Group Of Scientific Experts Research Articles

The time for ambitious action is now: Science-based recommendations for plastic chemicals to inform an effective global plastic treaty

The ubiquitous and global ecological footprint arising from the rapidly increasing rates of plastic production, use, and release into the environment is an important modern environmental issue. Of increasing concern are the risks associated with at least 16,000 chemicals present in plastics, some of which are known to be toxic, and which may leach out both during use and once exposed to environmental conditions, leading to environmental and human exposure. In response, the United Nations member states agreed to establish an international legally binding instrument on plastic pollution, the global plastics treaty. The resolution acknowledges that the treaty should prevent plastic pollution and its related impacts, that effective prevention requires consideration of the transboundary nature of plastic production, use and pollution, and that the full life cycle of plastics must be addressed. As a group of scientific experts and members of the Scientists' Coalition for an Effective Plastics Treaty, we concur that there are six essential “pillars” necessary to truly reduce plastic pollution and allow for chemical detoxification across the full life cycle of plastics. These include a plastic chemical reduction and simplification, safe and sustainable design of plastic chemicals, incentives for change, holistic approaches for alternatives, just transition and equitable interventions, and centering human rights. There is a critical need for scientifically informed and globally harmonized information, transparency, and traceability criteria to protect the environment and public health. The right to a clean, healthy, and sustainable environment must be upheld, and thus it is crucial that scientists, industry, and policy makers work in concert to create a future free from hazardous plastic contamination.

Tyre wear nanoparticles as test for a nano risk governance framework

The Horizon 2020 consortia NanoRigo, Gov4Nano and RiskGONE jointly developed a nano risk governance framework (NRGF), fit for use for the practice of nanomaterials’ development and use, understandable and executable for stakeholders involved in manufacturing, using or regulating nanomaterials, or confronted with incidental exposure to generated nanomaterials. The NRGF includes risk management models, tools and approaches relevant to nanomaterials, as well as nano-oriented LCA and grouping, and takes into account socio-economic aspects and risk-benefit assessment. Special attention was paid to operationalizing concern assessment within the framework of the risk governance approach, emphasizing the different nature of quantitative risk assessment and qualitative concern assessment. The usefulness and added value of the NRGF was tested by means of a case study on rubber tyres. This case study performed a “mock-up” risk and concern assessment of the use of manufactured nanomaterials in the rubber tyre tread and the environmental release of tyre wear particles (TWP) from this tread during car driving. With a focus on the release and hazards of nano-TWP, an approach using the NRGF methodology was defined in collaboration with a group of real-life stakeholders. Simultaneously a group of scientific experts assessed the usefulness of the available tools and methods for assessing this nano-TWP release and investigated related broader societal concerns. The exercise concludes that so far, an exclusive risk assessment of nano-TWP is a step too far, due to the lack of nano-specific health- and environmental exposure and hazard data. Moreover, it seems that public concern about nano-sized TWP emissions is still limited, contrary to emerging scientific concerns. The case study underlines the complexity of deriving robust recommendations for “real-life” cases. Many questions remain on how to weigh the available technical and social evidence in nano risk governance.

Treatment of inflammatory diseases of the nose and paranasal sinuses from the standpoint of bioregulatory systemic medicine

One of the most frequent otorhinolaryngological pathologies is inflammatory diseases of the nose and paranasal sinuses. In Russia, according to the Ministry of Health and Social Development, 15% of adults and 5% of children suffer from chronic rhinosinusitis. According to analysis of medical records, indicators of ENT diseases do not decrease, and long-established treatment regimens prove to be ineffective, despite the large number of different medications. One of the hypotheses existing at the present stage attributes this tendency to the underestimation of the complexity of regulatory systems in the era of reductionism, when the organism is unable to fully adapt to the influence of the environment. In this connection, the concept of bioregulatory systems medicine (BrSM), developed by an international group of scientific experts and clinicians of different specialties, whose underlying principles are the perception of the human being as a complex and integrated system, acquires particular significance. The development of any process is carried out through multilevel interaction between the various systems of the body, the so-called intra-network interactions. According to the views accepted in BrSM, multipurpose therapy is justified to influence different links of pathogenesis. Thus, the bioregulatory approach is multitargeted, i.e., it involves the use of multicomponent drugs affecting the body as a single system. The purpose of this study is to consider treatment regimens for inflammatory diseases of the nose and paranasal sinuses from the perspective of bioregulatory systems medicine. It is concluded that bioregulatory nasal spray therapy is safe and well tolerated, has anti-inflammatory, antiviral, moisturizing effects, and stimulates mucosal regeneration, is combined with other medicines, and is an excellent alternative to traditional methods of treatment, has no side effects and limitations typical of them.

