Han Population Of Sunan Region Research Articles

ASSA13-01-11 The Correlation of the Serum C-Reactive Protein Leve with Its Gene T-757C Polymorphism in Patients with Acute Myocardial Infarction

<h3>Objective</h3> To explore the association of the serum C-reactive protein (CRP) level with the CRP gene T-757C polymorphism and risk of acute myocardial infarction (AMI) in Chinese Han population of Sunan region. <h3>Methods</h3> The CRP gene T-757C polymorphism was genotyped by polymerase reaction restriction-fragment length polymorphism analysis, and the serum CRP level was measured by enzyme-linked immune sorbent assay in 213 AMI patients (AMI group) and 173 subjects without coronary heart disease (CHD) (control group). <h3>Results</h3> ➀In Chinese Han population of Sunan region, there were CRP gene T-757C polymorphisms in patients with AMI and in subjects without CHD; ➁The serum CRP level in AMI patients (5.985/6.527μg/ml) was significantly higher than those in non CHD subjects (3.262/1.356μg/ml) (<i>P</i> &lt; 0.01) and there were still significant differences after adjustment for gender, age, smoking, hypertension, diabetes and dyslipidemia (<i>P</i> &lt; 0.01); ➂In AMI patients, no significant differences were found in the serum CRP level among any genotype (CC, TC or TT) of the CRP gene T-757C (4.069/2.493 pg/ml <i>vs</i> 5.745/6.321 pg/ml <i>vs</i> 6.127/6.629 pg/ml), and there also were no significant differences in the serum CRP level among any genotypes in this locus within the same gender and age (<i>P</i> &gt; 0.05). <h3>Conclusions</h3> The serum CRP level in AMI patients is significantly higher than those in non CHD subjects but not influenced by CRP gene T-757C polymorphism in Chinese Han population of Sunan region.

ASSA13-01-12 The Effects of Monocyte Chemoattractant Protein-1 Gene A-2518G Polymorphism, Its Serum Levels on AMI in Chinese Han Population of Sunan Region

ObjectiveTo investigate the effects of monocyte chemoattractant protein-1 (MCP-1) A-2518G genetic polymorphism and its serum levels on acute myocardial infarction (AMI) in Chinese Han population of Sunan region.MethodsThe A-2518G polymorphism...

THE CORRELATION OF THE SERUM C-REACTIVE PROTEIN LEVEL WITH THE C-REACTIVE PROTEIN GENE T-757C POLYMORPHISM AND RISK OF ACUTE MYOCARDIAL INFARCTION

ObjectivesTo explore the association of the serum C-reactive protein (CRP) leve with the CRP gene T-757C polymorphism and risk of acute myocardial infarction (AMI) in Chinese Han population of Sunan...

RELATIONSHIP OF ARACHIDONATE 5-LIPOXYGENASE ACTIVATING PROTEIN GENE SG13S114T/A POLYMORPHISM WITH ACUTE MYOCARDIAL INFARCTION

ObjectivesTo investigate the association between 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A polymorphism and acute myocardial infarction (AMI) in the Chinese Han population of Sunan region.MethodsAll of 300 patients with AMI...

ASSOCIATIONS OF THE SERUM LEUKOTRIENE B4 LEVEL WITH ARACHIDONATE 5-LIPOXYGENASE ACTIVATING PROTEIN GENE POLYMORPHISMS AND THE RISK OF ACUTE CORONARY SYNDROME

ObjectivesTo explore the associations of the arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A or SG13S89G/A polymorphisms with the serum leukotriene (LT) B4 levels in acute coronary syndrome (ACS) patients and...

THE RELEVANCE AMONG SERUM CRP LEVEL, CRP GENE C+1444T POLYMORPHISM AND THE RISK WITH ACUTE MYOCARDIAL INFARCTION

ObjectivesTo investigate the relationship between serum CRP level, CRP gene C+1444T polymorphism and the risk with AMI from Sunan Chinese population.MethodsThe serum CRP level was measured by enzyme linked immunosorbent...

