In this study, the response of 6-month-old cocoa (Theobroma cacao L.) seedlings to elevated CO2 concentration [ECO2], elevated temperature [ET], and their interaction with water deficit stress was studied in an open top chamber (OTC). Each OTC was maintained at chamber control (400ppm CO2), [ECO2] 550ppm, [ECO2] 700ppm, ET 3°C above chamber control, and ET 3°C + [ECO2] 550ppm. Inside each OTC, a set of plants received moisture at 100% FC, while the other set was at 50% FC, which was the water deficit stress treatment. Increasing the CO2 concentration in cocoa increased photosynthesis (Pn) by 27%, which resulted in high biomass accumulation, thus improving the whole plant water use efficiency (WUE). The impact of high temperature (Tmax), around 39°C in ET treatment against 36°C in chamber control, is quite severe on Pn, leaf Ψ, and biomass accumulation. Similarly, water deficit at 50% FC resulted in the leaf Ψ reducing to - 14.06 bars at which Pn, leaf area, and biomass were significantly reduced. [ECO2] could ameliorate the negative effect of high temperature and water deficit stress to certain extent. However, the relative response of cocoa seedlings to [ECO2] in improving Pn, leaf Ψ, biomass, and WUE was greater under 50% FC compared to plants at 100% FC suggested additional advantage of [ECO2] to cocoa under water limited conditions.