Bilateral Historical Committees as an Example of Scientific Diplomacy

An article by the famous Russian historian A. O. Chubaryan is devoted to the gradual development of science diplomacy as an independent scientific discipline, the implementation of its principles and ideas in practice and the study of Russian experience in this area. The author dwells in particular detail on the work of bilateral commissions of historians, which have become an example of genuine science diplomacy. Despite the initial skepticism, the constructive approach, on the one hand, of Russian historians, and, on the other hand, of their German, Austrian, Polish and Lithuanian colleagues, has made it possible in recent years to publish a number of joint books for secondary school teachers on the most problematic and topical issues of history. The author calls for more active use of the experience of the Cold War, when international scientific expert groups were formed, which jointly searched for ways to alleviate international tension and exit from the acute phase of the Cold War. The publication of archival documents also plays an important role in realizing the goals of science diplomacy. In general, in recent years, despite the aggravation of the international situation, Russian historians have gained considerable experience in international cooperation, the best confirmation of which was the holding of the first ever World Congress of School History Teachers in Moscow in 2021, and in September 2022 in St. Petersburg — conferences with the participation of authors of school textbooks from around the world.

The Crowdfunding Model, Collective Intelligence, and Open Innovation

In recent years, crowdfunding has attracted the attention of tech startups. It has become a good alternative way to readily raise funds, especially during the early startup stages. However, in the case of mass intelligence, it is quite difficult to ensure the accuracy and reliability of knowledge. Individual investors who are not experts in science and technology often face difficulties investing in technology companies. In this regard, a new type of collective intelligence formed by accredited professionals needs to be attempted. This paper explores an alternative crowdfunding model for enhancing access to technology investments by the general population through an investor acceptance model. We developed an investor acceptance model to examine how the crowdfunding model involving scientists and engineers is adopted by individual investors using survey data from the general population. The results revealed that individual investors have a positive attitude towards investing through the crowdfunding model when they perceive that the information provided by a group of scientific experts is useful. We found that the perceived usefulness of the information from scientists and engineers is affected by the perceived quality of the information and perceived credibility of the scientists and engineers. We also suggest a basic concept for the crowdfunding model utilizing the collective intelligence of scientists and engineers for tech startups. The results could suggest a policy direction for promoting innovation.

The place expert’s opinions in Soviet technological project of first half 1960th: the case Astrakhan and Selenga paper and cardboard mills

In the article discussed history of building Astrakhan and Selenga paper and cardboard mills. The author on base archival materials is analyzing the impact of expert commentary on the building paper and cardboard mills. The main purpose of the article is to show, on the example of the construction of the CCC, the process of relations between scientific expert groups and government representatives on the issue of environmental safety in the design and location of the country's production facilities. In addition, the author emphasizes that for the Soviet leadership, issues of the environmental component of enterprises often became secondary, departing from economic necessity. At the same time, the scientific community itself did not in some cases have a single position on a particular issue, since a conflict arose between representatives of departmental and scientific academic structures, which was most pronounced during the construction of the Selenginsky pulp and cardboard plant. In the case of the Astrakhan pulp and cardboard plant project, it is shown that underestimating the capabilities of the resource base of production can lead to environmental problems. Author marked that despite of scientific and technological inspection, scientific opinions was ignored by government leaders in cases large technological objects.

Planetary Protection in the New Space Era: Science and Governance

Committee of Space Research’s Planetary Protection Policy is a triumph of technocratic governance in the global sphere. The Policy is produced by a group of scientific experts and subsequently enjoys high regard among the scientific and space community. However, as Committee of Space Research is an independent organization without any legal mandate the Planetary Protection Policy is an example of so-called “soft law” or a non-binding international instrument, in short, no one is under any legal obligation to comply with them. The policy is linked to Article IX of the Outer Space Treaty and its provision calling for the avoidance of “harmful contamination” of the Moon and other celestial bodies. While space activities beyond Earth orbit have been the exclusive preserve of government scientific space agencies this has posed little problem. However as private and “non-science” space activities proliferate and begin to spread their reach beyond Earth orbit, the Planetary Protection Policy is being tested. This paper will examine the challenges of developing and maintaining an effective planetary protection regime in this “New Space” era. This will involve looking at the existing policies, as well as the governance framework they sit within. However, it is also necessary to consider and understand the scientific basis not just for the specifics of the policy itself but the necessity of it. Finally, this paper will consider whether a broader “environmental” framework is needed as space activities diversity in type and location.

