Gravity Dependence Research Articles

Performance characteristics of ultra-thin flat plate oscillating heat pipes with alternate channels and auxiliary micro-grooved structures

Two flat plate oscillating heat pipes (FPOHPs) characterized by the same thickness of 1 mm and alternating channel widths were fabricated using the wet etching technique. HFE-7100 was used as a working fluid at volumetric filling ratios ranging from 30%–60%. The startup and heat transfer characteristics of FPOHPs with and without embedded parallel microgrooves on the bottom wall of wider channels were experimentally compared and evaluated. The dual-diameter FPOHPs could operate at both horizontal and vertical orientations. The introduction of microgrooves reduced the duration of the startup time, lowered the startup temperature, and avoided the temperature overshoot. Furthermore, the microgrooves significantly reduced the temperature of the evaporator. At the combined condition of 30% filling ratio and 24 W power input, the effective thermal conductivities (ETCs) of the FPOHP with microgrooves were 1241 and 1226 W/(m·°C), respectively, at horizontal and vertical orientations, approximately 25.6% and 18.8% higher than those without microgrooves, or approximately 3.1 times higher than pure copper. At the horizontal orientation, the heat transfer enhancement was more pronounced for the micro-grooved FPOHP compared to that without micro-grooves. The micro-grooved structures facilitated the unidirectional fluid circulation and reduced the gravity dependence, showing the application prospects at both terrestrial and microgravity conditions.

Assessment of Pulmonary Ventilation Using 3D Ventilation Flow Capacity-Weighted and Ventilation-Weighted Maps From 3D Ultrashort Echo Time (UTE) MRI.

Three-dimensional (3D) ventilation flow capacity-weighted (VFCW) maps together with 3D ventilation-weighted (VW) maps may help to better assess pulmonary function. To investigate the use of 3D VFCW and VW maps for evaluating pulmonary ventilation function. Prospective. Two patients (one male, 85 years old; one female, 64 years old) with chronic obstructive pulmonary disease (COPD) and nine healthy subjects (all male; 23-27 years). 3-T, 3D radial UTE imaging. 3D VFCW and VW maps were calculated from 3D UTE MRI by voxel-wise subtraction of respiratory phase images. Their validation was tested in nine healthy volunteers using slow/deep and fast/shallow breathing conditions. Additional validation was performed by comparison with single photon emission computed tomography (SPECT) ventilation maps of one healthy participant. For comparison, gravity dependence of anterior-posterior regional ventilation was assessed by one-dimensional plot of the mean signal intensity for each coronal slice. Structural similarity index measure was also calculated. Finally, VW maps and VFCW maps of two COPD patients were evaluated for emphysema lesions with reference to CT images. Wilcoxon sign-rank tests for regional Ventilation and ventilation flow capacity, analysis of variance, post-hoc t-tests and Bonferroni correction, coefficient of variation, Kullback-Liebler divergence. A P-value <0.05 was considered statistically significant. The validation of 3D VFCW and VW maps was shown by statistically significant differences in ventilation flow capacity and ventilation between the breathing conditions. Additionally, UTE-MRI and SPECT-based ventilation maps showed gravitational dependence in the anteroposterior direction. When applied to patients with COPD, the use of 3D VFCW and VW maps was able to differentiate between two patients with different phenotypes. The use of 3D VFCW and VW maps can provide regional information on ventilation function and potentially contribute to assessment of COPD subtypes and disease progression. 2 TECHNICAL EFFICACY: Stage 1.

