Parents In Group Research Articles

Preliminary reliability and validity of the PedsQL™ Family Impact Module in parents of children with congenital muscular dystrophy

PurposeThis study examines the preliminary reliability and validity of the PedsQL™ Family Impact Module (PedsQL™ FIM) in parents of children with congenital muscular dystrophy (CMD).MethodsThe participants in this study were 28 parents of children with CMD and 39 parents of unaffected children. Both groups of parents completed the PedsQL™ FIM and a demographic information form. Cronbach’s alpha was used to examine the internal consistency reliability, and the known-groups method was used to assess construct validity. Three distinct models were used to estimate the mean score differences of the PedsQL™ FIM between the two groups: an unadjusted model, a multivariate regression model, and propensity score matching with inverse probability of treatment weighting.ResultsCronbach’s alpha coefficients for all scales exceeded 0.70, supporting evidence for the internal consistency reliability of the PedsQL™ FIM. The construct validity of the PedsQL™ FIM demonstrated that the mean differences between the CMD and unaffected groups were significantly different (p < .05). This indicated that the instrument could discriminate between the two groups.ConclusionsThe results of this study demonstrated the good preliminary reliability and validity of the PedsQL™ FIM in assessing parental health-related quality of life and family functioning of children with CMD.

Parental Ability to Detect Visual or Ocular Anomalies in Their Children

INTRODUCTION: Children typically depend on their parents to seek eyecare. Visual and ocular disorders can be challenging for parents to identify with the absence of apparent symptoms. This may hinder timely clinical diagnosis for children who need treatment. Parental awareness regarding common paediatric eye and vision anomalies along with eye care seeking behaviour has been reported, but there is a lack of studies that demonstrate parental ability to identify a presenting eye or vision disorder in their own children. AIM: This study aimed to determine parental ability to recognise a significant eye problem in their children. METHODS: The study population consisted of beneficiaries of Jaber Al Ahmad Armed Forces Hospital in Kuwait. Structured history and symptoms were taken from parents and comprehensive eye examinations were conducted for their children. Parental responses were compared to the eye test results to attain the study purpose. RESULTS: A total of 188 parental interviews and 188 eye test results data were collected from 137 parents and their children. Only a few parents (18.1%) were able to detect significant visual or ocular anomalies in their children. One-third of the parents (33%) were under the assumption that the visual or ocular status of their children was within the norm, while the eye test results showed that the children had clinically significant issues. Overall, 41.5% of the entire group of parents were wrong in their assumption about the children&amp;rsquo;s visual or ocular status. CONCLUSION: The findings suggest that a large proportion of parents may not be able to identify a presenting eye disorder in their children. This emphasises the significance of routine eye examinations at an early age.

The gap between the need for parental support and support provided during the COVID-19 pandemic: a qualitative study with first-time mothers’ experiences

BackgroundBecoming a parent can be challenging. Becoming a parent for the first time during the COVID-19 pandemic might pose additional challenges, as the pandemic has imposed restrictions on society, thus affecting parental support. There were changes in parental support from child health services and preschools available for all children and their parents, so called open preschools, have been closed. This study explored first-time parents’ experiences of the parental support they received during the COVID-19 pandemic.MethodsA qualitative study involving individual semi-structured interviews with nine first-time mothers who had been on parental leave during the pandemic was conducted. Data were analyzed with inductive content analysis and the results are presented in a main category with three generic categories.ResultsThe main category is entitled, A gap between the needs of parental support and the support provided, and it encompasses three generic categories: The first category, Formal support, refers to support from child health nurses and open preschools. The second category, Lack of formal support, encompasses the lack of person-centred support and lack of parental groups. The third category, Informal support, encompasses support from family, friends, and social media.ConclusionsThe findings indicate that under the restrictions imposed by the pandemic, first-time mothers expressed the need for person-centred support to both parents which will ensure that all parents get the support they expect and need. The participants also expressed a desire for adapted parental groups that are feasible despite the restrictions to allow them to connect with other parents and build networks.