THE ASSOCIATION OF MCP-1 -2518 G/A POLYMORPHISM, ITS SERUM LEVELS WITH UNSTABLE ANGINA PECTORIS

ObjectivesTo investigate the effects of monocyte chemoattractant protein-1 (MCP-1) -2518 G/A genetic polymorphism on its serum levels and unstable angina pectoris (UAP), and the association of MCP-1 serum level with...

CORRELATION ANALYSIS OF THE SERUM LEUKOTRIENE B4 LEVEL WITH SUSCEPTIBILITY OF ACUTE CORONARY SYNDROME

ObjectivesTo investigate the changes of the serum leukotriene (B4) level and its correlation with susceptibility in acute coronary syndrome (ACS).MethodsThe serum LTB4 level was measured by ELISA in 403 patients...

RELATIONSHIP OF ARACHIDONATE 5-LIPOXYGENASE ACTIVATING PROTEIN GENE SG13S114T/A POLYMORPHISM WITH THE SERUM LEUKOTRIENE B4 LEVEL IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

ObjectivesTo investigate the association of the serum leukotrienes (LT) B4 level with the ALOX5AP gene SG13S114T/A polymorphism in patients with acute myocardial infarction (AMI) in Chinese Han population of Sunan...

Associations among MCP-1 gene -2518 G/A polymorphism, the serum MCP-1 level and acute coronary syndrome

ObjectiveTo investigate the associations among MCP-1-2518 G/A polymorphism, MCP-1 serum levels and ACS in Chinese Han population of Sunan region.MethodsAfter obtaining informed consent, 166 patients with ACS including 94 cases...

Correlation of the pregnancy-associated plasma protein-A gene IVS6+95 polymorphism with the serum PAPP-A level in patients with acute myocardial infarction

ObjectiveTo investigate the association between PAPP-A gene IVS6+95 polymorphism and the serum level of PAPP-A in patients with AMI from the Chinese Han population of Sunan region.MethodsFifty-six patients with AMI...

Association of ALOX5AP gene SG13S114T/A polymorphism with acute coronary syndrome

ObjectiveTo investigate the distribution of ALOX5AP gene SG13S114T/A polymorphism and the association of the ALOX5AP gene SG13S114T/A polymorphism with acute coronary syndrome (ACS) in the Chinese Han population of Sunan...

Relationship between 5-lipoxygenase activating protein gene SG13S89G/A polymorphism and acute coronary syndrome

ObjectiveTo investigate the distribution of ALOX5AP gene SG13S89G/A polymorphism and the relationship between the ALOX5AP gene SG13S89G/A polymorphism and acute coronary syndrome (ACS) in the Chinese Han population of Sunan...

Associations of pregnancy-associated plasma protein-A gene IVS6+ 95 polymorphism with acute coronary syndrome

ObjectiveTo investigate the associations of pregnancy-associated plasma protein-A (PAPP-A) gene IVS6+95 polymorphism with the susceptibility of acute coronary syndrome (ACS) in the Chinese Han population of Suwan region.MethodsFour hundred and...

Association of pregnancy-associated plasma protein-A (PAPP-A) gene IVS6+ 95 polymorphism with acute myocardial infarction

ObjectiveTo investigate the association of pregnancy-associated plasma protein-A (PAPP-A) gene IVS6+95 polymorphism with acute myocardial infarction (AMI) in the Chinese Han population of Sunan region.MethodsTwo hundred and fifty three patients...

Association of 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A polymorphism with the elderly ACS

ObjectiveTo investigate the possible association between 5-lipoxygenase activating protein (ALOX5AP) gene SG13S114T/A polymorphism and acute coronary syndrome (ACS) in the elderly (age≥60 years).MethodsA case-control study was conducted in 377 aged...

Association of the MCP-1 gene A-2518G polymorphism with acute coronary syndrome Guoping

ObjectiveTo investigate the impossible association of the monocyte chemoattractant protein-1 (MCP-1) gene A-2518G single nucleotide polymorphism (SNPs) in the promoter region with acute coronary syndrome (ACS) in Chinese Han population...