Thermal performance of a vapor chamber with synergistic effects of droplet jumping and pillared-wick capillarity

• Thermal performance of jumping-droplet vapor chamber was experimentally studied. • The number of auxiliary wick columns shows nonmonotonic effect on the performance. • Increased inner chamber height reduces thermal resistance and gravity dependence. • Jumping droplets may not directly reach the evaporator surface. • The minimum thermal resistance of the vapor chamber reaches 0.064 K/W. When condensate droplets coalesce on a superhydrophobic surface, the released surface energy may yield the merged droplet to jump off the substrate. Based on such principle, jumping-droplet vapor chamber (JDVC) has been proposed as a novel type of heat spreader for hot spot cooling, while the internal working mechanism is rather complicated and still remains inadequately understood. In the present work, the thermal performance of JDVC with auxiliary capillary pillars were experimentally studied, with particular interest on understanding the synergistic effects of droplet jumping and pillared-wick capillarity. Five JDVC samples were fabricated (with a fixed diameter of 97.6 mm, three different overall chamber heights of 3.4 mm, 3.9 mm and 4.4 mm, and a fixed heating area of 1.5 cm 2 ) to investigate the effect of filling ratio, number of auxiliary wick columns and inner chamber height on performance. Results show that, the thermal resistance shows a non-monotonic variation of “decrease-increase” with increasing filling ratio, with a higher heat flux favoring a higher optimal filling ratio. The temperature homogeneity is improved under bottom heat mode compared to under top heat mode, which could be possibly attributed to the improved efficiency of droplet removal. The number of auxiliary wick columns shows non-monotonic effect of “enhance-suppress” on the thermal performance, suggesting that a moderate number of auxiliary wick columns helps to gather the jumped-off droplets in space and facilitates stable capillary-driven working fluid circulation. Increasing the inner chamber height yields reduced thermal resistance and improved gravity independence, indicating that direct arrival of jumping droplets on the evaporator surface may not be the primary way of working fluid recirculation, otherwise the thermal performance should degrade since less jumping droplets are able to reach a higher evaporator surface. Among the results, the minimum thermal resistance of the vapor chamber reaches 0.064 K/W and the critical heat flux exceeds 253.2 W/cm 2 .

On the physical nature of the Wilson–Bappu effect: revising the gravity and temperature dependence

ABSTRACT We present a sample of 32 stars of spectral types G and K and luminosity classes I–V, with moderate activity levels, covering four orders of magnitude of surface gravity and a representative range of effective temperature. For each star we obtained high signal-to-noise ratio (S/N) spectra from the Telescopio Internacional de Guanajuato Robótico-Espectroscópico (TIGRE–HEROS) with a spectral resolving power of $R\approx 20\, 000$ and measured the Ca ii K line widths of interest, W0 and W1. The main physical parameters are determined by means of iSpec synthesis and Gaia EDR3 parallaxes. Mass estimates are based on matching to evolution models. Using this stellar sample, which is highly uniform in terms of spectral quality and assessment, we derive the best-fitting relation between emission-line width and gravity g, including a notable dependence on effective temperature Teff, of the form $W_1 \propto g^{-0.229} T_{\rm eff}^{+2.41}$. This result confirms the physical interpretation of the Wilson–Bappu effect as a line saturation and photon redistribution effect in the chromospheric Ca ii column density, under the assumption of hydrostatic equilibrium at the bottom of the chromosphere. While the column density (and hence W1) increases towards lower gravities, the observed temperature dependence is then understood as a simple ionization effect: in cooler stars, Ca ii densities decrease in favour of Ca i.

Deformation of a rotated granular pile governed by body-force-dependent friction.

Although the gravity dependence of granular friction is crucial to understand various natural phenomena, its precise characterization is difficult. We propose a method to characterize granular friction under various gravity (body force) conditions controlled by centrifugal force; specifically, the deformation of a rotated granular pile was measured. To understand the mechanics governing the observed nontrivial deformation of this pile, we introduced an analytic model considering local force balance. The excellent agreement between the experimental data and theoretical model suggests that the deformation is simply governed by the net body force (sum of gravity and centrifugal force) and friction angle. The body-force dependence of granular friction was precisely measured from the experimental results. The results reveal that the grain shape affects the degree of body-force dependence of the granular friction.

