Granulation Of Mixtures Research Articles

WET GRANULATION TECHNOLOGY IN INDUSTRIAL PHARMACY

Abstract. This review discusses wet granulation technology, a process that helps particles of different materials bind to each other, thereby reducing the possibility of separation of materials in subsequent processing steps during their processing and increasing the likelihood of proper dosage uniformity in the dosage form. Granulation is a size-enlarging process in which individual particles of a powder, usually composed of several different components, are combined together to form a larger, structured particle in which the original particles may differ. Granulation makes it possible to change the properties of the solid granular material. Increasing the particle size reduces the potential hazard or harmful effects of the dust. The structure of the granules improves the flowability and compaction of the powder, and also helps to ensure the uniformity of the composition of the powder mass in the case of mixing materials. Wet granulation is a particle size coarsening process widely used in the manufacture of dosage forms. There are several reasons for wet granulation of pharmaceutical mixtures. An increase in particle size leads to an improvement in fluidity. The wet granulation process physically binds the mixed particles, thereby reducing the chance of separation of substances and causing possible dosing uniformity problems. Another reason for granulation is to reduce the possibility of separation of the pharmaceutical substance and/or excipients. Granulation technology always guarantees good flow properties and a uniform bulk density of the powder before compression, which is especially important in pharmaceutical development, and also reduces the risk of delamination by creating multi-component granules with a more uniform composition compared to a powder mixture.

FORMULASI DAN EVALUASI GRANUL DISPERSI PADAT EKSTRAK KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DENGAN PERBANDINGAN KITOSAN:PVP K-30 1:2

Background: Mangrove crab shells (Scylla serrata) contain chitosan which functions as an anticholesterol. Chitosan is insoluble in water but soluble in acids such as acetic acid. In the process of increasing the solubility, a solid dispersion system is made. The solid dispersion is then formulated into granules. Objective: The purpose of this study was to determine the physical properties of the solid dispersion chitosan granules (FI) and the physical mixture granules (FII). Methods: The method used for the manufacture of solid dispersions is solvent evaporation using PVP K-30 (1:2) as a carrier. The solid dispersion will be made in the form of granules by wet granulation method which will then evaluate the quality of the granules. Results: From this study, the granule flow rate FI=12.89 g/second, and FII=24.58 g/second. The angle of repose of the granules FI=22,13o, and FII=9,46o. The compressibility and Hausner granule FI ratio were found to be 20% and 1.25; while FII obtained 9.90% and 1.11. The percentage of water content of FI granules is 6.38%, and FII is 2.04%. Conclusion: The formulation in this study was able to produce granules that met the requirements, and there was a significant difference between the physical properties of FI and FII granules.

Ways of disposal of objective fuel sediments for fuel

Accumulated sludge from sewage treatment plants in large cities is obsolete, due to which they have lost the vast majority of nutrients, become too mineralized and practically unsuitable for direct use as fertilizer.The research is devoted to the development of a unified approach to the efficient processing of sludge as a fuel with the addition of flammable fillers such as milling peat, buckwheat husk, wood waste (sawdust).Identified factors influencing the energy efficiency of the processes of preparation of raw materials, drying and granulation of composite mixtures based on peat, obsolete sludge and biomass, which allowed to obtain quality pellets and briquettes.The problem of processing obsolete sludge is the low content of organic matter, excessive ash content and high humidity, so they are not suitable for incineration in its pure form and for agriculture. To reduce ash content, it is advisable to add biomass and peat to sludge and dry to reduce moisture.The article presents studies of drying kinetics of composite granules based on peat, obsolete sludge and biomass on an experimental convective drying stand. The convective drying stand allows to carry out heat treatment of composite granules at a temperature of drying agent of 30–150°C and speed of movement of 0,5–5 m/s. A comparison of the drying time of the sludge-peat composition and its components is performed, which shows that during the drying of the composite granules the intensification of the drying process is observed.The presented comparison of drying kinetics of two- and three-component granules shows the same nature of the drying curves and the drying time is in the range of 17–18 minutes. The optimal ratio of components for quality granulation is selected. Effective drying regimes of composite granules based on sludge, peat and biomass are determined. Equilibrium humidity of composite granules not exceeding standard fuel humidity is determined.

