Growth Of Different Organs Research Articles

The pathological growth of the prostate gland in atherogenic contexts.

The human prostate is an androgen-dependent gland where an imbalance in cell proliferation can lead to benign prostatic hyperplasia (BPH), which results in voiding lower urinary tract symptoms in the elderly. In the last decades, novel evidence has suggested that BPH might represent an element into the wide spectrum of disorders conforming the Metabolic Syndrome (MS). The dyslipidemic state and the other atherogenic factors of the MS have been shown to induce, maintain and/or aggravate the pathological growth of different organs, with data regarding the prostate being still limited. We here review the available epidemiological and experimental studies about the association of BPH with dyslipidemias. In particular, we have focused on Oxidized Low-Density Lipoproteins (OxLDL) as a potential trigger for vascular disease and cellular proliferation in atherogenic contexts, analyzing their putative molecular mechanisms, including the induction of specific extracellular vesicles (EVs)-derived miRNAs. In addition to the epidemiological evidence, OxLDL is proposed to play a fundamental role in the upregulation of prostatic cell proliferation by activating the Rho/Akt/p27Kip1 pathway in atherogenic contexts. miR-21, miR-141, miR-143, miR-145, miR-155, and miR-221 would be involved in the transcription of genes related to the proliferative process. Although much remains to be investigated regarding the impact of OxLDL, its receptors, and molecular mechanisms on the prostate, it is clear that EVs and miRNAs represent a promising target for proliferative pathologies of the prostate gland.

Development and growth of digestive system organs of European and Japanese quail at 14 days post-hatch

The objective of this study was to evaluate the development and growth of the digestive system organs, from the 11th day of incubation until the 14 d post-hatch in European and Japanese quail. On days 11, 13 and 15 of incubation at hatch and at 4, 7, 10 and 14 d post-hatch, embryos or chicks of European and Japanese quail were analyzed. After 15 d of incubation, samples from stomach and small intestine were analyzed by microscopy. European quail had significantly heavier body weight at 15 d of incubation and after 4 d post-hatch. The digestive system weight progressively increased with age and was similar between European and Japanese quail at 11, 13, and 15 d of incubation and 10 d post-hatch, while relative weight of digestive system was similar between quail type with great values at 4 d post-hatch. For relative weight of the small intestine + pancreas, the weight of the proventriculus and of the gastric ventricle increased significant by among ages analyzed in both types of quail. At hatch, proventriculus had functional secretory cells and mucosa of gastric ventricle had a thin coilin membrane. In small intestine segments, at 15 d of incubation the height of the villi was similar among duodenum, jejunum, and ileum (80μm). Villi had elongated shape towards the intestinal lumen, covered by enterocytes and dispersed goblet cells with PAS+ and AB+ contend in all segments. The number of goblet cell/villi increased in segments until 7 to 10 d post-hatch. Duodenum increases the villi up to 14 d, while the jejunum and ileum up to 10 and 4 d, respectively. Based on our data in digestive system growth, a shorter period of post-hatch fast and specific diets to quail during first days of growth is recommended to both quail types. It is concluded that the development and growth of different organs of the digestive system up to 14 d of age was similar between European and Japanese quail.

The Ambivalent Role of lncRNA Xist in Carcinogenesis.

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.