Uniform Forward-modeling Analysis of Ultracool Dwarfs. II. Atmospheric Properties of 55 Late-T Dwarfs

Abstract We present a large uniform forward-modeling analysis for 55 late-T (T7–T9) dwarfs, using low-resolution (R ≈ 50–250) near-infrared (1.0–2.5 μm) spectra and cloudless Sonora–Bobcat model atmospheres. We derive the objects’ effective temperatures, surface gravities, metallicities, radii, masses, and bolometric luminosities using our newly developed Bayesian framework, and use the resulting population properties to test the model atmospheres. We find (1) our objects’ fitted metallicities are 0.3–0.4 dex lower than those of nearby stars; (2) their ages derived from spectroscopic parameters are implausibly young (10 Myr–0.4 Gyr); (3) their fitted effective temperatures show a similar spread to empirical temperature scales at a given spectral type but are ∼50–200 K hotter for ≥T8 dwarfs; and (4) their spectroscopically inferred masses are unphysically small (mostly 1–8 M Jup). These suggest the Sonora–Bobcat assumptions of cloudless and chemical-equilibrium atmospheres do not adequately reproduce late-T dwarf spectra. We also find a gravity and metallicity dependence of effective temperature as a function of spectral type. Combining the resulting parameter posteriors of our sample, we quantify the degeneracy between the fitted surface gravity and metallicity such that an increase in Z combined with a 3.4× increase in logg results in a spectrum that has similar fitted parameters. We note the systematic difference between the late-T dwarf spectra and Sonora–Bobcat models is on average ≈2%–4% of the objects’ peak J-band fluxes over the 1.0–2.5 μm range, implying modeling systematics will exceed measurement uncertainties when analyzing data with J-band S/N ≳ 50. Using our large, high-quality sample, we examine the spectral-fitting residuals as a function of wavelength and atmospheric properties to discern how to improve the model assumptions. Our work constitutes the largest analysis of brown dwarf spectra using multimetallicity models and the most systematic examination of ultracool model atmospheres to date.

Panchromatic calibration of Ca II triplet luminosity dependence

Context. The line strength of the near-infrared Ca II triplet (CaT) lines are a proxy for measuring metallicity from integrated and individual stellar spectra of bright red giant stars. In the latter case it is a mandatory step to remove the magnitude (proxy for gravity, temperature, and luminosity) dependence from the equivalent width (EW) of the lines before converting them into metallicities. For decades the working empirical procedure has been to use the relative magnitude with respect to the horizontal branch level or red clump, with the advantage that it is independent from distance and extinction. Aims. The V filter is broadly adopted as the reference magnitude, although a few works have used different filters (I and Ks, for example). In this work we investigate the dependence of the CaT calibration using the griz filters from the Dark Energy Camera (DECam) and the Gemini Multi-Object Spectrograph (GMOS), the G filter from Gaia, the BVI filters from the Magellanic Clouds photometric survey (MCPS), and the YJKs filters from the Visible and Infrared Survey Telescope for Astronomy (VISTA) InfraRed CAMera (VIRCAM). We use as a reference the FOcal Reducer and low dispersion Spectrograph 2 (FORS2) V filter used in the original analysis of the sample. Methods. Red giant stars from clusters with known metallicity and available CaT EWs were used as reference. Public photometric catalogues were taken from the Survey of the MAgellanic Stellar History (SMASH) second data release, VISTA survey of the Magellanic Clouds system (VMC), Gaia, MCPS surveys, plus VIsible Soar photometry of star Clusters in tApi’i and Coxi HuguA (VISCACHA) GMOS data, for a selection of Small Magellanic Cloud clusters. The slopes were fitted using two and three lines to be applicable to most of the metallicity scales. Results. The magnitude dependence of the CaT EWs is well described by a linear relation using any filter analysed in this work. The slope increases with wavelength of the filters. The zero point (i.e. reduced EW), which is the metallicity indicator, remains the same. Conclusions. If the same line profile function is used with the same bandpasses and continuum regions, and the total EW comes from the same number of lines (2 or 3), then the reduced EW is the same regardless the filter used. Therefore, any filter can be used to convert the CaT equivalent widths into metallicity for a given CaT calibration.

