Gum Arabic Research Articles

Microencapsulation of hop bioactive compounds by spray drying: Role of inlet temperature and wall material

This study explores the effect of spray-drying (SD) inlet temperatures (Tinlet 120 and 150 °C) and wall material on the chemical and physico-chemical properties of microencapsulated hop extracts (MHE). Hop extract was formulated with maltodextrin (MD) and gum Arabic (GA) used in single or in combination with β-cyclodextrin (βCD). MHE were evaluated for physical properties, bitter acids (BA), total polyphenol content (TPC) and encapsulation efficiency (TPC EE), and antioxidant capacity (AOC). Powders produced at Tinlet 150 °C exhibited the highest flowability and generally higher TPC yield. Besides Tinlet, MD enabled the obtaining of MHE with the highest encapsulation efficiency. Other physico-chemical and antioxidant properties differently varied depending on the Tinlet. Overall, the βCD addition positively affected α-acids, and β-acids of MHE obtained at Tinlet 120 °C. ATR-FTIR analysis showed hydrogen bond formation between hop compounds and βCD. Multifactorial ANOVA highlighted that Tinlet, W, and their interaction influenced almost all the chemical and physico-chemical properties of MHE.

Physicochemical and Emulsifying Properties of Melia azedarach Gum.

Naturally occurring hydrophilic colloids are versatile excipients in drug delivery systems. They are often used as coating materials, disintegrating agents, binders, emulsion stabilizers, and other applications. This study sought to investigate the physicochemical and emulsifying properties of gum extracted from Melia azedarach (MA). The gum was harvested, authenticated, and purified using ethanol precipitation. Physicochemical, microbial, and proximate analyses were performed on the purified gum. Oil of olive emulsions containing different amounts (5-15%w/v) of the gum as emulsifiers were prepared by homogenization. The zeta potential, creaming index, and average droplet size of products were assessed. The effects of pH changes, temperature, and monovalent and divalent electrolytes on the stability of the emulsions were also investigated. The yield of the gum after purification was 68.3%w/w. The gum has low moisture content and good swelling properties. Lead, copper, cadmium, and mercury were not detected. Emulsions containing 15%w/v of acacia or MA gum had the smallest average (Z-average) droplet size (acacia: 1.837 ± 0.420 μm; MA gum: 2.791 ± 0.694 μm) and the highest zeta potential (acacia: -30.45 mV; MA gum: -32.867 mV). Increasing the concentration of the gums increased the emulsion viscosity with MA gum emulsions being more viscous than corresponding acacia emulsions. MA gum emulsions had higher emulsion capacity and stability but lower creaming index relative to acacia gum emulsions of similar concentrations. Potassium chloride (KCl) reduced zeta potential but increased Z-average for emulsions prepared with either gum. Calcium chloride (CaCl2) produced a similar but more pronounced effect. When the pH was decreased from 10 to 2, the zeta potential of the droplets was reduced, but the droplet size of emulsions prepared from either gum was increased. Increasing temperature from 25 to 90°C produced no significant (p value >0.9999) change in droplet size. These findings suggest that MA gum is a capable emulsifying agent at 15%w/v.

The Use of Zein and Arabic Gum to Produce Cinnamon Bark Oil‐Loaded Pickering Emulsion with Improved Stability, Antioxidant, and Antibacterial Properties

The Use of Zein and Arabic Gum to Produce Cinnamon Bark Oil‐Loaded Pickering Emulsion with Improved Stability, Antioxidant, and Antibacterial Properties

Ratio Variation of Maltodextrin and Gum Arabic as Encapsulant on White Jack Bean Tempe Protein Concentrate

The physical and chemical properties of encapsulated substance is directly influenced by the choice of the encapsulant. Different ratios of maltodextrin (MD) and Gum Arabic (GA) produce varying material properties. Therefore, this study aimed to obtain the optimal encapsulant ratio for white jack bean tempe protein concentrate based on physical and chemical characteristics. To achieve this, a descriptive method was employed along with One-Way ANOVA. The results showed that varying encapsulant ratio led to distinct protein content, moisture content, encapsulation efficiency, and yield. The treatment with maltodextrin and Gum Arabic ratio of 20:80 showed the highest effectiveness, with protein content, moisture content, encapsulation efficiency, and yield at 26.10 ± 0.45%, 7.93 ± 0.42%, 95.84 ± 0.71%, and 14.27%, respectively.

