GPS and InSAR observations of the first ∼1.5 years of postseismic deformation caused by the 2021 MW 7.4 Maduo earthquake provide a valuable opportunity to investigate fault interactions and regional rheological structure, as well as the future seismic potential around the Bayan Har block, northeastern Tibetan Plateau. We develop an integrated model to simulate the afterslip and viscoelastic relaxation contributions to the observed postseismic displacements, and found that afterslip driven by the coseismic stress is concentrated downdip of rupture, and dominates the postseismic deformation in the early stage (∼0.4 year after the event). Because afterslip decays quickly over time, viscoelastic relaxation should become the main postseismic mechanism as time goes on. The two mechanisms produce similar displacements during 0.4–1.5 years after the earthquake, but at 1.5 years after the earthquake the velocity caused by viscoelastic relaxation is larger than that caused by afterslip. Viscoelastic models assuming either a Burgers body or power-law rheology produce very similar predictions, with the Burgers body model having a slightly lower overall misfit. The rheological structure constrained by the postseismic observations supports the 35-km thick elastic upper crust overlying a Burgers body viscoelastic lower curst with a Maxwell viscosity of 3 × 1019 Pa s (5 - 50 × 1018 Pa s at 95% confidence), assuming the Kelvin viscosity is equal to 10% of that value. This is different from the regional rheology inferred by the postseismic investigations on the 2001 MW 7.8 Kokoxili and the 2008 MW 7.8 Wenchuan events, and the preferred thickness of the elastic crust is also different from that inferred from magnetotelluric profiles deployed in previous studies. We thus infer that the rheological structure within the Bayan Har block is possibly heterogeneous from west to east. Finally, the normal stress changes triggered by the coseismic rupture and postseismic process are estimated to be negative, but the shear stress changes to be positive on the western Kunlun fault, the eastern Dari fault and Bayan-Har Mountain fault. However, the current observations and studies are quite insufficient on those fault segments, therefore, we need to focus on their faulting behavior and seismic risk in the future.