Gravitational Loading Research Articles

The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue

Microgravity (µG) experienced during space flights promotes adaptation in several astronauts’ organs and tissues, with skeletal muscles being the most affected. In response to reduced gravitational loading, muscles (especially, lower limb and antigravity muscles) undergo progressive mass loss and alteration in metabolism, myofiber size, and composition. Skeletal muscle precursor cells (MPCs), also known as satellite cells, are responsible for the growth and maintenance of muscle mass in adult life as well as for muscle regeneration following damage and may have a major role in µG-induced muscle wasting. Despite the great relevance for astronaut health, very few data are available about the effects of real µG on human muscles. Based on the MyoGravity project, this study aimed to analyze: (i) the cellular and transcriptional alterations induced by real µG in human MPCs (huMPCs) and (ii) the response of human skeletal muscle to normal gravitational loading after prolonged exposure to µG. We evaluated the transcriptomic changes induced by µG on board the International Space Station (ISS) in differentiating huMPCs isolated from Vastus lateralis muscle biopsies of a pre-flight astronaut and an age- and sex-matched volunteer, in comparison with the same cells cultured on the ground in standard gravity (1×g) conditions. We found that huMPCs differentiated under real µG conditions showed: (i) upregulation of genes related to cell adhesion, plasma membrane components, and ion transport; (ii) strong downregulation of genes related to the muscle contraction machinery and sarcomere organization; and (iii) downregulation of muscle-specific microRNAs (myomiRs). Moreover, we had the unique opportunity to analyze huMPCs and skeletal muscle tissue of the same astronaut before and 30 h after a long-duration space flight on board the ISS. Prolonged exposure to real µG strongly affected the biology and functionality of the astronaut’s satellite cells, which showed a dramatic reduction of responsiveness to activating stimuli and proliferation rate, morphological changes, and almost inability to fuse into myotubes. RNA-Seq analysis of post- vs. pre-flight muscle tissue showed that genes involved in muscle structure and remodeling are promptly activated after landing following a long-duration space mission. Conversely, genes involved in the myelination process or synapse and neuromuscular junction organization appeared downregulated. Although we have investigated only one astronaut, these results point to a prompt readaptation of the skeletal muscle mechanical components to the normal gravitational loading, but the inability to rapidly recover the physiological muscle myelination/innervation pattern after landing from a long-duration space flight. Together with the persistent functional deficit observed in the astronaut’s satellite cells after prolonged exposure to real µG, these results lead us to hypothesize that a condition of inefficient regeneration is likely to occur in the muscles of post-flight astronauts following damage.

An improved two phases-two points SPH model for submerged landslide

This research proposes an improved two phases-two points SPH model designed to simulate interactions between water and soil, particularly suitable for scenarios such as submerged landslides. This model treats water as a weakly compressible Newtonian fluid and soil as a cohesive-frictional material following an elastoplastic constitutive law, utilizing two layers of SPH particles to separately represent these two phases. An adaptive drag force formula is proposed that automatically switches between linear and nonlinear seepage modes based on the motion state of the porewater. Additionally, to improve the precision and stability of the model, a modified solid boundary condition and a method for calculating soil volume fraction are proposed, along with an SPH discretization formula that incorporates the effects of the volume fraction in a more effective way. The reliability of the improved two phases-two points SPH model is initially verified through two cases: a dry granular landslide and a submerged soil mass subjected to gravitational loading. Then, the effectiveness of the proposed improvement methods is further tested and validated through three submerged landslide cases with different grain diameters, demonstrating the applicability of the current model in simulating submerged landslides and its superiority in accuracy and stability compared to previous models.

The effects of mechanical imperfections on the stability behavior of double-layer Scallop domes

Mechanical imperfections are almost inevitable in large-span spatial domes with hundreds of members and joints. The lack of fit in members is the most common form of imperfections in double-layer domes which influences the behavior of these structures under gravitational or seismic loads. In this study, the probabilistic effect of mechanical imperfections (lack of fit) on the stability behavior of double-layer Scallop domes with sinusoidal arching style under symmetric and asymmetric snow-loading is investigated. On some double-layer scallop domes, nonlinear static and dynamic analyses are carried out using Abaqus/CAE and MATLAB. The behavior of the structures with randomly distributed imperfect members is compared with those of the ideally perfect structures. A Monte Carlo simulation approach is used to statistically assess the effects of uncertainties on the response parameters and the ultimate capacity of the structures. In the first approach, named here as the “rigorous probabilistic approach”, the amount and the distribution of imperfect members are all treated as random variables, and in the second approach, named as “concise approach”, a fixed amount of imperfections are applied to a number of randomly selected critical members. No simplification method is used in the rigorous probabilistic approach to achieve a reliable assessment of the effect of uncertain parameters. Results show that the collapse behavior of double-layer Scallop domes is sensitive to random imperfections and a considerable decrease is seen in their load-bearing capacity.

