Abstract This paper presents an experimental analysis and performance evaluation of a grid-connected photovoltaic plant installed on the rooftop of the Electronics Research Institute in Cairo, Egypt. Cairo is classified as a hot-desert climate region according to the standard Koppen-Geiger climate classification system. Over a year, we monitored real-time data to assess key system performance metrics, such as energy yield, efficiencies, performance ratio, capacity factor, and losses. Based on the obtained experimental results, the highest final yield of 5.2498 hr/day was observed in the summer, whereas the lowest yield of 3.439 hr/day occurred in the winter months. The photovoltaic plant had an average annual system efficiency of 15.8%, while the photovoltaic and inverter had mean yearly efficiencies of 17.1% and 97.2%, respectively. The average annual performance ratio is 83.03%, and the capacity factor is 18.72%. The monthly total loss exhibited a linear rise alongside increasing ambient temperature and solar irradiance. The ambient temperature affected the system efficiency, photovoltaic efficiency, and performance ratio. The findings can help strengthen forecasts of future large-scale photovoltaic plants in hot desert climates. Moreover, they can guide the design, optimization, operation, and maintenance of new grid-connected photovoltaic systems.