An experiment was conducted at Krishi Vigyan Kendra, Ferozepur, Punjab during rainy (kharif) seasons of 2018 and 2019 to study the effects of nitrogen levels and weed management in direct-seeded rice (Oryza sativa L.) (DSR). The results indicated that pendimethalin + bispyribac (W1) (5.25 and 2.95 m2) and oxadiargyl + bispyribac (W2) (6.05 and 3.95 m2) application reduced the density of narrow-leaved weeds (NLW) and broad-leaf weeds (BLW) followed by oxadiargyl + fenoxaprop (W3) (7.0 and 4.55 m2) during both the years. Application of W1 decreased the total weed biomass by 84–98.2%, respectively compared to weedy check (W5) (80.1 and 94.8 g/m2) in both years. Treatment W1 and W2 recorded at par values of grain and straw yield followed by W3. An increase (48.6–72.0%) in grain yield was registered with weed practices compared to weedy check in DSR. W1 and W2 significantly recorded higher N uptake in grain (61.45 and 60.85 kg/ha) and total (100.8 and 99.45 kg/ha) followed by W3 (53.85 and 90.35 kg/ha, respectively). The high infestation of BLW with W3 resulted in the lowest weed control efficiency (WCE) (46.2–53.9%) among the weed control practices. N at 120 and 150 kg/ha recorded the low density and biomass of NLW and BLW. Application of 120 and 150 kg N/ha enhanced the grain yield (4.89 and 5.25 t/ha) and net returns (55.1 and 60.5 × 103 ₹/ha) in both years. No N application recorded lowest N uptake in grain (87.71 kg/ha) and total (80.26 kg/ha) compared to 150 kg N/ha in both years. N levels at 120 and 150 kg/ha recorded higher values of water control efficiency (WCE). Based on the findings, it may be concluded that pendimethalin + bispyribac and oxadiargyl + bispyribac with N 120 kg/ha application can reduce weed flora diversity with higher grain yield of direct-seeded rice in Punjab.