Interaction of the Russian Far East and Asia-Pacific Countries: Assessment of Institutional and Tariff Barriers to Trade

Due to the considerable distances from the major sales markets of Russia, the Far East has close ties with markets of the countries in the Asian-Pacific region (APR). The current expansion of trade and economic interactions with these countries has a positive effect on the economic development of the Far East. Reducing various barriers to trade with the APR countries can increase the scale of bilateral trade, acting as a source of growth and development for the economy of the Far East. To determine the ranges for increasing trade, the potential for trade interactions arising from the leveling of various barriers was quantified. It is shown that for the Far East a gradual change in the intensity of foreign trade relations was observed in favor of geographically close foreign markets, the Asia-Pacific countries. Based on the constructed gravity dependence, trade barriers for interactions between the Far East and Asia-Pacific countries were estimated and decomposed into the ad valorem equivalent. It was determined that the major source of tariff barriers was the tariff burden on exports and imports, formed by the Russian side. The decomposition assessment showed that the comparative institutional barriers between the Far East and the Asia-Pacific countries were significantly greater than the comparative tariff barriers. This circumstance indicated the insufficiency of reducing tariff barriers for intensifying the bilateral trade between the Far East and the Asia-Pacific countries. The analysis made it possible to assume that the introduction of various types of weakly motivated trade restrictions by the Russian side led to a shift in the customs burden from tariff barriers to institutional ones. In addition to the Republic of Korea, a general vector of intensification of trade between the Far East and the Asia-Pacific countries was observed for China. The estimates obtained suggest that the comparative institutional barriers between the Far Eastern regions and China will continue to decline. It is shown that the leveling of comparative institutional barriers between the Far East and Japan can significantly increase trade interactions between the Russian macroregion and the APR market.

COol Companions ON Ultrawide orbiTS (COCONUTS). I. A High-gravity T4 Benchmark around an Old White Dwarf and a Re-examination of the Surface-gravity Dependence of the L/T Transition

Abstract We present the first discovery from the COol Companions ON Ultrawide orbiTS (COCONUTS) program, a large-scale survey for wide-orbit planetary and substellar companions. We have discovered a comoving system COCONUTS-1, composed of a hydrogen-dominated white dwarf (PSO J058.9855+45.4184; d = 31.5 pc) and a T4 companion (PSO J058.9869+45.4296) at a 40.″6 (1280 au) projected separation. We derive physical properties for COCONUTS-1B from (1) its near-infrared spectrum using cloudless Sonora atmospheric models, and (2) its luminosity and the white dwarf’s age ( Gyr) using Sonora evolutionary models. The two methods give consistent temperatures and radii, but atmospheric models infer a lower surface gravity and therefore an unphysically young age. Assuming evolutionary model parameters ( K, dex, ), we find that cloudless model atmospheres have brighter Y- and J-band fluxes than the data, suggesting that condensate clouds have not fully dispersed around 1300 K. The W2 flux (4.6 μm) of COCONUTS-1B is fainter than models, suggesting non-equilibrium mixing of CO. To investigate the gravity dependence of the L/T transition, we compile all 60 known L6−T6 benchmarks and derive a homogeneous set of temperatures, surface gravities, and masses. As is well known, young, low-gravity late-L dwarfs have significantly fainter, redder near-infrared photometry and ≈200–300 K cooler temperatures than old, high-gravity objects. Our sample now reveals such gravity dependence becomes weaker for T dwarfs, with young objects having comparable near-infrared photometry and ≈100 K cooler temperatures compared to old objects. Finally, we find that young objects have a larger amplitude J-band brightening than old objects, and also brighten at H band as they cross the L/T transition.

Velocity storage: its multiple roles.

Our research described in this article was motivated by the puzzling finding of the Skylab M131 experiments: head movements made while rotating that are nauseogenic and disorienting on Earth are innocuous in a weightless, 0-g environment. We describe a series of parabolic flight experiments that directly addressed this puzzle and discovered the gravity-dependent responses to semicircular canal stimulation, consistent with the principles of velocity storage. We describe a line of research that started in a different direction, investigating dynamic balancing, but ended up pointing to the gravity dependence of angular velocity-to-position integration of semicircular canal signals. Together, these lines of research and the theoretical framework of velocity storage provide an answer to at least part of the M131 puzzle. We also describe recently discovered neural circuits by which active, dynamic vestibular, multisensory, and motor signals are interpreted as either appropriate for action and orientation or as conflicts evoking motion sickness and disorientation.

