis, adjusting for age, sex, and body mass index, showed an association between narrow arteriolar caliber and hand OA, as well as knee replacement. After adjustment for other covariates, including statin therapy, this association was significant for both hand OA in men and women [OR 1.10(1.03-1.17), p < 0.01] (per unit standard deviation decrease in CRAE) and TKR prevalence [OR 1.15 (1.01-1.32), p = 0.04], especially for men [OR 1.22 (1.00-1.51) p = 0.04] and also for incident TKRs in men [OR 1.50 (1.07-2.10), p = 0.04]. Narrow venular caliber was associated with hand OA in women [OR 1.10 (1.01-1.21), p = 0.03]. Retinal arterial narrowing in hand and knee OA is present in males as well as females. Venular narrowing in hand OA in women was an unexpected finding and is in contrast with the venular widening usually observed in cardiovascular diseases.

Prevalence and incidence of clinically diagnosed knee, hip and hand osteoarthritis in women with polycystic ovary syndrome: a National Register-Based Study

Purpose: Osteoarthritis (OA) is the most common form of arthritis associated with high morbidity and increased risk of early cardiovascular mortality. Obesity is associated with metabolic dysregulation and an increased risk of developing OA even in non-weight bearing joints. Polycystic ovary syndrome (PCOS) is a very common endocrinology problem among women associated with reproductive and metabolic features, and as a result, these women have increased risk of stroke and thrombosis when compared with a general population. Assessing incidence and prevalence of OA in this group represent a great natural experiment for testing association between metabolic dysregulation and risk of OA. The main objective of this study was to investigate the prevalence and incidence risk of clinically diagnosed OA affecting different site(s) (knee, hip and hand) in PCOS compared to a control population. Methods: A PCOS cohort based on a Danish national register (NPR) study was compared with matched controls. All incident PCOS cases were defined according to the Rotterdam criteria and/or diagnosis of hirsutism, and were based on the International Classification of Diseases (ICD) 10 codes from the Danish NPR available between 1995 and 2012. Women in the control cohort were randomly selected, matched 1:3 to PCOS cases on age and index date. The outcome was clinically diagnosed knee, hip and hand OA according to the ICD-10 codes. Incidence rates of clinical OA were estimated in women with and without PCOS, both overall and per age categories. Person-time at risk for each woman was estimated as the time each woman remains free of OA during the follow-up period (up to 17 years). Hazard ratio (HR) and 95% confidence of intervals (CIs) were assessed to estimate the risk of OA at the three different joints in PCOS cohort compared to the control group. Cox proportional hazard regression was used. Results: Data was available for 75,089 patients: 18,923 women with PCOS and 56,166 controls, with a median age of 29 years (24–36). During the observation period (median follow-up of 11.1 years (range: 6.9–16.0)), 2253 women were identified with OA, 4.3% and 2.6% in the PCOS and control cohorts, respectively. A high prevalence at index date for Charlson comorbidity and cardiometabolic diseases were observed in the PCOS cohort, including obesity, diabetes, dyslipidaemia and hypertension. In 2012, the most prevalent joint OA was knee OA (4.9%), followed by hip OA (1.6%) and then hand OA (0.5%). Significant higher incidence rates were observed in PCOS cohort compared with the control cohort (2.8 vs. 1.5, 0.8 vs. 0.6 and 0.3 vs. 0.1 cases per 1000 person years, for knee, hip and hand, respectively) (Table 1). The hazards of developing OA was 90% higher (HR 1.9, 95% CI: 1.7 to 2.1) for knee, 30% (HR 1.3, 95% CI: 1.1 to 1.6) for hip and 80% (HR: 1.8, 95% CI: 1.3-2.4) for hand (Table 1) in PCOS cohort compared to the control cohort. There was a trend between higher incidence rates of knee, hip and hand OA and greater age. Women at the age of 50–60 were more likely to develop OA that those younger than 45 years old. Conclusions: Women with PCOS have a greater risk of OA when compared to the control population. Given the high risk of metabolic syndrome (MetS) in PCOS population, understanding their metabolic profile, including metabolomics, might provide us with a better understanding of the shared pathogenesis of MetS and OA. Furthermore, this population might also benefit more from targeted secondary prevention for both OA and MetS. Weight loss and exercise interventions are already recommended as first line treatment for PCOS. Further investigations into the effects of modifiable risk factors on OA are needed.