Biological Effects of Magnetic Water on Human and Animals

The aim of the present study was to investigate the beneficial effects of magnetized water for human and animals. There was an improvement in water quality when exposed to the magnetic field with considerable change in the pH, total dissolved solids, total hardness, conductivity, salinity, dissolved oxygen, evaporating temperature, minerals, organic matter and total count of bacteria. Therefore it’s penetration into cell wall would be facilitated which can accelerate ordinary diffusion of water that is vital for growth of different organs. Patients uses magnetic water for digestive, urinary and nervous problems, ailments like mastitis, pains and swellings, painful urination and many other disorders. Magnetized water has been found effective in alleviating colds, coughs, bronchitis, all types of fever and more, arthritis pain, reducing blood pressure, recovering quickly from a stroke, and it helpful in the regularization of women's menses. Also, treatment with magnetic water was very effective in breaking up kidney and gall bladder stones into small particles. The water also prevented further formation of stones in the kidneys and gallbladder. Magnetic water may prevent aging and fatigue by increasing the cell membrane permeability. Effectiveness of magnetized water in the prevention and treatment of atherosclerosis has been shown in some animal and human studies. It has been reported that magnetic water help unclog the arteries and veins of deposits of cholesterol and salts and normalize the circulatory system. Also, magnetized water can be helpful in weight control, as an adjutant to a correct diet because this water improves metabolic activity, it may be helpful in burning up excessive fatty tissue. Magnetized drinking water improves nutrient digestibility, saves water consumption, optimizing rumen fermentation parameters, and it could an effective way to reduce methane production and contributing to mitigate environmental impact in livestock, positive animal health, which is reflected in the increase in milk yield and its component and improves blood picture and antioxidant status. Magnetized drinking water caused increase milk production, mutton, and wool in sheep not only that, but more weight gain in geese and egg production and hatchability in turkey can be achieved, and increasing in milk yields in dairy cows and ewes. It can be concluded that magnetic water treatment improved blood picture, biochemical parameters, semen quality, and antioxidant status in human and animals. So, magnetic water must be used to mitigate the harmful effects of drugs, toxins, and environmental pollutant on human and animals.

Temperature dependence of needle and shoot elongation before bud break in Scots pine

Knowledge about the early part of needle growth is deficient compared with what is known about shoot growth. It is however important to understand growth of different organs to be able to estimate the changes in whole tree growth in a changing environment. The onset of growth in spring has been observed to occur over some certain threshold value of momentary temperature or temperature accumulation. We measured the length growth of Scots pine (Pinus sylvestris L.) needles and shoots from March until bud break over 3 years. We first compared needle growth with concurrent shoot growth. Then, we quantified threshold temperature of growth (i) with a logistic regression based on momentary temperatures and (ii) with the temperature sum accumulation method. Temperature sum was calculated with combinations of various time steps, starting dates and threshold temperature values. Needle elongation began almost concurrently with shoot elongation and proceeded linearly in relation to shoot growth until bud break. When studying the threshold temperature for growth, the method with momentary temperature effect on growth onset yielded ambiguous results in our conditions. The best fit of an exponential regression between needle growth or length and temperature sum was obtained with threshold temperatures -1 to +2 °C, with several combinations of starting date and time step. We conclude that although growth onset is a momentary event the process leading to it is a long-term continuum where past time temperatures have to be accounted for, rather than a sudden switch from quiescence to active growth. Further, our results indicate that lower temperatures than the commonly used +5 °C are sufficient for actuating the growth process.

Interaction of carbon nanohorns with plants: Uptake and biological effects

Single-walled carbon nanohorns (SWCNHs) are a unique carbon-based nanomaterial with promising application in different fields including, medicine, genetic engineering and horticulture. Here, we investigated the biological response of six crop species (barley, corn, rice, soybean, switchgrass, tomato) and tobacco cell culture to the exposure of SWCNHs. We found that SWCNHs can activate seed germination of selected crops and enhance growth of different organs of corn, tomato, rice and soybean. At cellular level, growth of tobacco cells was increased in response to exposure of SWCNHs (78% increase compared to control). Uptake of SWCNHs by exposed crops and tobacco cells was confirmed by transmission electron microscopy (TEM) and quantified by microwave induced heating (MIH) technique. At genetic level, SWCNHs were able to affect expression of a number of tomato genes that are involved in stress responses, cellular responses and metabolic processes. We have concluded that SWCNHs can be used as plant growth regulators and have the potential for plant-related applications.

Xylem formation can be modeled statistically as a function of primary growth and cambium activity.