TOPSE for babies in Norwegian: Examining the reliability of a tool to measure parenting self-efficacy

Abstract Background Parents’ confidence in their parenting abilities and self-efficacy (PSE) is an important factor for parenting practices. The Tool to measure Parenting Self-Efficacy (TOPSE) is a questionnaire created to evaluate parenting programs by measuring PSE. Initially, it was designed for parents with children between 0-6 years old. A modified version specifically for parents of infants aged 0-6 months (TOPSE for babies) is currently being piloted. In this study, we have investigated the reliability of the Norwegian version. Methods The study included 123 parents of children aged 0-18 months who completed a digital version of the TOPSE questionnaire. Professional translators performed the translation from English to Norwegian and a back translation in collaboration with the author group. Mean and standard deviation were calculated for each of the questionnaire’s six domains, and a reliability analysis was conducted using a Bayesian framework for the total sample (parents of children aged 0-18 months) and specifically for the parents of the youngest group of children (0-6 months). Results The overall Bayesian alpha coefficient for the six domains ranged from 0.54 to 0.83 for the entire sample, and from 0.63 to 0.86 for parents with children aged 0-6 months. For two of the domains, one item in each proved to primarily contribute to the low alpha coefficients and removing them improved the reliability, especially for parents of the youngest group of children. Conclusions Reliable tools to assess PSE and evaluate parenting programs is important. The Norwegian version of TOPSE for babies seems to be a reliable tool for measuring PSE, although there are variations across the children’s age groups and domains. Key messages • The findings from this study indicate that TOPSE in Norwegian is a reliable tool for assessing PSE. • While our findings are promising, further research is warranted to establish a more robust evaluation, across both mothers and fathers, parental age and socioeconomic groups.

The effects of hypothetical psychological interventions on alcohol use in European young adults

Abstract Background Low psychosocial well-being (PWB) and high emotion-driven impulsiveness (EDI) are associated with alcohol. Yet, it is unclear whether a hypothetical intervention targeting one or the other in adolescence might be more effective in reducing alcohol consumption (AC) in young adulthood. Therefore, we aimed to compare the separate causal effects of PWB and EDI in adolescence on AC in young adulthood. Methods We included 505 European young adults from the IDEFICS/I.Family cohort (mean age: 20.2 years; age range: 18.2-23.5 years) who did not drink alcohol at study entry. AC was operationalized as the amount of weekly consumed alcoholic beverages (mean: 4.2 drinks per week; range: 0.3-70 drinks per week). EDI was assessed using the negative urgency subscale from the UPPS-P Impulsive Behaviour Scale. PWB was assessed using the KINDLR Health-Related Quality of Life Questionnaire. Following the principles of target trial emulation, we estimated, separately, the average causal effects of PWB and EDI on AC accounting for relevant confounders and applying a semi-parametric doubly robust method (targeted maximum likelihood estimation). We stratified the results by sex and parental education. Results If all adolescents, hypothetically, had high levels of PWB, compared to low levels, we estimated a decrease in the average amount of alcoholic beverages in young adulthood by 0.1 drinks per week [95%-confidence interval: -2.3; 2.1]. Furthermore, if all adolescents had low levels of EDI, compared to high levels, we estimated an increase in alcoholic beverages in young adulthood by 1.5 drinks per week [0.1; 2.9]. Different effects for sex and parental education groups were found. Conclusions Hypothetical interventions targeting PWB in adolescents were not found to have effects on reducing AC in young adulthood. Interventions targeting EDI, however, would lead to an increase in AC. This may be due to unmeasured confounding and the missing distinction between drinking motives. Key messages • We demonstrate that causal inference methods, compared to traditional ones, improve the robustness of estimated effect measures and address important sources of bias in European cohort data. • To inform public health interventions on reducing alcohol consumption, future research should investigate different drinking motives, e.g. alleviating negative emotions or enhancing positive emotions.

