This paper proposes new mathematical models of representation, which can describe the dynamic behavior of large-scale nonlinear systems, such as an extended mathematical model of Volterra series, interconnected Hammerstein structures, and interconnected Wiener structures. In this research, we focus on the class of large-scale nonlinear systems, which are composed of several interconnected nonlinear subsystems. In this context, a discrete nonlinear mathematical model with unknown time-varying parameters, mono-variable, characterizes each interconnected subsystem operating in a deterministic or stochastic environment. An illustrative numerical simulation example of two interconnected nonlinear processes is provided to prove the validity and the performance of the developed theoretical results.