Laminar thermally developing gas flow in a two-dimensional parallel plate channel with real gas radiation has been investigated numerically. Real gas spectral radiation effects are accounted for by using the Spectral Line Weighted-sum-of-gray-gases model. Gas mixtures of H2O and CO2, either alone in mixture with N2 or as a mixture of H2O and CO2 are considered. The phenomena are investigated for a range of differences between wall and inlet gas temperature, mole fraction of the radiating species, and total pressure. Predictions for the cases of gas heating and gas cooling are contrasted with results presented by the classical no-radiation case, commonly known as the Graetz solution. The impact of gas radiation on the local mean temperature, convective and radiative wall heat fluxes, and the convective, radiative, and total local Nusselt numbers are studied.The predictions reveal that the inclusion of participating gas radiation results in a much more rapid change in temperature of the gas in the channel than for the convection-only case, for both the gas heating and gas cooling cases. Further, unique differences in the heat transfer behavior for gas cooling (wall temperature below the inlet gas temperature) and gas heating (wall temperature above the inlet gas temperature) scenarios are shown. However, significant differences between the cases of heating and cooling exist. In the classical Graetz solution, for constant thermophysical properties and using appropriately nondimensionalized heat transfer parameters (e.g., Nusselt number, inverse Graetz number) the predictions for fluid heating and cooling are identical. However, the results of this study including the influence of gas radiation demonstrate that the heat transfer behavior depends heavily on whether the gas is heated or cooled. An apparent thermally fully developed condition may exist for the case of gas cooling, whereas the variation in local Nusselt number with dimensionless axial location exhibits a local minimum for the case of gas heating. Further, the case of gas heating results in a more rapid streamwise change in mean temperature in the channel than for the cooling case. The thermal physics of the developing flow for combined convective-radiative transfer with real gas effects are explored for a range of wall and gas inlet temperatures, radiating species mole fractions, and total pressures.