The inside story of the Group of Scientific Experts and its key role in developing the CTBT verification regime

ABSTRACT This article provides an inside view of the sustained effort by the Group of Scientific Experts (GSE) which was key to the development of the international seismic network included in the 1996 Comprehensive Nuclear-Test-Ban Treaty (CTBT). Over the course of the GSE’s twenty-year-long journey, part of which was at the height of the Cold War, the GSE went from being a little-known entity that reviewed and encouraged research to designing and testing elements of a seismic verification system. Their work eventually included full-scale testing of the seismological component of the final global system that is now implemented by the Preparatory Commission of the CTBT Organization. The other three monitoring networks comprised in the treaty—radionuclide, hydroacoustic, and infrasound—are modeled after the seismic network. The article identifies some key conditions that made GSE a successful endeavor. Prime among these was the strong engagement among scientists and scientific institutions in many countries that contributed large resources. The formal work at the Conference on Disarmament in Geneva was just the tip of the iceberg, but very important. This official intergovernmental framework provided a connection to the political community, and a frame for organizing extensive global development and testing activities. GSE was given long-term mandates and self-determination of management and leadership, facilitating a sustained and goal-oriented process. Based on their leadership experience in the GSE and the CTBTO Preparatory Commission Verification Working Group, the authors also provide some reflections on how the concept of scientific expert groups and new scientific developments could prove useful in future efforts toward nuclear-disarmament verification.

PROTECTION OF HUMAN RIGHTS IN THE CONTEXT OF THE DEVELOPMENT OF BIOETHICS AND GENOMICS (THEMATIC REVIEW OF THE INTERNATIONAL ROUND TABLE)

The article presents a description of the main theses of reports and presentations during the thematic meeting in the framework of an interdisciplinary group of scientific experts and students of law schools from Russia and Italy. The problems of the legalization of genetic research, the regulation of ethical, legal-social and international legal issues, as well as the problems of biomedical influence on the sphere of human rights are analyzed.

Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015.

Pediatric rare lung disease (PRLD) is a term that refers to a heterogeneous group of rare disorders in children. In recent years, this field has experienced significant progress marked by scientific discoveries, multicenter and interdisciplinary collaborations, and efforts of patient advocates. Although genetic mechanisms underlie many PRLDs, pathogenesis remains uncertain for many of these disorders. Furthermore, epidemiology and natural history are insufficiently defined, and therapies are limited. To develop strategies to accelerate scientific advancement for PRLD research, the NHLBI of the National Institutes of Health convened a strategic planning workshop on September 3 and 4, 2015. The workshop brought together a group of scientific experts, intramural and extramural investigators, and advocacy groups with the following objectives: (1) to discuss the current state of PRLD research; (2) to identify scientific gaps and barriers to increasing research and improving outcomes for PRLDs; (3) to identify technologies, tools, and reagents that could be leveraged to accelerate advancement of research in this field; and (4) to develop priorities for research aimed at improving patient outcomes and quality of life. This report summarizes the workshop discussion and provides specific recommendations to guide future research in PRLD.

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.

Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European interdisciplinary Ewing sarcoma research summit” assembled a large group of scientific experts in the field to discuss their latest unpublished findings on the way to the identification of novel therapeutic targets and strategies. Ewing sarcoma is characterized by a quiet genome with presence of an EWSR1-ETS gene rearrangement as the only and defining genetic aberration. RNA-sequencing of recently described Ewing-like sarcomas with variant translocations identified them as biologically distinct diseases. Various presentations adressed mechanisms of EWS-ETS fusion protein activities with a focus on EWS-FLI1. Data were presented shedding light on the molecular underpinnings of genetic permissiveness to this disease uncovering interaction of EWS-FLI1 with recently discovered susceptibility loci. Epigenetic context as a consequence of the interaction between the oncoprotein, cell type, developmental stage, and tissue microenvironment emerged as dominant theme in the discussion of the molecular pathogenesis and inter- and intra-tumor heterogeneity of Ewing sarcoma, and the difficulty to generate animal models faithfully recapitulating the human disease. The problem of preclinical development of biologically targeted therapeutics was discussed and promising perspectives were offered from the study of novel in vitro models. Finally, it was concluded that in order to facilitate rapid pre-clinical and clinical development of novel therapies in Ewing sarcoma, the community needs a platform to maintain knowledge of unpublished results, systems and models used in drug testing and to continue the open dialogue initiated at the first two Ewing sarcoma summits.