Parental awareness and dental health behavior of children with congenital heart disease, with diabetes mellitus, or undergoing anti-cancer treatment, compared to healthy children

IntroductionChildren with chronic diseases tend to experience a considerably higher burden of oral disease compared to their healthy peers. Low awareness of the impact of systemic diseases on oral health, lack of motivation, and discomfort may render the maintenance of good oral hygiene challenging. We conducted a study of four groups of parents: of children with congenital heart disease (CHD), with diabetes mellitus type 1 (DM), and undergoing anti-cancer treatment (ACT); and a control group of healthy children (C). We aimed to compare between the groups, parental attitudes and knowledge of their children's oral health, and their reports of their children's dental habits.MethodsParents who arrived with their children for routine check-ups at three main clinics: cardiology, endocrinology, and hematology-oncology were asked to respond to a questionnaire regarding their children's oral and dental health.ResultsA total of 287 questionnaires were collected from 76 parents of children with CHD, 100 parents of children with DM, 50 parents of children undergoing ACT, and 61 parents who comprised group C. Compared to the CHD and DM groups, the ACT group demonstrated significantly more awareness of the importance of maintaining oral and dental health following diagnosis of their children's medical condition. Mothers’ education was found to correlate with dental health knowledge. Most children in the DM and C groups had previous dental examinations, compared to only half in the CHD and ACT groups. A higher proportion of the children in the C than the other groups brushed teeth twice daily. The groups were similar in their consumption of sugary drinks, and of sweets and snacks. The children's specialist physicians were the main source of information on oral health, especially in the ACT group.ConclusionsAlthough most of the parents reported awareness to the oral health aspects of their children's disease, only part of them reported that their children visited dentists, and brushed their teeth twice daily. For the parents of children with CHD, DM, and ACT, their children's treating specialists were the primary source of information regarding oral health. This highlights the importance of clear and continuous communication between pediatric specialists and dentists.

Exploring the Feasibility of Social Skills Programs for Autistic Youth Through Virtual Reality.

Many autistic individuals may desire support and services primarily in the areas of adaptive functioning and social well-being throughout their lifetime. There is a need for community-informed and person-centered social programs targeted for autistic adolescents and adults. New technology, such as virtual reality (VR), is being researched to assess the feasibility of providing therapeutic services to autistic individuals. This qualitative study aims to better understand and explore the perceptions of parents and autistic adolescents regarding social development and thoughts around social skills interventions delivered through technologies such as VR. Eight autistic adolescents between the ages of 12 to 17, and five parents participated across five focus groups. The focus group interviews were semi-structured, and qualitative data analysis was conducted through an open thematic approach and inductive coding process. Seven primary themes with sub-themes were identified throughout the focus group interview discussions: Social Skills of the participating autistic adolescents as reported by their parents and by self-report, Family Dynamics affecting social relationships within the family, Social Skills Goals both groups hoped to develop and improve, the existence and quality of In-Person vs. Online Friendships, Experience/Comfort With Technology, Openness to Virtual Environments, and Concerns for Virtual Environments. Researchers identified these themes across both parent and adolescent focus groups. This study provides guidance to the research community on investigating different innovative approaches for offering a social program that is supported by autistic individuals.

Psychometric Evaluation of the Multidimensional Assessment of Parenting Scale in LGBTQIA+ Parents.

