Objective To observe the clinical effect of dexamethasone combined with dezocine on the ultrasound guided interscalene brachial plexus block. Methods Accordance with the random number table, 80 patients with ASAⅠ~Ⅱ undergoing upper extremity operations were divided into four groups, with 20 cases in each group: group A was treated with 0.45% ropivacaine mesylate 20mL; group B was treated with 0.45% ropivacaine mesylate combined with dexamethasone 0.1mg/kg 20mL; group C was treated with 0.45% ropivacaine mesylate combined with dezocine 0.1mg/kg 20mL; group D was treated with 0.45% ropivacaine mesylate combined with dexamethasone 0.1mg/kg and dezocine 0.1mg/kg 20mL.The onset time, maximum block time, analgesia duration and the incidence of adverse reactions were recorded in the four groups. Results The onset time of group C and group D were faster than group A and group B[group C(3.65±0.88)min vs.group A(5.60±0.88)min, group B(5.35±0.81)min, t=7.303, 6.367, all P=0.000; group D(3.30±0.80)min vs.group A, group B, t=8.614, 7.678, all P=0.000], the maximum block time of group C and group D were faster than those of group A and group B[group C(8.45±1.19)min vs.group A(12.75±2.05)min, group B(12.65±1.90)min, t=8.583, 8.383, all P=0.000; group D(7.80±0.89)min vs.group A, group B, t=9.880, 9.680, all P=0.000]. The analgesia duration of the other groups were longer than those of group A[group B(430.50±30.86)min, group C(435.00±38.46)min, group D(534.50±46.73)min vs.group A(314.50±33.32)min, t=9.696, 10.072, 18.388, all P=0.000], group D was the best(group D vs.group B, group C, t=8.693, 8.317, all P=0.000), there were no significant differences between group B and group C(group C vs.group B, t=0.376, P=0.708). In the 80 patients, only one case of group C had postoperative nausea and vomiting symptoms, there were no significant differences between the groups(all P>0.05). Conclusion Dexamethasone combined with dezocine on the ultrasound guided interscalene brachial plexus block is a method with faster onset time, shorter maximum block time, longer analgesia duration, and it has less adverse reactions and better anesthetic effect, and it is more suitable for upper extremity operations. Key words: Neuromuscular blockade; Brachial plexus; Ultrasonography; Dexamethasone; Dezocine
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