Stability of home based care arrangements for people with dementia : Development of a consensus definition of stability using expert focus groups

The majority of people with dementia in Germany live at home. These informal care arrangements, which are mostly coordinated by informal carers, are the backbone of home-based dementia care. Creating and maintaining stability is an underlying theme in informal care; however, a definition of the complex phenomenon of 'stability' in this context is still lacking. The aim was to develop a working definition of stability of home-based care arrangements for people with dementia, which can be applied in current and future research projects at the German Center for Neurodegenerative Diseases in Witten (DZNE Witten) and others. Ensuing from prior research a preliminary version of the definition was formulated. This definition was discussed in a focus group of scientific experts with expertise in dementia research and care (n = 8). After data analysis using content analysis, the definition was revised during a scientific colloquium (n = 18) and a consensus was finally reached. There were four major themes which were considered by the experts as being relevant for the definition of stability: (1) creating and maintaining stability as a continuous adaptation process, (2) a qualitative component of stability, (3) persons with dementia and informal carers as pivotal players and (4) transitions to residential care. The working definition introduced in this article reflects the authors' understanding of the phenomenon of stability of home-based care arrangements for people with dementia. In times of increasing need for evidence-based interventions it is necessary to develop elaborated definitions of complex phenomena in order to be able to systematically evaluate the efficacy of interventions on the basis of a common understanding.

Harmonization of regulatory guidelines on efficacy of ectoparasiticides for companion animals: Status and missing points

Ectoparasites of major clinical significance in companion animals include fleas, ticks, lice, mange, mite, mosquitoes and sandflies, as well as biting flies. Obtaining a marketing authorization (or licence) for an ectoparasiticide relies on the assessment by regulatory agencies of a comprehensive data package to confirm the quality, safety and efficacy of the product when used in the target animal species for the proposed claims. Such approval is done under a highly regulated system. However, the global regulatory framework for pet ectoparasiticides is complex, since these products may be classified either as pesticides or as pharmaceuticals depending on the country or even within a given country, based on the presentation or mode of action. Within each jurisdiction, regulatory guidelines provide standards relating to study designs, relevant parasite species, efficacy calculation and acceptable thresholds, and define the corresponding acceptable label claims. Despite some similarities, there is no formal international harmonization for development requirements. In some areas, gaps and/or inconsistencies are more marked than others. Published recommendations from scientific expert groups (e.g. W.A.A.V.P. guidelines) are therefore a useful tool for regulatory bodies, researchers, developers and animal health companies. These expert recommendations reflect the current position of the scientific community and potentially address aspects not covered satisfactorily by regulatory texts while taking into account the latest advancements in experimental methodologies. Since the changes to official regulatory texts generally occur at a slower pace than the scientific state-of-the-art, and because of the lack of a harmonized approach, both scientific and regulatory guidance documents are necessary.The main objective of this review is to explore the complexity of the international regulatory framework for pet ectoparasiticides and to highlight some areas that are insufficiently addressed, or where differences are found between jurisdictions. These gaps and differences may lead to barriers in product development, and to scientific or user confusion. The need of further harmonization effort with the support of parasitology expert working groups is thus advocated.

Three Criteria for Consensus Conferences

Consensus conferences are social techniques which involve bringing together a group of scientific experts, and sometimes also non-experts, in order to increase the public role in science and related policy, to amalgamate diverse and often contradictory evidence for a hypothesis of interest, and to achieve scientific consensus or at least the appearance of consensus among scientists. For consensus conferences that set out to amalgamate evidence, I propose three desiderata: Inclusivity (the consideration of all available evidence), Constraint (the achievement of some agreement of intersubjective assessments of the hypothesis of interest), and Evidential Complexity (the evaluation of available evidence based on a plurality of relevant evidential criteria). Two examples suggest that consensus conferences can readily satisfy Inclusivity and Evidential Complexity, but consensus conferences do not as easily satisfy Constraint. I end by discussing the relation between social inclusivity and the three desiderata.