Evaluation of the analgesic and anesthetic properties of silver nanoparticles supported over biodegradable acacia gum-modified magnetic nanoparticles

Abstract An ecofriendly and green procedure was adopted to immobilize Ag NPs over acacia gum (GA)-modified magnetic nanoparticles (Fe3O4-GA/Ag NPs) with analgesic and anesthetic properties. In the stepwise modification method, the pre-synthesized Fe3O4 NPs were coated by the gum acacia (GA) that has hydroxyl groups on its backbone and can be used for as a capping, reducing, and stabilizing agent for immobilized Ag nanoparticles. The capped Ag ions were reduced and immobilized over the acacia gum because of hydrogen bonding of the hydroxyl groups. The final bio-material was characterized by various analytical techniques such as X-ray diffraction, energy dispersive X-ray spectroscopy, inductively coupled plasma-optical emission microscope, transmission electron microscopy, field emission scanning electron microscopy, and fourier transformed infra red spectroscopy. In the in vivo design, the results of anesthetic activity indicated that the Fe3O4-GA/Ag NPs made local anesthetic effects in guinea pig and frog models. After oral administration of Fe3O4-GA/Ag NPs, paw edema was significantly decreased in mice. Acetic acid-induced writhing episodes were dose-dependently and significantly decreased in all groups treated with Fe3O4-GA/Ag NPs. In addition, the analgesic and anti-inflammatory properties were determined in several doses of Fe3O4-GA/Ag NPs. The above results protect the analgesic and anesthetic properties of silver nanoparticles supported over biodegradable acacia gum-modified magnetic nanoparticles for the next research or clinical trial studies in human.

PERFORMANCE CHARACTERISATION OF GUM ARABIC BONDED PARTICLE BOARD MADE FROM RICE HUSK AND CANDLE WAX

Particle boards from wood sources have negative impacts on the environment through deforestation. Binders from synthetic sources are also not economical due to high costs in some parts of the world. Agricultural waste materials like rice husk (RH) and readily available natural binders like gum Arabic (GA) are proposed as alternative component materials in particle board manufacture. This study therefore investigates the engineering performance of gum Arabic bonded particle board made from rice husk and candle wax. RH was kept at a constant 70% in the mixture, CW and GA were alternated at 0/30%, 5/25%, 10/20%, 15/15%, 20/10%, and 25/5 % respectively. The mixture was passed through cold and hot presses with compressions to produce particle board samples. The samples were micro-characterised using scanning electron microscopy (SEM) and Energy-dispersive spectroscopy (EDS). The Gum arabic bonded particle board were subjected to various engineering tests. The SEM results showed poor compaction of the material especially as CW content increased. The EDS results showed that caron and silica constituted about 75% of the matrix indicating free of toxic substances. The maximum compressive, flexural and split tensile strengths were 3.88, 0.33 and 1.90 N/mm2 respectively at 10/20% mix even with the lowest density of 565.29 kg/m3. The water absorption and swelling in thickness decreased significantly with increase of CW with values of 2.72 and 0.00% at 25/5 %. The boards may be classified as medium-density since the densities were above 560Kg/m3.

Role of gum Arabic combined with cinnamic acid coating on quality and cell wall degradation enzymes of mango fruits at low temperature

Mango exhibits a short shelf life when kept under ambient conditions. Therefore, this study was carried out to assess the synergistic effect of gum Arabic (GA) and cinnamic acid (CA) coatings on mango fruits stored for 28 days at 12 ± 1 °C. The treatments included GA 10 and 20 % sole and its formulation with CA 0.2 % while the uncoated fruits were used as control. The results revealed that GA + CA coatings exhibited reduced weight loss, flesh firmness, delayed respiratory peak, retained soluble solids content (SSC), titratable acidity (TA) and skin colour, retarded spoilage, and decreased electrolyte leakage of fruit as compared to uncoated fruit during storage. Among all, the coating GA 20 % + CA 0.2 % maintained higher firmness (16.6 N), SSC (20.1 %), TA (0.71 %), total flavonoid content (152 mg/kg) and total carotenoids content (45.1 mg/kg) and retained the higher sensory quality of mango fruit at the end of storage. Additionally, the GA 20 % + CA 0.2 % coating suppressed activities of polygalacturonase (PG), cellulase (CL) and pectin methyl esterase (PME) in stored mango fruits.

Design of Experiment for Optimizing Microencapsulation by the Solvent Evaporation Technique.

