Gravidarum In Women Research Articles

Cholestasis gravidarum in women in the second and third trimester of gestation, clinical and specific pharmacological treatment and its benefits

Introduction: cholestasis gravidarum is a syndrome that usually occurs in pregnant women in the second or third trimester of pregnancy and ends in the puerperium. It is clinically characterized by the presence of predominantly nocturnal pruritus that is palmoplantar at first and then generalized. Alterations in liver function with or without jaundice and elevated serum bile acid levels, biochemical cholestasis is classified as mild to moderate in severity.This pathology does not have significant consequences for the mother, but it is associated with a high risk of affecting the newborn, such as premature delivery, fetal distress, fetal arrhythmias and intrauterine death. Objective: diagnostic methods and behaviors in their pharmacological treatments that provide the best results for those patients. Methods: systematic review with qualitative database from the PUBMED platform. The articles were downloaded from the PUBMED platform and Zotero was used to make the proper citations and references. In the investigation, the population will be composed of adult female patients who were admitted to any health care unit during the second and third trimesters. Results: the PUBMED database was used with the following MESH terms (cholestasis of pregnancy) that generated 2 597 results. 28 articles were analyzed in more depth, of which 12 articles were finally selected for the final analysis. Ursodeoxycholic acid (UDCA), a beta epimer of chenodeoxycholic acid, is a more polar bile acid than primary bile acids, with substantial choleretic and multiple other chemoprotective effects. The mechanism of action is not fully understood, but studies have shown that after treatment there is a reduction in total serum bile acids in both maternal and umbilical cord serum and a qualitative change in bile acid pool. serum. When compared to all controls, UDCA was also found to be associated with a decreased incidence of preterm birth, neonatal respiratory distress, and the number of neonatal intensive care unit admissions

Cholestasis gravidarum in women in the second and third trimester of gestation, clinical and specific pharmacological treatment and its benefits. An evidence-based approach

Introduction: Cholestasis gravidarum is a syndrome that usually occurs in pregnant women in the second or third trimester of gestation and ends in the puerperium. It is clinically characterized by the presence of predominantly nocturnal pruritus that is initially palmo-plantar and then generalized. With alterations in liver function with or without jaundice and elevated serum bile acid levels, biochemical cholestasis is classified as mild to moderate severity. Objective: Diagnostic methods and pharmacological treatment approaches that provide the best results for these patients. Methods: Systematic review using the terms MESH (cholestasis of pregnancy) that generated 2597 results. Results: 28 papers were analyzed in more detail, of which 12 papers were finally selected for the final analysis. Treatment: Ursodeoxycholic acid (UDCA), a beta epimer of chenodeoxycholic acid, is a bile acid more polar than primary bile acids, with substantial choleretic and other multiple chemoprotective effects. The mechanism of action is not completely understood, but studies have shown that after treatment there is a reduction in total serum bile acids in both maternal and cord serum and a qualitative change in the serum bile acid pool. When compared with all controls, UDCA was also found to be associated with a decrease in the incidence of preterm birth, neonatal respiratory distress, and the number of neonatal admissions to intensive care units. Conclusions: The treatment of cholestasis gravidarum is oral administration of ursodeoxycholic acid is effective and safe in the treatment of patients with cholestasis gravidarum.

Hubungan KEK dengan Anemia Gravidarum pada Ibu Riwayat BBLR

KEK (Chronic Energy Deficiency) is a condition of the mother suffering from lack of calories and protein (malnutrition) that lasts chronic (chronic) at risk of causing complications in the mother one of which is anemia gravidarum. Anemia in pregnancy is a decrease in Hb levels, so that the carrying capacity of oxygen for the needs of vital organs in the mother and fetus is reduced. The purpose of this study is to determine the relationship of KEK with anemia gravidarum in mothers with low birth weigth history. The correlation analytic research design is a case control study approach, the population is 68 mothers with low birth weight history, using simple random sampling technique, the sample is calculated using Slovin formula, the number of 58 low birth weight history mothers fulfills the inclusion criteria. The research instrument used observation sheets to look at secondary data on cohorts of pregnant women, data analysis using the chi square test obtained a p value of 0, 001 means that p <0.05 indicates the relationship of KEK with anemia gravidarum in women with low birth weight history with a close relationship is sufficient. The value of the Contingency Coefficient in the Chronic Energy Deficiency variable is 0.39, which means that the relationship between KEK and anemia gravidarum is sufficient. The Odds Ratio (OR) value in the Chronic Energy Deficiency variable is 6.9, which means that pregnant women with nutritional status of Chronic Energy Deficiency have a 6.9 times greater risk of anemia during pregnancy than those who are not. Inadequate nutritional needs have a greater risk of anemia during pregnancy and the risk of giving birth to Low Birth Weight Babies. Researchers suggest providing counseling to women of adolescence, women of childbearing age and especially pregnant women so that they can add more information about the importance of nutritional status in pregnant women, the dangers of anemia during pregnancy and also the importance of consuming blood booster tablets during pregnancy. So that it is expected to reduce the incidence of anemia pregnant women case and low birth weight history.