Peat-vermiculite compositions for granulated material production

The paper presents the research results of peat-vermiculite compositions for the production of granulated material with heat-insulating properties, that can be used in the construction of low-rise buildings. The paper considers the possibility of producing a heat-insulating granulated material based on a peat-vermiculite mixture. The obtained data on various methods of the peat-vermiculite mixture granulation are analyzed. It is found that the optimum concentration of the Akvasil water-repelling is 10% in the mixing water. This concentration allows reducing the water absorption of peat-vermiculite compositions by 16% and increasing the material strength by 20%. Further increase in the Akvasil concentration in the mixing water does not lead to a significant change in the water absorption, and the strength properties decrease.

Granular Aggregates Based on Finely Dispersed Substandard Raw Materials

It is necessary to solve the ecological problems of regions where there is large-tonnage storage of various finely dispersed materials, including technogenic ones. This article presents the results of an investigation into the possible use of substandard dispersed quartz sands to obtain effective granular aggregates, with the purpose of putting them to use in mortars and concrete. The study used standard and original experimental research methods related to the analysis and preparation of raw materials, technological tests, and the study of the properties of finished composites. Investigations were carried out to obtain composite binders in the component composition of which the use of different ratios of Portland cement and substandard quartz sands prepared in a vortex jet mill was envisaged. It was found that the obtained composite binders had high physical and mechanical characteristics, which was due to the high specific surface area and hydration activity. On the basis of composite binders and finely dispersed quartz sands (fineness from ≤0.16 mm to 1 mm), the granulation of mixtures of 36 types of component compositions was performed. The developed compositions of granular aggregates (GAs) showed the possibility of obtaining them with sufficiently high strength values in cement stone. The studies carried out make it possible to recommend finely dispersed substandard and technogenic materials for the production of GAs, which would ensure the economy of binding materials as well as contribute to the reuse of large-tonnage waste of ferrous and nonferrous metallurgy and the chemical and mining industries.

Математическая модель процесса гранулообразования дисперсных смесей на основе молочной сыворотки в аппаратах тарельчатого типа

Introduction. In Russia, production of juice, whey, milk, and flavor powders is complicated by the lack of effective manufacturing technologies. Thus, a new technological flow for simultaneous use of moisturizing additives and structured capillary-porous granules remains an urgent task as it would allow combining a polydisperse system with instantiation reliability. The research objective was to create a mathematical model of the process of granulation of dispersed mixtures, as well as scientific substantiation for the new technology of instant polydisperse granular beverage mixes.
 Study objects and methods. The research featured a disk-type granulator with an activator and a polydisperse whey-based mix. The fractional composition of the mix included cranberry pulp (20%), whey (40%), potato starch (5%), powdered sugar (20%), premixes (5%), etc.
 Results and discussion. The research revealed the effect of granulation modes, granulator operation modes, and the phase composition of the initial mix on the profile of the resulting granulated product. The mathematically obtained results were proved experimentally: the model accurately reflected the physical essence of the granulation process of the polydisperse mixes based on local raw materials and whey.
 Conclusion. The study provided methods for regulating the process of granulation of polydisperse whey-based mixes n in disktype granulators. The article introduces a mathematical model of the process based on the hypothesis of the stochastic nature of the processes. The granulation process was described as a combination of seven states depending on the granular composition and granulation time.

Technical, Environmental, and Qualitative Assessment of the Oak Waste Processing and Its Usage for Energy Conversion

The article analyses and evaluates the possibilities of using oak bark, oak leaves, and their mixtures for biofuel. The preparation of this waste for the burning process (milling, granulation) has been investigated and the results have been presented together with the analysis of the prepared granules’ properties—humidity, density, strength, elemental composition, ash content, caloric value, and others. The moisture content of the oak waste granules ranged from 8.1% to 12.5%, and the granules’ density ranged from 975.8 to 1122.2 kg m−3 DM (dry matter). The amount of oak ash found was very high (from 10.4% to 14.7%)—about 10 times higher than that of wood waste granules. The calorific value determined after burning the oak bark and leaves pellets was sufficiently high, ranging from 17.3 to 17.7 MJ kg−1. This thermal value of oak waste granules was close to the calorific value of the herbaceous plant species and some types of wood waste. The environmental impact of burning the granules of oak waste was also assessed. The harmful emissions of carbon monoxide and dioxide, nitrogen oxides, and unburnt hydrocarbons into the environment were found to be below the permissible limits for the incineration of oak waste granules. The highest CO gas concentration, determined when burning the oak leaves, was 1187.70 mg m−3, and the lowest NOx concentration, determined when burning the oak bark and leaf mixture granules, was 341.2 mg m−3. The coefficient of energy efficiency R of the granulated oak leaves biofuel, when the oak waste biomass moisture content was reduced by 10%, reached 3.64. It was very similar to the results of previous studies of various types of granulated straw biofuel (3.5–3.7). The research results presented show that, given that the main parameters of oak waste meet the basic requirements of solid biofuel, oak bark, leaves, and their mixture can be recommended to be used as solid biofuels.