Tectonic setting and Pan-African structural evolution of the western Saldania Belt, South Africa

Abstract The western Saldania Belt records the closure of the Adamastor Ocean and amalgamation of southwest Gondwana in the latest Neoproterozoic and early Phanerozoic, but the geodynamic setting and evolution of the belt remains controversial. Regional mapping and the integration of structural data presented in this paper document the juxtaposition of domains with distinct fabric development and kinematics. Structures record Pan-African strains and a strike-slip dominated sinistral transpression during southeast-directed subduction and convergence at low angles to the continental margin. Two main, structurally overlying domains – an upper and a lower domain – can be distinguished. Rocks of the upper domain record the partitioning of the transpressional strain into (1) broad regions of more or less upright, north to northwesterly-trending folds (F2) that record horizontal, mainly coaxial, east-northeast to west-southwest directed shortening at high angles to the continental margin, and (2) the northwesterly-trending, sinistral strike-slip Colenso Fault Zone that accommodates the margin-parallel, non-coaxial component of deformation between ca. 555 and 520 Ma. The strike-slip partitioning was promoted by strain localisation into synkinematic plutons of the Cape Granite Suite. In contrast, rocks in the pervasively transposed, mélange-like lower domain in the central Swartland region record episodes of vertical, coaxial shortening alternating with non-coaxial top-to-the-west and -northwest thrusting. The coaxial shortening strains relate to the thickening and gravitational loading of the succession in response to thrusting and tectonic underplating. Non-coaxial strains denote episodes of seismic slip during underthrusting. The different fabric domains are interpreted to represent a section through a fore-arc region, from the deeper level accretionary prism (lower domain) to the overlying, folded fore-arc basin succession (upper domain). Regional-scale klippen structures indicate the transfer of lower-domain phyllites into the overlying fore-arc sequence. The proposed fore-arc setting of the Saldania Belt suggests the subduction of the Adamastor Ocean below the leading edge of the Kalahari Craton. This challenges stratigraphic and structural correlations between the Saldania Belt and the Gariep Belt to the immediate north.

Cardiovascular responses to leg-press exercises during head-down tilt.

Physical exercise and gravitational load affect the activity of the cardiovascular system. How these factors interact with one another is still poorly understood. Here we investigate how the cardiovascular system responds to leg-press exercise during head-down tilt, a posture that reduces orthostatic stress, limits gravitational pooling, and increases central blood volume. Seventeen healthy participants performed leg-press exercise during head-down tilt at different combinations of resistive force, contraction frequency, and exercise duration (30 and 60 s), leading to different exercise power. Systolic (sBP), diastolic (dBP), mean arterial pressure (MAP), pulse pressure (PP) and heart rate (HR) were measured continuously. Cardiovascular responses were evaluated by comparing the values of these signals during exercise recovery to baseline. Mixed models were used to evaluate the effect of exercise power and of individual exercise parameter on the cardiovascular responses. Immediately after the exercise, we observed a clear undershoot in sBP (Δ = -7.78 ± 1.19 mmHg), dBP (Δ = -10.37 ± 0.84 mmHg), and MAP (Δ = -8.85 ± 0.85 mmHg), an overshoot in PP (Δ = 7.93 ± 1.13 mmHg), and elevated values of HR (Δ = 33.5 ± 0.94 bpm) compared to baseline (p < 0.0001). However, all parameters returned to similar baseline values 2 min following the exercise (p > 0.05). The responses of dBP, MAP and HR were significantly modulated by exercise power (correlation coefficients: rdBP = -0.34, rMAP = -0.25, rHR = 0.52, p < 0.001). All signals' responses were modulated by contraction frequency (p < 0.05), increasing the undershoot in sBP (Δ = -1.87 ± 0.98 mmHg), dBP (Δ = -4.85 ± 1.01 and Δ = -3.45 ± 0.98 mmHg for low and high resistive force respectively) and MAP (Δ = -3.31 ± 0.75 mmHg), and increasing the overshoot in PP (Δ = 2.57 ± 1.06 mmHg) as well as the value of HR (Δ = 16.8 ± 2.04 and Δ = 10.8 ± 2.01 bpm for low and high resistive force respectively). Resistive force affected only dBP (Δ = -4.96 ± 1.41 mmHg, p < 0.0001), MAP (Δ = -2.97 ± 1.07 mmHg, p < 0.05) and HR (Δ = 6.81 ± 2.81 bpm, p < 0.0001; Δ = 15.72 ± 2.86 bpm, p < 0.0001; Δ = 15.72 ± 2.86 bpm, p < 0.05, depending on the values of resistive force and contraction frequency), and exercise duration affected only HR (Δ = 9.64 ± 2.01 bpm, p < 0.0001). Leg exercises caused only immediate cardiovascular responses, potentially due to facilitated venous return by the head-down tilt position. The modulation of dBP, MAP and HR responses by exercise power and that of all signals by contraction frequency may help optimizing exercise prescription in conditions of limited orthostatic stress.

