The rapid monitoring of drugs has robust global desire for environment has high efficacy. In this study the Zinc Oxide/Graphene Oxide modified carbon paste electrode (ZnO/GO/MCPE) was used for the voltammetric determination of Bisphenol-A (BPA) and Sulfadiazine (SFZ). The characterization of synthesized ZnO NP’s done by XRD, SEM and EDX technique; the morphological character of procured graphene oxide is done by SEM and ZnO/GO/MCPE brings the tremendous sensitivity towards the detection of BPA and SFZ utilizing CV and LSV techniques. The pH, concentration and scan rate parameters investigation were performed for BPA and SFZ, the ZnO/GO/MCPE is employ for SFZ and BPA in simultaneous determination. the limit of detection was established to be 0.209 µM and 2.760 µM respectively.