We employed microemulsion combined with the solvent evaporation technique to produce biodegradable polycaprolactone (PCL) MCs, containing encapsulated isophorone diisocyanate (IPDI), to act as crosslinkers in high-performance adhesive formulations. The MC production process was optimized by applying a design of experiment (DoE) statistical approach, aimed at decreasing the MCs' average size. For that, three different factors were considered, namely the concentration of two emulsifiers, polyvinyl alcohol (PVA) and gum arabic (GA); and the oil-to-water phase ratio of the emulsion. The significance of each factor was evaluated, and a predictive model was developed. We were able to decrease the average MC size from 326 μm to 70 µm, maintaining a high encapsulation yield of approximately 60% of the MCs' weight, and a very satisfactory shelf life. The MCs' average size optimization enabled us to obtain an improved distributive and dispersive mixture of isocyanate-loaded MCs at the adhesive bond. The MCs' suitability as crosslinkers for footwear adhesives was assessed following industry standards. Peel tests revealed peel strength values above the minimum required for casual footwear, while the creep test results indicated an effective crosslinking of the adhesive. These results confirm the ability of the MCs to release IPDI during the adhesion process and act as crosslinkers for new adhesive formulations.

Gum Arabic tree biomass derived activated carbon for fluoride sequestration in batch and fixed bed processes: kinetics, thermodynamics and column adsorption modeling

The biomass obtained from the stem of Gum Arabic tree was used to prepare a thermally activated carbon through pyrolysis at 800 °C. The activated carbon tagged GAAC-800 was used as adsorbent for the fluoride sequestration in a batch and a fixed-bed reactor in a continuous column systems. The surface morphology, elemental composition as well as particle size distribution of the adsorbent was investigated with Scanning Electron Microscopy (SEM), Elemental and Particle Size Analyzers. Also, the influence of initial fluoride concentrations, column packing height and the flow rate on the column efficiency were examine while the efficiency of batch process as a function of contact time and temperature was also investigated. It was found that the kinetic of the process was best fitted with second order model, while the mechanism was best explained by interparticle diffusion model. In addition, the Langmuir Isotherm model showed that the maximum monolayer adsorption capacity of fluoride removal was 71.93 mg/g. The breakthrough curve from the fixed bed adsorption data were well modeled by Adams-Bohart, Yoon-Nelson and Clark model. The models were judged using Akaike Information Criteria (AIC) values after statistical evaluation. GAAC-800 removed fluoride from aqueous solution comparably higher than other adsorbent in its category in batch and continuous column systems.

Enhancing Enzyme Stability and Functionality: Covalent Immobilization of Trypsin on Magnetic Gum Arabic Modified Fe3O4 Nanoparticles.

This study aimed to fabricate gum Arabic (GA)-coated Fe3O4 nanoparticles bearing numerous active aldehyde groups on their surface, followed by an assessment of their capability as a magnetic support for the covalent immobilization of the trypsin enzyme for the first time. FT-IR, XRD, TGA, and SEM results demonstrated the successful synthesis of GA-coated Fe3O4 nanoparticles, along with the covalent immobilization of the enzyme onto the support. Immobilization enhanced the relative enzymatic activity across a range of aqueous solution pH levels (ranging from 4 to 11) and temperatures (ranging from 20 to 80 °C) without altering the optimum pH and temperature for trypsin activity. Kinetic studies using Michaelis-Menten plots revealed changes in kinetic parameters, including a lower Vmax and higher Km for immobilized trypsin compared to the free enzyme. The immobilization onto magnetic gum Arabic nanoparticles resulted in an improved stability of trypsin in the presence of various solvents, maintaining a stability order comparable to that of the free enzyme due to the stabilizing effect of the support. The reusability results showed that the immobilized enzyme can retain over 93% of its activity for up to 15 cycles.

Effects of seaweed (Kappaphycus alvarezii) based edible coating on quality and shelf life of minimally processed mango (Mangifera indica L. king)

Coating of minimally processed mango fruit (Mangifera indica L. king) with seaweed paste (SP) and gum Arabic (GA) has been found to increase their overall quality and shelf -life. The main purpose of this study was to find out the effect of seaweed and gum Arabic on the physicochemical properties, microbial analysis and sensory quality of minimally processed mango fruits. Coating minimally processed mangoes with seaweed (Kappaphycus alvarezii) enhanced their shelf-life and postharvest quality. Different concentrations of seaweed paste (0, 10%, 20%) and gum Arabic (0, 5%, 10%) were used for the formulation of the edible coating for minimally processed mango cube and stored at 5°C for 14 days. The result of the study showed that coatings with a 10% and 20% (w/ w) seaweed paste mixed with 5% and 10% (w/w) gum Arabic had significantly (P<0.05) higher sensory quality and reduced microbial load. This combination of 10% seaweed paste, and 5% gum Arabic can be recommended to use as an edible coating for minimally processed mango fruit.

