Urban green infrastructure construction and economic growth are necessary ways and important supports to promote sustainable development. Exploring their coupling coordination relationship is important for achieving high-quality economic development. This study uses the entropy method, coupling coordination degree, kernel density estimation, the Dagum Gini coefficient, and spatial autocorrelation to explore the spatial-temporal pattern characteristics and coupling coordination relationship between green infrastructure construction and economic development for 273 cities in Chinese mainland in 2010–2020. The results show that the level of China’s green infrastructure construction and economic development gradually increased during 2010–2020. There were significant regional differences in space, exhibiting a decreasing spatial pattern from east to west. The coupling coordination degree was constantly improving. The overall Gini coefficient shows an upward trend. Among the four regions, eastern China has the greatest intraregional variation. The uneven level of coupled coordination is mainly from interregional variation. There was a significant positive spatial autocorrelation relationship, and cities that had a higher degree of coupling coordination tended to agglomeration development. Meanwhile, it also had certain spatial heterogeneity. China’s entire level of coupling coordination degree still has much room for improvement. The study is of great significance in reducing disparities between regions and strengthening regional spatial coordination development.