Bioactive lipids in osteoarthritis: risk or benefit?

Lipids are bioactive molecules that can affect several biological functions. Technological developments allowing identification of novel lipid species and the study of their function have led to a significant advance in our understanding of lipid biology and their involvement in various diseases. This is particularly relevant for diseases associated with obesity in which lipid accumulation could be involved in pathogenesis. Here, we focus on osteoarthritis, a chronic joint disease aggravated by obesity, and will present the latest findings regarding the involvement of lipids in disease development and progression. Recent studies indicate a possible involvement of n-3 poly-unsaturated fatty acid and their anti-inflammatory and proresolving derivatives in osteoarthritis. These lipids were identified in the osteoarthritis joint, were found to have beneficial effects on cartilage in vitro and reduced pain in humans and animal models. Moreover, increased levels of cholesterol transport molecules, such as LDL particles, were recently associated with a higher risk of developing hand osteoarthritis in women and with more severe inflammation and osteophyte formation in osteoarthritis animal models. Together, these findings indicate that lipids are a promising target for future therapeutic intervention in osteoarthritis and open exciting possibilities for future research.

SAT0350 Glucose and Insulin Concentrations in Association with Hand Osteoarthritis: The Neo Study

BackgroundBody mass index (BMI) is an important risk factor for osteoarthritis (OA), however the underlying causal pathways are unclear. Earlier studies showed an association of diabetes mellitus and OA, suggesting...

TNF-α is elevated in synovial fluid of patients with an anterior cruciate ligament rupture 5 years after the injury. Pro-inflammatory cytokines in synovial fluid and serum – a prospective longitudinal study

s / Osteoarthritis and Cartilage 21 (2013) S63–S312 S72 Purpose: Hand osteoarthritis (OA) is one of the most common localization of OA, affecting predominantly women. Patients with knee, hip or spine OA exhibit increased cartilage type II collagen degradation as detected by the urinary excretion of C-terminal crosslinking telopeptide of type II collagen (CTX-II), but data on hand OA are lacking. The aim of this study was to investigate the relationship between urinary CTX-II and hand OA in women. Subjects and Methods: We investigated 590 women from the OFELY population-based study (mean age: 61.8 years 10.2) including 475 postmenopausal women. Clinical hand OAwas defined according to the ACR criteria (Altman et al, 1990) slightly modified (without functional complains). At the same time of hand OA evaluation, knee and spine OA were assessed by radiographs and self-reported hip OA was recorded. Levels of urinary CTX-II measured by ELISA (Urine CartiLaps , IDS) in the 186 women with hand OA (mean age: 67.2 years 8.4) were compared to those of the 404 other women without hand OA (mean age: 59.4 years 10.1). All analyses were adjusted for age and concomitant knee, hip or spine OA. Results: Urinary CTX-II levels were significantly increased in women with hand OA (+ 45% vs controls, p1⁄4 0.001) after adjustment for age and for knee, spine and hip OA). When urinary CTX-II concentrations were considered in quartiles, subjects with levels in the highest quartile had an increased risk of presenting with hand OA, with an odds-ratio of 2.06 (95% CI: 1.3-3.2; p 1⁄4 0.002) after adjustment for OA at the other anatomical sites. Conclusion: Hand OA is characterized by increased type II collagen degradation. Urinary CTX-II could be a useful biomarker for the clinical investigation of hand OA. 118 TNF-a IS ELEVATED IN SYNOVIAL FLUID OF PATIENTS WITH AN ANTERIOR CRUCIATE LIGAMENT RUPTURE 5 YEARS AFTER THE INJURY. PRO-INFLAMMATORY CYTOKINES IN SYNOVIAL FLUID AND SERUM – A PROSPECTIVE LONGITUDINAL STUDY M. Hansson y, S. Larsson y, R. Frobell y, L.S. Lohmander y,z, A. Struglics y. y Lund Univ., Clinical Sci. Lund, Lund, Sweden; zRes. Unit for Musculoskeletal Function and Physiotherapy, and Dept.s of Orthopaedics and Traumatology, Univ. of Southern Denmark, Odense, Denmark Purpose: Trauma induced cytokine response in knee injuries may play a role in the development of osteoarthritis (OA) since knee injuries are Table 1 Cytokine concentrations (pg/ml) in SF and serum expressed as medians (25th–75th percen at different time. Half LLOQ values: IL-10, 1.0; IL-6, 0.3; IFN-g, 0.6.