The Evolution of Physical Activity on Prescription (FaR) in Sweden

In 1996, the first Report of the US Surgeon General on Physical Activity and Health provided an extensive knowledge overview about the positive effects of physical activity (PA) on several health outcomes and PA recommendations. This contributed to an enhanced interest for PA in Sweden. The Swedish Professional Associations for Physical Activity (YFA) were appointed to form a Scientific Expert Group in the project “Sweden on the Move” and YFA created the idea of Physical Activity on Prescription (FaR) and the production of a handbook (FYSS) for healthcare professionals. In Swedish primary care, licensed healthcare professionals, i.e. physicians, physiotherapists and nurses, can prescribe PA if they have sufficient knowledge about the patient’s current state of health, how PA can be used for promotion, prevention and treatment and are trained in patient-centred counselling and the FaR method. The prescription is followed individually or by visiting local FaR providers. These include sport associations, patient organisations, municipal facilities, commercial providers such as gyms, sports clubs and walking clubs or other organisations with FaR educated staff such as health promoters or personal trainers. In clinical practice, the FaR method increases the level of PA in primary care patients, at 6 and at 12 months. Self-reported adherence to the prescription was 65% at 6 months, similar to the known compliance for medications. In a randomised controlled trial, FaR significantly improved body composition and reduced metabolic risk factors. It is suggested that a successful implementation of PA in healthcare depends on a combination of a systems approach (socio-ecological model) and the strengthening of individual motivation and capability. General support from policymakers, healthcare leadership and professional associations is important. To lower barriers, tools for implementation and structures for delivery must be readily available. Examples include handbooks such as FYSS, the FaR system and the use of pedometers.

Ergebnisse und Empfehlungen zur beruflichen Rehabilitation aus dem Entwicklungsprojekt RehaFutur

The overall project RehaFutur, which has been initiated and funded by the Federal Ministry of Labour and Social Affairs and which involves all the actors of the vocational rehabilitation system, is aimed at advancing the development of the vocational rehabilitation system, so as to prepare it for the challenges ahead. The project started with a group of scientific experts, who formulated 8 fields of action for further developing the vocational rehab system. On this basis, 4 working groups were set up in the framework of a development project to elaborate concrete recommendations on how to implement the necessary changes in vocational rehabilitation. The topics dealt with by the working groups were "self-determination and self-responsibility", "regulation of the overall process", "occupation and working environment" as well as "research". The process was supervised by a steering group, the results were moreover discussed in workshops. Recommendations have been made for 10 subject areas: "consultation and information", "joint service points", "use of the internet", "quality assurance", "individualisation and greater flexibility", "orientation towards the working environment", "participation of the beneficiaries", "research", "legislation", "cooperation of the actors". The next step of the RehaFutur overall project is implementation of those recommendations. This needs to be done in an interdisciplinary manner and conjointly by the agencies and providers involved, including the beneficiaries as experts. As different framework conditions have to be taken into account, the process is a complex one and needs to be supported by systematic research.

Concern that “EMF” magnetic fields from power lines cause cancer

In 2002, the International Agency for Research on Cancer (IARC, 2002) categorized extremely low frequency (ELF) (including the power frequencies of 50 and 60Hz) magnetic fields as “possibly carcinogenic to humans.” That was based on pooled analyses of epidemiological research that reported an association between exposure to low-level magnetic fields and childhood leukemia. In 2007 a task group of scientific experts convened by the World Health Organization (WHO) acknowledged the IARC categorization but found that the laboratory studies and other research results did not support the association. Taking all evidence into account WHO reported that it could not confirm the existence of any health consequences from exposure to low-level magnetic fields.There remains continuing concern by some people that exposure to power frequency magnetic fields may cause adverse health effects, particularly childhood leukemia. Public health authorities need to fully understand the reasons for that ongoing concern and effective ways to address it. This paper describes what drives the concern, including how people perceive risks, how WHO and other public health authorities assess scientific research to determine whether health risks exist and the conclusions they have reached about power frequency magnetic fields. This paper also addresses the scientific basis of international exposure guidelines for power frequency magnetic fields and what precautionary measures are warranted to address the concern.

