The present research comprehensively examines the influences of different input variables, such as cabinet load level, ambient temperature, relative humidity, door opening time and day, on the output parameters of frosting amount, recovery time, and total energy consumption of the upright domestic freezer following the door opening operation. Moreover, a holistic statistical methodology, which is known as the GLM-ANOVA, was implemented for determining the parametric experimental results. Meanwhile, the effects of binary interactions between the input factors on the output parameters were extensively evaluated using statistical methods. As a consequence, the amount of frost increases with an upward gradient as the load level within the cabinet escalates from 25 °C to 32 °C. Both the duration of door openings and the relative humidity level have a double impact on the frosting. Moreover, the duration required for the system to recover from half load to full load more than doubles with an increase in ambient temperature from 25 °C to 32 °C. On the other hand, at an outdoor temperature of 25 °C, the recovery time demonstrates a close to linear relationship with the load level of the cabinet. Furthermore, the duration of door openings and the load capacity within the cabinet are considered two important factors that simultaneously influence the daily energy consumption. The infiltration of ambient air into the freezer compartment and the presence of moisture in the air substantially increase the energy consumption, especially when the relative humidity fluctuates between 30 % and 65 % and the door opening duration stretches from 10 to 20 s, respectively.