In LGBTQIA+ adults, 36% are parents, but there are a limited number of parenting scales that have undergone psychometric evaluation in LGBTQIA+ parents. This study assessed the Multidimensional Assessment of Parenting Scale (MAPS) in LGBTQIA+ parents, addressing a gap in parenting scales considering both positive and negative aspects for this group. Our study includes two racially and ethnically diverse national samples of parents (n = 2,299, mean age = 37.05 years, 32.84% LGBTQIA+). We explored measurement invariance between LGBTQIA+ and non-LGBTQIA+ parents. The analysis revealed a modest fit for configural and metric invariance, indicating the MAPS structure and item loadings were consistent across groups, although scalar invariance was only partially supported. Subscales showed good internal consistency for both parent groups. Importantly, following false discovery rate corrections, interactions between LGBTQIA+ status and specific MAPS subscales (supportiveness, physical control) were significantly, but differentially, related to various child psychopathology dimensions, suggesting parenting impacts may differ for LGBTQIA+ families. These findings underscore the importance of including LGBTQIA+ perspectives in parenting research to develop tailored interventions that address their unique strengths and challenges. Acknowledging and supporting the diverse experiences of LGBTQIA+ parents can enhance targeted resources and interventions, contributing to better outcomes for all families.

Parents' income has influence on levels of physical activity and sedentary behaviour of junior high school student

This study aims to determine physical activity (PA level) and sedentary behavior (SB level) in students with various parents' income levels. This study used a cross-sectional design. The subjects used in this study were 900 students from 10 schools and ten cities in East Java, Indonesia. Data on students' parents' income were grouped into five categories based on their income level (very low: n = 360; low: n = 231; medium: n = 123; high: n = 79; very high: n = 107). The research instruments used were the Children’s Physical Activity Questionnaire (CPAQ) to measure the level of physical activity (PA level) and the Adolescent Sedentary Activity Questionnaire (ASAQ) to measure the level of sedentary behavior (SB level). The results of the Mann-Whitney statistical test showed significant differences in PA level and SB level between the very low-income group of parents and the low, medium, high, and very high-income groups (p&lt;0.05). In conclusion, the higher the level of parental income, the better the students' physical activity, and the lower their sedentary behaviour. Keywords: Family monthly income, physical activity, sedentary behavior, junior high school student

Exploring Parent Perspectives on Autonomy Supportive Environments: A Qualitative Recreational Therapy Approach

The purpose of this study was to explore the ways par-ents provide autonomy supportive environments to their child with type 1 diabetes. Self-determination theory (SDT) is focused on interplay between extrinsic forces acting on persons and the intrinsic motive and needs of human beings. This study adopted SDT as its theoreti-cal framework, with emphasis on autonomy supportive environments. Interview questions were formulated and prepared according to components within the SDT. Between January 2023 and March 2023, seven parents consented and participated in interviews via Zoom. In-terviews followed a pre-constructed interview protocol which included 10 questions centered on the fostering of competence, relatedness, autonomy, choice provision, ra-tional provision, perspective taking, and advocacy. While it is known that parenting children with type 1 diabetes poses many challenges, our findings support giving a child autonomy to lead to more effective diabetes management. Also, findings indi-cated the importance of involvement in social groups, such as parent groups and medi-cal specialty camps. Recreational therapist (RT) professionals can measure outcomes as well as additional insight into parent perspective through camp involvement. This further supports RT using the self-determination theory within the practice of diabetes camps to improve health. Authors provide suggestions for future studies and practice implications for parental camp involvement.

Feasibility Evaluation of a Parenting Group for Latina Survivors of Intimate Partner Violence.

Intimate partner violence (IPV) is a pervasive concern among Latina women that requires accessible and culturally appropriate services for survivors, including programs to support parenting in the context of IPV. Evaluations of such programs are sparse, limiting understanding of how agencies can best serve Latina survivors who are parents. We conducted a feasibility study of a parenting group for Latina IPV survivors that included an analysis of administrative data, focus groups with program participants (n = 17), and interviews with facilitators (n = 4). Findings center on demand, acceptability, implementation, and recommendations. Overall, the program was well received, and results include suggestions to enhance the program.

Factors affecting human papillomavirus vaccine acceptance among parents of Primary 4 to 6 boys and girls in Hong Kong.