Gas permeability and mechanical properties of dust grain aggregates at hyper- and zero-gravity

Abstract Particle-particle and particle-gas processes significantly impact planetary precursors such as dust aggregates and planetesimals. We investigate gas permeability (κ) in 12 granular samples, mimicking planetesimal dust regoliths. Using parabolic flights, this study assesses how gravitational compression – and lack thereof– influences gas permeation, impacting the equilibrium state of low-gravity objects. Transitioning between micro- and hyper-gravity induces granular sedimentation dynamics, revealing collective dust-grain aerodynamics. Our experiments measure κ across Knudsen number (Kn) ranges, reflecting transitional flow. Using mass and momentum conservation, we derive κ and calculate pressure gradients within the granular matrix. Key findings: 1. As confinement pressure increases with gravitational load and mass flow, κ and average pore space decrease. This implies that a planetesimal’s unique dust-compaction history limits sub-surface volatile outflows. 2. The derived pressure gradient enables tensile strength determination for asteroid regolith simulants with cohesion. This offers a unique approach to studying dust-layer properties when suspended in confinement pressures comparable to the equilibrium state on planetesimals surfaces, which will be valuable for modelling their collisional evolution. 3. We observe a dynamical flow symmetry breaking when granular material moves against the pressure gradient. This occurs even at low Reynolds numbers, suggesting that Stokes numbers for drifting dust aggregates near the Stokes-Epstein transition require a drag force modification based on permeability.

Predicting muscle function and mass with electrical impedance myography: A study in rat analogs of micro- and partial gravity

IntroductionSpaceflight results in marked muscle atrophy and a corresponding loss in muscle strength. Methods to evaluate spaceflight-induced changes to muscle size and strength are difficult to achieve within the tight confines of spacecrafts. Therefore, convenient methods to non-invasively monitor muscle that are predictive of actual muscle function are critical for future missions to ensure the health and safety of crew members. PurposeEvaluate the ability of non-invasive in vivo electrical impedance myography (EIM) combined with statistical models to predict muscle size and strength in rodent models of micro- and partial gravity. MethodsMale and female Fisher rats (N = 120), half gonadectomized, were divided into three different weightbearing (WB) conditions of 40 animals each, including 0%WB (0 % of weight-bearing, simulated microgravity), 40%WB (40 % of weight-bearing, simulated Martian gravity), and 100%WB (100 % of weight-bearing, full weight-bearing controls). Rats remained in designated interventions for 28 days. Afterward, rats underwent a series of musculoskeletal strength assessments and measurement of EIM. Rats were then euthanized and gastrocnemius tissues collected. Machine-learning (ML) algorithms were applied to full spectrum EIM data to predict various muscle parameters. Results40%WB and 0%WB rats had lower grip strength and plantar flexion compared to 100%WB. Correspondingly, 40%WB and 0%WB also had reduced gastrocnemius mass compared to 100%WB. EIM resistance values demonstrated a dose-dependency response, with greater resistance values associated with reduced gravitational load. ML-enhanced EIM yielded strong predictions of muscle plantar flexion force and muscle mass, with root mean squared errors of 18.4 % of 22.0 %, and R2 values of 0.87 an 0.88, respectively. ConclusionML-enhanced EIM may be a helpful tool to non-invasively monitor muscle changes predictive of muscle force production and mass during exposure to reduced gravity.