Blend of guar/acacia gum as a partial substitute of lecithin in white chocolate: Optimization, characterization, and shelf-life evaluation

Lecithin is potentially used in various food applications due to its emulsifying and stabilizing properties. However, overconsumption of lecithin may cause several diseases and side effects in the human body. Therefore, in this study, we used a blend of guar and acacia gums as a partial replacement for lecithin in white chocolate. Different concentrations of the blend (25–75 %) were used to replace lecithin and white chocolate containing 75 % lecithin, 15 % acacia gum and 10 % guar gum blend (75GAGL) exhibited comparable rheological properties as compared to the control sample. Consequently, the selected sample was characterized using different analytical techniques. FTIR results showed a similar peak of various functional groups of sugars, proteins, and uronic acids for 75GAGL and control samples. Physicochemical analysis and shelf-life evaluation were conducted during the 150-day storage period. Lower fat content (41.64 ± 1.23 %) and highest protein content (5.41 ± 0.08 %) were observed for the 75AGGL sample as compared to the control on the 0th day and a non-significant difference was shown on the 150th day. Overall, physicochemical data revealed minor changes in the nutritional aspects for both control and 75GAGL samples. DSC and TGA data proved that 75GAGL and the control sample have similar heat stability (melting point) and the peak was observed at 36.93 °C for 75GAGL and 37.11 °C for control. The addition of gum blend in chocolate 75GAGL (9985 g force in 2.24 Sec) displayed similar hardness as compared to the control sample (12,448 g force in 2.68 Sec). Results of texture analysis for 5AGGL and control samples exposed similar hardness values. Furthermore, the color assessment showed a non-significant difference in color values of both chocolates during 150 days of storage. 75AGGL received comparable scores to the control sample during sensory analysis. Overall, it could be proven that plant-derived gums can be effectively used for the partial replacement of lecithin for white chocolate production with desirable textural and sensory properties.

Effect of ultrasound-assisted Maillard reaction on glycosylation of goat whey protein: Structure and functional properties

Goat whey protein (GWP) has a rich amino acid profile and good techno-functional attributes but still has limited functional performance for certain applications. This study introduces an innovative ultrasound-assisted Maillard reaction to enhance GWP's functional properties by conjugating it with either gum Arabic (GA) or citrus pectin (CP). Sonication accelerated the Maillard reaction, and the glycosylation of GWP was significantly enhanced after optimization of the conjugation conditions. Gel electrophoresis examination verified the creation of GWP-polysaccharide conjugates, while scanning electron microscopy analysis revealed structural modifications caused by polysaccharide grafting and sonication. The use of ultrasound in the Maillard reaction notably enhanced the solubility, foaming capacity, and emulsifying attributes of the GWPs. Among the conjugates, the GWP-GA ones exhibited the best functional properties. Our findings suggest that this approach can notably improve the functional attributes of GWPs, thus broadening their potential uses in the food sector and beyond.

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Nanogels combine the characteristics of nanomaterials with hydrogels. To meet the expanding demands from various areas, a sizable number of nanogels have been designed and manufactured using the emulsion solvent diffusion nano precipitated method, emulsion evaporation of the solvent method, reverse micellar method and modified diffusion emulsification method. Thermosensitive nanogel, pH-sensitive nanogel, ultrasound-sensitive magnetic response, response to multiple stimuli, chain transfer polymerization, photo-induced crosslinking polymerization and modifications for active targeting are the types of nanogels based on response towards stimuli and polysaccharide, chitosan, pullulan, hyaluronic acid, alginate, cyclodextrin, gum acacia, protein are used to prepare nanogel. Nanogels have considerable potential and novelty within the biomedical sector due to their uniformity, adjustable dimensions, little toxicity, resilience in the presence of serum, and capacity for responsive behavior with a comparatively high drug encapsulation capacity. Nanogels have considerable potential in bioactive substance delivery, organ targeting, and chemotherapy. The article highlighted the preparation, types, evaluation and applicability of nanogel as a targeted delivery system.