Experimental hint for gravitational CP violation

An equality of particle and antiparticle gravitational interactions holds in general relativity and is supported by indirect observations. Gravity dependence on rotation or spin direction is experimentally constrained for non-relativistic matter. Here, a method based on high-energy Compton scattering is developed to measure the gravitational interaction of accelerated charged particles. Within that formalism, the Compton spectra measured at HERA rule out the speculated anti-gravity possibility for antimatter at a confidence level close to 100%. The same data, however, imply a gravitational CP violation around 13 GeV energies, by a maximal amount of [Formula: see text] for the charge and [Formula: see text] for the space parity. The detected asymmetry hints for a stronger gravitational coupling to left helicity electrons relative to right helicity positrons.

The gravity dependence of pharmacodynamics: the integration of lidocaine into membranes in microgravity

To realize long-term manned space missions, e.g. to Mars, some important questions about pharmacology under conditions of different gravity will have to be answered to ensure safe usage of pharmaceuticals. Experiments on the International Space Station showed that the pharmacokinetics of drugs are changed in microgravity. On Earth, it is well known that the incorporation of substances into cellular membranes depends on membrane fluidity, therefore the finding that membrane fluidity is gravity dependent possibly has effects on pharmacodynamics of hydrophobic and amphiphilic substances in microgravity. To validate a possible effect of gravity on pharmacodynamics, experiments have been carried out to investigate the incorporation of lidocaine into plain lipid membranes under microgravity conditions. In microgravity, the induced increase in membrane fluidity associated with lidocaine incorporation is smaller compared to 1g controls. This experiment concerning the gravity dependence of pharmacodynamics in real microgravity clearly shows that the incorporation of amphipathic drugs into membranes is changed in microgravity. This might have significant impact on the pharmacology of drugs during long-term space missions and has to be investigated in more detail to be able to assess possible risks.

A Search for Variability in Exoplanet Analogues and Low-Gravity Brown Dwarfs

We report the results of a $J$-band survey for photometric variability in a sample of young, low-gravity objects using the New Technology Telescope (NTT) and the United Kingdom InfraRed Telescope (UKIRT). Surface gravity is a key parameter in the atmospheric properties of brown dwarfs and this is the first large survey that aims to test the gravity dependence of variability properties. We do a full analysis of the spectral signatures of youth and assess the group membership probability of each target using membership tools from the literature. This results in a 30 object sample of young low-gravity brown dwarfs. Since we are lacking in objects with spectral types later than L9, we focus our statistical analysis on the L0-L8.5 objects. We find that the variability occurrence rate of L0-L8.5 low-gravity brown dwarfs in this survey is $30^{+16}_{-8}\%$. We reanalyse the results of Radigan 2014 and find that the field dwarfs with spectral types L0-L8.5 have a variability occurrence rate of $11^{+13}_{-4}\%$. We determine a probability of $98\%$ that the samples are drawn from different distributions. This is the first quantitative indication that the low-gravity objects are more likely to be variable than the field dwarf population. Furthermore, we present follow-up $J_S$ and $K_S$ observations of the young, planetary-mass variable object PSO 318.5-22 over three consecutive nights. We find no evidence of phase shifts between the $J_S$ and $K_S$ bands and find higher $J_S$ amplitudes. We use the $J_S$ lightcurves to measure a rotational period of $8.45\pm0.05~$hr for PSO 318.5-22.

