As a representative structure with an acute radial gradient in terms of residual stress (RS) and grains, the induction-hardened railway S38C axle exhibits excellent mechanical properties and fatigue resistance. To investigate the effect of gradient features on fatigue crack growth (FCG) behaviors, we designed three-point bending (TPB) tests with different gradient features, including the negative-gradient, positive-gradient, and matrix specimens. Finite element modeling was introduced to simulate the FCG of the TPB specimens in terms of the cyclic J-integral (ΔJ) and equivalent plastic strain at the growing crack tip. The results reveal that the FCG rates in both negative- and positive-gradient structures decrease and a more pronounced tendency of decline is achieved in the positive-gradient ones. The substantial compressive residual stress (CRS) within the negative-gradient structure directly influences the crack tip area, while the CRS in the positive-gradient structure indirectly mitigates the crack driving force by impeding the overall structural deformation. Coarser grains aid in enhancing energy absorption along the zigzag crack path, thereby diminishing the crack driving force. ΔJ and the equivalent plastic zone surrounding the crack tip indicate significant reductions in the presence of CRS.