Human papillomavirus (HPV) poses a substantial but underestimated healthcare burden in Hong Kong. This study investigated factors affecting parental acceptance of HPV vaccination after the introduction of an immunisation programme for primary school girls. We assessed parental perceptions and related factors concerning HPV vaccination for both boys and girls. We conducted a cross-sectional survey between December 2021 and February 2022 among parents of Primary 4 to 6 students in Hong Kong. Our self-administered online survey collected data regarding socio-demographic characteristics, awareness and knowledge of HPV vaccination, attitudes towards HPV vaccination, and acceptance of HPV vaccination. Characteristics were compared between boys' parents and girls' parents. Factors associated with vaccine acceptance were analysed by multivariate logistic regression. We observed high awareness of HPV vaccination among boys' parents and girls' parents; however, they demonstrated relatively poor knowledge of HPV and the HPV vaccine. An alarming low HPV vaccination uptake rate was also observed. Attitudes towards the HPV vaccine were similar between parent groups. A majority of parents believed that the HPV vaccine was safe and effective in preventing infection. Parents of boys showed lower HPV vaccine acceptance. Factors associated with acceptance differed between parent groups. High awareness of HPV and HPV vaccine is predictive of vaccine acceptance. Boys' parents are less likely to accept HPV vaccination and emphasis should be placed on addressing potential HPV vaccine hesitancy in this group. Public education should also aim to raise awareness of government vaccination programme, and implementation of catch-up vaccination programme to school children beyond primary school should be considered.

Analysis of Perceptions and Requirements for Creative Experiential Activity Curriculum for the Revision of Special Education in South Korea

This study investigates the perspectives of key stakeholders—teachers, principals, and parents of students with disabilities—regarding the 2022 Revised Curriculum, which integrates sustainability and climate change education into the Creative Experiential Activity (CEA) curriculum in special education. It focuses on their perceptions and needs for improving CEA to reflect hands-on learning and sustainable development goals (SDGs), particularly in areas like ICT integration and social inclusion. Through a focus group interview (FGI) and the KJ method of analysis, key themes were derived and organized into six levels to structure the transcripts. The teacher group identified 69 perceptions and 73 needs, with main themes related to ‘extracurricular operation status’, ‘evaluation of extracurricular activities’, and ‘experience activities’. Their needs highlighted ‘suggestions for the revised curriculum’ and ‘expectations for new activities’. The school expert group recognized 37 issues and expressed 74 needs, focusing on incorporating ICT and SDGs, particularly SDG 4 (Quality Education) and SDG 10 (Reduced Inequalities) into the revised curriculum. The parent group, with 58 recognitions and 56 needs, expressed perceptions of extracurricular activities in terms of ‘related knowledge’, ‘negative emotions’, ‘school status’, and ‘positive attitude toward their child’s participation’. Their primary needs included ‘request for student guidance’, ‘expectation for successful social integration of children (SDG 3: Good Health and Well-being)’, and ‘opportunities for participation in education’. Furthermore, this study addresses gaps previously unexamined in the field of special education by analyzing the distinctive needs of special education settings and proposing concrete solutions to address these unmet needs. The findings underscore the necessity of tailoring educational content to the diverse needs of students with disabilities, promoting inclusive practices that align with SDGs and reflect the evolving educational landscape in special education.

Development of a toolkit to help parents/caregivers manage feeding problems in autistic children: A protocol for a realist synthesis and toolkit co-design.

