The Asia Minor Catastrophe caused the uprooting of thousands of Greeks from Asia Minor and their arrival in Greece. Especially in the areas around Piraeus, there was a large settlement of refugee populations. During that period, a small hospital was created, the "American Women's Hospital," by an initiative of the "American Women's Union," with the aim of treating and caring for suffering refugees. Within a decade, the hospital expanded and became a general hospital. In 1934, after the departure of the "American Women's Service" from Greece, it was renamed "Refugee Hospital of Nea Kokkinia," and then a year later (1935), it was renamed again to "Protypo Laiko Iatreio" (Model Public Clinic). In 1939, the construction of a larger hospital in Nea Kokkinia began. During World War II, the hospital managed to respond to the difficult conditions of the period and was renamed "General Hospital of Piraeus, Saporta Warehouse Building." After the war, in 1953, it was renamed to General Hospital of Piraeus "Queen Frederika." In 1986, it was renamed to Regional General Hospital of Nikaia "Damon Vassileiou" in honor of the Professor of Medicine of the University of Athens Damon Vassileiou who was one of the greatest Greek doctors. In 2001, it was renamed again to its current name General Hospital of Nikaia "Agios Panteleimon," becoming one of the largest hospitals in the Balkans.