Ground-glass Opacity Lung Adenocarcinoma Research Articles

Asymptomatic SARS-CoV-2 infection and CT lung lesions: how reliable is the hypothesised association?

Asymptomatic SARS-CoV-2 infection and CT lung lesions: how reliable is the hypothesised association?

Surgical Outcomes of Lobectomy Versus Limited Resection for Clinical Stage I Ground-Glass Opacity Lung Adenocarcinoma 2 Centimeters or Smaller

BackgroundTo compare the surgical outcomes of patients with clinical stage I ground-glass opacity (GGO) lung adenocarcinomas with maximum diameters of ≤ 2 cm who underwent lobectomy versus limited resection. Patients and MethodsWe retrospectively reviewed cases of clinical stage I GGO lung adenocarcinoma with a diameter ≤ 2 cm that were treated via lobectomy or limited resection in our department between January 2011 and September 2018. The clinical characteristics and surgical outcomes were analyzed using a propensity score–matched comparison and a Cox regression model. ResultsA total of 552 patients were identified; 128 patients with pure GGO were excluded. Four hundred twenty-four patients met our criteria, including 242 (57.1%) who underwent lobectomy and 182 (42.9%) who underwent limited resection. No perioperative mortality occurred in either group. The overall 5-year survival rate of the entire cohort was 88%. Patients who underwent limited resection tended to have a shorter operation time, smaller blood loss volume, fewer removed nodes, and a shorter postoperative stay. However, the groups did not differ in terms of postoperative complications. Lobectomy and limited resection could lead to equivalent overall survival in patients with GGO-dominant tumor, while lobectomy showed better overall survival than limited resection in patients with solid-dominant tumor. ConclusionPatients with small GGO lung adenocarcinoma had a favorable prognosis after surgery. The oncologic surgical procedures of lobectomy and limited resection yielded comparable outcomes in patients with clinical stage I GGO-dominant lung adenocarcinomas ≤ 2 cm, while lobectomy showed better survival than limited resection in patients with solid-dominant tumor.

Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma?

BackgroundLung adenocarcinoma (LUAD) with ground-glass opacity (GGO) can become aggravated, but the reasons for this aggravation are not fully understood. The goal of this study was to analyze the genetic features and causes of progression of GGO LUAD.MethodsLUAD tumor samples and normal tissues were analyzed using an Illumina HiSeq 4000 system. After the tumor mutational burden (TMB) was calculated, the identified mutations were classified as those found only in GGO LUAD, those present only in non- GGO LUAD, and those common to both tissue types. Ten high-frequency genes were selected from each domain, after which protein interaction network analysis was conducted.ResultsOverall, 227 mutations in GGO LUAD, 212 in non-GGO LUAD, and 48 that were common to both tumor types were found. The TMB was 8.8 in GGO and 7.8 in non-GGO samples. In GGO LUAD, mutations of FCGBP and SFTPA1 were identified. FOXQ1, IRF5, and MAGEC1 mutations were common to both types, and CDC27 and NOTCH4 mutations were identified in the non-GGO LUAD. Protein interaction network analysis indicated that IRF5 (common to both tissue types) and CDC27 (found in the non-GGO LUAD) had significant biological functions related to the cell cycle and proliferation.ConclusionIn conclusion, GGO LUAD exhibited a higher TMB than non-GGO LUAD. No clinically meaningful mutations were found to be specific to GGO LUAD, but mutations involved in the epithelial-mesenchymal transition or cell cycle were found in both tumor types and in non-GGO tissue alone. These findings could explain the non-invasiveness of GGO-type LUAD.

P2.09-26 Inadequate Surgical Margins at Video-Assisted Thoracoscopic Wedge Resection of Ground-Glass Opacity Lung Adenocarcinoma

P2.09-26 Inadequate Surgical Margins at Video-Assisted Thoracoscopic Wedge Resection of Ground-Glass Opacity Lung Adenocarcinoma

Computed tomography-guided percutaneous microwave ablation for treatment of peripheral ground-glass opacity-Lung adenocarcinoma: A pilot study.

The purpose of the study is to retrospectively evaluate the safety and efficacy of microwave ablation (MWA) for the treatment of ground-glass opacity (GGO)-lung adenocarcinoma. From December 2013 to June 2017, a total of 51 patients (22 males and 29 females, mean age of 69.4 ± 10.1 years) were included in this study, with 51 lung adenocarcinoma lesions showing GGO (mean long-axis diameter of 18.7 ± 6.05 mm). They received a total of 52 sessions of percutaneous computed tomography-guided (CT-guided) MWA. First, lung adenocarcinoma with GGO was histologically defined by needle biopsy under the guidance of CT. Second, the efficacy of CT-guided MWA was analyzed, including the feasibility, safety, 3 years local progression-free survival (LPFS), 3 years disease-specific survival, and 3 years overall survival (OS). Final, complications after MWA were also summarized. The technical success rate was 100%, without MWA procedure-related death. At the median follow-up period (27.02, range: 7-45 months), the rates of 3 years LPFS, cancer-specific survival, and OS were 98%, 100%, and 96%, respectively. The complications after MWA included pneumothorax (48.1%, 25/52), hemoptysis (28.8%, 14/52), pleural effusion (23.1%, 12/52), and pulmonary infection (7.7%, 4/52). CT-guided percutaneous MWA was a feasible, safe, and effective therapeutic approach for treating GGO-lung adenocarcinoma.

Abnormal air bronchogram within pure ground glass opacity lung adenocarcinoma: value for predicting histopathologic subtypes

Objective To analyze the value of abnormal air bronchogram for predicting the invasiveness of lung adenocarcinoma with pure ground-glass nodule (pGGN). Methods From April 2014 to February 2016, 157 patients with 165 pGGN lung adenocarcinomas confirmed by surgical pathology were selected. There were 30 pre-invasive lesions (AAH+AIS), 39 minimally invasive adenocarcinoma (MIA), and 96 invasive adenocarcinoma (IAC). CT characteristics including lesion size, density, abnormal air bronchogram were recorded. All lesions were divided into two groups: normal group (no air bronchogram or normal air bronchogram) and abnormal air bronchogram group. Chi-square test was used to analyze the difference of pathological subtypes between the two groups. Mann-Whitney rank test was used to analyze the size difference of pGGN between the two groups. Two-independent samples t-test was used to analyze the lesion density difference of pGGN between the two groups. Results Of the 165 lesions, 85 were found to have air bronchogram, there were 12 lesions in 30 pre-invasive lesions (AAH+AIS), 17 in 39 MIAs, 56 in 96 IACs. Abnormal air bronchogram were demonstrated in 61 lesions which was 1 in 30 pre-invasive lesions (IACs+AIS), 13 in 39 MIAs and 47 in 96 IACs, significant differences were found between two groups (χ2=25.943, P<0.01). The mean size of the IACs were (10.8±4.2) mm for normal group, (17.0±6.7) mm for abnormal air bronchogram group, the mean density were (-519±118) HU and (-518±124) HU, respectively. There was a significant difference in lesion diameter between two groups (Z=-6.197, P<0.01), but not in density (t=-0.042, P=0.966). Conclusions Abnormal air bronchogram can be used to predict the invasiveness of pGGN lung adenocarcinoma, and is correlated with lesion size, but not with density. Key words: Lung neoplasms; Pure ground glass nodule; Pathology; Tomography, X-ray computed