Primary (budburst, foliage and shoot) growth and secondary (cambium and xylem) growth of plants play a vital role in sequestering atmospheric carbon. However, their potential relationships have never been mathematically quantified and the underlying physiological mechanisms are unclear. We monitored primary and secondary growth in Picea mariana and Abies balsamea on a weekly basis from 2010 to 2013 at four sites over an altitudinal gradient (25-900m) in the eastern Canadian boreal forest. We determined the timings of onset and termination through the fitted functions and their first derivative. We quantified the potential relationships between primary growth and secondary growth using the mixed-effects model. We found that xylem formation of boreal conifers can be modeled as a function of cambium activity, bud phenology, and shoot and needle growth, as well as species- and site-specific factors. Our model reveals that there may be an optimal mechanism to simultaneously allocate the photosynthetic products and stored nonstructural carbon to growth of different organs at different times in the growing season. This mathematical link can bridge phenological modeling, forest ecosystem productivity and carbon cycle modeling, which will certainly contribute to an improved prediction of ecosystem productivity and carbon equilibrium.

Genetic and physiological controls of growth under water deficit.

The sensitivity of expansive growth to water deficit has a large genetic variability, which is higher than that of photosynthesis. It is observed in several species, with some genotypes stopping growth in a relatively wet soil, whereas others continue growing until the lower limit of soil-available water. The responses of growth to soil water deficit and evaporative demand share an appreciable part of their genetic control through the colocation of quantitative trait loci as do the responses of the growth of different organs to water deficit. This result may be caused by common mechanisms of action discussed in this paper (particularly, plant hydraulic properties). We propose that expansive growth, putatively linked to hydraulic processes, determines the sink strength under water deficit, whereas photosynthesis determines source strength. These findings have large consequences for plant modeling under water deficit and for the design of breeding programs.

Palatoplastia com biomembrana natural de látex com polilisina 0,1% em cães com defeito palatino experimentalmente induzido

The palatoplasty is a correction surgery to restore the isolation between the oral and nasal cavity, avoid breath of food. There are many techniques to repair palatal defects, and the most used is mucoperiosteal flap. Grafts and prothesis, can be used too. Scientific works with Natural Latex Biomembrane with 0,1% Polylisine reveals properties like biocompatibility, improve and accelerate the cicatricial process, the stimulation of new vessels and organized tissue growth in different organs. Seven dogs were arranged in two groups and were submitted to experimental hard palate cleft. Five dogs received palatal repair with the natural latex biomembrane with 0,1% polylisine. Two animals did not receive any repair (control group) and the defect healing by second intention. After surgery, the groups were observed macroscopically and clinically to evaluate the results. The healling of cleft palate of group I was faster than control group, and this fact suggests that the biomembrane is an accelerator factor for cicatricial process.

The growths of leaves, shoots, roots and reproductive organs partly share their genetic control in maize plants

We have tested to what extent the growth ability of several organs of maize share a common genetic control. Every night, leaf elongation rate reaches a maximum value (LERmax ) that has a high heritability, is repeatable between experiments and is correlated with final leaf length. Firstly, we summarized quantitative trait loci (QTLs) of LERmax and of leaf length in three mapping populations. Among the 14 consensus QTLs (cQTLs) of leaf length, seven co-located with cQTLs of LERmax with consistent allelic effects. Nine cQTLs of LERmax (4% of the genome) were highly reliable and confirmed by introgression lines. We then compared these QTLs with those affecting the growths of leaves, shoots, roots or young reproductive organs, detected with the same mapping populations in three field experiments or in literature datasets. Five of the nine most reliable cQTLs of LERmax co-located with QTLs involved in the growth of other organs (but not in flowering time) with consistent allelic effects. Reciprocally, two-thirds of the 20 QTLs of growth of different organs co-located with cQTLs of LERmax . Hence, LERmax , as determined in a phenotyping platform, is an indicator of the growth ability of other organs of the plant in controlled or in-field conditions.

Variation in intra‐annual wood formation, and foliage and shoot development of three major Canadian boreal tree species

