The Godavari geothermal field in India is one of the potential areas manifested by several geothermal waters and groundwaters. The geothermal waters of the area are near neutral (pH: 6.5–7.3) with surface temperature ranging from 30 to 55 °C while groundwaters are also near neutral (pH: 6.6–7.5) with surface temperature ranging from 24 to 28 °C. The hydrogeochemistry of the geothermal waters suggests that the geothermal waters show a Na-Ca-SO4-HCO3 to a Ca-HCO3 type and groundwaters are of the Ca-HCO3 to Na-Ca-HCO3 type while groundwaters and river waters are of the Ca-Na-SO4 types. The geothermal waters of the study area are enriched in SO42– and Cl–, due to the interaction with the pyrite-bearing Gondwana sediments and granitic gneiss basement rocks. Furthermore, enrichment of Ca2+, Mg2+ and an increased HCO3/Cl ratio in geothermal water is caused by the exchange and/or mixing process that takes place during water-rock interaction at an elevated temperature while ascending to the surface. This type of behavior of water is also observed during the water-rock interaction experiment at 100 °C.Studies on geothermal gas geochemistry suggest the deeper circulation of geothermal waters in the crust and high helium concentration as a thermal gas that can be utilized for commercial purposes. Estimated reservoir temperatures from quartz and Na-K-Ca geothermometry are in the range 110–195 °C. Therefore, the geothermal water of the study area is categorized as a moderate enthalpy geothermal system. Thermal logging in the borewell and depth range from 50 to 1000 m suggest that the geothermal gradient in the Manuguru area ranges from 22.5 to 105.5 °C/km and heat flow ranges from 83 to 388 mW/m2, which is higher than the regional condition. Therefore, 3584 MWe power can be produced by using the Organic Rankine Cycle (ORC) from the Manuguru geothermal area of Godavari valley.