Influence of natural and forced gravity conditions during directional columnar solidification

In a recent study, the present authors reported an analysis of a transient process of directional solidification of TiAl alloys in the absence of convection (Battaglioli et al., 2017). The adopted front tracking model, also coupled with indirect methods for predicting columnar to equiaxed transition (CET), showed how the development of different grain regions, namely axial columnar, radial columnar and equiaxed, depends on process parameters such as temperature distribution and applied cooling rates, as well as on properties such as the degree of inoculation of the melt and nucleation undercooling required for equiaxed growth. In this paper, the previous front tracking model is significantly developed, by including the solution of Navier-Stokes equations in order to predict thermal convection in the liquid region as well as in the columnar mush (treated as an isotropic porous medium). This improvement is introduced with the aim to investigate TiAl alloys solidification under different gravity conditions. Accordingly, the simulation setup employed in the study reproduces the one used in experimental campaigns carried out on the MAXUS 9 sounding rocket (microgravity) and on ESA’s Large Diameter Centrifuge (hypergravity), within the framework of ESA’s GRADECET (Gravity Dependence of CET in TiAl alloys) project. The ability of the model in predicting thermal convection is demonstrated by considering several case studies. Results show that the evolution of fluid flow patterns in the samples depends on the external forces considered, combined to the transient change of axial and radial temperature gradients that occur during the solidification process. A parametric study of the directional solidification process on a centrifuge is performed by changing the value of the centrifuge arm and rotation rate and results are compared to predictions derived from non-dimensional considerations.

Assessment of pulmonary structure-function relationships in young children and adolescents with cystic fibrosis by multivolume proton-MRI and CT.

Lung disease is the most frequent cause of morbidity and mortality in patients with cystic fibrosis (CF), and there is a shortage of sensitive biomarkers able to regionally monitor disease progression and to assess early responses to therapy. To determine the feasibility of noncontrast-enhanced multivolume MRI, which assesses intensity changes between expiratory and inspiratory breath-hold images, to detect and quantify regional ventilation abnormalities in CF lung disease, with a focus on the structure-function relationship. Retrospective. Twenty-nine subjects, including healthy young children (n = 9, 7-37 months), healthy adolescents (n = 4, 14-22 years), young children with CF lung disease (n = 10, 7-47 months), and adolescents with CF lung disease (n = 6, 8-18 years) were studied. 3D spoiled gradient-recalled sequence at 1.5T. Subjects were scanned during breath-hold at functional residual capacity (FRC) and total lung capacity (TLC) through noncontrast-enhanced MRI and CT. Expiratory-inspiratory differences in MR signal-intensity (Δ1 H-MRI) and CT-density (ΔHU) were computed to estimate regional ventilation. MR and CT images were also evaluated using a CF-specific scoring system. Quadratic regression, Spearman's correlation, one-way analysis of variance (ANOVA). Δ1 H-MRI maps were sensitive to ventilation heterogeneity related to gravity dependence in healthy lung and to ventilation impairment in CF lung disease. A high correlation was found between MRI and CT ventilation maps (R2 = 0.79, P < 0.001). Globally, Δ1 H-MRI and ΔHU decrease with increasing morphological score (respectively, R2 = 0.56, P < 0.001 and R2 = 0.31, P < 0.001). Locally, Δ1 H-MRI was higher in healthy regions (median 15%) compared to regions with bronchiectasis, air trapping, consolidation, and to segments fed by airways with bronchial wall thickening (P < 0.001). Multivolume noncontrast-enhanced MRI, as a nonionizing imaging modality that can be used on nearly any MRI scanner without specialized equipment or gaseous tracers, may be particularly valuable in CF care, providing a new imaging biomarker to detect early alterations in regional lung structure-function. 3 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:531-542.

A simple hydrodynamic model of a laminar free-surface jet in horizontal or vertical flight