(Ti,Cr)C-Based Cermets with Varied Nicr Binder Content via Elemental SHS for Perspective Cutting Tools

The effects of granulation of reactive mixtures Ti-Cr-C and Ti-Cr-C-Ni on the combustion temperature and velocity, as well as phase composition and mechanical properties (crushing ability) of combustion products, were studied. Granulation was associated with a 1.5-fold increase in combustion velocity, caused by a nearly 10-fold increase in gas permeability. Secondary reactions between TiC, Cr7C3, and molten Ni led to the formation of (Ti,Cr)C FCC solid solution and Ni2.88Cr1.12 intermetallics. After the combustion of Ti-Cr-C-Ni mixtures, prolonged fluorescence was registered, suggesting the exothermic nature of secondary phase formation reactions. The introduction of the nickel binder decreased the content of Cr in the solid solution (Ti,Cr)C owing to the formation of the Ni2.88Cr1.12 phase. To prevent the Cr depletion from the carbide solid solution, Ni-20%Cr binder was added to the granulated 80%(Ti + C)/20%(3Cr + 2C) mixture. Combustion of granulated mixture yielded brittle porous sinter cake, which was easy to crush and mill, whereas the combustion products from the powdered mixtures were more ductile and harder to crush.

Fabrication of three-dimensional interconnected porous blocks composed of robust carbonate apatite frameworks

In scaffolds used for bone regeneration, osteogenic ability increases and mechanical strength decreases with increasing porosity. To ensure both mechanical strength and osteogenesis, an optimal pore architecture is necessary. Porous glass has high porosity and high mechanical strength, as it is framed with a rigid interconnected silica network and void interspaces in the silica network. In this context, based on the porous structure of glass, we fabricated porous blocks composed of carbonate apatite (CO3Ap), which is the major component of human bone mineral, with both high mechanical strength and high porosity. To fabricate the CO3Ap blocks, first, calcite-polymethyl methacrylate (PMMA) mixture granules were prepared. Next, the calcite-PMMA granules were allowed to join together in the mold by fusing PMMA, resulting in the formation of porous blocks composed of interconnected calcite-PMMA granules. Next, PMMA was thermally removed and the resultant interconnected calcite granules were partially sintered. Finally, the composition of the interconnected granules was converted from calcite to CO3Ap in a dissolution-precipitation reaction. Consequently, CO3Ap blocks with a continuous pore architecture were successfully fabricated. The porosity and diametral tensile strength were controllable within the range of 60‒70% and 1.0‒1.5 MPa, respectively, by filling the space between the calcite-PMMA granules. As these values are suitable for clinical use, the porous CO3Ap blocks have potential applications as scaffolds for bone regeneration.

Characterization of mannitol granules and powder: A comparative study using two flowability testers

In the manufacture of tablets, especially in direct tableting processes, the flowability of excipient powders and formulated powders is one of the most important characteristics. In the past two decades, orally disintegrating tablets (ODTs) have been prepared as popular solid dosage forms for elderly patients. Many types of mannitol granules have been developed and marketed as new pharmaceutical excipients for ODTs, owing to the solubility and palatability of mannitol. Characterizing the flow behaviors of these mannitol granules is essential to their use.The flowability of mannitol excipients was the focus of the present study. A fine crystalline mannitol powder, eight commercial types of mannitol granules and four types of mannitol mixture granules were evaluated. Two flowability testers were used for comparing and analyzing the samples’ flowabilities. A variety of methodologies were used: an assessment using Carr’s index, a shear test and a dynamic flow test. Mannitol powder showed the lowest Carr’s index, meaning the lowest flowability. Spherical mannitol granules showed the lowest angle of internal friction in the shear test and extremely low basic flow energy in the dynamic flow test. Larger granules showed relatively high values for Carr’s index, but also a relatively high total flow energy.