The Key Role of Floors for the Sustainability of Retrofit Interventions in Older Existing Reinforced Concrete Buildings

In recent decades, the seismic performance of existing reinforced concrete (RC) buildings has played a key role. Nevertheless, the performance and reliability verification of important structural elements such as floors has often been neglected. Floors are primary structural elements that can affect the life cycle life of a building. However, the widespread lack of maintenance planning over time and the original construction practice (which was not always correct) are frequently the cause of unpredictable local or global collapse. In addition, although recent standards and codes recognize the importance of floors by prioritizing their verification with respect to gravitational load conditions, the verification of floor reliability with respect to the load combinations required by modern standards and codes is often not satisfied. Consequently, the intervention costs could be significantly affected by the floor conditions, and their overall amount might even discourage the implementation of interventions. The main purpose of this study is to evaluate the effects (in terms of sustainability) of interventions on residential RC buildings, considering the need to retrofit their existing floors. To this aim, the most vulnerable and potentially most degraded floor types are identified, and their capacity–demand relationships are evaluated. In the case of unverified floors, the main and most popular intervention methods are evaluated and related to the overall intervention costs, taking into account the main uncertainties in performance and cost predictions. The problems and critical issues of floors are key in determining the safety of the building and the cost-effectiveness (i.e., sustainability) of the retrofit intervention. Professionals and decision makers could benefit from the proposed study cost model to define intervention strategies on a regional or national scale.

A Review paper Advancements in Shear Wall Design for Seismic Resistance in Residential Buildings: A Comprehensive Review

This comprehensive review synthesizes diverse studies, providing valuable insights into the advancements, challenges, and future directions in shear wall design for seismic resistance in multi-story residential buildings. It serves as a reference for researchers, engineers, and practitioners seeking a deeper understanding of shear wall dynamics in the context of structural stability and seismic resilience. Shear walls are a prevalent feature in multi-story constructions as they effectively counteract horizontal forces and offer substantial rigidity and durability within the same plane. This unique quality allows them to carry both significant horizontal loads and provide support for vertical or gravitational loads, thereby presenting a valuable asset in the realm of structural engineering applications. The location and arrangement of shear walls in a building are important factors in their effectiveness in resisting seismic loads. Studies have shown that shear walls arranged in the form of a core at the center of the building are the most effective in reducing top-story displacement during earthquakes. Corrugated steel plate shear walls (CPSW) have been introduced as an alternative to flat steel plate shear walls (FPSW) due to their advantages in terms of stiffness, strength, and ductility. Double layer corrugated steel plate shear walls (DCPSW) have been found to have the highest inelastic deformations, which can be considered an advantage over CPSWs. End shear walls in tall buildings have been shown to decrease maximum inter-story drift and improve seismic performance. Keywords: Shear walls, multi-story residential buildings, lateral support, seismic performance, structural integrity, retrofitting, literature review

How Well Do We Know the Seasonal Cycle in Ocean Bottom Pressure?

AbstractWe revisit the nature of the ocean bottom pressure (pb) seasonal cycle by leveraging the mounting GRACE‐based pb record and its assimilation in the ocean state estimates produced by the project for Estimating the Circulation and Climate of the Ocean (ECCO). We focus on the mean seasonal cycle from both data and ECCO estimates, examining their similarities and differences and exploring the underlying causes. Despite substantial year‐to‐year variability, the 21‐year period studied (2002–2022) provides a relatively robust estimate of the mean seasonal cycle. Results indicate that the pb annual harmonic tends to dominate but the semi‐annual harmonic can also be important (e.g., subpolar North Pacific, Bellingshausen Basin). Amplitudes and short‐scale phase variability are enhanced near coasts and continental shelves, emphasizing the importance of bottom topography in shaping the seasonal cycle in pb. Comparisons of GRACE and ECCO estimates indicate good qualitative agreement, but considerable quantitative differences remain in many areas. The GRACE amplitudes tend to be higher than those of ECCO typically by 10%–50%, and by more than 50% in extensive regions, particularly around continental boundaries. Phase differences of more than 1 (0.5) months for the annual (semiannual) harmonics are also apparent. Larger differences near coastal regions can be related to enhanced GRACE data uncertainties and also to the absence of gravitational attraction and loading effects in ECCO. Improvements in both data and model‐based estimates are still needed to narrow present uncertainties in pb estimates.