In a warming climate, boreal trees may have adjusted their growth strategy (e.g., onset and coordination of growth among different organs such as stem, shoot, and foliage, within and among species) to cope with the extended growing seasons. A detailed investigation into growth of different organs during a growing season may help us assess the potential effects of climate change on tree growth in the boreal forest. The intra-annual growth of stem xylem, shoot tips, and foliage area of Pinus banksiana, Populus tremuloides, and Betula papyrifera was monitored in a boreal forest in Quebec, Canada during the growing season of 2007. Xylem formation was measured at weekly intervals, and shoot elongation and foliage expansion were measured three times per week from May to September. Growth indices for stem, shoot, and foliage were calculated and used to identify any climate-growth dependence. The time periods required for stem growth, branch extension, and foliage expansion differed among species. Of the three species, P. banksiana had the earliest budburst (20 May) yet the latest completion date of the foliage growth (2 August); P. tremuloides had the latest budburst (27 May) yet the earliest completion date of the foliage growth (10 July). Air temperature positively affected shoot extension growth of all three species. Precipitation positively influenced stem growth of the two broadleaf species, whereas growing season temperature positively impacted stem growth of P. banksiana. The results show that both the timing of growth processes and environmental dependences differ among co-occurring species, thereby leading to different adaptive capability of these boreal tree species to climate change.

KLUH/CYP78A5-Dependent Growth Signaling Coordinates Floral Organ Growth in Arabidopsis

Growth control in animals and plants involves mobile signals. Depending on their range of action, these signals coordinate the growth of cells within an organ or the growth of different organs in a larger, functionally integrated structure. In plants, flowers are such integrated structures, yet it remains poorly understood how growth of the constituent organs is coordinated to ensure their correct relative sizes. The cytochrome P450 KLUH/CYP78A5 and its homolog CYP78A7 promote organ growth via a non-cell-autonomous signal; however, the range of this signal and thus its developmental function are unknown. Here we use a system for the predictable generation of chimeric plants to determine the range of the KLUH-dependent signal. In contrast with the largely autonomous behavior of another tested growth-control gene, we find that KLUH activity extends beyond individual organs and flowers. Its overall activity is integrated across an inflorescence to determine final organ size, which is largely independent of the genotype of the individual organs. Thus, the KLUH-dependent signal appears to move beyond individual organs in a flower, providing a mechanism for coordinating their growth and ensuring floral symmetry as an important determinant of a plant's attractiveness to pollinators.

QTL analysis of plant development and fruit traits in pepper and performance of selective phenotyping

A QTL analysis was performed to determine the genetic basis of 13 horticultural traits conditioning yield in pepper (Capsicum annuum). The mapping population was a large population of 297 recombinant inbred lines (RIL) originating from a cross between the large-fruited bell pepper cultivar 'Yolo Wonder' and the small-fruited chilli pepper 'Criollo de Morelos 334'. A total of 76 QTLs were detected for 13 fruit and plant traits, grouped in 28 chromosome regions. These QTLs explained together between 7% (internode growth time) and 91% (fruit diameter) of the phenotypic variation. The QTL analysis was also performed on two subsets of 141 and 93 RILs sampled using the MapPop software. The smaller populations allowed for the detection of a reduced set of QTLs and reduced the overall percentage of trait variation explained by QTLs. The frequency of false positives as well as the individual effect of QTLs increased in reduced population sets as a result of reduced sampling. The results from the QTL analysis permitted an overall glance over the genetic architecture of traits considered by breeders for selection. Colinearities between clusters of QTLs controlling fruit traits and/or plant development in distinct pepper species and in related solanaceous crop species (tomato and eggplant) suggests that shared mechanisms control the shape and growth of different organs throughout these species.

Effects of the Combined Application of Ethephon and Gibberellin on Growth of Rice (Oryza sativa L.) Seedlings

Improvement of early seedling growth, such as seedling emergence and vigor is one of the most important agronomic traits in direct seeding rice cultivation. The effects of two plant growth regulators (PGRs), gibberellic acid (GA3) and ethephon (ET), on seedling growth under flooded soil conditions at different temperatures and water depths were investigated. The PGRs were applied during the seed soaking process. A single treatment with GA3 or ET increased seedling growth. However, combined application of GA3 and ET was more effective than that of GA3 or ET alone in many cases at both growing temperatures (15 and 20ºC). The growth of different organs in the rice seedlings, such as the coleoptiles, first leaves, and second leaves was also increased by PGR treatment. The nitrogen concentration of the shoot and the ratio of shoot dry weight to shoot length did not differ significantly among the treatments. The results of our study show that rice seedling growth in direct seeding cultivation may be improved by treatment with GA3 and ET in combination.