Many autistic children have feeding problems, typically eating a limited range of foods. Feeding problems affect quality of life, health, and development. Research suggests that parents are often unsure when to or whether to seek help. When they do, local provision of help across the UK is often lacking. A toolkit could offer a tailored, accessible, and scalable early intervention to support parents. We aim to develop the blueprint of a toolkit to help parents/caregivers manage feeding problems in their autistic children. Medical Research Council guidance on developing complex interventions informs three successive work packages: Realist review: a literature search and analysis using realist theory of logic to construct programme theory(s) in line with RAMESES (Realist And Meta-narrative Evidence Syntheses: Evolving Standards) guidance.Realist evaluation: interviews of three groups: autistic children, young people and adults (experts), parents/caregivers of autistic children (parents), and professionals who help parents manage feeding problems (professionals) across the UK. Analysis of verbatim interview transcripts using realist theory of logic to refine programme theory(s).Co-design of the toolkit blueprint: behaviour change theory applied to the programme theory(s) will generate candidate components for the online tool. A blueprint (a detailed textual outline) will be co-designed. A participatory research team of experts, parents, and professionals will be involved in each work package. Where consensus is needed it will be reached by asynchronous nominal group technique. A PPI (public and patient involvement) advisory group of experts and parents will ensure the project is relevant, respectful, and accessible. Findings of each step will be disseminated via journal publications, conferences, social media, as well as PPI-co-produced webinars and a dissemination event. On completion, this project will provide the foundation for the subsequent development and refinement of the prototype toolkit.

Can SARS-CoV-2 Infection Status in Preschool Children be Predicted by Pandemic-related Attitudes and Concerns of their Parents? Data from the Würzburg Daycare Centre Studies (Wü-KiTa-CoV, 2020-2022)

As part of the Würzburg KiTa-CoV study series, SARS-CoV-2 pandemic-related attitudes/concerns of parents of preschool children attending day care centres were surveyed over a 21-month period. We expected associations between these parental attitudes/concerns and their change over the course of the pandemic, on the one hand, and the SARS-CoV-2 infection status of the children, on the other. Parents of children from nine day-care centres who completed a survey on pandemic-related attitudes/concerns in October 2020, July 2021 and July 2022, were included in the analysis. In July 2022, the children's infection status was determined by measuring nucleocapsid protein antibodies (N-AK) and, in the case of N-AK negative, unvaccinated children, the measurement results of spike protein antibodies (S-AK) against SARS-CoV-2 as indicators of previous infection were also taken into account. Changes in parental attitudes/concerns were analysed using trend tests, and their significance in predicting the child's infection status was analysed using multiple binomial regression analyses. Data were available from parents of 159 children (mean age 3.2 years). The overall group of parents showed an increasingly relaxed attitude towards the pandemic over the study period, although the parents' concerns towards a possible infection of their own increased. The infection status of the children could not be predicted from the initial attitudes and concerns of the parents. However, the subgroup of parents with an uninfected child tended to have a higher level of concerns over the course of the pandemic than the parents with an infected child and did not show the same increasing composure towards the pandemic event. The parents' increasing composure is understandable in the context of the reduced virulence of the virus variants prevailing over time, the increasing availability of testing strategies and vaccinations, and the withdrawal of pandemic-related restrictions. In addition, the mildness of most children's infections may have contributed to their parents' sense of security. The seemingly contradictory increase in parental concerns about infection may be related to the strong increase in the incidence due to omicron variant infections in the population since January 2022. It is possible that the higher level of concerns among parents of uninfected children had a protective effect behaviourally.

Comparison of the production performance of some phenotypic groups and their crosses of quail birds

The study aimed to determine the production efficiency of local quail phenotypic groups with different feather colors (white, brown, and desert) and their crosses. The results showed significant differences between groups in average body weight at 2, 4, and 6 weeks of age, and in weight gain at 2 and 4 weeks of age in favor of the T6 cross followed by the T5 cross, while T1 recorded the lowest body weight and weight gain compared to other hybrids. Significant differences in feed consumption were observed at 2 and 6 weeks, with no significant differences at 4 weeks. The highest feed consumption was recorded at 6 weeks for hybrids compared to pure groups, and feed conversion efficiency improved at 2 weeks for T5 and T6. At 4 weeks of age, T5, T7, and T6 recorded the best feed conversion efficiency. Positive heterosis in weight at 4 weeks was observed in favor of T5, T6, and T7, while it was negative in T4. Body weight at 6 weeks increased in hybrids T5, T6, and T7 compared to their expected value in the parental groups, and feed conversion efficiency improved at 6 weeks in hybrids T4 and T7. We conclude that heterosis increases the economic value of hybrids, with T6 and T5 being the best hybrids.