A useable model for laminar free-surface jet evolution during flight, for both horizontal and vertical jets, is developed through joint analytical, experimental, and simulation methods. The jet’s impingement centerline velocity, recently shown to dictate stagnation zone heat transfer, encompasses the entire flow history: from pipe-flow velocity profile development to profile relaxation and jet contraction during flight. While pipe-flow is well-known, an alternative analytic solution is presented for the centerline velocity’s viscous-driven decay. Jet-contraction is subject to influences of surface tension (We), pipe-flow profile development, in-flight viscous dissipation (Re), and gravity (Nj = Re/Fr). The effects of surface tension and emergence momentum flux (jet thrust) are incorporated analytically through a global momentum balance. Though emergence momentum is related to pipe flow development, and empirically linked to nominal pipe flow-length, it can be modified to incorporate low-Re downstream dissipation as well. Jet contraction’s gravity dependence is extended beyond existing uniform-velocity theory to cases of partially and fully developed profiles. The final jet-evolution model relies on three empirical parameters and compares well to present and previous experiments and simulations. Hence, micro-jet flight experiments were conducted to fill-in gaps in the literature: jet contraction under mild gravity-effects, and intermediate Reynolds and Weber numbers (Nj = 5–8, Re = 350–520, We = 2.8–6.2). Furthermore, two-phase direct numerical simulations provided insight beyond the experimental range: Re = 200–1800, short pipes (Z = L/d · Re ≥ 0.01), variable nozzle wettability, and cases of no surface tension and/or gravity.

Membrane Fluidity Changes, A Basic Mechanism of Interaction of Gravity with Cells?

All life on earth has been established under conditions of stable gravity of 1g. Nevertheless, in numerous experiments the direct gravity dependence of biological processes has been shown on all levels of organization, from single molecules to humans. According to the underlying mechanisms a variety of questions, especially about gravity sensation of single cells without specialized organelles or structures for gravity sensing is being still open. Biological cell membranes are complex structures containing mainly lipids and proteins. Functional aspects of such membranes are usually attributed to membrane integral proteins. This is also correct for the gravity dependence of cells and organisms which is well accepted since long for a wide range of biological systems. However, it is as well established that parameters of the lipid matrix are directly modifying the function of proteins. Thus, the question must be asked, whether, and how far plain lipid membranes are affected by gravity directly. In principle it can be said that up to recently no real basic mechanism for gravity perception in single cells has been presented or verified. However, it now has been shown that as a basic membrane parameter, membrane fluidity, is significantly dependent on gravity. This finding might deliver a real basic mechanism for gravity perception of living organisms on all scales. In this review we summarize older and more recent results to demonstrate that the finding of membrane fluidity being gravity dependent is consistent with a variety of published laboratory experiments. We additionally point out to the consequences of these recent results for research in the field life science under space condition.

Gravity dependence of the effect of optokinetic stimulation on the subjective visual vertical

Accurate and precise estimates of direction of gravity are essential for spatial orientation. According to Bayesian theory, multisensory vestibular, visual, and proprioceptive input is centrally integrated in a weighted fashion based on the reliability of the component sensory signals. For otolithic input, a decreasing signal-to-noise ratio was demonstrated with increasing roll angle. We hypothesized that the weights of vestibular (otolithic) and extravestibular (visual/proprioceptive) sensors are roll-angle dependent and predicted an increased weight of extravestibular cues with increasing roll angle, potentially following the Bayesian hypothesis. To probe this concept, the subjective visual vertical (SVV) was assessed in different roll positions (≤ ± 120°, steps = 30°, n = 10) with/without presenting an optokinetic stimulus (velocity = ± 60°/s). The optokinetic stimulus biased the SVV toward the direction of stimulus rotation for roll angles ≥ ± 30° (P < 0.005). Offsets grew from 3.9 ± 1.8° (upright) to 22.1 ± 11.8° (±120° roll tilt, P < 0.001). Trial-to-trial variability increased with roll angle, demonstrating a nonsignificant increase when providing optokinetic stimulation. Variability and optokinetic bias were correlated (R2 = 0.71, slope = 0.71, 95% confidence interval = 0.57-0.86). An optimal-observer model combining an optokinetic bias with vestibular input reproduced measured errors closely. These findings support the hypothesis of a weighted multisensory integration when estimating direction of gravity with optokinetic stimulation. Visual input was weighted more when vestibular input became less reliable, i.e., at larger roll-tilt angles. However, according to Bayesian theory, the variability of combined cues is always lower than the variability of each source cue. If the observed increase in variability, although nonsignificant, is true, either it must depend on an additional source of variability, added after SVV computation, or it would conflict with the Bayesian hypothesis.NEW & NOTEWORTHY Applying a rotating optokinetic stimulus while recording the subjective visual vertical in different whole body roll angles, we noted the optokinetic-induced bias to correlate with the roll angle. These findings allow the hypothesis that the established optimal weighting of single-sensory cues depending on their reliability to estimate direction of gravity could be extended to a bias caused by visual self-motion stimuli.