The associations between finger length pattern, osteoarthritis, and knee injury: Data from the Framingham community cohort

To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. We found no significant associations between 2D:4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women.

Job-Related Osteoarthritis of the Knee, Foot, Hand, and Cervical Spine

To assess the influence of occupational exposures on risk of site-specific radiographic osteoarthritis (OA) of the knee, hand, foot, and cervical spine. Using a cross-sectional design, data collected from men and women aged 40 years and older participating in the Clearwater Osteoarthritis Study were analyzed (n = 3436). Subjects' occupational exposures were queried using the study intake form, including stair climbing, standing on a rigid surface, squatting, and jolting. Physical examinations including radiographs of the knee, hand, foot, and cervical spine were conducted. The Kellgren and Lawrence ordinal scale was used to determine evidence of radiographic OA. Both the unadjusted and adjusted odds ratios (ORs) for men and women indicated that age and body mass index were associated with OA. There were no other significant odds ratios for the cervical spine. Among men, there were significant associations with knee OA for stair climbing and jolting of the legs and with foot OA with stair climbing. Among women, there was a significant association between standing on a rigid surface and knee OA. For hand OA in women, there was a significant association for jolting of the hands. Although the association with stair climbing was found in other investigations for knee OA, it was also associated with foot OA in this study. In addition, the jolting feature was seen in only one other study for men (knees) and novel for women (hands).

Hand osteoarthritis in Chuvashian population: prevalence and determinants

The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and 384 females, age 50.8 ± 16.3 years). OA was evaluated for 14 joints of each hand according to the Kellgren and Lawrence grading scheme. Statistical analyses included prevalence estimation, linear, logistic and polynomial regressions, and χ2 tests. After the age of 65 years, 89.2% of males and 97.6% of females had at least one affected joint. For males and females the best-fitted and most parsimonious model of association between age and number of affected hand joints was the two interval linear one. After adjustment for age, no association between prevalence of hand OA and BMI was found in males. However, females with obesity have almost three times higher risk of development of hand OA than those with normal weight. No association was found between smoking and prevalence of hand OA. Moderate alcohol consumption showed protective effect on prevalence of hand OA in women.

Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosis: the AGES Reykjavik study

Objective:There is evidence that atherosclerosis may contribute to the initiation or progression of osteoarthritis. To test this hypothesis, the presence and severity of hand osteoarthritis (HOA) was compared with markers...

Age, body composition, and reproductive indices as predictors of radiographic hand osteoarthritis in Chuvashian women

Objectives: In our observational cross‐section population‐based study, we evaluated the predictors (age, body composition indices, age at menarche, and age at menopause) of radiographic hand osteoarthritis (OA) from a sample of women of European origin, who were not receiving any medication for prevention or treatment of OA.Methods: Our population consisted of 745 Chuvashian females with a mean age of 48.65 years (range 18–84 years) residing in peripheral villages of the Russian Federation. OA was evaluated using the Kellgren and Lawrence grading scheme. To evaluate the relationship between age, age at menarche, age at menopause, body composition indices [body mass index (BMI), waist circumference (WC), waist–hip ratio (WHR), somatotypes (ectomorphy, mesomorphy, and endomorphy)], and an individual’s osteoarthritis score (Tot28) as the dependent variable, we used multiple linear regression analysis (stepwise method).Results and conclusions: Statistically significant predictors of hand OA in women were found to be the following: age (β = 0.748, p = 0.000), mesomorphy (β = 0.120, p = 0.000), WHR (β = 0.117, p = 0.001), endomorphy (β = −0.089, p = 0.006), and age at menarche (β = −0.066, p = 0.012). Age was the most powerful factor in determining hand OA. Mesomorphy, the measure of muscular development was a significant predictor of hand OA. Endomorphy showed a very small, but significant, negative association with hand OA. However, BMI and WC showed no association, leading us to conclude that obesity is a mechanical rather than a systematic risk factor for OA. Age at menarche was negatively associated with hand OA, possibly because early menarche is associated with an increased rate of the general ageing process.