Effect of pre-briquetting on the granulation of sinter mixture containing high proportion of specularite concentrate

Specularite concentrate assays high iron grade and little impurities, but has been blended in sinter mixtures only with lower ratio because of its poor granulating performance. Nearly all of existing methods for improving granulation of sinter mixtures comprising specularite concentrate all need finely grinding of it, which means higher energy consumption and production cost. In this paper, granulating characteristics of specularite concentrate were investigated and the pre-briquetting process was employed to improve granulation of sintering mixture containing specularite concentrate. The experimental results show that granulating efficiency was debased obviously when the ratio of specularite fines in sinter blends exceeded 24%. Most specularite particles distributed in the fine granules of −1 mm and adversely affected the permeability of sinter bed. In granulation with specularite concentrate pre-briquetted, the average granule size and permeability of sinter bed increased by 11.17% and 12.69% respectively when the sinter blend contained 36% of specularite concentrate, compared with that in traditional granulation. The pre-briquetting process made the specularite concentrate into independent quasi particles preliminarily, thus changed granulation model and distribution of specularite particles in sinter bed and improved the granulation of sinter mixture containing high ratio of specularite concentrate.

Uticaj veličine čestica pripalne smeše na gradijent pritiska pripale raketnog motora

The paper discusses the influence of ignition mixture granulation onto the regime of rocket motor ignition. Igniter tests were performed in manometric bomb and pressure distribution was measured. In each test different granulations of the same mixture in powder form were tested. After that, two different ignition mixture compositions in the form of pressed tablets were tested. Total masses of ignition mixtures were equal in all the tests. In the first series of the igniter tests, very carefully chosen different granulation of the powder was used in each test, with the particles in a narrow range. From one to another test, only the granulation of the mixture was changed. The purpose was to determine if there exists an influence of the mixture granulation onto the pressure gradient and thus also onto the regime of the rocket motor ignition. It turned out, surprisingly, that there were no visible differences in the regimes of pressure increase due to the different granulation of the ignition mixtures. In another series of tests the mixture was prepared in the form of pressed tablets, with various sizes from test to test. Two different mixtures were tested, and the mass of each single charge of the igniter was the same as in the first series of tests. It is shown that the form of the pressed tablets, as well as their composition, may considerably affect the mode of rocket motor ignition.

Conceptual design of the mobile granulation line for production fertilizers from digestates and ash mixtures

Paper presents a concept of the mobile line for the production of granulated fertilizer from digestates and ash mixtures. The main assumption of the designed line is its mobility which allows line work in the place of production of digestate. The premise for developing such model of line was the fact that the transport of highly hydrated digestate, as well as its dried form, is not advisable for economic reasons. More advantageous solution is to collect the digestate at the place of its production and it is processed into a fertilizer. Loose components, characterized by high bulk density, can be delivered to the place of production and the same means of transport can be used to transport the produced fertilizer to warehouse. This production model allows to process the digestate produced in several biogas plants, using one production line and reducing the cost of production. of fertilizer granules and the mobile line is transported to the next post-fermentation production point. Based on an analysis of the raw material characteristics and preliminary research on the raw materials mixture granulation process it was assumed that the stage of 3 hrs mixture stabilization time is required in the line.

Development of Charge Pelletizing Technology Based on Electric Arc Furnace Dust for Pyrometallurgical Processing in Rotary Kilns

New technology is developed for Waelz treatment of electric arc furnace dust with the addition of calcium oxide to a charge. In this case, lead and halides are transferred into distillates. Calcium ferrite and zinc oxide remain in clinker. Clinker is sent for leaching zinc followed by zinc electrolysis from solution. The insoluble residue of calcium ferrite is used in ferrous metallurgy. The efficiency of this technology is determined by the process of charge preparation for loading into a Waelz kiln. In order to provide complete reaction of zinc ferrite with calcium oxide, it is necessary to provide effective component mixing; in order to provide selectivity of halide and lead liberation, reducing distillate volume, a powder mixture is pelletized. Exploratory research is conducted for preparing pellets of a mixture of electric arc furnace dust with lime, and the effect of some binder reagents on pellet strength is demonstrated. The following optimum parameters are determined for charge pelletizing from electric arc furnace dust and calcium-containing flux under conditions of a plate-like granulator: pelletizing duration 15 min; granule moisture content 19–20%. With the use of an intense type mixer-pelletizer, the optimum moisture content is 13–14%, which is connected with the improved conditions for pellet compaction. Comparison of various inorganic and organic additives for mixture granulation shows that the best are additives containing sodium hydrate sulfate, although their optimum consumption is unacceptable for the technology of material pyrometallurgical treatment. The presence in the production mixture of calcium-containing flux makes it possible to use it also as a binding additive for pelletizing calcium hydroxide in the form of an aqueous suspension. Feeding a pelletized mixture of electric arc furnace dust with lime into a Waelz kiln makes it possible to provide effective reaction of charge components in the kiln and to reduce to reduce escape of dust.

