To explore the effects of different irrigation approaches, mulching, and their interaction on greenhouse melon (Cucumis melo L.) production and water use, a field experiment was conducted in Northern China using four treatments: mulching drip irrigation (MDI), mulching furrow irrigation (MFI), drip irrigation (DI), and furrow irrigation (FI; CK). The plant biomass, yield, water consumption, and water use efficiency (WUE) of melons were measured at different growth stages. The results showed that mulching has significant positive impacts on the growth as well as the fruit yield of melons. However, the water use characteristics of the plant were more greatly determined by the various irrigation approaches, and there was a significant interaction between the irrigation approach and mulching for both the total water consumption and WUE of the greenhouse melon. Of these treatments, MDI resulted in the highest yield of 38.49 t/hm2, which was significantly higher than the yields obtained with DI (32.36 t·hm−2) and FI (CK, 30.34 t·hm−2). In addition, the water consumption under MDI was 45.80% lower than FI (CK), which resulted in the promotion of WUE under MDI. The WUE range of the greenhouse melon is as follows: MDI (334.77 kg·mm−1·hm−2) > DI (244.84 kg·mm−1·hm−2) > MFI (189.78 kg·mm−1·hm−2) > FI (CK; 142.94 kg·mm−1·hm−2). The findings of this study indicate that mulching can boost melon yield, and drip irrigation can limit water consumption. This study provides a reference point for policymakers, indicating that drip irrigation with plastic mulching could be a feasible adaptation strategy for increasing greenhouse melon production in Northern China, as well as other agriculture regions that suffer from water shortages.