Blood Glucose Levels In Group Research Articles

Antidiabetic Activity of Isolated Compounds of Crinum solapurense Leaves Extract in Albino Wistar Rats

Background: The leaves extracts of Crinum solapurense are examined for in-vivo antidiabetic pharmacological action. Methods: Plant material including different multi-component mixes has a large number of bioactive chemicals. Therefore, it is crucial to separate and determine these compounds which have active phytoconstituents are responsible for the pharmacological action. The extracts for action in-vivo antidiabetic investigation from the leaves extract of Crinum solapurense are the subject of the current research project. From the leaves, ethanolic extracts of the medicinal plant Crinum solapurense, two alkaloid compounds—gulonic acid & shikimic acid—were identified. The alkaloids found in the phytoconstituents of Crinum solapurense leaves may be the cause of their pharmacological action. Results: In the DNSA inhibition assay method the IC50 value was observed to be 5.31 & 11.17 μg/ml for shikimic acid & gulonic acid correspondingly. In the Iodine-Starch Technique the IC50 value was observed to be 9.91 & 12.70 μg/ml for shikimic acid & gulonic acid correspondingly. In the In-vivo animal study of Gulonic acid in the group that was not given any treatment, diabetic rats displayed considerable weight loss at the end of the trial (p ˂0.001). When dexamethasone was administered, the diabetic group's blood glucose levels significantly increased in comparison to the control group (p is equal to 0.01). Two parameters were improved in a dosage-dependent way when mice were given glibenclamide or gulonic acid at a dose of 50.00 or 100.00 milligrams per kilogram body weight. Diabetes led to a substantial rise in HbA1c (p˂0.05) in the group of diabetics who were not receiving treatment. Conclusion: Based on the in-vivo animal study it was concluded that the leaves extracts of Crinum solapurense show significant effects of antidiabetic pharmacological action in diabetes induced animals.

Effect of Ethanol Extract of Sala (Cynometra ramiflora Linn.) leaves for reducing Blood Glucose Levels in Male Wistar Rats Induced by Alloxan

Diabetes is a chronic illness brought on by either insufficient insulin production by the pancreas or inefficient insulin utilisation by the body. There is currently no proven diabetes treatment. The development of current therapies is solely focused on preserving and enhancing patients' quality of life. In addition to utilising oral hypoglycemic medications or insulin injections to control blood sugar, several medicinal plants have also undergone pharmacological testing and can be used experimentally. There were 5groups, namely negative control group (0.5% Na CMC), positive control (glibenclamide 0.9mg/kg), ethanol extract of Sala leaves at doses of 250, 500, and 1000mg/kgBW. Each group was induced by alloxan 150mg/kg intraperitoneal body weight before fasting blood glucose levels 200mg/dL. Each group's blood glucose levels were taken and checked as pre alloxan, post alloxan, 7 and 10 days after treatment. The results showed that the ethanol extract of Sala leaves with doses of 250, 500, and 1000mg/kg for 7 and 10 days after treatment showed glucose-lowering activity (p<0.05) on all alloxan induction. The ethanolic extract of the leaves of the Sala plant (Cynometra ramiflora Linn.) with doses of 250, 500, and 1000mg/kgBW for 7 and 10 days showed significant glucose-lowering activity (p<0 0.05) in alloxan-induced mice.