Human-wildlife coexistence has become increasingly pressing in sub-Saharan Africa, especially Uganda, highlighting the need for an effective conservation education programme. The relationship between Conservation education and Human-wildlife coexistence in Uganda remains an open question. Therefore, this study aimed to assess the influence of conservation education on pro-wildlife sustainability behaviour at the eco-centric zone of Budongo Central Forest Reserve (CFR) in Uganda. Two specific objectives guided the research which include to: document the existing conservation education programs involved in enhancing human-wildlife coexistence around Budongo CFR; and to determine the influence of conservation education programs towards enhancing human-wildlife coexistence around Budongo CFR. The study employed a descriptive survey design where mixed-methods approach, including quantitative and qualitative surveys were carried out. Key informant interviews were carried out to elicit information from some community leaders and teachers. In addition, field observations were done to gauge the success of these programs towards fostering human-wildlife co-existence. The study revealed various conservation education programs in place, including environmental education in schools, community outreach programs, ecotourism, sustainable agriculture, and forest restoration. Notably, conservation education in schools played a significant role, contributing 59.1% to the variance in human-wildlife co-existence. A Pearson Correlation Coefficient analysis indicated a strong positive significant relationship between conservation education programs and improvements in human-wildlife co-existence (r=0.973, Sig=0.000). The findings showed that well-designed conservation education programs have the potential to enhance community awareness, reduce conflict incidents, and encourage sustainable co-habitation practices. However, challenges such as cultural nuances and resource limitations pose significant hurdles to program effectiveness. In conclusion, this research demonstrates the effectiveness of conservation education programs in enhancing human-wildlife coexistence around Budongo CFR. These programs have not only increased knowledge and positive attitudes but also fostered local capacity to conservation. There should be a continued investment in these programs by the government, NGOs, CBOs, and industry experts aimed at promoting sustainable coexistence and conservation in the Budongo CFR and similar areas in the country.