Choice of Binder and Optimization of Slag-Forming Mixture Granulation Technology to Improve Granule Strength

A procedure is described for qualitative evaluation of the effect of binders on granulated slag-forming mixture (SFM) strength. A relationship is established for slip density and finished granulate bulk density on water content. Industrial tests are conducted for a new binder and a test batch of granulated SFM is prepared with a low proportion of dusty fraction for pouring steel in a CBCM at MMK.

Compactible powders of omega-3 and β-cyclodextrin

Omega-3 fatty acids are used in both nutraceuticals and pharmaceuticals in the form of triglycerides and ethyl esters. Administration forms available for omega-3 include bulk oil, soft gel capsules, emulsions and some powder compositions. Cyclodextrins are substances well known for their ability to encapsulate lipophilic molecules. In the present work, powders loaded with omega-3 oil, ranging from 10 to 40% (w/w), have been prepared by vacuum drying, freeze drying or spray granulation of aqueous mixtures of omega-3 oil and β-cyclodextrin. The powders were found to be partially crystalline by powder X-ray diffraction and to contain crystalline phases not present in pure β-cyclodextrin, indicating true complexation. The compactibility of the powders has been explored, revealing that a dry and compactible powder can be prepared from various omega-3 oils and β-cyclodextrin. Spray granulation was found to be the superior drying method for the preparation of compactible powders.

Optimising method for improving granulation effectiveness of iron ore sintering mixture

The structure of granules has been investigated and a model of granulation determined. The results show that a granule consists of an adhesive layer and a nucleus. Particles with diameter under 0.5 mm act as adhesive fines, while the remainders act as nuclei. By studying the influencing factors of granulation, two significant particle characteristics assessing granulation performance were determined. One is the relative proportion of adhesive fines and nucleus particles, and the other is the specific surface area of adhesive fines. The method of optimising granulation of sinter mixtures is proposed as follows: the proportion of adhesive fines should be 40–50% and the specific surface area should exceed 1000 cm2 g−1, which contributes to achieving a better bed permeability, a faster sintering speed and higher productivity.

High shear granulation of binary mixtures: Effect of powder composition on granule properties

The granular product being designed in this work required the use of two different powders namely limestone and teawaste; these materials have different bulk and particle densities. The overall aim of the project was to obtain a granular product in the size range of 2 to 4mm. The two powders were granulated in different proportions using carboxymethylcellulose (CMC) as the binder. The effect of amount of binder added, relative composition of the powder, and type of teawaste on the product yield was studied. The results show that the optimum product yield was a function of both relative powder composition and the amount of binder used; increasing the composition of teawaste in the powder increased the amount of binder required for successful granulation. An increase in the mass fraction of teawaste in the powder mix must be accompanied by an increase in the amount of binder to maintain the desired product yield.

Intelligent Control of Sintering Mixture Moisture Based on RBF Model of Permeability

The process of lead-zinc sintering presents nonlinear, time-varying and strong coupling characteristics. Sintering mixture granulation water is an important part of lead-zinc smelting.By analysis mechanism and the relativity of technology parameters, the RBF neural network model of permeability is developed. Combining with the synthesize estimation model of permeability, an intelligent control method of sintering mixture moisture based on permeability is established. The model then further optimized through intelligent search algorithm. Thereby controlling the granulation mixture moisture to improve permeability.Simulation results show the proposed model could achieve better results. It could improve the quality and yield of sintering production.

End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression

This study showed near Infrared (NIR) and Raman spectroscopy with a multivariate calibration approach were very effective to determine blend uniformity end-point. A set of 36 trimebutine samples containing magnesium stearate, stearic acid, colloidal silicon oxide, talc as excipients (0.9%∼1.8%) was acquired from six positions during blending processing with U-type blender from 0 to 30 min. Principle component analysis (PCA) with NIR and Raman spectral data was used to confirm the end-point of blending. After 30 min, the scores of principle component (PC) 1 and principle component (PC) 2 for samples moved into one point, which clearly indicated the mixture of sample became homogenous. In addition, NIR and Raman spectroscopy has been applied to the quantitative analysis of 20 trimebutine samples containing 2∼40% in mixture granules, which divided into a calibration set of 15 samples and a prediction set of 5 samples for NIR spectral data. The standard error of calibration (SEC) and standard error of prediction (SEP) are 0.15% and 0.13%, respectively using NIR while SEC and SEP of 0.95% and 0.91% are obtained using Raman spectroscopy. The results showed the NIR and Raman spectroscopy with a multivariate calibration such as PCA and PLS provide the possibility of real time monitoring of homogeneity and content uniformity during blending process.