Are tumours angiogenesis-dependent?

The final proof of principle that cancer patients can be effectively treated with angiogenesis inhibitors is eagerly awaited. Various preclinical in vivo experiments have proven that most tumours need new vessel formation in order to grow and to form metastases. First of all, tumours do not grow in avascular corneas until new blood vessels reach the implant. Secondly, the introduction of only one angiogenic gene can cause a switch from tumour dormancy to progressive tumour growth. Thirdly, tumour growth can be inhibited and sometimes tumour regression can be obtained just by attacking the vascular compartment with specific angiogenesis inhibitors. These three examples of preclinical experiments and many others have led to the conclusion that, in general, tumours are angiogenesis-dependent. Supported by disappointing clinical results, the angiogenesis dependency of tumours has been questioned, mainly because of the immaturity and the presumed lack of a functional blood supply (oxygen delivery and discarding of waste products) from a newly formed tumour vasculature. However, human tumours are highly heterogeneous in vascular architecture, differentiation, and functional blood supply. Vascular immaturity is a natural consequence of a genetically based unlimited expansion of tumour cells, compared to the well-regulated growth of different organs during embryonic development, for example. Unlimited tumour expansion and therefore the continuous stimulation of vessel outgrowth prevent endothelial cells from generating a mature vasculature, but instead continuously stimulate them to expand the vascular compartment of the growing tumour. In this review, the translation of angiogenesis inhibitors as a treatment for cancer from preclinical experiments to the clinic is evaluated. The preclinical evidence that tumours are angiogenesis-dependent is summarized and explanations are put forward for why the clinical results so far are not as exciting as was expected from preclinical studies. Reviewing the translation, one may conclude that human tumours are heterogeneous in their vascular architecture and function and that tumour-induced angiogenesis in humans is a more complex (multifactorially regulated) process compared with angiogenesis in preclinical cancer models.

Costs and benefits of mycorrhizal infection in a spring ephemeral, Erythronium americanum

summarySpring ephemerals have evolved specific growth strategies that take advantage of the high photon fluence rates of early spring. These strategies involve a sequential growth of different organs. Erythronium americanum (Ker‐Gawl), a common spring ephemeral of northern maple forests, produces its roots in the autumn, although stems and leaves develop in the spring. Mycorrhizal infection of the root system occurs very rapidly and intensively. The fungi thus depend on carbohydrate reserves accumulated in the corm (underground reserve organ) for their growth and development through the winter. We found that the presence of mycorrhizas drastically decreases root growth during the cold period and is more costly of carbohydrate reserves than root growth alone. However, during the spring, the presence of mycorrhizas fully benefits the plant: we measured an annual growth rate of mycorrhizal plants twice that of fungicide‐treated plants which were non‐mycorrhizal. We suspect that E. americanum is highly susceptible to water stress during the growing season and might rely on its mycorrhizas for water supply to a greater extent than for nutrient supply. Nutrient uptake might occur mainly in the autumn when arbuscules are at their most abundant.

Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.

We used reovirus reassortant genetics and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific immunity. Adult SCID mice infected with reovirus serotype 1 strain Lang (T1L) died after 20 +/- 6 days, while infection with serotype 3 strain Dearing (T3D) was lethal after 77 +/- 22 days. One hundred forty-five adult SCID mice were infected with T1L, T3D, and 25 different T1L x T3D reassortant reoviruses, and gene segments associated with the increased virulence of T1L were identified. Gene segments S1, L2, M1, and L1 accounted for > 90% of the genetically determined increase in T1L virulence. Gene segment M1 was independently important for virulence, with S1, L2, and L1 alone or in combination also playing a role. T1L grew to higher titers in multiple organs and caused more severe hepatitis than T3D. Seventy adult SCID mice, T1L, T3D, and 15 T1L x T3D reassortant viruses were used to map genetic determinants of viral titers in the brain, intestines, and liver, as well as the severity of hepatitis. Different sets of gene segments were important for determining viral titers in different organs. Gene segments L1 (encoding a core protein) and L2 (encoding the core spike of the virion) were important in all of the organs analyzed. The M1 gene segment (encoding a core protein), but not the S1 gene segment, was a critical determinant of reovirus titer in the liver and severity of hepatitis. The S1 gene segment (encoding the viral cell attachment protein and a nonstructural protein), but not the M1 gene segment, was a critical determinant of titers in intestines and brains. These studies demonstrate that viral growth in different organs is dependent on different subsets of the genes important for virulence. The virion-associated protein products of the four gene segments (L1, L2, M1, and S1) important for virulence and organ tropism in SCID mice likely form a structural unit, the reovirus vertex. Organs (the brain and intestines versus the liver) differ in properties that determine which virulence genes, and thus which parts of this structural unit, are important.