Investigation of the binding properties of purified Pentadesma butyracea gum: Anatural alternative to a synthetic polymer

Abstract: The focus of most pharmaceutical research in recent times has been the use of natural products like gums as pharmaceutical excipients because they are safer, economical and readily available. This study aimed to investigate the applicability of gum extracted from the exudates from the stem bark of Pentadesma butyracea as a binder in conventional release tablets using acacia gum as a reference polymer. The purified Pentadesma butyracea gum (PBG) was precipitated from the crude gum mucilage using 96% ethanol. Conventional-release paracetamol tablets were formulated using seven (7) different concentrations of the PBG mucilage (0.5 – 6 %w/w) as a binder via wet granulation (PB1 – PB7). The same approach was used for the reference conventional release paracetamol tablets (AC1- AC7). The drug-excipients and excipients-gum compatibility studies were evaluated using the FTIR. The formulated tablets were evaluated using both pharmacopoeia and non-pharmacopoeia tests. Appropriate mathematical models were used to determine the similarity (f2) and the difference (f1) factors of the dissolution profiles of the test and reference formulations. Granules for batches PB1, AC1, PB2, AC2 and AC3 had fair flow properties, whereas the rest had good flow properties. The FTIR studies showed no interactions between the drug and excipients. All formulations passed the pharmacopoeia and non- pharmacopoeia tests except for formulations PB1, PB2, PB3 and AC1 which failed the friability test, PB1 and AC1 which failed the hardness test, and AC7 which also failed the disintegration test. An increase in gum concentration led to a corresponding increase in the mechanical properties of the tablets. A comparative study showed no significant difference in the hardness and tensile strength of the test and reference tablets. All formulations except PB6 were similar to their reference formulations since f1 > 50 and f2 < 15. In conclusion, the PBG exhibited a good binding property comparable to acacia gum.

In Situ ATR Spectroscopy Study of the Interaction of Acacia senegal Gum with Gold Nanoparticles Films at the Solid-Liquid Interface.

The adsorption process of Acacia gum (A. senegal), a complex heteropolysaccharide, was followed by using a spectroscopic method to unravel the relative contribution of the protein moieties and the carbohydrate blocks on the adsorption process. In situ ATR-FTIR was used to investigate the kinetics and conformational changes associated with the adsorption of A. senegal gum on gold nanoparticle films (Au-NPs) at different pHs. The results of this thorough study highlighted the adsorption of A. senegal gum through its protein moieties, in particular, AGPs of low molecular weight and high protein content, close to the Au-NPs surface. Isotherm experiments, by gradually increasing the concentration, showed that the gum adsorption was heterogeneous and followed the Freundlich model for the amide part, while the polysaccharide part followed the Langmuir model. In addition, the hydration and structural organization of the gum layer depended on the gum concentration. A. senegal gum adsorbed irreversibly on Au-NPs whatever the pHs, but the adsorbed layer presented a different behavior depending on pH. A more aggregated and less hydrated structure was observed at acidic pH, while a very hydrated and continuous layer was detected at higher pH. The secondary structure analysis through amide III band revealed a change in the gum secondary structure at high pH with the increase in β-turn while random coil decreased.

Characterization of microencapsulated spinach extract obtained by spray-drying and freeze-drying techniques and its use as a source of chlorophyll in a chewing gum based on Pistacia atlantica

This study aimed to extract and encapsulate spinach extract as a source of chlorophyll (CHL) through freeze- (FD) and spray-dried techniques (SD), followed by utilizing microencapsulated CHL (mCHL) in development a functional chewing gum (CG) based on Pistacia atlantica. The characteristics of mCHL underwent significant alterations through the employment of various concentrations (25 and 35% w/w) and amalgamations of Arabic gum (0–8.75 g) and maltodextrin (18.75–35 g). The mean values for powder yield and encapsulation efficiency in FD powders at 25% total solid content (TS) were 19.24% and 5.28% greater, respectively, than those of spray-dried samples, while SD microcapsules exhibited significantly enhanced storage stability. Microscopic analysis revealed the considerable impact of drying method, carrier type, concentration, and ratio on both the size and surface properties of FD- and SD-mCHL. An increase in TS from 25% to 35% resulted in a significant increase in mean particle size for SD powders from 7.19 μm to 10.96 μm. The textural analysis of CG demonstrated that the incorporation of CHL, in both free and encapsulated forms, did not negatively affect its hardness, adhesiveness, springiness, cohesiveness, chewiness, and resilience. Furthermore, the sensorial attributes of the CG samples, including appearance, spinach taste, and overall acceptability, were improved. Oral release analysis showed that after 15 min of chewing, the CHL release from CG samples was 94.5% and 70.3%, respectively, indicating that SD provided a slow release mechanism for CHL. In conclusion, both FD and SD CHL exhibited favorable technological traits and can be utilized as a delivery vehicle towards development of functional food products.