Practical analytical steady-state temperature solution for annealed pyrolytic graphite heat spreader

PurposeThe purpose of this paper is to supply an analytical steady-state solution to the heat transfer equation permitting to fast design investigation. The capability to efficiently transfer the heat away from high-powered electronic devices is a ceaseless challenge. More than ever, the aluminium or copper heat spreaders seem less suitable for maintaining the component sensitive temperature below manufacturer operating limits. Emerging materials, such as annealed pyrolytic graphite (APG), have proposed a new alternative to conventional solid conduction without the gravity dependence of a heat-pipe solution.Design/methodology/approachAn APG material is typically sandwiched between a pair of aluminium sheets to compose a robust graphite-based structure. The thermal behaviour of that stacked structure and the effect of the sensitivity of the design parameters on the effective thermal performances is not well known. The ultrahigh thermal conductivity of the APG core is restricted to in-plane conduction and can be 200 times higher than its through-the-thickness conductivity. So, a lower-than-anticipated cross-plane thermal conductivity or a higher-than-anticipated interlayer thermal resistance will compromise the component heat transfer to a cold structure. To analyse the sensitivity of these parameters, an analytical model for a multi-layered structure based on the Fourier series and the superposition principle was developed, which allows predicting the temperature distribution over an APG flat-plate depending on two interlayer thermal resistances.FindingsThe current work confirms that the in-plane thermal conductivity of APG is among the highest of any conduction material commonly used in electronic cooling. The analysed case reveals that an effective thermal conductivity twice as higher than copper can be expected for a thick APG sheet. The relevance of the developed analytical approach was compared to numerical simulations and experiments for a set of boundary conditions. The comparison shows a high agreement between both calculations to predict the centroid and average temperatures of the heating sources. Further, a method dedicated to the practical characterization of the effective thermal conductivity of an APG heat-spreader is promoted.Research limitations/implicationsThe interlayer thermal resistances act as dissipation bottlenecks which magnify the performance discrepancy. The quantification of a realistic value is more than ever mandatory to assess the APG heat-spreader technology.Practical implicationsConventional heat spreaders seem less suitable for maintaining the component-sensitive temperature below the manufacturer operating limits. Having an in-plane thermal conductivity of 1,600 W.m−1.K−1, the APG material seems to be the next paradigm for solving endless needs of a thermal designer.Originality/valueThis approach is a practical tool to tailor sensitive parameters early to select the right design concept by taking into account potential thermal issues, such as the critical interlayer thermal resistance.

Cytosolic Calcium Concentration Changes in Neuronal Cells Under Clinorotation and in Parabolic Flight Missions

All life on earth has been established under conditions of stable gravity of 1g. Nevertheless, in numerous experiments the direct gravity dependence of biological processes has been shown on all levels of organization, from single molecules to humans. To study the effects especially of microgravity on biological systems, a variety of platforms are available, from drop towers to the ISS. Due to the costs of these platforms and their limited availability, as an alternative, numerous simulators have been developed for so called “simulated” microgravity. A classical systems is a clinostat, basically rotating a sample around one axis, and by integration of the gravity vector for 360° arguing that thus the effects of gravity are depleted. Indeed, a variety of studies has shown that taking out the direction of gravity from a biological system often results in consequences similar to the exposure of the system to real microgravity. Nevertheless, the opposite has been shown, too, and as a consequence the relevance of clinostats in microgravity research is still under discussion. To get some more insight into this problem we have constructed a small fluorescence clinostat and have studied the effects of clinorotation on the cytosolic calcium concentration of neuroglioma cells. The results have been compared to experiments with identical cells in real microgravity, utilizing parabolic flight missions. Our results show that in case of a cell suspension used in a small florescence clinostat within a tube diameter of 2mm, the effects of clinorotation are comparable to those under real microgravity, both showing a significant increase in intracellular calcium concentration.