A DYNAMIC TOMATO GROWTH AND YIELD MODEL (TOMGRO)

ABSTRACT Models of the greenhouse environment and of crops are needed to determine optimal strategies for environment control in regions where new greenhouse industries are developing. In this research, a physiological model of tomato crop development and yield was developed. A series of differential equations represent the changes in numbers and weights of leaves, fruit, and stem segments and in the areas of leaves, as new organs are initiated, age, and senesce or are picked. The model uses a source-sink approach for partitioning carbohydrate into growth of different organs. An experiment was conducted in six outdoor, controlled environment, growth chambers to quantify the effects of temperature, CO2, and light on tomato growth processes for calibrating the model. The model accurately described the differences in growth and yield of tomatoes that were observed in the experiment. With additional testing, the model can be used to help determine strategic and tactical decisions concerning greenhouse environment control over practical ranges of CO2 and temperature.

The growth of different organs of normal and dwarfed Snell mice, before and during growth hormone therapy.

Abstract. This study was performed in order to obtain more insight in the relationship between the growth of different organs of normal Snell mice and their dwarfed littermates before and during growth hormone therapy. Beside body weight the weights of the following organs were studied: liver, kidneys, heart, the muscles quadriceps femoris and gastrocnemius, submandibular salivary glands, testes, epididymal fatpads, thymus, spleen and skinfold thickness. The data show that, similar to body weight, growth of these organs in dwarf mice is arrested at approximately 2½ weeks of age, after which little further growth occurs, leaving their absolute weight far below normal. Related to body weight the liver is close to normal, lower values are obtained for the heart and very low ones for the kidneys, the lymphoid organs, thymus and spleen, and the epididymal fatpads. At two weeks of age the weight of the brain is only slightly less than normal, but gradually stays behind until it is only 2/3 of normal at the age of 17 weeks. Due to the small weight of the dwarfs the contribution to body weight of the brain is higher than normal. Growth hormone, after 4 weeks of treatment, had induced significant growth of all organs studied, except for the testes and the thickness of the skinfold. After 10 weeks of treatment all organ weights were significantly increased. Growth was most marked in the lymphoid organs, spleen and thymus, and the epididymal fatpads (155–173% of controls). The submandibular salivary glands and the testes increased more than body weight (respectively 141 and 136% vs. 123%). Increase proportional to body weight was found for the muscles quadriceps femoris and gastrocnemius, heart, liver and kidneys. In contrast, increase of the brain (106%) and skinfold (111%) was much lower.

The changes in the growth pattern of organs ofChenopodium rubrum photoperiodically induced to flowering

The relationship between photoperiodically changed growth of leaves, cotyledons, hypocotyl, roots and flowering has been investigated inChenopodium rubrum. It was found that all the growth characteristics recorded in leaves and cotyledons,i.e. length, area, dry weight and chlorophyll content, were inhibited during three inductive photoperiods (16 h darkness, 8 h light-SD) as compared with control plants grown under continuous illumination. Similarly, the cessation of root elongation and a decrease in root dry weight were observed. On the contrary, the elongation and dry weight of hypocotyl are stimulated by SD. The degree of the effect exerted by SD on the growth of different organs depends both on actual growth stage and the number of SD photoperiods. Increased relative rate of growth of roots and cotyledons was recorded in plants transferred after SD treatment to continuous illumination. However, this rise possesses only transitional character and the relative growth rate of treated plants equals that of control ones afterwards. The above growth changes are discussed as a possible modifying factor of floral differentiation.