“Shape Analysis” is an interesting research area which contains many thought-provoking problems and mathematical challenges, especially at the representation level. Shape of an object is considered as the enclosing surface (the boundary) or the enclosed interior. One of the major challenges is to define representations of “shapes” that can be manipulated by image processing methods. This is an important need in practice because more often than not shapes need to be extracted or recovered from raw images; moreover, the process of recovering shapes from raw images highly benefits from prior knowledge of candidate shapes. One of the key means of shape representation is the Euclidean Distance Transform (EDT), which is governed by the Eikonal Equation. The values of the EDT at each interior point give the distance to the nearest boundary point. This distance notion is used in almost any problem that requires integrating shape and image information; e.g., a rich variety of shape guided image-processing or shape extraction tasks. Especially in the 1990s, the idea of embedding shapes as zeros of the signed EDT is highly popularized by the level-set framework and its fast implementation, leading to a booming research area in implicit shape representations. However, as challenging problems are developed, formulations that move beyond the classical Eikonal Equation emerged. This special issue consists of six papers each exploring an interesting direction moving beyond the Eikonal formulation in the field of Shape Analysis. The first two papers, “Analysis and Approximation of some Shape–from–Shading Models for non-Lambertian Surfaces” and “A Unified Variational Volume Registration Method based on Automatically Learned Brain Structures”, deal with two key applications that jointly involve shapes and images. In the first paper, Silvia Tozza and Maurizio Falcone present a unified mathematical formulation of some non-Lambertian models, which lead to more complex stationary nonlinear partial differential equations of Hamilton-Jacobi type which can be regarded as a generalization of the classical Eikonal Equation corresponding to the Lambertian case. In the second paper, Carl Lederman et al. present an active volume technique employing level sets of the distance function. Unlike the common practice, the level sets in their formulation are only utilized on their respective regions and not on the whole domain, making the computations feasible as the number of regions increases. The next four papers propose alternative distance notions or computations. They are briefly discussed as follows. In “Affine Invariant Distance Using Multiscale Analysis”, Luis Alvarez et al. present a distance transform for planar shapes that is invariant under any planar projection of the