Safety assessment of masonry undamaged and damaged arches subjected to gravitational loads and horizontal forces. A numeric procedure to identify the optimal thrust line

In 2019 the authors formulated a numerical procedure for assessing the safety of masonry arches based on their geometry and the shape of the thrust line. The thrust line is calculated to be nearest to the geometric axis of the arch, because it is that corresponding to the optimal inner stress state. The original procedure, which focused on the safety analysis of undamaged fixed arches subject to gravitational loads, is reformulated here to also consider arches on pinned supports as well as damaged arches, i.e. one- and two-hinged arches. The procedure is further extended to also assess safety against horizontal actions, such as those resulting from an earthquake. Finally, safety is evaluated by identifying the domain of admissible thrust lines within the thickness of the arch and by computing the degree of safety in terms of the capacity of the thrust line to be moved vertically within the domain. The reformulation and extension of the procedure exploits the technique of partitioned matrices to enable automation and easy implementation in structural calculation software.

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept

Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that produce movement through joint rotation. Conversely, the microgravity of spaceflight reduces tensile loads in working skeletal muscles, causing an adaptive muscle atrophy. Unfortunately, the design of stable, physiological bioreactors to model skeletal muscle tensile loading during spaceflight experiments remains challenging. Here, we tested a bioreactor that uses initiation and cessation of cyclic, tensile strain to induce hypertrophy and atrophy, respectively, in murine lineage (C2C12) skeletal muscle myotubes. Uniaxial cyclic stretch of myotubes was conducted using a StrexCell® (STB-1400) stepper motor system (0.75 Hz, 12% strain, 60 min day^-1). Myotube groups were assigned as follows: (a) quiescent over 2- or (b) 5-day (no stretch), (c) experienced 2-days (2dHY) or (d) 5-days (5dHY) of cyclic stretch, or (e) 2-days of cyclic stretch followed by a 3-day cessation of stretch (3dAT). Using ß-sarcoglycan as a sarcolemmal marker, mean myotube diameter increased significantly following 2dAT (51%) and 5dAT (94%) vs. matched controls. The hypertrophic, anabolic markers talin and Akt phosphorylation (Thr308) were elevated with 2dHY but not in 3dAT myotubes. Inflammatory, catabolic markers IL-1ß, IL6, and NF-kappaB p65 subunit were significantly higher in the 3dAT group vs. all other groups. The ratio of phosphorylated FoxO3a/total FoxO3a was significantly lower in 3dAT than in the 2dHY group, consistent with elevated catabolic signaling during unloading. In summary, we demonstrated proof-of-concept for a spaceflight research bioreactor, using uniaxial cyclic stretch to produce myotube hypertrophy with increased tensile loading, and myotube atrophy with subsequent cessation of stretch.

Estimation of Additional Costs by Seismic Safety in Shallow Foundations Projects

Additional costs for seismic safety in shallow foundation projects for five reinforced concrete buildings with different dimensions in plan and prop, in the city of Santiago de Cuba, an area of greatest seismic danger in Cuba are evaluated. Costs of foundation plates for seismic, wind load and gravity loads are compared separately. Physical mechanical properties were obtained from testing soil samples by SPT test at the construction area. Requirements for designing foundation plates result from the structural modeling using SAP 2000 NL version 14 for combination load according to current Cuban regulations. The book Excel DISCAR 3.0 was used for designing the geotechnical and structural foundation. Budgets were calculated by using the PRESWIN program, showing increases costs for seismic safety of foundation plates between 34 to 66% in relation to similar costs obtained by wind loads or gravitational loads, significantly increasing the dimensions of foundation's plates, concrete and excavation volumes as well as total reinforcing steel weight for seismic loads.

Changes in the pulmonary circulation due to gravitational loads in high altitude conditions.

