In the field of High Performance Computing (HPC), which is changing very quickly, using Graphics Processing Units (GPUs) has become essential for getting a lot of computing power and speed. This study gives a thorough mathematical analysis of a GPU system that is meant to improve scalability, stability, and configurability, all of which are very important for next-generation HPC apps. The suggested framework uses complex mathematical models and methods to make the best use of GPU resources, cut down on delay, and guarantee strong performance across a wide range of tasks. Scalable parallel processing methods are built into the framework so it can adapt to changing computing needs, making the most of speed and resource use. Fault-tolerant methods that lessen the effects of hardware breakdowns and computing mistakes also improve reliability, making sure that results are always correct and consistent. The framework can be set up in different ways because it is based on flexible design, which makes it easy to change and adapt to the needs of each application without affecting speed. In diverse computer settings, where different apps may have different working needs, this ability to change is very important. The mathematical analysis includes performance measures like speed, delay, and mistake rates, which give a solid basis for judging how well the system works. Additionally, tests comparing the suggested system to current GPU tools show that it is more reliable and scalable. This study helps make better, more reliable computer systems by looking at some of the biggest problems in GPU-based high-performance computing. The results show that using this method can greatly improve the skills of HPC systems, which can lead to progress in scientific study, data analysis, and complex models. In the end, this work shows how advanced GPU systems can help drive innovation in HPC, leading to more powerful, reliable, and flexible computing options.