RETRACTED: Evaluation of the severity of striae gravidarum in women with pelvic organ prolapse

ObjectiveTo evaluate the severity of abdominal striae in women presenting with pelvic organ prolapse. Study designA cross sectional study conducted in the outpatient clinics of obstetrics and gynecology department, Suez Canal University hospitals. We recruited patients over a six months period from January 2019 to June 2019 presenting with symptomatic pelvic organ prolapse (96) and abdominal striae. A control group with no evidence of striae and presenting with symptomatic organ prolapse were recruited also. The degree of prolapse was evaluated using the pelvic organ prolapse quantification system. The evaluation of striae was done using the Davey’s scale. ResultsMild, moderate and severe striae affected 20 (20.8 %), 34 (35.4 %), and 42 (43.8 %) women, respectively. Severe striae were noted in women with increased parity (5 ± 2.03). Apical prolapse was more prominent in women with severe striae [42 (100 %)]. Advanced grades of prolapse (grade 3 and 4) were noted in women with severe striae [25 (59.5 %) and 9 (21.5 %) respectively]. Using simple linear regression analysis, abdominal striae was considered a risk factor for the development of POP (P value <0.001); however, when combined with other risk factors in a multivariate model, it had no effect on the development of POP. ConclusionWomen with severe abdominal striae were found to have advanced degrees of POP with the apical compartment affected obviously.

Risk factors for the formation of striae gravidarum in women in Jiangsu Province of China

ObjectiveWe study the risk factors that affect the formation of striae gravidarum in women in Jiangsu Province of China under current living habits. Materials and methodsThis sample is based on 400 primiparas from obstetric of the Affiliated Hospital of Jiangnan University in Wuxi from February 2017 to October 2017. Among them, there are 200 pregnant women with striae gravidarum and 200 without striae gravidarum. Striae gravidarum predictors were selected such as age, height, pre-pregnancy BMI, postpartum BMI, daily sitting time, weight gain during pregnancy, fetal weight, and diet on maternal. Results(1) The pregnant women who had striae gravidarum were generally lower in height than those who did not have striae gravidarum and had a higher BMI index than those who did not have striae gravidarum before and after childbirth. (2) In the pregnant women who have had striae gravidarum, the incidence of abdominal striae gravidarum in sedentary women is significantly lower than those in non-sedentary women, the incidence of striae gravidarum in legs is higher than those in non-sedentary women, and no significant difference in hip striae gravidarum. (3) In all pregnant women who have striae gravidarum, abdomen striae gravidarum tend to be lighter and leg striae gravidarum tends to be heavier in sedentary women, but no significant effect on the hip. (4) Regular consumption of honey, milk, trotters, freshwater fish, eggs, and tremella can reduce the incidence of striae gravidarum. ConclusionThe lifestyle and eating habits have a certain influence on the formation and severity of stretch marks.

Risk factors of striae gravidarum in Chinese primiparous women.

BackgroundStriae gravidarum is a common skin problem of considerable cosmetic concern for many pregnant women. Various risk factors associated with the development of striae have been reported, with conflicting results.ObjectivesTo analyze the risk factors of striae gravidarum in Chinese primiparous women and to provide evidence relevant to the prevention of this condition.MethodsSingleton primiparous pregnant women who were hospitalized for delivery were included, and relevant data were collected. Independent risk factors associated with striae gravidarum in women with and those without striae gravidarum were identified using logistic regression.ResultsAmong 213 singleton primiparous pregnant women, 125 had striae gravidarum, yielding a prevalence of up to 58.9%. There was a significant variation (P < 0.05, odds ratio >1) between the striae gravidarum and non-striae gravidarum groups in terms of several factors, including younger maternal age, weight gain during pregnancy, body mass index gain, uterine height, abdominal girth, and positive family history. Factors such as maternal height, birth weight, systemic disease, skin type, and neonatal gender did not significantly differ between the 2 groups.ConclusionThis study showed that the independent risk factors for striae gravidarum in primiparous women were younger maternal age, weight gain during pregnancy, body mass index gain, uterine height, abdominal girth, and a positive family history. The severity of striae gravidarum was associated with weight gain during pregnancy, body mass index gain, abdominal girth, and timing of the onset of striae gravidarum.

Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth.

BackgroundProgesterone administration prevents spontaneous preterm birth (sPTB) in women at increased risk. Progesterone concentration is lower in women with subsequent sPTB. Conversely, high concentrations of progesterone are implicated in the pathogenesis of hyperemesis gravidarum (HG). We hypothesized that women at increased risk of sPTB or spontaneous late miscarriage would be less likely to have a diagnosis of HG. To explore this hypothesis, we compared the incidence of HG in women at increased risk of sPTB and women with no identifiable risk factors.MethodsWomen at increased risk of sPTB were identified from a specialist Preterm Birth Clinic (PTBC) database where criteria for PTBC attendance are previous cervical surgery, previous sPTB <34 weeks, previous spontaneous late miscarriage, incidental sonographic cervical shortening, and uterine anomaly. Hospital antenatal booking and coding records for the same time period were examined to identify HG admissions. Women with multiple gestations, trophoblastic disease, or pre‐existing abnormal thyroid function were excluded. The incidence of HG among PTBC (n=394) and non‐PTBC attendees (n=4762) was calculated.ResultsThe incidence of HG was lower in women at increased risk of sPTB (1.52%, n=6) compared with women with no identifiable risk factor for sPTB (3.33%, n=159; P=.049).ConclusionHospital admission for HG is reduced in women with risk factors for sPTB compared with those without risk factors. Exploration of the pathogenesis of HG may improve understanding of the mechanisms underlying sPTB.

Epidemiología de las estrías gravídicas en España

ObjectiveTo assess the influence of different factors on the presence of striae prior to pregnancy as well as the development of new lesions during and after pregnancy. Subjects and methodsAn observational epidemiologic study was carried out on the prevalence and incidence of striae gravidarum and stretch marks in pregnant women. Data from 519 pregnant women were registered, including obstetric history, family history of striae gravidarum, weight prior to pregnancy, skin type, Fitzpatrick skin phototype, and current use of body creams and lotions. A multivariate analysis was used to determine the factors associated with the incidence of striae gravidarum during current pregnancy. ResultsThe prevalence of pre-pregnancy stretch marks was 85.5%, mainly observed in patients with a first pregnancy (OR=2.6), body mass index≥25 (OR=2.2), and family history of striae gravidarum (OR=2.1). The overall incidence of striae gravidarum during pregnancy was 36.8% and most of these patients had a body mass index≥25 (OR=2.2) and were younger (<30 years old; OR=1.9). Risk analysis of all the variables registered indicated a higher risk of striae gravidarum in women who were overweight prior to pregnancy (OR=1.8), those aged under 30 years (OR=2.4), and those with previous pregnancies (OR=4.3). ConclusionsPrevention of striae gravidarum should be recommended in all cases, with special emphasis on younger women and those who are overweight or obese due to their higher risk for the development of these marks during pregnancy.

Striae gravidarum as a predictor of spontaneous preterm delivery: A case control study

Background/Aims: The association between striae gravidarum (SG) and preterm delivery may be postulated because of sharing similar poor organization of extracellular matrix in both skin and cervix. Our goal was to compare the frequency of striae gravidarum in women who gave preterm birth and women who gave term birth. Methods: A case-control study was conducted in women who gave preterm birth (n = 66) and age matched women who gave term birth (n = 68). Cases and controls were recruited from puerperal women consequently seen at delivery wards of perinatology unit. All women underwent dermatologic examination in terms of SG blindly to theirs gestational weeks of delivery. The frequency of SG was compared in all groups. Results: The frequency of SG was 63.6% in women with preterm birth and 54.4% in women with term birth (p = 0.278). SG is five times more common in late preterm group than in women with term group, but this difference was not statistically significant [(p = 0.227, OR: 5.02, CI 95% (0.5 - 44.0)]. The rate of preventive cream usage was not statistically different in women with SG and without SG (p = 0.245). Conclusions: It seems that there was no statistically significant association between the risk of preterm labor and the presence of striae gravidarum. Larger prospective observational studies are needed to state expressly the probable clinical association between the presence of SG and preterm delivery.