Influence of nontoxic biopolymer Arabic Gum as stabilizing and reducing agents in the formation of nanosilver in aqueous and micellar media

Biosynthesis of the nanosilver using Arabic Gum (AG, nontoxic natural polymer) as reducing and stabilizing agents in the absence and presence of surfactants was investigated. The results indicate that AG has a dual role in the in the formation of nanosilver as a stabilizing and an efficient reducing agent. The rate of the synthesis of nanosilver is enhanced in alkaline medium over the pH range (10.83–12.00). The reaction between silver(I) and AG was studied under pseudo-first-order condition using excess concentration of AG. At higher temperature (>50 °C), AG act as reducing and stabilizing agents but at lower temperature as stabilizing agent. The rate of the formation of nanosilver increases with increasing [CTAB] but Triton X-100 had no effect. The yellow color of the silver sols was monitored using UV-spectrophotometry, showing that the color of silver sols is more stable for long time in the presence AG as stabilizing. The characterization of nanosilver by FTIR, EDS, SEM, and TEM was investigated, confirming that the formation of the small uniform size of the nanoparticles.

Effect of Arabic Gum and technomus as a prebiotic in some blood parameters of Cyprinus carpio L.

This study was conducted at the first agricultural research and experiment station, Agriculture college, Al-Muthanna university, for 85 days, including the localization period (for the period from 25/9/2022 to 20/12/2022), to determine the effect of adding Arabic Gum and technomus as a prebiotic on growth triats. 162 common carp were used, with an average weight of 75±5 gm per fish, in 27 small tanks (baskets) of 0.107 cubic meters, they were randomly distributed to nine treatments with three replicates (6 fish for each replicate), were as followed: T1: (control treatment; without adding). T2: add 0% technomus with 0.5% Arabic Gum to the diet. T3: add 0% technomus with 1.0% Arabic Gum to the diet. T4: add 0.5% technomus with 0% Arabic Gum to the diet. T5: add 0.5% technomus with 0.5% Arabic Gum to the diet. T6: add 0.5% technomus with 1.0% Arabic Gum to the diet. T7: add 1.0% technomus with 0% Arabic Gum to the diet. T8: add 1.0% technomus with 0.5% Arabic Gum to the diet. T9: add 1.0% technomus with 1.0% Arabic Gum to the diet. The results of examining RBC and WBC showed that T7 and T8 were significantly (P≤0.05) superior, T1 and T3 were significantly decreased (P≤0.05) compared with other treatments. significantly (P≤0.05) superior in T6, T7 and T8 on hematocrit (PCV) and hemoglobin (Hb) compare with others. A significant (P≤0.05) superiority for all treatments compare with T6 on albumin, while T3 decreased on glucose concentration compare others. As for globulin, all treatments showed significant superiority over T2.

The therapeutic efficacy of silver loaded rhenium disulfide nanoparticles as a photothermal agent for cancer eradication

Cancer is a life-threatening disease when it is diagnosed at a late stage or treatment procedures fail. Inhibiting cancer cells in the tumor environment is a significant challenge for anticancer therapy. The photothermal effects of nanomaterials are being studied as a new cancer treatment. In this work, rhenium disulfide (ReS2) nanosheets were made by liquid exfoliation with gum arabic (GA) and coated with silver nanoparticles (AgNPs) to produce reactive oxygen species that destroy cancer cells. The synthesized AgNP-GA-ReS2 NPs were characterized using UV, DLS, SEM, TEM, and photothermal studies. According to the DLS findings, the NPs were about 216 nm in size and had a zeta potential of 76 mV. The TEM and SEM analyses revealed that the GA-ReS2 formed single-layered nanosheets on which the AgNPs were distributed. The photothermal effects of the AgNP-GA-ReS2 NPs at 50 μg/mL were tested with an 808 nm laser at 1.2 W cm−2, and they reached 55.8 °C after 5 min of laser irradiation. MBA-MB-231 cells were used to test the cytotoxicity of the newly designed AgNP-GA-ReS2 NPs with and without laser irradiation for 5 min. At 50 μg/mL, the AgNP-GA-ReS2 showed cytotoxicity, which was confirmed with calcein and EtBr staining. The DCFH-DA and flow cytometry analyses demonstrated that AgNP-GA-ReS2 nanosheets under NIR irradiation generated ROS with high anticancer activity, in addition to the photothermal effects.