The impact of gravity on the existence of all living things has long been of interest to scientists. The force of the Earth's gravity combined with hypoxia significantly affects blood circulation and blood accumulation in various parts of the human and animal body. To date, the relationship between body position and blood circulation in pulmonary circulation under hypobaric hypoxia has not been sufficiently studied. Therefore, the research aims to determine the possibility of changing the body position in space on the reactions in the pulmonary circulation in the plains and highlands. For this purpose, research was conducted on male Wistar rats, 44 of whom spent 150 days at an altitude of 3200 m above sea level, and 25 representatives of the control group - at an altitude of 164 m. The study revealed that gravitational redistribution of blood in mountainous conditions is less pronounced compared to the control group. This is explained by the remodeling of the vascular wall and an increase in its stiffness. It was found that a change in pulmonary artery pressure at the time of a change in body position was recorded both on the plains and in the highlands. On the plains, when the body position of rats was changed to passive orthostatic, a decrease in systolic and diastolic pulmonary artery pressure was noted, and when the body position was changed to passive anti-orthostatic, an increase in pulmonary artery pressure was observed. The increase in pulmonary artery pressure was a compensatory mechanism due to the increased stiffness of the pulmonary vasculature. The practical significance of this research is to expand the understanding of the pathogenesis of pulmonary hypertension in high-altitude hypoxia.

A study on the dynamics of a novel seven degrees of freedom spray-painting robot with a telescopic forearm

In this article, the dynamics of a seven degrees of freedom robot with a telescopic forearm for the spray-painting of large workpiece is investigated. A novel two-step inverse kinematic solving method that combines numerical and analytical approaches is proposed to solve the inverse kinematics of the seven degrees of freedom robot with two redundant degrees of freedom for spray-painting applications. Based on the kinematic model, the dynamic model is derived using the Newton–Euler method. For the dynamic parameter identification, the dynamic model is written in a linear form with respect to dynamic parameters. Considering the effect of the telescopic forearm on the dynamics of the robot, two novel performance indices concerning the inertial load and gravitational load in the joint space are proposed to evaluate the effect of the telescopic forearm on the dynamic load of the robot. Monte Carlo method is used to solve these two indices. This work is essential for the motion planning and control of the seven degrees of freedom spray-painting robot with a telescopic forearm.

Investigation on A Viscoelastic Creep Damage Constitutive Model for HTPB Propellant and Its Application in Finite Element Analysis

Solid rocket motor (SRM) is typically kept in storage for a significant portion of its lifespan. During storage, the propellant grain creeps under the action of gravity. To investigate the creep properties of hydroyl-terminated polybutadiene (HTPB) propellant under long-term loading, a creep damage constitutive model is developed based on the generalized Kelvin model and continuum damage mechanics theory. Parameters for this model are determined through creep tests conducted on HTPB propellant under various stress levels. Furthermore, to enable the application of the developed propellant constitutive model in the finite element analysis of SRM, the derived constitutive equation is transformed into an incremental form and integrated into the user subroutine UMAT of the finite element analysis platform ABAQUS. Subsequent to this, a three-dimensional SRM model containing the case, the insulator, and the propellant grain is established. The mechanical response of the grain under thermal and gravitational loads is calculated and analyzed. The results indicate that the stress concentration region in the grain is located at the stress release boot in the forward dome of the motor, where damage occurs. The methods employed in this paper and the conclusions drawn can serve as a reference for evaluating the structural integrity and storage lifespan of the SRM.

Beam modeling in a floating frame of reference for torsion dynamics of helicopter rotor blades

AbstractIn the ongoing development of DLR’s Versatile Aeromechanics Simulation Tool, an elastic-beam model is integrated into the multibody system based on the floating frame-of-reference formulation. Although the application of this formulation for one-dimensional beam models has already been addressed in the literature, the challenge remains to properly model the torsion dynamics of rotor blades – especially under high centrifugal loads. To this aim, this work suggests the consideration of rotational shape functions in the inertia shape integrals and in the application of gravitational, inertial, and external loads. This modified approach is validated based on the structural analysis of a rotor blade with complex geometrical properties.