Integrating diverse scientific and practitioner knowledge in ecological risk analysis: A case study of biodiversity risk assessment in South Africa

Ecological risk analysis (ERA) is a structured evaluation of threats to species, natural communities, and ecosystem processes from pollutants and toxicants and more complicated living stressors such as invasive species, genetically modified organisms, and biological control agents. Such analyses are typically conducted by a narrowly-focused group of scientific experts using technical information. We evaluate whether the inclusion of more diverse experts and practitioners in ERA improved the ecological knowledge base about South African biodiversity and the potential impacts of genetically modified (GM) crops. We conducted two participatory ERA workshops in South Africa, analyzing potential impacts of GM maize on biodiversity. The first workshop involved only four biological scientists, who were joined by 18 diverse scientists and practitioners in the second, and we compared the ERA process and results between the two using descriptive statistics and semi-structured interview responses. The addition of diverse experts and practitioners led to a more comprehensive understanding of biological composition of the agro-ecosystem and a more ecologically relevant set of hazards, but impeded hazard prioritization and the generation of precise risk assessment values. Results suggest that diverse participation can improve the scoping or problem formulation of the ERA, by generating an ecologically robust set of information on which to base the subsequent, more technical risk assessment. The participatory ERA process also increased the transparency of the ERA by exposing the logic and rationale for decisions made at each step.

Radiation protection of medical staff in the latest draft of the revised Euratom Basic Safety Standards directive

Abstract The European Union has a long and successful history of legislating in the area of radiation protection of the public, workers and individuals submitted to medical exposure, the first Euratom “Basic Safety Standards” (BSS) adopted in 1959 and subsequently updated and supplemented with other Directives. The recent revision of this legislation aims to update it in the light of the latest knowledge and experience and to simplify it by consolidating the current legal acts into one Directive. The draft of the revised Euratom BSS Directive has been approved by the group of scientific experts under Euratom Treaty Article 31 and is currently undergoing the European Commission’s procedures. This draft contains several new or amended provisions relating to protection of medical staff, among them: (i) a streamlining of the annual dose limit provisions, (ii) enhancing the use of dose constraints in optimization of protection, and (iii) ensuring better recording and transfer of occupational dose data including in cases of trans-border movement of workers. The Community action to radiation protection of workers is not restricted to passing relevant legislation but also includes ‘soft action’ as issuing guidance, supporting research and stakeholders’ involvement, etc. In August 2010 the Commission issued a Communication to the Council and the European Parliament dealing with the issues in the medical uses of ionizing radiation, including those relating to radiation protection of medical staff.

2009 SIPREC Consensus Document – Executive Summary

Cardiovascular diseases still represent the leading cause of mortality and hospitalization, worldwide. As a consequence of the marked demographic changes observed in the general population, the improved survival rate after an acute cardiovascular event and the progressive rise of costs (mostly due to technological and pharmacological innovations), the estimated burden of cardiovascular diseases will be soon become insurmountable for national healthcare systems. In this view, an integrated approach aimed at improving strategies for cardiovascular disease prevention and, thus, limiting the negative outcomes, would probably be successful. Such an approach may not only achieve long-term benefits, but even significant advantages in the short to medium term, mostly in asymptomatic high-risk individuals. Indeed, this latter population of asymptomatic high-risk individuals would mostly benefit from extensive application and improvement of strategies for cardiovascular disease prevention with a favourable cost-benefit ratio. The Italian Society for Cardiovascular Disease Prevention — Societa Italiana per la Prevenzione Cardiovascolare (SIPREC) — has recognized this strategic aim, focusing a significant part of its institutional actions on the effort for providing educational supports and consensus documents, which represent an overview of the scientific knowledge and personal clinical expertise by national and international key opinion leaders. Expert committees periodically generate ‘state-of-the-art’ documents on specific scientific topics with relevant socioeconomic implications and large clinical impact. The present article is dedicated to healthcare professionals, is based on the available evidence, and provides information on diagnostic algorithms and therapeutic options on abnormal glucose regulation (or dysglycaemia). The relationship between abnormalities in glucose metabolism and cardiovascular complications represents an important and relatively early target for cardiovascular disease prevention. SIPREC identified, even in this clinical setting, a group of scientific experts in order to form a multidisciplinary ‘task force’. This group has been asked to explain in a short, simple and effective fashion the epidemiological impact and the pathophysiological nature of the problem, its clinical features, potential diagnostic algorithms and therapeutic options, and its influence on the clinical practice of both specialist physicians and general practitioners. This work provides the background for discussing novel future strategies for cardiovascular prevention. It is also aimed at highlighting the importance of an emerging marker of cardiovascular risk, which is often not recognized and underestimated.