PurposeThis study aimed at exploring SDM implementation and its influencing factors, and preferences towards SDM among parents of children with cancer in China. Design and methodsThis cross-sectional study recruited 204 participants from 2 grade-A tertiary hospitals in Guangzhou, China. The preferences towards decision-making, the status of SDM were measured by CPS-P and SDM-Q-9. The nurse support were measure by NPST, the needs of parents were measured by Questionnaire for Needs of Parents Whose Children are in PICU, and sociodemographic and disease-related questionnaires were used to investigate general information of children and parents. Descriptive statistics, univariate analysis, and multivariable linear regression were used for data analysis. ResultsOf 204 participants, about half of parents (55.4 %) tended to choose SDM, however, 40.2 % of them still show passive attitudes. The mean SDM-Q-9 score was 31.07 ± 8.74, and the result showed that age (β = 2.480, P<0.05), relapse (β = 4.407, P<0.01), course of disease (β = −5.213, P<0.01), relationships with doctors (β = −4.05, P<0.05), trust in doctors (β = −2.796, P<0.05), and communication and information support from nurses (β = 0.651, P<0.01) were the main factors influencing SDM for parents. ConclusionsOver half of Chinese parents tended to choose SDM, but their real participation in SDM is unsatisfactory. Parents who were older, had good relationships with doctors, trusted in doctors, received more communication and information support from nurses, and whose children had shorter course of disease, suffered relapses, participated in SDM better.