A wireless device with a long battery life and great sensitivity becomes difficult to develop since there is a huge demand for low-power, low-cost wireless gadgets. The power amplifier (PA) is the most crucial part of radio frequency (RF) transceivers because of its massive power consumption. Consequently, in order to minimize power loss, a very effective and low-power consumption PA is needed. In this paper, high efficiency two-stage CMOS PA designed in 0.13-μm process for 2.4 GHz IoT transmitter applications is presented. The driver stage and power stage are the two stages that make up the two-stage topology of the proposed CMOS PA. To attain high efficiency and great power gain, a class E PA is used at the power stage. The LC matching network at the output is used for harmonic rejection filter at 2.4 GHz with an additional parallel capacitor helps for better harmonic rejection. In addition, a layout has been successfully designed and optimized. All the components in the proposed PA are designed on-chip. The pre-layout and post-layout simulations have been conducted to verify the proposed PA's performance. The pre-layout simulation of the proposed PA can deliver 19.19 dBm output power and 45.2% PAE at 2.0 V power supply into a 50-Ω load. On the other hand, the proposed PA produced an output power of 17.33 dBm and 46% PAE, according to the results of the post-layout simulation with a similar power supply of 2.0 V. The chip area for the proposed layout design is 1.05 mm2.