MECP2 Variants in Males: More Common than Previously Appreciated

BackgroundTo assess the age and MECP2 variants of recently identified males and set the stage for further study of clinical features in males. MethodsGenetic information on the specific MECP2 variant was acquired from the coordinator (K.F.) of the Parent Group for Males. Data were collected indicating whether these variants were de novo or transmitted from the mother and whether males who appeared to meet the diagnostic criteria for Rett syndrome had mosaicism for the MECP2 variant. ResultsFifty-nine males were identified through the parent group. Their ages ranged from 2 to 28 years, with the median age being 7.0 years and the mean age being 10.8 years. Of these variants, 46 (78.0%) were de novo, nine (15.3%) were maternally inherited, and for four (6.8%) inheritance was not known. Eleven (18.6%) were mosaic, 10 with somatic mosaicism and one with Klinefelter syndrome (47XXY). Together with males reported previously from the US Natural History Study, the total group represents 85 males, of whom 27 are deceased. ConclusionsThese data on males with MECP2 variants are important to caregivers, physicians, and researchers to begin to characterize their historical and clinical features, improve diagnostic recognition and overall care, and accelerate access to therapeutic studies including gene replacement strategies. Equal access to such therapies for males is critical.

Combined genomic evaluation of Merino and Dohne Merino Australian sheep populations.

The Dohne Merino sheep was introduced to Australia from South Africa in the 1990s. It was primarily used in crosses with the Merino breed sheep to improve on attributes such as reproduction and carcass composition. Since then, this breed has continued to expand in Australia but the number of genotyped and phenotyped purebred individuals remains low, calling into question the accuracy of genomic selection. The Australian Merino, on the other hand, has a substantial reference population in a separate genomic evaluation (MERINOSELECT). Combining these resources could fast track the impact of genomic selection on the smaller breed, but the efficacy of this needs to be investigated. This study was based on a dataset of 53,663 genotypes and more than 2 million phenotypes. Its main objectives were (1) to characterize the genetic structure of Merino and Dohne Merino breeds, (2) to investigate the utility of combining their evaluations in terms of quality of predictions, and (3) to compare several methods of genetic grouping. We used the 'LR-method' (Linear Regression) for these assessments. We found very low Fst values (below 0.048) between the different Merino lines and Dohne breed considered in our study, indicating very low genetic differentiation. Principal component analysis revealed three distinct groups, identified as purebred Merino, purebred Dohne, and crossbred animals. Considering the whole population in the reference led to the best quality of predictions and the largest increase in accuracy (from 'LR-method') from pedigree to genomic-based evaluations: 0.18, 0.14 and 0.16 for yearling fibre diameter (YFD), yearling greasy fleece weight (YGFW) and yearling liveweight (YWT), respectively. Combined genomic evaluations showed higher accuracies than the evaluation based on the Dohne reference only (accuracies increased by 0.16, 0.06 and 0.07 for YFD, YGFW, and YWT, respectively). For the combined genomic evaluations, metafounder models were more accurate than Unknown Parent Groups models (accuracies increased by 0.04, 0.04 and 0.06 for YFD, YGFW and YWT, respectively). We found promising results for the future transition of the Dohne breed from pedigree to genomic selection. A combined genomic evaluation, with the MERINOSELECT evaluation in addition to using metafounders, is expected to enhance the quality of genomic predictions for the Dohne Merino breed.