Seismic Retrofit of Concrete Buildings Damaged by Corrosion: A Case Study in Southern Italy

A case study of a building in southern Italy, subjected to high degradation by corrosion and waiting to be assessed for retrofit interventions, is presented. The owner required modifications to the building configuration, including a new layout of the floors and retrofitting for a high level of seismic load. A double strategy of an assessment and retrofit was carried out: dynamic linear and static non-linear analyses were performed, and the results were compared. Afterwards, a global strategy of mass and stiffness redistribution was implemented together with different retrofit interventions on the foundations, columns, and beams of the framed structure, such as reinforced concrete and steel jacketing, the application of FRP plates and fabrics, new steel elements, and steel–concrete composite floors. The results of the intervention are discussed and the implications of corrosion on the structures are explored. From the results obtained, it is possible to see how the use of different techniques for strengthening and passive seismic protection strategy can allow engineers to obtain the result of structural adaptation to earthquakes with low-cost interventions. The widespread adoption of steel jackets, coupled with the construction of floors using a steel–concrete composite structure, grants a good confinement of the beam–column r.c. joints, together with the overall strengthening of the existing structure. The adoption of CFRP wrapping at the lower edge of the beams implies a limited increase in thickness and the limited interventions of partial demolition from the existing structural members. A critical review of the steel jacketing aspects in terms of bending and shear strengthening is reported by considering this technique in the form of a steel exoskeleton containing the damaged concrete structure, by confining concrete elements, and by increasing the performance for both gravitational and seismic loads.

Investigating and monitoring central nave vaults of the Turin Cathedral with Acoustic Emissions and Thrust Network Analysis

Ancient masonry constructions and historical buildings, such as cathedrals, are exposed to considerable risks attributed to factors like ageing and long-term exposure to both dynamic and static variations in loading conditions. In this study, an innovative and promising monitoring approach was applied to assess the structural integrity of the vault in the central nave of the Turin Cathedral. Specifically, the outcomes obtained from Acoustic Emissions (AE) are correlated with the insights derived from the Thrust Network Analysis (TNA) conducted on the structure. This analysis considers the structural elements introduced early in the twentieth century to mitigate horizontal forces. Acoustic Emission (AE) is a commonly employed technique in structural monitoring to detect and analyze elastic waves generated by crack formation, providing valuable information about structural damage. The Thrust Network Analysis (TNA) is an approach that applies Heyman's principles to represent stress in masonry vaults. This method models the stresses as a discrete network of forces, achieving equilibrium with gravitational loads. In this context, the results obtained by TNA analysis are strictly correlated with AE localization results.

Influence of professional sports activities on bone mineral density (&lt;i&gt;literature review&lt;/i&gt;)

Introduction. The positive effect of physical activity on the state of bone has been proven by many researchers. Professional sports activity is a model of the constant impact of physical activity on the human body, acting as the most powerful mechanism for activating and mobilizing the functional reserves of an athlete, which, against the background of a progressive increase in the volume, intensity and duration of exposure, shows an increase in the incidence of injuries and stress fractures, one of the leading causes of which is a decrease in bone mineral density (BMD) up to the development of osteoporosis. The risk factors for the development of the pathology of the musculoskeletal system, which have a direct impact on the formation of the BMD, in elite sports include the volume and intensity of training loads, the stereotype of the main competitive exercise, the daily balance of energy intake.The aim is to study is to analyze modern scientific publications on the impact of professional sports activities on bone mineral density.Materials and methods. The review is based on publications from the PubMed, Google Scholar, Cyberleninka, eLIBRARY databases. Preference was given to articles published in refereed sources over the past 10 years.Results. The specificity of the main competitive exercise determines the presence of asymmetry in the distribution of the BMD in athletes, in addition, the level of BMD is higher in the leading limb compared to the opposite. Increasing the qualifications, experience and age of an athlete shows a positive impact on the performance of the BMD, with the exception of certain specializations. A different effect of sports with a high osteogenic effect of shock and weight load on the state of the BMD was noted compared to the general population. Power athletes, combat and game sports athletes have higher levels BMD compared to representatives of cycling, swimming, rowing, triathlon and long-distance running, characterized by the limitation of gravitational (shock) load or a large amount of low-intensity training exposure. Lower BMD were noted in athletes in sports specializations with weight categories, aesthetic and cyclic sports, where the problem of a relative energy deficiency in sport, which negatively affects bone metabolism.Conclusions. In athletes, the volume and intensity of training loads, the stereotype of performing the main competitive exercise, the daily balance of energy intake have a direct impact on the formation of the BMD with the allocation of risk groups for the pathology of the musculoskeletal system in elite sports.