Parental migration, socioeconomic deprivation and hospital admissions in preschool children in England: national birth cohort study, 2008 to 2014

BackgroundA third of children born in England have at least one parent born outside the United Kingdom (UK), yet family migration history is infrequently studied as a social determinant of child health. We describe rates of hospital admissions in children aged up to 5 years by parental migration and socioeconomic group.MethodsBirth registrations linked to Hospital Episode Statistics were used to derive a cohort of 4,174,596 children born in state-funded hospitals in England between 2008 and 2014, with follow-up until age 5 years. We looked at eight maternal regions of birth, maternal country of birth for the 6 most populous groups and parental migration status for the mother and second parent (UK-born/non-UK-born). We used Index of Multiple Deprivation (IMD) quintiles to indicate socioeconomic deprivation. We fitted negative binomial/Poisson regression models to model associations between parental migration groups and the risk of hospital admissions, including interactions with IMD group.ResultsOverall, children whose parents were both born abroad had lower emergency admission rates than children with parents both born in the UK. Children of UK-born (73.6% of the cohort) mothers had the highest rates of emergency admissions (171.6 per 1000 child-years, 95% confidence interval (CI) 171.4–171.9), followed by South Asia-born mothers (155.9 per 1000, 95% CI 155.1–156.7). The high rates estimated in the South Asia group were driven by children of women born in Pakistan (186.8 per 1000, 95% CI 185.4–188.2). A socioeconomic gradient in emergency admissions was present across all maternal regions of birth groups, but most pronounced among children of UK-born mothers (incidence rate ratio 1.43, 95% CI 1.42–1.44, high vs. low IMD group). Patterns of planned admissions followed a similar socioeconomic gradient and were highest among children with mothers born in Middle East and North Africa, and South Asia.ConclusionsOverall, we found the highest emergency admission rates among children of UK-born parents from the most deprived backgrounds. However, patterns differed when decomposing maternal place of birth and admission reason, highlighting the importance of a nuanced approach to research on migration and health.

Optimizing purebred selection to improve crossbred performance.

Crossbreeding is a widely adopted practice in the livestock industry, leveraging the advantages of heterosis and breed complementarity. The prediction of Crossbred Performance (CP) often relies on Purebred Performance (PB) due to limited crossbred data availability. However, the effective selection of purebred parents for enhancing CP depends on non-additive genetic effects and environmental factors. These factors are encapsulated in the genetic correlation between crossbred and purebred populations ( ). In this study, a two-way crossbreeding simulation was employed to investigate various strategies for integrating data from purebred and crossbred populations. The goal was to identify optimal models that maximize CP across different levels of . Different scenarios involving the selection of genotyped individuals from purebred and crossbred populations were explored using ssGBLUP (single-step Genomic Best Linear Unbiased Prediction) and ssGBLUP-MF (ssGBLUP with metafounders) models. The findings revealed an increase in prediction accuracy across all scenarios as values increased. Notably, in the scenario incorporating genotypes from both purebred parent breeds and their crossbreds, both ssGBLUP and ssGBLUP-MF models exhibited nearly identical predictive accuracy. This scenario achieved maximum accuracy when was less than 0.5. However, at = 0.8, ssGBLUP, which exclusively included sire breed genotypes in the training set, achieved the highest overall prediction accuracy at 73.2%. In comparison, the BLUP-UPG (BLUP with unknown parent group) model demonstrated lower accuracy than ssGBLUP and ssGBLUP-MF across all levels. Although ssGBLUP and ssGBLUP-MF did not demonstrate a definitive trend in their respective scenarios, the prediction ability for CP increased when incorporating both crossbred and purebred population genotypes at lower levels of . Furthermore, when was high, utilizing paternal genotype for CP predictions emerged as the most effective strategy. Predicted dispersion remained relatively similar in all scenarios, indicating a slight underestimation of breeding values. Overall, the value emerged as a critical factor in predicting CP based on purebred data. However, the optimal model to maximize CP depends on the factors influencing . Consequently, ongoing research aims to develop models that optimize purebred selection, further enhancing CP.